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alansaghatelian.bsky.social

@alansaghatelian.bsky.social
380 followers 419 following 5 posts
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 20/11/2025
This week, scientists in David Liu’s lab at the @broadinstitute.org report on a single gene therapy that they say might someday address many genetic diseases. cen.acs.org/biological-c... #chemsky 🧪
cen.acs.org
Prime editing suppressor transfer RNAs for gene therapy
Liu lab suggests technique could provide ‘nonstop’ treatment for genetic diseases
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Sylvie Callegari @sylviecallegari.bsky.social · 13/03/2025
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 27/02/2025
Mindblowing new study by @raflynn5.bsky.social @bostonchildrens.bsky.social, cell surface RNA-binding proteins form nanoclusters with #glycoRNA and mediate cell-penetrating peptide entry into cells 👏 www.cell.com/cell/abstrac...
cell.com
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.
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Jonathan Rosenblum @jsrosenblum.bsky.social · 24/02/2025
#chemsky
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 23/02/2025
Thank you @nplb.bsky.social for speaking out in defense of patients, the US economy and our citizenship. Encouraged to see biopharma and investors among patients, health care providers, scientists and policy makers. www.nopatientleftbehind.org/defending-th...
nopatientleftbehind.org
Defending the NIH, the NSF and the foundation of American science — No Patient Left Behind
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George Conway ⚖️🇺🇸 @gtconway.bsky.social · 22/02/2025
Better not call it a “vaccine” or it might not get approved. Maybe market it as a recreational drug.
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Hoodlum 🇺🇸 @nothoodlum.bsky.social · 21/02/2025
When Rupert Murdoch’s rags turn on you …
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Ryan Potts - real @pottslab.bsky.social · 18/02/2025
New @biorxivpreprint.bsky.social preprint from Amgen induced proximity group and @dannomura.bsky.social lab just posted that describes Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells. Read on for an overview 1/7 www.biorxiv.org/content/10.1...
biorxiv.org
Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or expression of truncated varia...
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 16/02/2025
Got word that several NIH employees in a group working on cancer clinical trials got terminated via email this evening. “The [cancer research] trials will literally not be able to function without us.” Trump and Musk are killing cancer research. 🧪
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Mark Cuban @mcuban.bsky.social · 14/02/2025
You can sell with the truth. It’s still about presentation. “Inflation is painful for everyone. But what can destroy a family, the price of Gatorade going up , or the price of medications not being affordable? The republicans have a concept of a plan for drug pricing. We have a solution.
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Jeremy Berg @jeremymberg.bsky.social · 14/02/2025
(Sorry I took a brief timeout for uncontrollable weeping) In other NIH news, I have heard from multiple sources that NIH plans to fire most, if not all, probationary employees this afternoon. The numbers I am hearing are >5000. Lots of folks extramural staff, intramural scientists, etc.
media.tenor.com
a man with glasses and a mustache is making a sad face
ALT: a man with glasses and a mustache is making a sad face
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Heather Cox Richardson (TDPR) @hcrichardson.bsky.social · 13/02/2025
Folks: I am NOT affiliated with the group that is using my name to support an economic boycott. Please spread this post, if you would.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 13/02/2025
Discovery of a new Cu-dependent cellulose degrading enzyme for biomass conversion #glycotime (trying to overlook the extraneous proton, see if you can find it) www.nature.com/articles/s41...
nature.com
A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion - Nature
A metalloenzyme capable of oxidatively cleaving cellulose, found in a microbial community specialized in lignocellulose degradation, could enable sustainable biofuel production.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 12/02/2025
Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs… “I think they're being short-sighted, because fear does that to you.”
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Sean Ryder @seanryderphd.bsky.social · 12/02/2025
This youtube video, also from AAU, is great for friends and families that might not understand. www.youtube.com/watch?v=yxTD...
youtube.com
Facilities and Administrative (F&A) Costs Explainer
YouTube video by Association of American Universities
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Jeremy Berg @jeremymberg.bsky.social · 12/02/2025
This is outstanding! Watch it and share...
