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Aleyah E. Goins @goinsyeah.bsky.social · 03/09/2026

Pure bliss to have worked with an amazing mentor @alleslab.bsky.social who supported me pushing into the wild and wonderful field of neuroimmune pain mechanisms! Thank you to my co-authors for your contributions!!! Bueno bye PhD dissertation 🎉💚❤️

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StanfordPain @stanfordpain.bsky.social · 09/02/2026

Gabapentin has been an effective medication for many people living with pain. It is particularly helpful for neuropathic pain when used thoughtfully.

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Alles Lab @alleslab.bsky.social · 17/09/2025

Our final contribution to this collaboration is now online. We obtained electrophysiological recordings of DRG/TG neurons and Fos+ neurons of spinal dorsal horn & vlPAG in 2 models of neuropathic pain to study the actions of a humanized P2X4R scFv #PainResearch www.sciencedirect.com/science/arti...

sciencedirect.com

Physiological actions of a humanized P2X4 scFv on peripheral and central neurons in male mice with neuropathic pain

Neuropathic pain remains a challenging clinical condition due to its resistance to conventional analgesics. The purinergic P2X4 receptor (P2X4R), an A…

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Nesia Zurek, PhD @docnessmonster.bsky.social · 10/09/2025

⚡We are finally electrocuting DRG neurons in the @alleslab.bsky.social since moving to @cincychildrens.bsky.social! #PainResearch #ephys #NeuroSkyence

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Alles Lab @alleslab.bsky.social · 28/08/2025

First grant since joining @cincychildrens.bsky.social has been awarded!! Excited to get to work on NIH HEAL Initiative "Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome" with the de la Pena lab!!! #PainResearch

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Alles Lab @alleslab.bsky.social · 26/08/2025

One of our final papers from this collaborative effort involving collaborators at UNM, Mayo Clinic, & McGill. Here we validate a humanized scFv targeting hP2XR. Kudos to first-author @docnessmonster.bsky.social & former lab member Mark S. for making this happen! journals.sagepub.com/doi/10.1177/...

journals.sagepub.com

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

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Nesia Zurek, PhD @docnessmonster.bsky.social · 20/08/2025

📸 Big day in the lab! Our new electrophysiology rig is officially up and running — huge thanks to everyone who helped make this happen. Excited for the science ahead! 🧠⚡️ @alleslab.bsky.social @cincychildrens.bsky.social #PainResearch

Three lab members standing proudly in front of a newly assembled electrophysiology rig. The setup includes a micromanipulator, amplifier, and monitor, with cables neatly arranged. Everyone is smiling in casual lab attire, celebrating the milestone in a well-lit lab space.

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Aubin Moutal @aubinmoutal.bsky.social · 08/08/2025

I’m proud to share that our first paper from the lab has just been published in Nature Communications: www.nature.com/articles/s41... This work uncovers a mechanism by which autoantibodies targeting CRMP5 contribute to neuropathic pain in paraneoplastic syndromes. #PainResearch

nature.com

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats - Nature Communications

Lung and thymoma cancer patients often suffer from autoimmunity and related painful neuropathies. Here the authors show that patient-derived anti-CRMP5 autoantibody binds to rat dorsal root ganglia to...

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Alles Lab @alleslab.bsky.social · 14/07/2025

Our collaborative study with the de la Peña lab is now online! Here we analyzed ephys & transcriptomic actions of gabapentin on hDRG neurons. Kudos to co-first authors Jenna & @docnessmonster.bsky.social. Special thks to our donors & their families #PainResearch journals.sagepub.com/doi/10.1177/...

journals.sagepub.com

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

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Alles Lab @alleslab.bsky.social · 25/05/2025

Lab outing for a Reds game and we beat the Cubs... go @reds.com!

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Alles Lab @alleslab.bsky.social · 16/05/2025

Good times at the Cincy Neuroscience Retreat connecting with neuro people @cincychildrens.bsky.social & UC and exploring trails of Ohio! #neuroskyence

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tBerta Lab @tbertalab.bsky.social · 08/04/2025

🔬 Exciting discovery! We've been curious about the function of unique IBA1+ cell staining we observed around healthy human DRG neurons in the lab (indicated by red arrows). A new paper @cellpress.bsky.social finally provides some answers. Link: www.cell.com/cell/fulltex...

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Alles Lab @alleslab.bsky.social · 24/03/2025

Made it to Cincy and I found the trail! 🏃‍♂️

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Eric Topol @erictopol.bsky.social · 10/03/2025

Who funds biomedical research? @nature.com www.nature.com/articles/d41...

