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Tal Nuriel, PhD

@talnuriel.bsky.social
1.3K followers 317 following 460 posts

Assistant Professor at Columbia University Irving Medical Center. My lab studies the role of APOE4 in Alzheimer’s disease pathogenesis. Opinions are my own.

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Reposted by Tal Nuriel, PhD
Dementia Researcher @dementiaresearcher.bsky.social · 11/05/2026
Senior Associate Director role at Alzheimer’s Association leading scientific grants, peer review and clinical trial pipeline tracking in dementia research. www.dementiaresearcher.nihr.ac.uk/job/senior-a...
dementiaresearcher.nihr.ac.uk
Senior Associate Director: Scientific Grants
Alzheimer’s Association seeks a Senior Associate Director to lead scientific grants, peer review and clinical trial pipeline tracking in dementia research.
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Tal Nuriel, PhD @talnuriel.bsky.social · 17/04/2026
60 centiloids. Fascinating. www.alzforum.org/news/confere...
alzforum.org
Your Amyloid Load Determines When, and How Fast, Tangles Spread | ALZFORUM
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Tal Nuriel, PhD @talnuriel.bsky.social · 13/03/2026
My grant that I submitted in October finally got assigned to a study section scheduled for May 21. Quite the system we've got going here.
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Tal Nuriel, PhD @talnuriel.bsky.social · 04/03/2026
Gotta love a story about a nice Jewish boy listening to the advice of his mother. www.science.org/content/arti...
science.org
Meet three scientists who said no to Epstein
The warning signs included a web search, a mother’s doubts, and inklings of a “sexist attitude”
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Tal Nuriel, PhD @talnuriel.bsky.social · 27/02/2026
This is a very carefully worded way of saying that all funding decisions are coming from top from here on out. Also, no more paylines. grants.nih.gov/news-events/...
grants.nih.gov
NIH Institute and Center Director Perspectives on Implementing the NIH Unified Funding Strategy | Grants & Funding
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Tal Nuriel, PhD @talnuriel.bsky.social · 19/02/2026
I sure would like to have time to focus on completing and writing up the actual science. What a silly system we’ve got.
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Tal Nuriel, PhD @talnuriel.bsky.social · 05/02/2026
Why on earth would zoom’s default setting be to allow meeting attendees to annotate your shared screen? I gave a public seminar yesterday, and one of the attendees started drawing red lines on the presentation slides 🤦🏻‍♂️. I didn’t even know that was possible.
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Tal Nuriel, PhD @talnuriel.bsky.social · 30/01/2026
Bravo. This MIGHT be why. I wish every science joirnalism article framed it this way. theconversation.com/people-who-s...
theconversation.com
People who survive cancers are less likely to develop Alzheimer’s – this might be why
A new mouse study suggests some cancers release signals that help the brain clear Alzheimer’s-linked proteins, offering clues to a long-standing medical mystery.
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Reposted by Tal Nuriel, PhD
Dr. Cate Peña @cate-cholamine.bsky.social · 27/01/2026
This quantification of loss is staggering. And knowing some of the excellent people that make up these numbers… is heartbreaking www.science.org/content/arti...
science.org
U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office
A Science analysis reveals how many were fired, retired, or quit across 14 agencies
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Tal Nuriel, PhD @talnuriel.bsky.social · 25/01/2026
It looks like another government shutdown might be incoming. Which means more study section and council delays, and more scientists holding on by an ever thinning string. But you won’t see many scientists complaining, because I assume most of us agree that Congress needs to try and restrain ICE.
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Reposted by Tal Nuriel, PhD
Dementia Researcher @dementiaresearcher.bsky.social · 21/01/2026
Fully funded PhD programme at Kings College London training researchers to use human genetics AI and multi omics for therapeutic target discovery. Closing date: 28th February www.dementiaresearcher.nihr.ac.uk/job/phd-geno...
dementiaresearcher.nihr.ac.uk
PhD: Genome Data Science - DEMENTIA RESEARCHER
Kings College London offers fully funded PhDs using genome data science and AI to discover therapeutic targets for disease.
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Tal Nuriel, PhD @talnuriel.bsky.social · 10/01/2026
This study makes my head hurt. Can a gene variant that’s present in 95% of human beings (APOE3) be considered a risk allele? www.ucl.ac.uk/news/2026/ja...
ucl.ac.uk
Most Alzheimer’s cases linked to variants in a single gene
Potentially more than 90% of Alzheimer’s disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers.
