GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species...

Electronic health records (EHRs) have become the cornerstone of population-scale genetic studies1, but factors including patterns of healthcare use shape which and how diagnoses are recorded, leading ...

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The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

How to balance open data sharing and public responsibility

The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...

Group Leader Research Fellowship Sponsorship Scheme in the Department of Genetics at the University of Cambridge.

Molecular Psychiatry - Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

Molecular Psychiatry - Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

Sadowski et al. propose a framework to study the genetics of response to commonly prescribed drugs in large biobanks. They quantify the heritability of response to statins, metformin, warfarin, and methotrexate, and identify associated genes. Their analysis also shows the importance of accounting for drug use in genetic risk prediction.

Phenotype imputation increases the effective sample size of major depressive disorder cases in UK Biobank, enhancing study power and polygenic risk score (PRS) accuracy. A new pleiotropy metric enable...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

An Owner's Guide to the Human Genome