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Jon Grimm

@dyerfulchymist.bsky.social
995 followers 252 following 27 posts

Senior scientist and synthetic organic chemist working on fluorophore development in the Lavis lab at HHMI Janelia

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Jon Grimm @dyerfulchymist.bsky.social · 29/09/2026
Net loss $42B, operating loss $8B+, and this is what is propping up half the economy. 🔥😀🔥 www.reuters.com/business/fin...
reuters.com
EXCLUSIVE: Anthropic's IPO prospectus shows sweeping AI vision, surging costs
Anthropic is making a massive bet that AI will transform the global economy more profoundly than ​industrialization, electricity and the internet, according to its IPO prospectus seen by Reuters. But ...
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Carl Quintanilla @carlquintanilla.bsky.social · 26/08/2026
“We’ll grow our way out of it.” 🇺🇸
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robert j bennett, ceo, results omega @robertjbennett.bsky.social · 13/05/2026
a lot of the pundit class is constantly saying "what is the one liberal tenant that democrats must vigorously denounce in order to win the next election???" and the answer at the moment is "mercy"
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Brian Beutler @brianbeutler.bsky.social · 12/05/2026
Yep. This is the best way to understand the events of the past couple weeks. They have to dispense with the artifice of principle, because the risks of Dems winning and coming to power bent on accountability are simply too great. www.offmessage.net/p/republican...
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Katelyn Burns @katelynburns.com · 18/03/2026
For my newsletter, I wrote about all the ways @katmabu.bsky.social's campaign challenged the conventional thinking about modern campaigning: www.burnsnotice.com/kat-abughaza...
burnsnotice.com
Kat Abughazaleh Changed What's Possible in Political Campaigning
Ignore the specific issues for a second, and look at how she operated her campaign. She taught us lessons on a new way to run for office. You're not supposed to run for congress in a city you just mo...
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HHMI @hhmi-science.bsky.social · 15/03/2026
Beautiful, & built for discovery. These next-gen fluorescent dyes (developed by the Lavis Lab at our Janelia Research Campus) are brighter, more photostable, & more versatile — advancing how scientists visualize biology inside cells.
Fluorescent dyes at the Lavis Lab at Janelia Research Campus
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Andrew Lawrence @ndrew.bsky.social · 15/03/2026
republicans are in charge of everything and they are getting everything theyve ever wanted and doing everything theyve ever wanted and the world is on fire and the global world order is collapsing. is there a correlation? who can say
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Santiago Mayer @santiagomayer.com · 13/03/2026
How do you know that @katmabu.bsky.social has momentum? Because big money interests are panicking and trying to slander her just 3 days before the primary. We can’t let these folks win. Vote Kat.
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Jon Grimm @dyerfulchymist.bsky.social · 13/03/2026
The establishment can't win based on their actual message, so they have to resort to smear campaigns and lies. @katmabu.bsky.social is an inspiration, and we would be lucky to have her in Congress. If you live in IL-09, please vote for her. Don't let the scum dark money special interest groups win.
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Jon Grimm @dyerfulchymist.bsky.social · 06/03/2026
Oh good, so I guess the AI bubble pop / economic collapse is going to coincide with a global oil crisis AND a war? Cool cool cool.
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Jon Grimm @dyerfulchymist.bsky.social · 06/03/2026
Unexpected?
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Justin Wolfers @justinwolfers.bsky.social · 06/03/2026
This is not good.
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Jon Grimm @dyerfulchymist.bsky.social · 20/02/2026
Hmm, I'd swear we've seen this type of floor plan before, but I just... can't... put... my finger... on it...
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Jon Grimm @dyerfulchymist.bsky.social · 09/02/2026
But bears like Coke 🤷‍♂️
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Catherine Rampell @crampell.bsky.social · 06/02/2026
www.theatlantic.com/newsletters/...
theatlantic.com
Should You Buy a Newspaper or a Yacht?
Advice for Jeff Bezos
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Philip Bump @pbump.com · 05/02/2026
Jeff Bezos’s wealth has increased an average of $70 million every day of 2026, meaning that he could have offset The Post’s losses with what he’s made since Monday.
