ALT: Sad Old Man Crying

Replication stress drives genomic instability, tumour evolution and therapeutic adaptation, yet also creates exploitable vulnerabilities. In this Review, Chen and Zou discuss how chronic replication stress shapes cancer biology and how emerging therapies are targeting the pathways that enable tumour cells to survive it.

President Trump announced plans to cancel $810 million in Congressionally approved spending, a move that some in his own party are calling illegal.

To cope with the threat of genome instability, cells have evolved an intricate network of mechanisms ranging from cell cycle checkpoints to specialized DNA repair pathways known as the DNA damage res…

Join us at the Keystone Symposia on DNA Replication: Pathway Crosstalk Shaping Physiology and Disease, April 2027, in London, with field leaders!

Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome...

Pennsylvania’s senators are demanding information about more than 150 health research grants canceled by the U.S. Department of Health and Human Services this summer.

House Appropriations Committee Ranking Member Rosa DeLauro (D-CT-03) has learned that officials at the Department of Defense (DoD) are working to divert billions of dollars from the National Institute...

House Appropriations Committee Ranking Member Rosa DeLauro (D-CT-03) has learned that officials at the Department of Defense (DoD) are working to divert billions of dollars from the National Institute...

It’s not just the federal government that’s telling grad students their work doesn’t matter.

The Munson Lab researches the mechanistic basis for the regulation of spatial and temporal specificity in membrane trafficking in the Biochemistry & Molecular Biotechnology Department at UMass Chan Me...