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Nathan Williams

@njw33.bsky.social
120 followers 159 following 1 posts

PhD Student at the John Innes Centre 🌱 Studying TKPs in the Banfield lab 🌾 Interested in plant immune receptors, pathogen effectors & protein design

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Reposted by Nathan Williams
Juliet Coates @julietccoates.bsky.social · 28/09/2026
We are crowdfunding for a bench in a peaceful spot at Winterbourne Botanic Garden in Birmingham in memory of Philippa Borrill. Please share widely. Please email me or @drelunadiez.bsky.social for more details. 💚🌾🌿🌳 If you would like to contribute, the link is below ⬇️.
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Helen Brabham @helenbrabs.bsky.social · 28/09/2026
Gb3 encodes a unique kinase fusion protein conferring greenbug resistance in wheat www.nature.com/articles/s41...
nature.com
Gb3 encodes a unique kinase fusion protein conferring greenbug resistance in wheat - Nature Genetics
Gb3 encodes an intracellular kinase–pseudokinase protein with a unique MAP3K-like domain that confers resistance to multiple greenbug biotypes in wheat.
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Jake Dalzell @bitheolaidhe.bsky.social · 28/09/2026
Why is it that the media never consult an ecologist on articles like this? They conflate meadow with a sown pasture with a few herbaceous perennials. The Chicory in the picture isn't even native! Of course there are few claims beyond “he believes”. www.theguardian.com/environment/...
theguardian.com
‘You can taste the land’: the Somerset farmer bringing wildflowers back to cheddar
Tom Calver has sacrificed milk yields to give his cows a more varied diet of plants and believes the result is better cheese and richer farmland
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John Innes Centre @johninnescentre.bsky.social · 25/09/2026
PRESS RELEASE - Can this biotech innovation halt the destructive march of a cereal killer? 🌾🦠 A UK-led research collaboration has taken a significant step in the global effort to protect crops from the devastating wheat fungus pathogen
okt.to
Can this biotech innovation halt the destructive march of a cereal killer? | John Innes Centre
A UK-led research collaboration has taken a significant step in the global effort to protect cereal crops from the devastating blast fungus pathogen...
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Tatsuya Nobori @tatsuyanobori.bsky.social · 07/09/2026
📣 Please share! We’re recruiting to build predictive models of gene regulation in plants. We’d love to hear from anyone with strong foundations in regulatory genomics or ML and fluency with coding agents. Any career stage; no plant background needed. noborilab.org 1/5
noborilab.org
Nobori Lab | The Sainsbury Laboratory
Decoding the molecular and cellular basis of plant-microbe interactions. Single-cell and spatial omics of plant immunity. Led by Tatsuya Nobori at TSL, Norwich, UK.
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Susan Schlimpert @s-lab.bsky.social · 04/09/2026
NLRs aren't just for immunity. Inspired by our colleagues working on plant NLRs, postdoc @maxljordan.bsky.social from my lab asked: Do bacterial NLR-type regulators found in antibiotic-producing #Streptomyces share a similar autoactivation switch? Turns out, yes! Read the full story and his 🧵👇
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Max Jordan @maxljordan.bsky.social · 04/09/2026
Really excited to share our new manuscript on how the #NLR protein #AfsR regulates #Streptomyces antibiotic production - and how we can use its similarity to plant NLR immune receptors to enhance this production! 📄🧵 (1/17) @johninnescentre.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
A conserved NLR activation switch governs global transcriptional control of antibiotic biosynthesis in Streptomyces
Nucleotide-binding and oligomerization domain-like receptors (NLRs) are conserved molecular switches that regulate innate immunity across diverse domains of life. While best known for their roles in i...
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NoCaSS @nocassofficial.bsky.social · 18/08/2026
Last week, we were delighted to host NoCaSS 2026, bringing together ECRs in plant and microbial sciences from Norwich and Cambridge. 🦠🌱🧬 The symposium featured scientific talks, a careers panel and an entrepreneurship workshop. Huge thank you to all participants, contributors and sponsors! ✨
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Sam Mugford @samtmugford.bsky.social · 12/08/2026
New pre-print from the @saskiahogenhout.bsky.social lab We (@qunliu07.bsky.social et al.) show that the aphid effector protein CathB6, in addition to suppressing plant immunity via EDS1, also alters the regulation of chloroplast-nuclear signalling to maintain photosynthetic gene expression. 1/n
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Josh Bennett @joshwbennett.bsky.social · 07/08/2026
I am really excited to share the first chapter of my PhD, where we characterise a genetically linked NLR/MLKL pair underpinning the Rwt3 resistance locus in wheat! With yet another KFP involved in monocot immunity 🌾 www.biorxiv.org/content/10.6...
