Antonio Camargo @apcamargo.bsky.social · 15/04/2026It’s that wonderful time of year again. A new GTDB release is out :) 0144
Reposted by Antonio CamargoSebastian Deorowicz @sdeorowicz.bsky.social · 14/04/202610 years after the first FAMSA paper, its successor is now published in Nat Biotech! We believe that FAMSA2 can enable analyses of large protein collections that were previously unattainable. Thank you, Andrzej and Cedric, for great collaboration www.nature.com/articles/s41...nature.comFast and accurate multiple-protein-sequence alignment at scale with FAMSA2 - Nature BiotechnologyFAMSA2 accurately aligns millions of protein sequences at high speed. 35923
Reposted by Antonio CamargoSimon Roux @simrouxvirus.bsky.social · 03/12/2025🦠🧪🧬🚨 New paper and database alert: the new IMG/VR release is now MetaVR ! We have a new website - meta-virome.org - with quick search capabilities for the >24M viruses, >12M vOTUs, and >42M protein clusters (including >790k with predicted structures !). academic.oup.com/nar/advance-...academic.oup.comMeta-virus resource (MetaVR): expanding the frontiers of viral diversity with 24 million uncultivated virus genomesAbstract. Viruses are ubiquitous in all environments and impact host metabolism, evolution, and ecology, although our knowledge of their biodiversity is st 16443
Reposted by Antonio CamargoMichael Kuhn @biocs.bsky.social · 15/08/2025We're very happy to release our new database Metalog metalog.embl.de ! It offers manually curated and harmonised contextual data for 110k metagenomics samples across the globe, incl. precomputed taxonomic profiles, for interactive browsing and for download 🧵 1/7 #microskymetalog.embl.deMetalogMetalog is a repository of manually annotated metadata (or contextual data) for metagenomic sequencing data from across the globe. 37345
Reposted by Antonio CamargoAxel Visel @axelvisel.bsky.social · 18/11/2025Soils contain an amazing diversity of functions encoded in plasmids. The Global Soil Plasmidome Resource: 98,728 soil plasmids from 6,860 samples. Led by @mattlabguy.bsky.social and @apcamargo.bsky.social at @jgi.doe.gov @biosci.lbl.gov @berkeleylab.lbl.gov www.nature.com/articles/s41... 0127
Antonio Camargo @apcamargo.bsky.social · 06/11/2025🚨New preprint out! We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8) www.biorxiv.org/content/10.1... 49047
Reposted by Antonio CamargoYunha Hwang @microyunha.bsky.social · 28/10/2025We're thrilled to announce SeqHub, an AI-enabled platform for biological sequence analysis. SeqHub brings together sequence search, genome annotation, and data sharing in one place. 34919
Reposted by Antonio Camargoace-gtdb.bsky.social @ace-gtdb.bsky.social · 22/10/2025Our @narjournal.bsky.social manuscript is out! It explores the growth of the GTDB (gtdb.ecogenomic.org) since its inception, as well as updates to the website, methodology, policies, and major taxonomic and nomenclatural changes over the past three years. academic.oup.com/nar/advance-...academic.oup.comGTDB release 10: a complete and systematic taxonomy for 715 230 bacterial and 17 245 archaeal genomesAbstract. The Genome Taxonomy Database (GTDB; https://gtdb.ecogenomic.org) provides a phylogenetically consistent and rank normalized genome-based taxonomy 06946
Antonio Camargo @apcamargo.bsky.social · 06/09/2025A BLAST update adding support for compressed files and csv output with headers is a Good Friday night surprise! blast.ncbi.nlm.nih.gov/doc/blast-ne...blast.ncbi.nlm.nih.gov2025 BLAST NEWS — BlastNews 0.1.1 documentation 03514
Reposted by Antonio CamargoRayan Chikhi @rayanchikhi.bsky.social · 03/09/2025🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024... 3218118
Reposted by Antonio CamargoBen J Woodcroft @benjwoodcroft.bsky.social · 16/07/2025Out in @natbiotech.nature.com: Metagenome taxonomy profilers usually ignore unknown species. SingleM is an accurate profiler which doesn't, even detecting phyla with no MAGs. Profiles of 700,000 metagenomes at sandpiper.qut.edu.au. A 🧵 713471
