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Alessio Vagnoni

@alessiovagnoni.bsky.social
378 followers 629 following 14 posts

Cell biologist. Interested in neurons, intracellular trafficking, ageing, and other things. Posting mainly about science. www.vagnonilab.com

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Reposted by Alessio Vagnoni
NC3Rs @nc3rs.bsky.social · 14/11/2025
Congratulations to @alessiovagnoni.bsky.social who has been announced as a recipient of this year’s AAALAC International Global 3Rs Award recognising his ongoing work in advancing the 3Rs: www.aaalac.org/awards/globa...
aaalac.org
Global 3Rs Winners
LEARN MORE / APPLY 2025 Award Winners ASIA-PACIFIC Bing Zhou, Ph.D., M.D. “Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11” Cell Metabolism Sha
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Alessio Vagnoni @alessiovagnoni.bsky.social · 13/09/2025
We have a postdoctoral position available in the lab europeandrosophilasociety.org/job/postdoct.... Get in touch if interested!
europeandrosophilasociety.org
Postdoctoral position at MIA, Coimbra, Portugal | European Drosophila Society
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Raffaele Sarnataro @rafsarnataro.bsky.social · 22/07/2025
1/ 🚨 Our new paper is online in @nature.com! As its first author, I’m enthusiastic to finally share it with you all! 🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 rdcu.be/ewwrA @oxforddpag.bsky.social @ox.ac.uk @medsci.ox.ac.uk 🧵 👇
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Professor James Hodge @docfly.bsky.social · 01/07/2025
Our BBSRC CircadiAgeing sLola project launches today with @hughp.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @mbra3.bsky.social @alessiovagnoni.bsky.social studying clock excitability, circadian rhythms and healthy ageing circadiageing.blogs.bristol.ac.uk
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Circadiageing @circadiageing.bsky.social · 30/06/2025
The CircadiAgeing project explores how disruptions in circadian rhythms, the natural 24-hour cycles of physiological and behavioural patterns, contribute to ageing and related health issues. circadiageing.blogs.bristol.ac.uk
circadiageing.blogs.bristol.ac.uk
Circadiageing | Clock excitability, circadian rhythms and healthy ageing
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Virtual Fly Brain @virtualflybrain.bsky.social · 12/06/2025
VFB works closely with the FlyBase team and we rely on their hard work to provide many of our features. Due to the current funding situation at FlyBase (flybase.org), we encourage our users to donate and help maintain this essential resource.
flybase.org
FlyBase Homepage
FlyBase: a database for drosophila genetics and molecular biology
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James N. Sleigh @jamessleigh.bsky.social · 30/05/2025
Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.sciencedirect.com/science/arti... @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging
sciencedirect.com
Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age
A healthy nervous system is reliant upon an efficient transport network to deliver essential cargoes throughout the extensive and polarised architectu…
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Alessio Vagnoni @alessiovagnoni.bsky.social · 23/05/2025
www.thelancet.com/journals/lan...
thelancet.com
Gaza has been failed by silence and impunity
Gaza is on the brink of famine. The Integrated Food Security Phase Classification, a multistakeholder global initiative aimed at enhancing food security and nutrition analysis, reports that the entire...
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Valentin Riedl @vavatin.bsky.social · 27/03/2025
The brain’s energy landscape as a potential window into brain health www.nature.com/articles/d41... (study led by Martin Picard and Michel Thiebaut de Schotten)
nature.com
First map of human brain mitochondria is ‘groundbreaking’ achievement
Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 01/04/2025
Microtubule acetylation is a biomarker of cytoplasmic health during cellular senescence www.biorxiv.org/content/10.1101/202…
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Alessio Vagnoni @alessiovagnoni.bsky.social · 28/03/2025
www.nature.com/articles/s41... Fun collab with T.Calì&M.Brini, led by postdoc Lucia Barazzuol and supported by Tatiana Tykhonenko and PhD student Tia Griffiths @kingsioppn.bsky.social @wohlmicroscopy.bsky.social @nc3rs.bsky.social
nature.com
Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters - Cell Death & Disease
Cell Death & Disease - Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters
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Cell Biology J-Club @cellclub.bsky.social · 26/03/2025
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease www.nature.com/articles/s41...
nature.com
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease - Nature Cell Biology
Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...
