The tech world is too busy dreaming up imaginary doomsday scenarios to focus on a very real one that flared up between nuclear powers.

Former Speaker of the House Newt Gingrich argues that the Democratic Party has ‘lost its head’ ahead of the midterms on ‘Jesse Watters Primetime.’

Brian Kobilka’s path to biochemical research might have been unconventional, but it led to a Nobel Prize.

Long COVID is an emerging chronic condition that results in substantial impairments in quality of life, physical function, and ability to maintain gainful em...

The AI hyperscalers will likely spend more than $1 trillion on data centers next year. Can they make enough money to sustain the infrastructure boom?

Muller et al. review how spiking and synaptic activity are often organized as traveling waves in single cortical areas that modulate excitability, perception, and behavior. Specific features of these ...

Ribosomal RNA (rRNA) transcription rates vary during development, and their dysregulation is linked to diseases such as cancer and ribosomopathies. Owing to their high abundance and genomic redundancy...

p53 shuts down the spatial signaling of a morphogen and prevents clonal cell expansion

Although tumor protein p53 (TP53) mutations are among the most common lesions in epithelial cancers, how p53 loss drives unrestrained clonal expansion remains unclear. Working with mouse epidermis, we...

PhD projects for the 2027 Crick PhD programme.

The 2026 class features one NBA player, three WNBA players, three coaches, one referee and one whole team.

Human APOBEC3 (A3) proteins restrict retrovirus infection by inducing hypermutations in viral cDNA. To counteract this restriction, lentiviruses, such as HIV-1 and HIV-2 encode the viral infectivity factor (Vif), which hijacks a host Cullin-RING E3 ubiquitin ligase complex to target A3 proteins for proteasomal degradation. Here, we present the cryo-EM structure of HIV-2 Vif in complex with human A3H and CBFβ. The structure reveals that A3H forms a dimer mediated by dsRNA where each A3H monomer directly interacts with an HIV-2 Vif and the host protein CBFβ. Both HIV-2 Vif-A3H and CBFβ-A3H interfaces are critical for A3H degradation. Notably, however, the HIV-2 Vif-A3H interface is entirely distinct from the previously determined cryo-EM structure of the HIV-1 Vif and A3H complex. These findings suggest that HIV-1 and HIV-2 Vif, which are the result of distinct cross-species transmissions from species with different A3H characteristics, have followed separate evolutionary trajectories to