NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Change: Early Expiration of NINDS Ruth L. Kirschstein National Research Service Award (NRSA) for Training of ...

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

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Molecular Psychiatry - Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau

Optimal brain function requires that neurons carry out extensive post-transcriptional RNA processing to produce a vast diversity of transcripts. Accurate reconstruction and quantification of highly pr...

Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control gene expression and human stem cell fate.

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

In this Journal Club, Nina Rzechorzek explores a 2003 article showing that, during hibernation, ground squirrels reversibly accumulate highly phosphorylated tau in the brain (a hallmark of Alzheimer’s...

Our genomes are peppered with DNA segments called retrotransposons that can move from place to place. When unleashed, some can kill nerves and promote inflammation — a discovery that may inspire treat...

Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The...

The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own

A pause to NIH funding has researchers scrambling for contingency plans at the University of Washington’s Alzheimer’s Disease Research Center. The center’s brain bank is preserving more than 4,000 bra...

But public-health specialists worry that misinformation and funding cuts could affect vaccination rates.

Background Therapeutic development for frontotemporal dementia (FTD) is hindered by the lack of biomarkers that inform susceptibility/risk, prognosis, and the underlying causative pathology. Blood gli...

npj Dementia - A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD)

Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behavio...

Such a shift would “put us back in the dark ages in terms of our science,” says neuroscientist Anne Murphy, who helped to formulate the original policy.

Executive orders’ impact on premier medical research agency has resulted in delayed projects and frozen funding