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Wohl Cellular Imaging Centre 🔬 @wohlmicroscopy.bsky.social · 07/03/2025
Drosophila larval motor neurons labelled with GFP (green) showing activated ATF4 expression (magenta) due to knockdown of the mitochondrial complex I subunit NDUFS1 #FluorescenceFriday Imaged by @batemanlab.bsky.social
Drosophila larval motor neurons labelled with GFP (green) showing activated ATF4 expression (magenta) due to knockdown of the mitochondrial complex I subunit NDUFS1
Two larger ridges of green vertically show green processes coming out from the centre with magenta cells along the central valley between the green in clusters as well as some along the green outer processes
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Alessio Vagnoni @alessiovagnoni.bsky.social · 05/03/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Amyloid beta precursor protein contributes to brain aging and learning decline in short-lived turquoise killifish (Nothobranchius furzeri)
Brain aging is a pivotal risk factor for many neurodegenerative diseases, yet its molecular and cellular mechanisms remain elusive. The amyloid-beta precursor protein (APP) is among the most studied p...
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Cell Biology J-Club @cellclub.bsky.social · 03/03/2025
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites www.nature.com/articles/s41...
nature.com
Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites - Nature Communications
Protein-mediated transport is implicated in trafficking fatty acids at contact sites of lipid droplets and mitochondria. Here, the authors use proteomics to catalogue the proteins at this contact site...
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Matthew Taliaferro @jmtali.bsky.social · 03/03/2025
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
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Alessio Vagnoni @alessiovagnoni.bsky.social · 21/02/2025
www.nejm.org/doi/10.1056/...
nejm.org
Risdiplam for Prenatal Therapy of Spinal Muscular Atrophy | NEJM
The alternate splicing small molecule risdiplam, administered to a fetus with spinal muscular atrophy, had an apparent ameliorating effect on the disorder through 30 months.
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Alessio Vagnoni @alessiovagnoni.bsky.social · 04/02/2025
imAGEin: one-in-a-kind 2Y Erasmus Mundus Joint Master @euerasmusplus.bsky.social on the Biology of #ageing. shorturl.at/n4jsd Partners: @ucoimbra.bsky.social @sorbonne-universite.fr @univcotedazur.bsky.social @unisevilla.bsky.social @unicologne.bsky.social. 15 scholarships available to cover costs.
life.univ-cotedazur.eu
imAGEin Programme - Life
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James N. Sleigh @jamessleigh.bsky.social · 02/02/2025
In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.biorxiv.org/content/10.1... Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al. @uclqsion.bsky.social #aging
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Christophe 🔬 Leterrier @christlet.bsky.social · 12/01/2025
Do you want to hear the latest and greatest about the neuronal cytoskeleton? Join us in Chile next April for #NeuroCyto2025, organized by @monicamsousa.bsky.social, Kassandra Ori-McKenney and Tomás Falzone! Registration is open until March 5: neurocytoskeleton.com/2025/
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Suliana Manley @sulianamanley.bsky.social · 23/12/2024
I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF
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Wallace Marshall @wallaceucsf.bsky.social · 23/12/2024
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...
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Alessio Vagnoni @alessiovagnoni.bsky.social · 23/12/2024
www.theguardian.com/society/2024... Good use of hospital records, biobank data, and AI
theguardian.com
NHS to begin world-first trial of AI tool to identify type 2 diabetes risk
Exclusive: Two London hospital trusts to trial tool that can predict those at risk up to 13 years before condition develops
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Professor James Hodge @docfly.bsky.social · 13/12/2024
Announcing award of our 5 year BBSRC sLola CircadiAgeing: clock excitability, circadian rhythms & healthy ageing grant with @hughp.bsky.social @MeganGJackson @mbra3.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @alessiovagnoni.bsky.social Edgar Buhl bristol.ac.uk/news/2024/de...