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Brian Liau @brianliau.bsky.social · 12/02/2025
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
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Derek Lowe @dereklowe.bsky.social · 12/02/2025
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late. Silence gives consent. And no one should consent to this.
science.org
Stand Up And Be Counted
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 09/02/2025
Mark Cuban on NIH. Yes. Public money also funded the basis of Netscape, Google, Intel, and Moderna. Those companies wouldn’t be in the US without government funding science. 1/2
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Krutika Kuppalli, MD FIDSA @krutikakuppalli.bsky.social · 08/02/2025
NIH doesn’t just support infectious disease research—it drives breakthroughs in cancer, childhood diseases, heart disease, diabetes & more. Thanks to NIH, we have: 💉 Cancer immunotherapy ❤️ Cholesterol-lowering statins 🩸 Insulin for diabetes Investing in NIH = investing in life-saving discoveries.
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Jeremy Berg @jeremymberg.bsky.social · 09/02/2025
F99/R00 AND K99/R00 DIVERSITY AWARD APPLICANTS If you have applied for a F99/R00 or K99/R00 Diversity award and the study section for review is not listed on your eRA Commons page, please reach out to me. DM me, email berg.grants.2029@gmail.com, Signal jeremymberg.78 THANK YOU
media.tenor.com
a picture of a cartoon character with the words call me on it
ALT: a picture of a cartoon character with the words call me on it
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 08/02/2025
Contacting your congressperson is fine. But contacting your local TV station is better. One interview on local TV saying your congressperson should act is worth 1,000 office calls.
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Rebekah Tromble @rebekahtromble.bsky.social · 08/02/2025
The NIH cuts are being spun as a way to eliminate bloated university bureaucracy. And looking at the sheer numbers, I get it. But in fact the story is the exact opposite. The federal research grants system is highly efficient. And it super charges American innovation. 🧵 1/
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 08/02/2025
Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...
washingtonpost.com
NIH cuts billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
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Matt Barber @biobarber.bsky.social · 08/02/2025
Executive wants to frame the NIH indirects cut as $4B in savings. But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
nih.gov
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
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Derek Lowe @dereklowe.bsky.social · 08/02/2025
Straight into court, and you can expect universities to be seeking injunctive relief immediately. This is the way Trump has always conducted himself, lawless and without honor or compunction.
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Mark A. Hanson @hansonmark.bsky.social · 08/02/2025
Today they went nuclear. Imagine all firefighters were told "You all still have salaries, but as of today the government will no longer pay for building maintenance, firetruck maintenance and repair, hydrant upkeep, or admin assistants." That's what they're doing to US universities.
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Carl T. Bergstrom @carlbergstrom.com · 08/02/2025
The NIH overhead cut doesn't just hurt universities. It's deadly to the US economy. The US is a world leader in tech due to the ecosystem that NIH and NSF propel. It drives innovation for tech transfer, creates a highly-skilled sci/tech workforce, and fosters academic/industry crossfertilization.
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Carl T. Bergstrom @carlbergstrom.com · 08/02/2025
8. It is difficult to overstate what a catastrophe this will be for the US research and education systems, particular in biomedical fields. It is deliberate and wanton devastation entirely out of scale with any concern about DEI activities on campuses. The goal is destroy US universities.
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Carl T. Bergstrom @carlbergstrom.com · 08/02/2025
6. The policy does not just affect funding going forward. All existing NIH grants will have their indirect rates cut to 15% as of today, the date of issuance. For a large university, this creates a sudden and catastrophic shortfall of hundreds of millions of dollars against already budgeted funds.
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Carl T. Bergstrom @carlbergstrom.com · 08/02/2025
5. Other schools may have even higher overhead rates. Harvard's is around 69%. This new order slashes that percentage to a maximum of 15%. This means cutting one of the most important sources of university funding nationwide by 75% or more. Universities cannot function with this scale of cut.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 07/02/2025
Decimating the NSF would be an act of violence against USA competitiveness in science, technology and innovation. Have any of these people seen Shanghai lately? arstechnica.com/science/2025...
arstechnica.com
White House budget proposal could shatter the National Science Foundation
“This kind of cut would kill American science and boost China.”…
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Harmit Singh Malik @harmitmalik.bsky.social · 07/02/2025
"Pursuant to this Supplemental Guidance, there will be a standard indirect rate of 15% across all NIH grants for indirect costs in lieu of a separately negotiated rate for indirect costs in every grant." grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 05/02/2025
The NSF is the US engine of basic science discovery and technology innovation. This decision is a gift to our overseas competitors.
