Neuropsychopharmacology - Dorsal raphe nucleus enkephalin peptide modulates behavioral preference

Listen to the top five travel awardees from the 2026 USASP Annual Meeting which took place from March 23-26, 2026 in Philadelphia, Pennsylvania. In this episode, we will learn on the current work fro

The research suggests that men’s immune systems have a better mechanism for shutting off pain, which could explain why women have more chronic symptoms.

Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.

Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp...

Sensory neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are critical for transmitting somatosensory information, including pain, to the central nervous system. In these neurons, a...

Neuropsychopharmacology - Central amygdalar PKCδ neurons mediate fentanyl withdrawal

Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...

Chronic low back pain (LBP), often correlated with intervertebral disc degeneration, is a leading source of disability worldwide, yet remains poorly understood. Current treatments often fail to provid...

Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...

The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

A new US population-based analysis shows significant increases in the prevalence of chronic pain, and of high-impact chronic pain, in the wake of the pandemic. The upsurges were apparent for almost al...

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Inflammatory joint pain features in numerous musculoskeletal disorders that affect millions globally. The Prdm12 gene encodes a conserved zinc finger transcriptional regulator expressed selectively in...

Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...

Sensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood. Autoantibodies ag...

A new US population-based analysis shows significant increases in the prevalence of chronic pain, and of high-impact chronic pain, in the wake of the pandemic. The upsurges were apparent for almost al...

A full-day symposium with 14 guest speakers from around the world.

Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...

Neuropsychopharmacology - Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol

Cancer pain is a complex problem that, when left unaddressed, can impact overall survival and decrease patients’ quality of life. Collaboration among medical oncologists, immunologists, and neurobiolo...

Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...