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Alles Lab @alleslab.bsky.social · 06/03/2025

Congrats to the newly minted Dr. Goins who passed with DISTINCTION!!! 🎉🎉 #PainResearch

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Alles Lab @alleslab.bsky.social · 04/03/2025

Excited to be a part of this latest preprint from the de la Pena lab exploring the circRNA landscape in hDRG! #PainResearch www.biorxiv.org/content/10.1...

biorxiv.org

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Alles Lab @alleslab.bsky.social · 24/02/2025

Super proud of @goinsyeah.bsky.social getting her thesis to her committee today!! You got this! 🍻#PainResearch

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Cincinnati Children's @cincychildrens.bsky.social · 12/02/2025

All kids deserve to feel the love on Valentine's Day! Be sure to send a free e-Card to our patients by February 14: give.cincinnatichildrens.org/site/SPageNa...

A Cincinnati Children's patient holds a Valentine's card

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Scheff Research Lab @schefflab.bsky.social · 30/01/2025

📢New publication out: Sensory Neurotransmission and Pain in Solid Tumor Progression! This review article by first author @andremartel.bsky.social details recent work on the bidirectional relationship between sensory neurons and #cancer cells. authors.elsevier.com/sd/article/S... #neurobiology

Proposed cycle between nociceptive input and autonomic output in cancer. Sensitization of nociceptive sensory neurons by the tumor microenvironment leads to propagation of orthodromic signaling towards the central nervous system (CNS).

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Felix Viana @neuroviana.bsky.social · 27/01/2025

Please help us advertise this new opening 🧠 in our research group. I am happy to answer any queries about it.

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Alles Lab @alleslab.bsky.social · 25/01/2025

Our lab started human DRG electrophysiology studies @unm.edu We are excited about building this pipeline at @cincychildrens.bsky.social to help improve our understanding of human pain #PainResearch

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Alles Lab @alleslab.bsky.social · 06/01/2025

Great way to kick off 2025 with a visit to see my buddy & fellow human tissue enthusiast @mikehildebrand7.bsky.social at Carleton University in my hometown 🇨🇦 #painresearch

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Alles Lab @alleslab.bsky.social · 18/12/2024

It is with great pride that I share the bulk of thesis work from my first PhD Cand @goinsyeah.bsky.social on neuroimmune mechanisms of chronic back pain! This is a new direction for the lab led by Aleyah's sheer curiosity and drive. Congrats Aleyah! #PainResearch www.biorxiv.org/content/10.1...

biorxiv.org

Neuroimmune mechanisms of a mouse model of chronic back pain

Chronic back pain (CBP) is the leading cause of disability affecting 1 in 10 people worldwide. Symptoms are marked by persistent lower back pain, reduced mobility, and heightened cold sensitivity. Her...

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Alles Lab @alleslab.bsky.social · 17/12/2024

Looks like all members of the @alleslab.bsky.social will be moving! Most of us to Cincy & one of us for a great postdoc opportunity elsewhere. Excited to see great things from each of you! 💪👩‍🔬🔬 #PainResearch @docnessmonster.bsky.social @goinsyeah.bsky.social @drjones26.bsky.social

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Luke Pattison @interlukein.bsky.social · 11/12/2024

Riding the year out on a high ✨ - latest paper out now in @pnas.org! ☺️ 🙏 Here we describe a role for the proton-sensing GPCR, GPR65 in mediating joint pain from fibroblast-like synoviocytes! www.pnas.org/doi/10.1073/... #PainResearch #Neuroskyence More on this work below 👇 🧵 [1/10]

pnas.org

Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain | PNAS

Inflammation is associated with localized acidosis, however, attributing physiological and pathological roles to proton-sensitive receptors is chal...

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Alles Lab @alleslab.bsky.social · 10/12/2024

Our latest work in collaboration with the de la Pena lab on the effects of neuropathic pain drug gabapentin on human DRG neurons is now online!! Spoiler alert: interesting donor-specific actions! #PainResearch

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Stéphanie C Koch @skochlab.bsky.social · 06/12/2024

We have an exciting postdoc opportunity to study the spinal circuits involved in spatial restriction of pain. Please spread the word and get in touch if you’re interested in joining our team. Application details to follow! @uclnpp.bsky.social @ucllifesciences.bsky.social #painscience #neuroskyence

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