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Tal Nuriel, PhD @talnuriel.bsky.social · 27/12/2025
Apparently 2025 was a big year for APOE4 publications
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Tal Nuriel, PhD @talnuriel.bsky.social · 10/12/2025
A powerful maiden speech by my senator, whose dad was recently diagnosed with Alzheimer’s disease. newjerseyglobe.com/congress/in-...
newjerseyglobe.com
In maiden Senate speech, Andy Kim promises to care for his father and for America - New Jersey Globe
Exactly one year after he was first sworn in as a U.S. Senator, Andy Kim gave his maiden speech on the Senate floor today. The speech, technically Kim’s
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Tal Nuriel, PhD @talnuriel.bsky.social · 19/11/2025
My lab member @arainhirra.bsky.social was saying that she thinks journals should pay scientists to publish their research. I hadn’t really thought about it, but now that I do…why haven’t there been smaller journals that have tried to leapfrog the larger journals by offering to buy high impact work?
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Reposted by Tal Nuriel, PhD
Hussein N. Yassine @yassinelab1.bsky.social · 16/11/2025
APOE-directed therapeutics in AD: My first substack post: open.substack.com/pub/hyassine...
open.substack.com
ApoE directed Therapeutics in Alzheimer's disease, SFN 2025
Alzheimer’s disease has historically been viewed through the lens of amyloid plaques and tau tangles, but accumulating evidence shows that these features alone cannot fully explain why some individual...
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Tal Nuriel, PhD @talnuriel.bsky.social · 16/11/2025
Currently watching Pluribus, and they’ve got their rats in mouse cages. Someone call IACUC.
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Tal Nuriel, PhD @talnuriel.bsky.social · 15/11/2025
www.nature.com/articles/d41...
nature.com
Three rising stars in ageing research
From Alzheimer’s to obesity, these researchers are tackling the most common age-related conditions.
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Tal Nuriel, PhD @talnuriel.bsky.social · 08/11/2025
Love this story (although the headline’s a little misleading). apple.news/A5noSQhLDRdu...
apple.news
6-year-old girl comes to the rescue of Harvard researchers studying the axolotl — CBS News
Earlier this year, a Harvard research team studying the axolotl, a salamander with the superpower to regrow body parts, lost almost all its government funding.
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Tal Nuriel, PhD @talnuriel.bsky.social · 06/11/2025
I feel slightly less guilty about using AI to help me write a grant about an AI-based project. But that might be how the machines want me to feel.
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Reposted by Tal Nuriel, PhD
Liisa Galea @liisagalea.bsky.social · 31/10/2025
While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from @bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
sciencedirect.com
Sex-specific factors and APOEε4 genotype alter functional connectivity at middle age
Cognitive aging is influenced by sex and sex-specific factors. Indeed, research has shown that parity (pregnancy and parenthood) uniquely alters bioma…
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Tal Nuriel, PhD @talnuriel.bsky.social · 31/10/2025
Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.
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Reposted by Tal Nuriel, PhD
Selina Wray @selinawray.bsky.social · 29/10/2025
In the mood for something sciency and spooky? How about the Halloween special of @uclbrainstories.bsky.social - where me and @caswell.bsky.social talk to @drjlange.bsky.social on some of the gothic stories in neuroscience! 👻 🧠 🎃 💀🧟‍♂️ spotify.link/2lHT9pLQRXb
spotify.link
Episode 23- Jenny Lange on the gothic history of neuroscience, a Halloween special
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Tal Nuriel, PhD @talnuriel.bsky.social · 29/10/2025
Don't worry folks! Pretty soon we'll go from having a 0% chance of getting grants (govt shutdown) to having a 5% chance of getting grants (continuing resolution and multi-year funding). But that's only temporary...eventually, it'll go back to the easy-peasy 10-15% funding lines we all know and love.
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Tal Nuriel, PhD @talnuriel.bsky.social · 29/10/2025
Very interesting
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Tal Nuriel, PhD @talnuriel.bsky.social · 28/10/2025
That's a hell of a figure. www.alzforum.org/news/researc...
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Tal Nuriel, PhD @talnuriel.bsky.social · 27/10/2025
Hmm. Reading about oxygen administration for preterm babies and the potential for hyperoxia and oxidative stress, and that is a topic that I’ve heard zero info about up until now.