Reposted by Antonio CamargoBonsai Sequence Bioinformatics @bonsaiseqbioinfo.bsky.social · 02/07/2025Preprint alert from the group 🚨 super fast grep-like sequence selection 065
Reposted by Antonio CamargoCameron Thrash @jcamthrash.bsky.social · 02/07/2025Scaling laws of bacterial and archaeal plasmids www.nature.com/articles/s41... #jcampubsnature.comScaling laws of bacterial and archaeal plasmids - Nature CommunicationsThe capacity of a plasmid to express genes is constrained by parameters such as its length and copy number. Here, Maddamsetti et al. present a computational method that enables rapid and accurate dete... 13713
Reposted by Antonio CamargoRobert Aboukhalil @robert.bio · 10/06/2025Excited to announce our first interactive article on sandbox.bio, about genomic ranges: sandbox.bio/concepts/gen... Move & resize the ranges to see how that affects bedtools operations like merge and intersect in real time! 15018
Reposted by Antonio CamargoSimon Roux @simrouxvirus.bsky.social · 13/06/2025New pre-print out \o/ All about CRISPR, metagenomes, and what you learn when you collect (a lot of) spacers from natural communities, with @apcamargo.bsky.social @urineri.bsky.social @lhug.bsky.social but also Uri Gophna, Nikhil George (not on Bsky I think) & others at JGI doi.org/10.1101/2025...doi.org 39245
Reposted by Antonio CamargoSebastian Schmidt @tsbschm.bsky.social · 03/06/2025The Koonin Law of Computatoinal Biology: Whenever you think you have a great idea in computational or evolutionary biology, it will already have been published by Eugene Koonin in the mid 90ies. 36910
Reposted by Antonio CamargoYunha Hwang @microyunha.bsky.social · 02/06/2025At Tatta Bio, we have been thinking deeply about the sequence-to-function problem. We believe that before AI can power functional prediction, we first need to rethink how we curate, manage, and share sequence data. Here, we share our initial ideas on what we are building next:tattabio.substack.comToday's sequence data infrastructure is set up for failure in the age of AI.Building an open and collaborative sequence platform for both Human and AI scientists. 184
Reposted by Antonio CamargoJim Shaw @jimshaw.bsky.social · 28/05/2025Announcing myloasm, a new long-read (ONT R10/PacBio) metagenome assembler that I've been working on during my postdoc in the Heng Li lab (@lh3lh3.bsky.social). myloasm-docs.github.iomyloasm-docs.github.iomyloasm - metagenomic assembly with (noisy) long reads 513378
Reposted by Antonio CamargoTábita Hünemeier @hunemeier.bsky.social · 15/05/2025Our new paper is out in @science.org! By exploring the rich genetic diversity of Brazil, we show how fine-scale genomic analyses reveal that this diversity, rooted in Indigenous ancestry and centuries of complex demographic history, plays a key role in population health. 3236
Reposted by Antonio CamargoEduardo Amorim @cegamorim.bsky.social · 15/05/2025Very proud of my colleagues and friends for their amazing publication out in Science today! Nunes et al. "Admixture’s impact on Brazilian population evolution and health" www.science.org/doi/10.1126/... @hunemeier.bsky.social @macscastro.bsky.social 👏science.orgAdmixture’s impact on Brazilian population evolution and healthBrazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world’s largest recently admixed population. In this study, we generated 2723 high-coverage who... 02110
Reposted by Antonio CamargoSTCmicrobeblog @stcmicrobeblog.bsky.social · 28/04/2025schaechter.asmblog.org/schaechter/2... #MicroSky #Archaea #ArchaeaSky #SymbioSkyschaechter.asmblog.orgCultivating the Ancestors (4|4)by Christoph — Having one or two 'Asgard' archaea under the microscope – after having cultivated them with great effort and even more patience – and looking them in the face is exciting, but a bit uns... 12011
