Study links norepinephrine nerve signaling to oral cancer pain and tumor growth, highlighting new targets for cancer neuroscience therapies.

Sympathetic-sensory nerve cross-talk drives tumor progression and neuropathic pain in oral cancer, implicating peripheral neuroplasticity as a target.

Peripheral sensory nerves are thought to play a role in solid tumor growth, particularly in oral squamous cell carcinoma (OSCC); however, the link bet…

Gomez, Wu, et al. demonstrate that breast cancer promotes blunted glucocorticoid diurnal rhythms via disinhibition of PVNCRH neurons. Restoration of normal glucocorticoid rhythms via endogenous activa...

Opioids remain a mainstay for managing moderate-to-severe cancer pain, yet accumulating evidence suggests that opioid analgesics can impair antitumor immunity. In their recent study, McIlvried et al p...

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YouTube video by Advanced Portfolio News

Oral squamous cell carcinoma (OSCC) is one of the most painful cancers, with patients frequently reporting spontaneous, neuropathic-like pain. While sympathetic and sensory nerves have been individual...

Cancer pain is a complex problem that, when left unaddressed, can impact overall survival and decrease patients’ quality of life. Collaboration among medical oncologists, immunologists, and neurobiolo...

Botulinum neurotoxin type A1 (BoNT/A1) is an effective treatment for chronic migraine, but its direct mechanism of action on human sensory neurons has not been fully elucidated. While rodent studies o...

The nervous and immune systems have co-evolved to respond to threats, including cancer. In this Review, Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.

UF Center for Advanced Pain Therapeutics and Research (CAPToR) hosts inaugural symposium.

In this study, McIlvried, Del Rosario, and colleagues show that mechanisms of adaptive plasticity are engaged in mouse and human sensory neurons after sust

Opioids are often first-line treatments for cancer-related pain, but they… Read more

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