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 07/08/2026
A wheat immune receptor pair executes cell death through a helper MLKL www.biorxiv.org/content/10.64898/20…
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Carl Zimmer @carlzimmer.com · 06/08/2026
Here's a new kind of virus that scientists have generated with AI. And here's my story about what it means for us to have gotten to this remarkable moment: nyti.ms/4bBhoWB (Gift link) 🧪
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Nature @nature.com · 05/08/2026
Nature research paper: Miniaturizing and modifying natural proteins with Raygun go.nature.com/4w2usM2
go.nature.com
Miniaturizing and modifying natural proteins with Raygun - Nature
Probabilistic sequence encoding from language model embeddings within a generative AI framework enables protein miniaturization, modification and augmentation while maintaining native architecture and functional integrity.
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Mary Williams @PlantTeaching @plantteaching.bsky.social · 05/08/2026
"I'm begging you: Never write with AI" Gift article. www.nytimes.com/2026/08/04/o...
nytimes.com
Opinion | I’m Begging You: Never Write With A.I. (Gift Article)
It’s bad for your brain and worse for democracy.
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Nick Talbot @talbotlabtsl.bsky.social · 24/07/2026
Worth a read www.science.org/content/blog...
science.org
The Assault On Science Funding Continues
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Phil Carella @philcarella.bsky.social · 21/07/2026
Georgia Yiasoumi from the Morris and Seung groups @johninnescentre.bsky.social explains a novel and comprehensive approach to identify key factors in wheat starch granule initiation. #PlantBiology2026
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Carl T. Bergstrom @carlbergstrom.com · 21/07/2026
13. Hence our dismal conclusion: rather than finding that LLMs free us to do a better job of what we were doing before they came along, they shift scientific incentives (and the playing field of academic competition) in ways that compel us to do more and more, faster and faster, less and less well.
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Karen Uchida @karenuchida.bsky.social · 15/07/2026
It's back live! Check out my week at TSL 🌱
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yuxuan-xi.bsky.social @yuxuan-xi.bsky.social · 11/07/2026
Our new preprint is out! Using AI-guided design (RFdiffusion + ProteinMPNN), we engineered a plant immune receptor to recognise non-cognate pathogen effectors. Huge thanks to our amazing co-authors for making this possible! doi.org/10.64898/202...
doi.org
Computational design of de novo integrated domains enables rational control of pathogen effector recognition in plant NLR immune receptors.
The rapid evolution of plant pathogens poses a persistent threat to global agricultural sustainability, often outpacing the discovery and deployment of natural disease resistance genes. While bioengin...
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The Sainsbury Laboratory @thesainsburylab.bsky.social · 13/07/2026
New Preprint: Computational design of de novo integrated domains enables rational control of pathogen effector recognition in plant NLR immune receptors (2026) www.tsl.ac.uk/publications...
tsl.ac.uk
Computational design of de novo integrated domains enables rational…
The Sainsbury Laboratory Norwich, United Kingdom © 2026. All rights reserved
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Nick Talbot @talbotlabtsl.bsky.social · 13/07/2026
Excited to preprint this collaborative study led by @adamrbentham.bsky.social in which computationally-designed protein binders were generated that recognise pathogen effectors leading to a plant immune response when deployed within NLR immune receptors. www.biorxiv.org/content/10.6...
biorxiv.org
Computational design of de novo integrated domains enables rational control of pathogen effector recognition in plant NLR immune receptors.
The rapid evolution of plant pathogens poses a persistent threat to global agricultural sustainability, often outpacing the discovery and deployment of natural disease resistance genes. While bioengin...
