The actual prevalence, researchers said, may be much higher.

Abstract. There is growing interest in whether adult vaccines such as shingles vaccine may slow biological aging beyond preventing acute infections. Using

SOUTH SAN FRANCISCO, Calif., Oct. 21, 2025 (GLOBE NEWSWIRE) -- Alector, Inc. (Nasdaq: ALEC), a clinical-stage biotechnology company focused on developing...

A Westlake Village man living with frontotemporal dementia has something few people with the condition do: the ability to describe his disease.

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How a bold idea and smart federal investment created jobs, built a company, and is helping diagnose Americans in all 50 states.

Amyotrophic lateral sclerosis (ALS) is a progressive and ultimately fatal neurodegenerative disorder that affects motor neurons responsible for initiating and controlling voluntary muscle movement and...

A growing body of research suggests that preventing the viral infection can help stave off cognitive decline.

TDP-43 pathology characterizes neurodegenerative diseases. Scialò et al. use in vitro-generated and patient-derived TDP-43 aggregates as seeds to show that seed-induced TDP-43 cytoplasmic aggregation ...

In one tiny town, more than a dozen people were diagnosed with the rare neurodegenerative disease ALS. Why?

Clinical trial of people destined to develop early-onset Alzheimer’s disease shows eliminating amyloid from brain may prevent symptoms, supports need for confirmatory studies

Background Therapeutic development for frontotemporal dementia (FTD) is hindered by the lack of biomarkers that inform susceptibility/risk, prognosis, and the underlying causative pathology. Blood gli...

O’Neill et al. present a deep exploration of molecular subtypes in ALS postmortem tissues from the NYGC ALS Consortium. Matched bulk and single-cell profiles demonstrate that ALS subtypes are a combin...

See Active FTD Biomarkers Initiative Award Recipients

Nature - The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

This weekend, I took some time to analyze the biggest #blockbusters in the #pharmaceutical industry. My goal? I was curious to determine what percentage of… | 30 comments on LinkedIn

A cohort study of over 15,000 US adults found that the lifetime risk of developing dementia from ages 55 to 95 is 42%, with the highest risk in APOE ε4 carriers, women and Black adults, and projected ...

The study may suggest that other researchers should be less optimistic about the prospects for treating a range of other conditions with newer weight-loss drugs.

Shedding light onto the role of phosphorylation in TDP-43 cytoplasmic mis-localization.

Generation and characterization of induced pluripotent stem cell (iPSC)-derived astrocytes from 44 aged humans reveals congruence of gene expression profiles between astrocyte cultures and brain and ...

Nature Communications - Misfolded α-synuclein propagates trans-neuronally through anatomically interconnected networks, but how this propagation impacts cellular and circuit activity is...

Preventing or treating infections could be a key means of warding off dementia, a new evidence review says.

Fraud in research needs to end.

Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whether existin...

Researchers facing

Recently, the U.S. Department of Health and Human Services (HHS) asked the National Institutes of Health (NIH) to take the lead in implementing the National Plan to End Parkinson's Act, with support f...

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A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?

In an effort to learn from scientific failure, The Journal of Trial Error only publishes “negative” results.