The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation, and pain. Upregulated intestinal proteolysis…

Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...

Brandow et al. describe how the gut microbiome drives chronic sickle cell disease (SCD) pain. SCD guts contain excessive heme catabolites, fewer bacteria that metabolize bilirubin, and low levels of A...

Despite being one of two cardinal disease symptoms, endometriosis pain is poorly understood. Using a validated mouse model, we demonstrate that endometriosis-associated vaginal dysbiosis is sufficient...

date there is no evidence supporting or opposing this hypothesis in humans. Here, we demonstrate that KCC2 expression is decreased in superficial dorsal horn neurons of organ donors who died with a do...

Neuroscience; Microbiome

oorganisms and the neuroimmune networks that drive pain in such diseases. More recently, microbiomes both inside and across the surface of the body have been recognized for driving sensory symptoms in...

Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...

Gastric pain has limited treatment options and the nociceptive ascending pathway remains largely unclear. Here, the authors identify a glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuit that provides...