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Nick Talbot @talbotlabtsl.bsky.social · 06/07/2026
PhD position in my group for entry in October 2026. Round 3 of the @nrpdtp.bsky.social BBSRC competition. Please RT👇 biodtp.norwichresearchpark.ac.uk/projects/van...
biodtp.norwichresearchpark.ac.uk
Vanishing Virulence: Investigating pathogenicity loss in a plant pathogenic fungus (TALBOT_S26DTP3) | Doctoral Training Partnership
What makes a plant killer lose its edge? This project will investigate why fungal pathogens lose virulence when they are grown in laboratory culture away from their host plant. Use cutting-edge…
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Rosemary Mosco @rosemarymosco.com · 06/07/2026
Heat waves. Thanks to @climateadam.bsky.social's most recent video, which helped inform this comic and gave me the kick I needed to make it.
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Becca Testa @beccatesta.bsky.social · 29/06/2026
Last month I attended #IWC2026 in Bologna. 🇮🇹 I am very grateful for the opportunity to present my research and to the @wheatinitiative.bsky.social for a travel grant to attend. It was amazing to meet wheat researchers from across the globe! 🌍 First international conference of the PhD ✅ 🎉
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Ran Blekhman @blekhman.bsky.social · 27/06/2026
I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...
open.substack.com
My Peer Review of The 1%
I wanted to like QED's new 1% ranking. I don't.
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Juan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 24/06/2026
Our latest work on immune receptor engineering for enhanced pathogen recognition is out in @theplantcell.bsky.social academic.oup.com/plcell/artic... #NLRs #Effectors #Exo70
academic.oup.com
Engineering an Exo70 integrated domain of a barley NLR for improved blast resistance
Engineering the barley NLR RGH2 enhances recognition of blast pathogen effectors from rice and wheat, leading to improved disease resistance.
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Stefan A. Rensing @rensingstefan.bsky.social · 18/06/2026
Updated @theplantjournal.bsky.social guidelines: avoid the use of terms such as “basal”, “early diverging lineage”, “primitive”, “ancestral plant”, “lower and higher plants” [..] recommends the use of specific terms such as “bryophytes”, “vascular plants” [..] onlinelibrary.wiley.com/page/journal...
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George Monbiot @georgemonbiot.bsky.social · 17/06/2026
If you say “I support Palestine Action”, they might put you in jail. If you incite a racist riot, they put you on TV.
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Diana Gómez De La Cruz @dianagdlc.bsky.social · 05/06/2026
So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵 and link to the original preprint thread on X👇 www.science.org/doi/10.1126/...
science.org
Molecular mimicry of a pathogen virulence target by a plant immune receptor
Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...
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Mauricio Contreras @mpcontreras.bsky.social · 04/06/2026
Molecular mimicry of a pathogen virulence target by a plant immune receptor | Science www.science.org/doi/10.1126/...
science.org
Molecular mimicry of a pathogen virulence target by a plant immune receptor
Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...
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Césarée Morier-Gxoyiya @cesaree-mg.bsky.social · 03/06/2026
One question that stuck with me early in my PhD was whether the experimental data underpinning wheat stem rust epidemiological models were still fit for purpose. Our new review digs into the evidence, how it’s used in models, and where the biggest gaps remain.
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Sholto David @sholtodavid.bsky.social · 02/06/2026
Today I'm posting a new blog about an astonishing scientific own goal. Hundreds of papers have reported using a totally wrong antibody to investigate the tumor suppressor p16. This mistake has happened because scientists have muddled the names of two proteins. forbetterscience.com/2026/06/02/m...
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 03/06/2026
The demonstration of a single origin for nodule evolution, with nodule engineering in a non-nodulating species www.biorxiv.org/content/10.64898/20…
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John Innes Centre @johninnescentre.bsky.social · 03/06/2026
This #PrideMonth, we revisit this blog by Leah Milner-Campbell on ‘Being proud of our authentic selves’ 🙌🌈 Read Leah’s thoughts on Pride Month, a time to celebrate resilience and living openly as our true selves, particularly in research environments where self-expression drives innovation
jic.ac.uk
Being proud of our authentic selves | John Innes Centre
June marks Pride Month, and Leah Milner-Campbell, Neurodiversity project officer, explores this as a time to celebrate authenticity, resilience, and the courage to live openly as our true selves.