Reposted by Antonio CamargoOliver Schwengers @oschwengers.bsky.social · 28/04/2025We happily present: “Bakta Web – rapid and standardized genome annotation on scalable infrastructures” @OxUniPress NAR’s Web Server issue doi.org/10.1093/nar/... Easy to use, no registration, fast, scalable, various visualizations, in sync with Bakta CLI: bakta.computational.bio (1/5)doi.orgBakta Web – rapid and standardized genome annotation on scalable infrastructuresAbstract. The Bakta command line application is widely used and one of the most established tools for bacterial genome annotation. It balances comprehensiv 14228
Reposted by Antonio CamargoAlex Crits-Christoph @acritschristoph.bsky.social · 25/04/2025Unique investigation of some errors in long read assemblers. In particular these remarkably chimeric contigs are 😱, if rare.... Improving long read assemblers is definitely the space to be in when it comes to the future of metagenomics, as short reads won't be part of it 😉 36438
Reposted by Antonio CamargoBen J Woodcroft @benjwoodcroft.bsky.social · 17/04/2025A 1.0 release for Sandpiper. 700,000 microbial community profiles (3x the last version, 4.7 Pbp metaG), searchable via the @ace-gtdb.bsky.social R226 taxonomy that just dropped. MetaGs are going exponential, but we are still nowhere near a MAG for all species. sandpiper.qut.edu.au #microsky 🧬🖥️ 1/2 34834
Reposted by Antonio Camargoace-gtdb.bsky.social @ace-gtdb.bsky.social · 18/04/2025GTDB release 10 based on RefSeq 226 (R10-RS226) is live at gtdb.ecogenomic.org. This release covers 732,475 genomes (22% increase) and has 143,6141 species clusters (37% increase). Release notes at: forum.gtdb.ecogenomic.org/t/announcing.... Release statistics at: gtdb.ecogenomic.org/stats/r226.gtdb.ecogenomic.orgGTDB - Genome Taxonomy DatabaseThe Genome Taxonomy Database (GTDB) is an initiative to establish a standardised microbial taxonomy based on genome phylogeny. 02717
Reposted by Antonio CamargoItai Yanai @itaiyanai.bsky.social · 11/04/2025Is the genome just a bag of genes? A new paper in Science now reports that for two thirds of an organisms' genes the position along the chromosome is actually very tightly constrained! Amazing work from my favorite night scientist Martin Lercher and his team! www.science.org/doi/10.1126/... 110230
Reposted by Antonio CamargoCameron Thrash @jcamthrash.bsky.social · 09/04/2025CoverM is published! CoverM: Read alignment statistics for metagenomics academic.oup.com/bioinformati... #jcampubsacademic.oup.comCoverM: Read alignment statistics for metagenomicsAbstractSummary. Genome-centric analysis of metagenomic samples is a powerful method for understanding the function of microbial communities. Calculating r 17231
Reposted by Antonio CamargoKaçar Lab at UW-Madison @kacarlab.bsky.social · 24/03/2025🚨New paper!🚨 A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬 Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏 Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social 39446
Reposted by Antonio CamargoRdRp Summit @rdrpsummit.bsky.social · 19/02/2025The abstract submission & registration for #RdRpSummit2025 is NOW OPEN!!! 🎉🙌 Do you work on RNA virus discovery using RdRps? Are you joining the #ViBioM2025 in Portugal? Consider submitting your research in one of our sessions! More info: RdRp.io 01413
Antonio Camargo @apcamargo.bsky.social · 18/02/2025Publishing a paper in Nature while based in Brazil is an incredible achievement. Huge congratulations to the authors! I'm excited to give this a proper read :) 030
Antonio Camargo @apcamargo.bsky.social · 22/01/2025One of the great things about bioinformatics is how open it can be. Contributing to a project you admire can actually get you involved in it :) 081
Reposted by Antonio CamargoA. Murat Eren (Meren) @merenbey.bsky.social · 17/01/2025I'm very happy to report that Matt Schechter's PhD work is now online as a pre-print: "Ribosomal protein phylogeography offers quantitative insights into the efficacy of genome-resolved surveys of microbial communities", www.biorxiv.org/content/10.1... Here's a little 🧵 about it. 13520
