Microtubules (MTs) undergo continuous cycles of growth and disassembly. Because the transitions between these states are stochastic, MT age varies widely within a population. As MTs age, they are thou...

Microtubules are key components of the eukaryotic cytoskeleton involved in vital functions in virtually every cell. Among the emerging molecular mechanisms to adapt microtubules to their diverse funct...

Motile cilia rely on highly stable axonemal microtubules reinforced by microtubule inner proteins (MIPs) that form a network within their lumen, yet the functions of individual MIPs remain poorly unde...

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This study shows that kinesin-driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self-repair and leads to filament failure. While curvature, motor motility, and...

Tubulin conservation presents a challenge to understanding microtubules’ diverse functions in eukaryotes. Here, the authors characterize the structures of P. falciparum microtubules to show how evolut...

This study presents a structural basis for understanding how microtubules can act as spatiotemporal signal sensors to control cellular responses.

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Proximity labeling allows proteomic mapping of subcellular structures. Here, Sroka et al. develop in situ APEX activation (iAPEX) to overcome limitations of labeling specificity and H2O2 toxicity, app...