Published in Nucleus (Vol. 17, No. 1, 2026)

America is suffering from a complete breakdown in social life and shared conception of the common good. Some prominent liberals want to keep it that way.

The recently identified post-translational modification lysine pyruvylation modulates gene expression, thereby directly linking glycolytic flux to chromatin-based transcriptional regulation.

Chinese researchers are testing DREADDs, a gene therapy to turn down neuronal activity, in the clinic

Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal represen...

Nature Biomedical Engineering, Published online: 13 August 2026; doi:10.1038/s41551-026-01749-wKey tissue features shared by fibrotic diseases are distilled into clear design rules for human in vitro models, with practical guidance on choosing cells, matrices and platforms for mechanistic studies and drug testing.

Few discoveries would be more consequential than identifying the specific neural structures responsible for subjective experience.

The Left can’t sit out the 2028 Democratic primary. If AOC chooses not to run for president, Eric Blanc argues that socialists should run a working-class candidate — even an unknown one — who can inject anti-billionaire politics into the race.

The mammalian liver possesses a regenerative capacity that is unmatched by any other organ. Following injury, liver epithelial cells can proliferate or even change their identity, enabling the organ t...

The metabolite α-ketoglutarate (αKG) is required for chromatin demethylation, but mechanisms that control αKG abundance in the nucleus are poorly defined. We designed a biosensor to monitor this metab...

Nature Metabolism, Published online: 03 July 2026; doi:10.1038/s42255-026-01561-5Lysine pyruvylation, a newly discovered histone modification installed by HAT1 and p300 and removed by SIRT3, connects the glycolytic metabolite pyruvate to transcriptional regulation, shedding light on metabolism–epigenetics crosstalk.

Omar Yaghi’s move comes amid cuts to US science and a campaign in China to recruit top international talent.

Nature Biomedical Engineering, Published online: 06 July 2026; doi:10.1038/s41551-026-01731-6A genetic circuit sensing microenvironment softness-induced calcium signalling can be rewired to express a synthetic antigen, boosting chimeric antigen receptor (CAR) T cell killing of stem-like tumour cells.

We will never know for sure if AI can be conscious. A neuroscientist argues that we shouldn’t wait for proof to decide how to treat it.

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

Nature Reviews Rheumatology, Published online: 29 June 2026; doi:10.1038/s41584-026-01398-yFindings indicate that sensory neuron-derived proteins regulate tendon repair and have a protective role in chronic tendinopathy.

Our genetic heritage is not a blueprint or an algorithm, as many biologists have imagined, but something else entirely.

This study shows that the epigenetic cold memory or ‘vernalized state’ in overwintering plants can be reset through somatic embryogenesis, overturning the long-standing idea that the vernalized state ...

Stiffening of the extracellular matrix, declining microvascular perfusion, and mitochondrial dysfunction reinforce one another to drive tissue aging. This perspective outlines a unifying matrix-vascular-metabolic axis and highlights potential entry points to preserve tissue resilience and function with age.

Wei et al. show that Meg3+ haematopoietic stem cells (HSCs) expand upon ageing and present with an increase in H3K23ac levels observed already at middle age. Inhibiting H3K23ac ameliorates megakaryocy...

Direct interactions between the cell’s powerhouses and nuclear pores might channel energy straight into the nucleus, fuelling cell division and differentiation.

They had ‘highly sensitized’ immune systems that usually reject donated organs, leaving them with few options for survival.

This Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance ...

Plants sense water deficiency through SAM8 protein condensation, which responds to reduced hydration and triggers stress adaptation by altering RNA export and gene translation.

TopoVelo infers cell differentiation stages and rate parameters of gene expression using spatially coupled differential equations.

Using xenograft inflammation–recovery models and single-cell multiomics, a haematopoietic stem cell population after inflammatory stress is identified.

Noboru Mizushima is Professor of Biochemistry and Molecular Biology at the University of Tokyo, Japan, where he runs a laboratory studying the mechanisms and physiological functions of autophagy and o...

Mapping of genome-wide DNA methylation patterns in human islet alpha and beta cells highlights age and type 2 diabetes dependent adaptations and compensatory responses to altered metabolic demands.

By Benjamin Boettner (BOSTON) — Inflammatory bowel disease (IBD), which comprises the inflammatory conditions Crohn’s disease and ulcerative colitis, affects about 1.6 million Americans, many of whom ...

Obesity represents a major global healthcare crisis, with childhood obesity rising at an alarming rate. Children with obesity are highly likely to carry it into adulthood, bringing numerous associated...