Reposted by Amelia Randich
How does a single methyl group activate bacterial defence?
Our new preprint, led by @pspatharas.bsky.social in collaboration with the group of @matthiaswilmanns.bsky.social, explains how a single DNA methylation event activates large retron assemblies.
www.biorxiv.org/content/10.6...
biorxiv.org
Single-site DNA methylation activates retron defence by enabling effector tetramerisation
Retrons are unique among bacterial defence systems in using DNA to sense phage infection. They achieve this by producing multicopy single-stranded DNA (msDNA) that monitors the activity of DNA-targeti...