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Tal Nuriel, PhD @talnuriel.bsky.social · 24/10/2025
Pushing through my skepticism to review these K99 and K01 applications I've been assigned. The good news is that there are some tremendous applicants that could contribute so much if given the chance. The bad news is that there's no way to give them a chance if the govt doesn't open back up.
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Reposted by Tal Nuriel, PhD
Matt Wall @mattwall.bsky.social · 24/10/2025
Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects. pubs.acs.org/doi/abs/10.1...
pubs.acs.org
Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics
Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...
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Tal Nuriel, PhD @talnuriel.bsky.social · 23/10/2025
Is it sad that my first thought was: a five year cell culture experiment isn't that bad. There would still be two years left to finish up their PhD or postdoc 😭 😭https://www.alzforum.org/news/research-news/neurons-born-and-raised-organoids-act-their-age
alzforum.org
Neurons Born and Raised in Organoids Act Their Age | ALZFORUM
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Reposted by Tal Nuriel, PhD
Selina Wray @selinawray.bsky.social · 22/10/2025
Link to buy below. Even as a 43yo neuroscientist I enjoyed a lot! I mean… who wouldn’ love a book that has monkeys with robot arms & pirate kittens! uk.bookshop.org/p/books/insi...
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Tal Nuriel, PhD @talnuriel.bsky.social · 20/10/2025
Currently reviewing grants for a study section that probably won't happen. Whose idea was it to link the success our scientific enterprise with the proper functioning of the federal government?
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Reposted by Tal Nuriel, PhD
Dementia Researcher @dementiaresearcher.bsky.social · 12/10/2025
Tenure-track Investigator Vacancy, Brown University Center for Alzheimer’s Disease Research. Join Carney Institute exploring neurodegeneration and dementia. Closing date: 1st November www.dementiaresearcher.nihr.ac.uk/job/assistan...
dementiaresearcher.nihr.ac.uk
Assistant Professor: Center for Alzheimer’s Research
Tenure-track Investigator, Brown University Center for Alzheimer’s Disease Research. Join Carney Institute exploring neurodegeneration and dementia.
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Reposted by Tal Nuriel, PhD
Dementia Researcher @dementiaresearcher.bsky.social · 12/10/2025
PhD position, University of Manchester. Study how APOE genotype, menopause and exercise interact to influence vascular dysfunction and dementia risk in Alzheimer’s. Closing date: 8th November www.dementiaresearcher.nihr.ac.uk/job/phd-alzh...
dementiaresearcher.nihr.ac.uk
PhD: Alzheimer’s risk in women, menopause, apoe & exercise
PhD position, University of Manchester. Study how APOE genotype, menopause & exercise interact to influence vascular dysfunction & dementia risk in Alzheimer’s
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Reposted by Tal Nuriel, PhD
Mark Peifer (He, him) @peiferlabunc.bsky.social · 12/10/2025
The 2nd of 6 faculty positions open at UNC Biology is for an Asst Professor studying critical questions in Plant Molecular Biology, focusing on molecular mechanisms illuminating fundamental aspects of plant biology, including interactions with other organisms 1/n unc.peopleadmin.com/postings/307...
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Reposted by Tal Nuriel, PhD
Jason Cohen, MD @memorydoc.bsky.social · 05/10/2025
Covid causes brain damage. Edit: Covid causes serious long term brain damage, and here's a whole lot more data "COVID-19 infection was associated with a 58% increased risk of all-cause dementia and a 105% increased risk of Vascular Dementia" Free article: www.nature.com/articles/s44...
nature.com
COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years - npj Dementia
npj Dementia - COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years
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Reposted by Tal Nuriel, PhD
catie profaci, phd @cprofaci.bsky.social · 01/10/2025
Rocío is an amazing scientist, mentor, and person in general!!! Please share this job opening with anyone who might be interested 🤩🤩
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Reposted by Tal Nuriel, PhD
Fernanda Ferreira @fernandaedi.bsky.social · 30/09/2025
Posting on behalf of Tamar Gollan, who is not on Bluesky: A postdoc position is open and available immediately in Dr. Tamar Gollan’s Laboratory of Aging Bilingualism at the University of California, San Diego, funded by NIH & NSF. See link for details! psychiatry.ucsd.edu/about/LAB_Go...
psychiatry.ucsd.edu
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Tal Nuriel, PhD @talnuriel.bsky.social · 28/09/2025
Attended a conference yesterday, and one of the speakers spent his whole talk airing his personal grievances about other scientists who he felt had wronged him throughout his career. Made me want to crawl out of my skin.