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Nick Greeves @nickgreeves.bsky.social · 21/01/2026
As someone who has used nBuLi a lot, 10 molar and rarely even tBuLi too, this sounds very interesting. I’ll never forget holding a syringe with 50 ml 10 M BuLi when an earthquake magnitude 6.6 struck… I was fine! #chemchat #chemsky www.chemistryworld.com/news/new-rea...
chemistryworld.com
New reagents take the burn out of butyllithium
Merck KGaA's non-pyrophoric butyllithium in poly(α-olefin) oil make BuLi stable to air and water
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David Ho @davidho.bsky.social · 20/01/2026
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...
This line graph illustrates the percentage change in agency staff levels from the previous year for nine major U.S. federal scientific and health organizations between the fiscal years 2016 and 2025. The agencies tracked include the CDC, Department of Energy, EPA, FDA, NASA, NIH, NIST, NOAA, and NSF. For the majority of the timeline between 2016 and 2023, the agencies show relatively stable fluctuations, generally staying within a range of +5% to -5% change per year. However, there is a dramatic and uniform plummet starting in the 2024–25 period. Every agency depicted shows a sharp downward trajectory, with staffing losses ranging from approximately -15% to over -25%. The Environmental Protection Agency (EPA) shows the most significant decline, dropping to roughly -26%, while the National Institute of Standards and Technology (NIST) shows the least severe but still substantial drop at approximately -15%.
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FactPost @factpostnews.bsky.social · 15/01/2026
21-year-old activist injured by ICE: I will be blind for life. I have fractures in my skull that they can't fix. They pulled a piece of plastic the size of a nickel out of my eye. I had shards of metal, glass, and plastic behind my eye and in my skull. They said it was a miracle I survived.
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Mr. Dan Zak @mrdanzak.com · 15/01/2026
Stunning photos from Minneapolis, including this one by John Locher for the Associated Press. www.theatlantic.com/photography/...
A family member reacts after a federal immigration officer used a battering ram to break down a door before making an arrest on January 11, 2026, in Minneapolis.
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Jon Grimm @dyerfulchymist.bsky.social · 15/01/2026
As one of your constiuents, thank you @repsuhas.bsky.social for having the spine that so many of your colleagues completely lack.
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Reality Winner @reazlepuff.bsky.social · 15/01/2026
Give them to me cause I'm good at keeping secrets
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Bill Corbett @billcorbett.bsky.social · 15/01/2026
For people elsewhere who have asked how to support Minnesota while we’re overrun with nazi thugs, here’s an excellent list of places that could use financial help. Lots of choices. Thank you so much! docs.google.com/document/d/1...
docs.google.com
Stand With Minnesota: Resource Hub
Causes to Donate to in Minnesota to Help Our Communities Defend Themselves from ICE This list is now available/shareable at standwithminnesota.org *Note: I am from Minnesota, and these come from peo...
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David Burbach 🇺🇸 @dburbach.bsky.social · 15/01/2026
Non-protesting dad just trying to hustle his kids, as young as 6mo, out of the neighborhood. ICE threw a flash-bang INTO HIS car, all 6 kids in the hospital now. If anyone wondered how things turn against occupying armies there's a case study playing out in front of you.
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Street Sharks Explained 🇨🇺🇵🇸 @gaykwon.bsky.social · 15/01/2026
This dude is intense and correct
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Jonathan C Slaght @jonathanslaght.com · 15/01/2026
My daughter's school in Richfield, MN (adjacent to Minneapolis) is closing tomorrow due of out-of-control federal agents. Fourth graders spent the week building walls of snow at recess to protect their classmates from ICE. This isn't about immigration enforcement, it's about terror.
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CJ Fogler @cjzero.bsky.social · 15/01/2026
That is what was relayed
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Ben Collins @bencollins.bsky.social · 09/01/2026
In America you drop your kid off at school, get your brains blown out on the ride home, then the Vice President drops everything for a week to call you a terrorist, to slander your family, to protect the circumstances that led to your death so they can do it again. It is government by Alex Jones.
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Sherrilyn Ifill @sifill.bsky.social · 08/01/2026
Make it viral.
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jamelle @jamellebouie.net · 08/01/2026
what you clearly see, CLEARLY, is a driver who is spooked by the agents grabbing her door, takes steps to drive away, and is immediately shot as moves her vehicle *away* from the agents.
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Mike Hixenbaugh @mikehixenbaugh.com · 08/01/2026
Forensic analysis of objective video evidence. This is how you serve readers searching for clarity.