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Alessio Vagnoni @alessiovagnoni.bsky.social · 12/12/2024
Really excited to be part of the CircadiAgeing team @docfly.bsky.social @mbra3.bsky.social @krasimiratsaneva.bsky.social, H.Piggins, M.Belle @official-uom.bsky.social
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Marco Brancaccio @mbra3.bsky.social · 12/12/2024
Excited to be part of one of the BBSRC larger and longer grants with such a great team. Healthy circadian aging is healthy brain aging… @imperialmed.bsky.social www.ukri.org/news/bbsrc-i...
ukri.org
BBSRC injects £20 million into long-term discovery research
BBSRC is backing four major research projects to help pioneer critical advances in healthy ageing, drug discovery and sustainable agriculture.
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Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 11/12/2024
The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging. www.nature.com/articles/nbt...
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Alessio Vagnoni @alessiovagnoni.bsky.social · 10/12/2024
Ye Olde endosymbiont never cease to surprise rdcu.be/d222K
rdcu.be
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria
Nature - Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two...
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Carlotta Martelli @crltt.bsky.social · 05/12/2024
There is an open PhD position in our Lab! In collaboration with the lab of @manuperisse.bsky.social we will study how flies evaluate negative experiences based on context. More info here: mrtlllab.uni-mainz.de/we-are-hiring/
mrtlllab.uni-mainz.de
We are hiring! - mrtlllab
We are hiring! Are you passionate about neuroscience and eager to understand how the brain processes negative experiences? The mrtllab is looking for a driven PhD candidate to study the neural mechani...
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Alessio Vagnoni @alessiovagnoni.bsky.social · 04/12/2024
High-pressure freezing EM and modelling to study membrane 'nanopearling' vs 'beading' in unmyelinated axons of the mouse brain www.nature.com/articles/s41...
nature.com
Membrane mechanics dictate axonal pearls-on-a-string morphology and function - Nature Neuroscience
Axons have always been assumed to be cylindrical. Using in silico modeling and cryopreservation of tissues, Griswold et al. demonstrate that unmyelinated axons of the mammalian central nervous system ...
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Gaynor Ann Smith @gaynorasmith.bsky.social · 23/11/2024
www.findaphd.com/phds/project...
findaphd.com
Peroxisome-organelle interplay under cellular stress conditions. BBSRC SWBio DTP PhD studentship 2025 Entry at University of Exeter on FindAPhD.com
PhD Project - Peroxisome-organelle interplay under cellular stress conditions. BBSRC SWBio DTP PhD studentship 2025 Entry at University of Exeter, listed on FindAPhD.com
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Christian Gonzalez-Billault @glezbillault.bsky.social · 27/11/2024
The 7th edition is in place!. It wil be held in Marbella, Chile next year and will be again part of the EMBO workshop series. The organizers are @monicamsousa.bsky.social, Kassandra Ori-Mckenney and Tomas Falzone. Registration is already opened neurocytoskeleton.com/2025/
neurocytoskeleton.com
Emerging Concepts of the Neuronal Cytoskeleton (7th Edition)
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Junyue Cao @junyuecao.bsky.social · 29/11/2024
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
tinyurl.com
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
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Alessio Vagnoni @alessiovagnoni.bsky.social · 01/12/2024
‘Change becomes inevitable when the right platform meets enough willing users’. It sounds like a great starting point @colemanlab.bsky.social colemanlab.brc.cam.ac.uk/blog/peer-re...
colemanlab.brc.cam.ac.uk
Peer review at a crossroads: the surprising power in your hands | Coleman Laboratory
Article by Prof Michael Coleman; illustrations by Dr Alice White Your stomach falls as you open the email: “Thank you for your submission to Journal X …after careful consideration and discussion with ...
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Cahir O'Kane @cahirokane.bsky.social · 29/11/2024
Opportunities to join us as a junior group leader. #Genetics As well as the advert, there's more general background, testimonials, etc., on our web page: www.gen.cam.ac.uk/join-us/grou...
gen.cam.ac.uk
Group Leader Opportunities | Department of Genetics
Opportunities for starting your research group in the Genetics Department Our vacancies for academic staff ("faculty positions") are advertised widely when they arise.
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Alessio Vagnoni @alessiovagnoni.bsky.social · 30/11/2024
Hello Bluesky! I came over from the other platform and slowly building up. Nice to re-connect with many familiar faces and with new ones.
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