Reposted by Antonio CamargoEduardo Rocha @epcrocha.bsky.social · 18/01/2025This preprint makes a point that is valid for a lot of machine learning approaches. Organisms or genes are linked by evolutionary history; they are not independent. This results in correlation between learning and test sets, and often in over-optimistic evaluations of the methods' outcome. 35927
Reposted by Antonio CamargoJoint Genome Institute @jgi.doe.gov · 17/01/2025In Science Advances: "We took a deep dive into over 1.8 million bacterial and archaeal genomes to see how much of their diversity we’ve actually captured. Turns out that despite all the genomes we’ve sequenced, we’ve only scratched the surface." -Dongying Wu 🖥️🧬🦠 biosciences.lbl.gov/2025/01/17/t...biosciences.lbl.govTaking Stock of the Known and Unknown Microbial Space - Biosciences AreaUsing publicly available genome sequence data generated over the past three decades, JGI researchers assess the known fraction of microbial diversity. 24315
Reposted by Antonio CamargoSimon Roux @simrouxvirus.bsky.social · 07/01/2025🚨Postdoc position(s) alert🚨 If you like to develop new bioinformatic tools for *human* microbiome analysis, are interested by virus/phages, we (JGI Viral Genomics and Microbiome Data groups) may have a great position for you ! No official job posting yet, but email or DM if you are interested ! 07476
Reposted by Antonio CamargoKnut Drescher @knutdrescher.bsky.social · 06/01/2025We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation. Details here 👇 www.nature.com/articles/s41...nature.comBacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature MicrobiologyPeptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation. 014256
Reposted by Antonio CamargoRyan Wick @rrwick.bsky.social · 31/12/2024New year, new assemblies! I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes! It's the successor to Trycycler, designed to be faster and less reliant on user intervention. Check it out: github.com/rrwick/Autoc... (1/5)github.comHomeA tool for generating consensus long-read assemblies for bacterial genomes - rrwick/Autocycler 215697
Reposted by Antonio CamargoMart Krupovic @mkrupovic.bsky.social · 30/12/2024RNA virologists, check out "The protein structurome of Orthornavirae and its dark matter" by Pascal Mutz, Valerian Dolja, Eugene Koonin et al (including @simrouxvirus.bsky.social, @apcamargo.bsky.social, @urineri.bsky.social, @anamarijabutkovic.bsky.social) journals.asm.org/doi/10.1128/...journals.asm.orgThe protein structurome of Orthornavirae and its dark matter | mBioAdvanced methods for protein structure prediction, such as AlphaFold2, greatly expand our capability to identify protein domains and infer their likely functions and evolutionary relationships. This i... 02210
Reposted by Antonio CamargoGav Armstrong @nchemgav.bsky.social · 10/12/2024Don't use red and green data lines/surfaces in the same panel please #chemsky. It can be difficult for some colorblind readers to differentiate them. I've accepted (in principle) 2 papers today, and both sets of authors were asked to remove red/green colour contrasts www.nature.com/articles/d41...nature.comColour me better: fixing figures for colour blindnessImages can be made more accessible by choosing hues, shapes and textures carefully. 411347
Reposted by Antonio CamargoMart Krupovic @mkrupovic.bsky.social · 17/12/2024An interesting paper for the EV (extracellular vesicle) fans by Patel et al. @ahnaskop.bsky.social lab: "Extracellular vesicles, including large translating vesicles called midbody remnants, are released during the cell cycle" www.molbiolcell.org/doi/10.1091/... 0113
Reposted by Antonio CamargoYunha Hwang @microyunha.bsky.social · 17/12/2024Can LLM agents discover novel protein functions? Introducing Gaia Agent 🌎 🤖: an AI biologist capable of reasoning across genomic contexts to predict functions of proteins! Gaia Agent is now integrated with Gaia Search at gaia.tatta.bio 23813