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Reposted by Tal Nuriel, PhD
James Harvey @keepof4worlds.bsky.social · 24/09/2025
Wonderful news. A salutary reminder of the absolute benefits of scientific progress, and the absolute evil of conspiracist bollocks. Huntington's disease successfully treated for first time www.bbc.com/news/article...
bbc.com
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that could transform lives, tearful doctors tell BBC
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Tal Nuriel, PhD @talnuriel.bsky.social · 24/09/2025
I just read the paper out of Harvard that prompted this tylenol autism announcement. They make a strong argument that acetaminophen use during pregnancy may be causal for neurodevelopmental disorders and that its use should be limited ehjournal.biomedcentral.com/articles/10....
ehjournal.biomedcentral.com
Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - Environmental Health
Background Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed...
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Tal Nuriel, PhD @talnuriel.bsky.social · 23/09/2025
Sadly…and all so that they could meet some arbitrary September deadline that RFK Jr randomly blurted out.
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Reposted by Tal Nuriel, PhD
Ian Kremer @wolverinebear.bsky.social · 23/09/2025
New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com #Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
thelancet.com
New landscape of the diagnosis of Alzheimer's disease
Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individu...
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Reposted by Tal Nuriel, PhD
Rik van der Kant @rikvanderkant.bsky.social · 22/09/2025
Proud to present our new paper in @natmetabolism.nature.com The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases lnkd.in/eVzFrmUY Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Tal Nuriel, PhD @talnuriel.bsky.social · 20/09/2025
Can someone who knows this stuff better than I do tell me if Trump’s new $100K H1-B rule applies to non-profits/Universities? I’m assuming no, but probably shouldn’t be assuming anything reasonable anymore.
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Reposted by Tal Nuriel, PhD
Harmit Singh Malik @harmitmalik.bsky.social · 17/09/2025
My awesome Drosophila colleague Akhila Rajan at Fred Hutch (Seattle) is recruiting both a staff scientist and a postdoc to study fat–brain communication, innate immunity, mitochondrial signaling, and brain senescence. Great team, great environment. Apply here: careers-fhcrc.icims.com/jobs/30062/j...
careers-fhcrc.icims.com
Fred Hutchinson Cancer Center
Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.
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Reposted by Tal Nuriel, PhD
Nixon Lab @nixonlab.bsky.social · 15/09/2025
Nixon Lab is hoping to recruit a postdoctoral fellow interested in alcohol-microglia and/or alcohol-neural stem cell interactions in recovery from alcohol-induced brain and behavioral damage/dysfunction. Open fellowships on our NIAAA-funded T32! Please spread the word!
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Reposted by Tal Nuriel, PhD
Sarah Harris @saraheharris99.bsky.social · 10/09/2025
Calling for your paper for the upcoming collection Brain metabolomics in dementia and neurological disease I’m honoured to be serving as the collection’s Guest Editor and eager to read your submission. #CallForPapers @natureportfolio.nature.com Learn more about the collection: go.nature.com/41S5bI3
go.nature.com
Brain metabolomics in dementia and neurological disease
This Collection invites original research using metabolomic platforms to explore the mechanisms of dementia and neurological disease or aid in its diagnosis ...
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Tal Nuriel, PhD @talnuriel.bsky.social · 05/09/2025
I don’t know if it’s overall a good thing or a bad thing for science, but I have to say…the papers I review now are a hell of a lot clearer and easier to read than they were before chatGPT was invented. Which honestly, I don’t mind.
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Reposted by Tal Nuriel, PhD
Andrew Iwaniuk @evoneuro.bsky.social · 04/09/2025
For anyone on the neuroscience job market, our ads are up. We are looking for anyone working in systems neuroscience of animals to join us in southern Alberta 🇨🇦 #academicsky #neuroskyence #neuroethology #academicjobs #Canada neurojobs.sfn.org/job/39049/as...
neurojobs.sfn.org
Assistant Professor (Neuroscience, Tenure Track) - Lethbridge (City), Alberta (CA) job with University of Lethbridge | 39049
Assistant Professor (tenure track) of the Department of Neuroscience at the University of Lethbridge, Alberta, Canada
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