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NoCaSS @nocassofficial.bsky.social · 02/06/2026
Registration for our long-awaited NoCaSS symposium is now open! Register here: nocass.org/registration... 🌱🦠✨ Join us for two days of fascinating science including ECR talks, poster sessions, workshops, industry presentations, and a career panel. Only for Cambridge and Norwich-based researchers
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Department of Plant Sciences Cambridge @camplantsci.bsky.social · 27/05/2026
Huge congratulations to Beverley Glover & Uta Paszkowski on being elected Fellows of the @royalsociety.org - a wonderful recognition of their significant contributions to plant sciences! 🎉 Read more: tinyurl.com/3vetucr4 @beverleycubg.bsky.social @paszkowskilab.bsky.social 🧪
Professor Beverley Glover (left) and Professor Uta Paszkowski (right) – new Fellows of the Royal Society 2026. Photos © University of Cambridge.
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Mauricio Contreras @mpcontreras.bsky.social · 20/05/2026
Check out our updated activation-and-release model. This one image condenses over 10 years of work from many legendary @kamounlab.bsky.social members 🤯 Big shoutout to Chih-Hang, @tolgaboz.bsky.social, Lida, Aki, Selvaraj, @jmadhuprakash.bsky.social, @hsuanpai.bsky.social, Ben and many more!
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Mauricio Contreras @mpcontreras.bsky.social · 20/05/2026
Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 22/05/2026
Decoy diversification underpins the regulation of an NLR-mediated autoimmunity www.biorxiv.org/content/10.64898/20…
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 22/05/2026
Canonical NLR immune receptor architecture enforces EDS1-dependency onto divergent TIR domains www.biorxiv.org/content/10.64898/20…
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 19/05/2026
A conserved structural logic underlies sensor-helper NLR communication in the NRC immune receptor network www.biorxiv.org/content/10.64898/20…
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Christine Faulkner @pdchristine.bsky.social · 19/05/2026
Emma Turley started her PhD expecting the effector ChEC108 would aid Colletotrichum establish infection, but she instead discovered that when it makes it's way to plasmodesmata it's bound by host HIPP6, triggering PD closure and impeding infection. #PlantScience
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 19/05/2026
Colletotrichum higginsianum effector ChEC108 binds a plasmodesmal HMA protein and elicits plant defence www.biorxiv.org/content/10.64898/20…
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Will Ratcliff @wcratcliff.bsky.social · 13/05/2026
1/23 New preprint! Been thinking about the origin of cellular life. Specifically, how protocells (or *any* compartments) just aren't enough to support the evolution of increasingly complex cells. You gotta de-Darwinize the parts! The ribosome/genome do this. www.biorxiv.org/content/10.6...
biorxiv.org
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NoCaSS @nocassofficial.bsky.social · 12/05/2026
We're excited to introduce our keynote speaker of NoCaSS 2026 – Dr. Helen Fones ✨ Helen is an expert in plant-pathogen interaction and microbial ecology. 🌱🦠 Join us at NoCaSS 2026 on the 12th-14th of August at the John Innes Centre. Registration will open soon – Stay tuned. ✨
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AmirAli Toghani @amiralito.bsky.social · 05/05/2026
UP TO ELEVEN - We expressed potato NRC7, imaged it by negative-stain EM, ran 2D classification. 🔬💥 Rings ~250 Å across — way bigger than canonical hexamers (~150 Å). 11 protomers. (5/n)
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Shawn "Smith" Peirce @silversmith1.bsky.social · 26/04/2026
@chrislhayes.bsky.social ICYMI, a piece that reminded me of Twilight Of The Elites, for obvious reasons. "a world with universal basic income is more meritocratic than a world without one" www.scottsantens.com/the-angine-d...
scottsantens.com
The Angine de Poitrine Argument for UBI
Why Angine de Poitrine's viral microtonal math rock KEXP session, Ireland's permanent basic income for artists, and Albert Einstein are three sides of the same human triangle Two guys in papier-mâc...
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Kenneth Loi @kenjmloi.bsky.social · 27/04/2026
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
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NoCaSS @nocassofficial.bsky.social · 12/04/2026
The Norwich Cambridge Science Symposium is back this summer! Save the date (13th-14th August). Check out our updated website : nocass.org, and follow @nocassofficial.bsky.social for upcoming updates on keynote speakers, panelists and workshops! (Registration opens 1st June).
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Sophien Kamoun @kamounlab.bsky.social · 25/03/2026
Kicking off now @APH_ISP @BBSRC @ukri.org Alternative Career Day. Mark @mjbanfield introducing the exciting program—several of whom are #CelebratingAlumni @johninnescentre.bsky.social @thesainsburylab.bsky.social
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