Reposted by Antonio CamargoYunha Hwang @microyunha.bsky.social · 15/12/2024If you are at #NeurIPS2024 don't miss @ancornman1.bsky.social's talk on OMG/gLM2 at 9AM! @workshopmlsb.bsky.social East meeting room 11,12 0123
Reposted by Antonio CamargoYunha Hwang @microyunha.bsky.social · 10/12/2024Excited to be at #NeurIPS this week. @ancornman1.bsky.social will give a spotlight talk at the @workshopmlsb.bsky.social on gLM2/OMG! Please reach out if you want to chat about gLM2/OMG/Gaia and our latest projects😇 www.biorxiv.org/content/10.1...biorxiv.orgThe OMG dataset: An Open MetaGenomic corpus for mixed-modality genomic language modelingBiological language model performance depends heavily on pretraining data quality, diversity, and size. While metagenomic datasets feature enormous biological diversity, their utilization as pretraini... 093
Reposted by Antonio CamargoRob Patro @robp.bsky.social · 04/12/2024Very cool work from Yang Lu et al. demonstrating miscalibration of BLASTP’s E-values and generating well-calibrated values via a knockoff-based approach (cc @mikelove.bsky.social) - academic.oup.com/bioinformati...! More analyses could benefit from knockoff-based approaches.academic.oup.comA BLAST from the past: revisiting blastp’s E-valueAbstractMotivation. The Basic Local Alignment Search Tool, BLAST, is an indispensable tool for genomic research. BLAST established itself as the canonical 23722
Reposted by Antonio CamargoPierre Peterlongo @pierrepeterlongo.bsky.social · 11/11/2024🧬🔍There are 50 petabases of freely-available DNA sequencing data. We introducing Logan Search which allows you to search for any DNA sequence in minutes, bringing Earth’s largest genomic resource to your fingertips. 🏔️ logan-search.org 🏔️ #Genomics #Bioinformatics #OpenScience 211156
Reposted by Antonio CamargoYunha Hwang @microyunha.bsky.social · 19/11/2024Hello 🦋 #protein / #microbio / #BioML community! We are excited to release Gaia🌎, a context-aware protein search tool, extending protein search and discovery capabilities beyond sequence and structure, to include *genomic context*. Search your favorite protein sequences with on gaia.tatta.bio 1023875
Reposted by Antonio CamargoMartin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 15/11/2024New GPU-based MMseqs2: 20x faster searches on a single L40S (approx. as fast as a RTX 4090) vs. a 128-core CPU. This work enables to set up a very cost-efficient ColabFold MSA GPU server. 🧵🧵 📄 www.biorxiv.org/content/10.1... 💾 mmseqs.com 🗞️ developer.nvidia.com/blog/boost-a... 217359
Reposted by Antonio CamargoAlex Crits-Christoph @acritschristoph.bsky.social · 02/10/2024The OMG dataset: An Open MetaGenomic corpus for mixed-modality genomic language modeling From friends at Tatta Bio GitHub: github.com/TattaBio/OMG www.biorxiv.org/content/10.1...biorxiv.orgThe OMG dataset: An Open MetaGenomic corpus for mixed-modality genomic language modelingBiological language model performance depends heavily on pretraining data quality, diversity, and size. While metagenomic datasets feature enormous biological diversity, their utilization as pretraini... 052
Reposted by Antonio CamargoÁkos T Kovács @evolvedbiofilm.bsky.social · 28/08/2024Terrabacteria: redefining bacterial envelope diversity, biogenesis and evolution #NatureRevMicro from Simonetta Gribaldo www.nature.com/articles/s41... 043
Reposted by Antonio CamargoAlex Crits-Christoph @acritschristoph.bsky.social · 22/08/2024AntiDefenseFinder! And it is available also as an option with DefenseFinder: defensefinder.mdmlab.fr Exploring the diversity of anti-defense systems across prokaryotes, phages, and mobile genetic elements www.biorxiv.org/content/10.1...biorxiv.orgExploring the diversity of anti-defense systems across prokaryotes, phages, and mobile genetic elementsbioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 11616