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Darby Saxbe @darbysaxbe.bsky.social · 04/02/2025
🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.
list of banned keywords
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 04/02/2025
Oh no, they said “bias” in the title: AI-mediated desk rejection at NSF www.nature.com/articles/s41...
nature.com
The role of ionic blockades in controlling the efficiency of energy recovery in forward bias bipolar membranes - Nature Energy
Bipolar membranes are increasingly being applied in a variety of electrochemical devices, yet understanding of how they operate in complex electrolyte environments is still limited. Here the authors o...
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Stephan Hacker @stephanhacker2.bsky.social · 29/01/2025
The proteins on the surface our cells are key to many important signalling pathways. In an amazing lecture at #EFMCISCB25, @berndwollscheid.bsky.social talked about his group's exciting research into better understanding the cell surfaceome at various levels. (1/4)
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bioRxivpreprint @biorxivpreprint.bsky.social · 29/01/2025
RIG-I Stimulation Enhances Effector Function and Proliferation of Primary Human CD8 T Cells www.biorxiv.org/content/10.1101/202…
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Jeremy Berg @jeremymberg.bsky.social · 26/01/2025
In the present discussions about NIH and the need for reform, two recurring points I am seeing are: (1) NIH doesn't fund truly high impact research (2) NIH needs to experiment with alternative approaches to peer review, particularly for high risk-high impact research 1/n
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George Conway ⚖️🇺🇸 @gtconway.bsky.social · 25/01/2025
The purpose of this is … what??
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 24/01/2025
Sam's phrase, "American supremacy in research," is politically potent. Make it clear to your elected representatives that the chaos at NIH and other agencies threatens to end that supremacy.
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Jeremy Baskin @jeremybaskin.bsky.social · 24/01/2025
Our latest story: a protein-protein interaction between an E3 ubiquitin ligase and an autophagy adaptor affects liquid-liquid phase separation and sequestration of a key mediator of antioxidant signaling — but not via ubiquitination! Bravo to Lin Luan and Xiaofu Cao! doi.org/10.1101/2025...
AlphaFold 3 prediction of the binding interface between SQSTM1/p62 and SHKBP1Lin LuanXiaofu Cao
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John Schneekloth (Jay) @jschneek.bsky.social · 22/01/2025
Check out this awesome paper from my colleague @eunayoo.bsky.social about activity-based probes for USP18! www.nature.com/articles/s41...
nature.com
Chemical tools to define and manipulate interferon-inducible Ubl protease USP18 - Nature Communications
USP18 is a multifunctional cysteine protease involved in IFN pathways. Here, the authors report chemical probes and chemoproteomics platforms that allow to detect and perturb USP18 activity in complex...
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Keri Backus @keribackus.bsky.social · 20/01/2025
First lab #Chemrxiv preprint of 2025 and first foray into AI-based discovery of reactive cysteines! Congrats to First author Lisa Boatner and thanks to @forlilab.bsky.social, @jeeberhardt.bsky.social, and the rest of the team for the stellar collaboration! chemrxiv.org/engage/chemr...
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Markus Lakemeyer @mlakemeyer.bsky.social · 19/01/2025
Thrilled to share our new preprint: The gut #microbe B. fragilis secretes a unique #protease (Bfp1) that activates the human PAR2 receptor, driving intestinal pain & inflammation—key features of #IBD. Huge thanks to the amazing teams of @mbogyo.bsky.social, Nigel Bunnett and Alan Lomax! t.ly/mqyPk
t.ly
Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2
Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation and pain. Upregulated intestinal proteolysis and PAR2-signaling are implicated in inflammatory ...
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Mark Cuban @mcuban.bsky.social · 09/01/2025
I was interviewed at CES this morning. We mentioned that consumers will decide whether they want to be on a platform that is “unfiltered free speech “ or “ moderated”. I mentioned that I loved @bsky.app , and spontaneously people started clapping 🔥.
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