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Nute @nutedawn.bsky.social · 06/01/2026
It’s genuinely wild that the United States spent decades building an elaborate rules-based international order which de facto cemented its permanent status as the dominant global hegemon, sustained by ideology rather than might, and now is just blowing it all up for literally no reason
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Yashar Ali 🐘 @yasharali.bsky.social · 22/12/2025
1. BREAKING Sharyn Alfonsi, a correspondent for 60 Minutes, sent an internal email to colleagues stating that CBS News editor in chief Bari Weiss “spiked our story” about the Trump administration and the transfer of deportees to a prison in El Salvador.
News Team,
These men risked their lives to speak with us. We have a moral
Thank you for the notes and texts. I apologize for not reaching out earlier.
and professional obligation to the sources who entrusted us
with their stories. Abandoning them now is a betrayal of the
Ilearned on Saturday that Bari Weiss spiked our story, INSIDE
most basic tenet of journalism: giving voice to the voiceless.
CECOT, which was supposed to air tonight. We (Ori and I) asked for a call to discuss her decision. She did not afford us
CBS spiked the Jeffrey Wigand interview due to legal
that courtesy/opportunity.
concerns, nearly destroying the credibility of this broadcast. It
Our story was screened five times and cleared by both CBS
took years to recover from that "low point." By pulling this story
attorneys and Standards and Practices. It is factually correct.
to shield an administration, we are repeating that history, but
In my view, pulling it now-after every rigorous internal check has been met is not an editorial decision, it is a political one.
for political optics rather than legal ones.
We requested responses to questions and/or interviews with
We have been promoting this story on social media for days.
DHS, the White House, and the State Department. Government
Our viewers are expecting it. When it fails to air without a
silence is a statement, not a VETO. Their refusal to be interviewed is a tactical maneuver designed to kill the story.
credible explanation, the public will correctly identify this as
If the administration's refusal to participate becomes a valid reason to spike a story, we have effectively handed them a "kill switch" for any reporting they find inconvenient.
corporate censorship. We are trading 50 years of "Gold
Standard" reputation for a single week of political quiet.
If the standard for airing a story becomes "the government must agree to be interviewed," then the government effectively
I care too much about this broadcast to watch it be dismantled
without a…
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Anna Bower @annabower.bsky.social · 22/12/2025
Per NY Times’s Michael Grynbaum on X, this is Sharyn Alfonsi’s email to her “60 Minutes” colleagues in full:
News Team,
Thank you for the notes and texts. I apologize for not reaching out earlier.
I learned on Saturday that Bari Weiss spiked our story, INSIDE CECOT, which was supposed to air tonight. We (Ori and I) asked for a call to discuss her decision. She did not afford us that courtesy/opportunity.
Our story was screened five times and cleared by both CBS attorneys and Standards and Practices. It is factually correct. In my view, pulling it now-after every rigorous internal check has been met is not an editorial decision, it is a political one.
We requested responses to questions and/or interviews with DHS, the White House, and the State Department. Government silence is a statement, not a VETO. Their refusal to be interviewed is a tactical maneuver designed
to kill the story.
If the administration's refusal to participate becomes a valid reason to spike a story, wehave effectively handed them a "kill switch" for any reporting they find inconvenient.
If the standard for airing a story becomes
"the government must agree to be
interviewed," then the government effectively gains control over the 60 Minutes broadcast.
We go from an investigative powerhouse to a stenographer for the state.
These men risked their lives to speak with us.
We have a moral and professional obligation to the sources who entrusted us with their
stories. Abandoning them now is a betrayal of the most basic tenet of journalism: giving voice to the voiceless.
CBS spiked the Jeffrey Wigand interview due to legal concerns, nearly destroying the credibility of this broadcast. It took years to recover from that "low point." By pulling this story to shield an administration, we are repeating that history, but for political optics rather than legal ones.We have been promoting this story on social media for days. Our viewers are expecting it.
When it fails to air without a credible
explanation, the public will correctly identify this as corporate censorship. We are trading 50 years of "Gold Standard" reputation for a single week of political quiet.
I care too much about this broadcast to watch
it be dismantled without a fight.
Sharyn
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Eric Columbus @ericcolumbus.bsky.social · 22/12/2025
Via @liamjscott.bsky.social at the other site here’s the full email from 60 Minutes correspondent Sharyn Alfonsi. She’s putting her career on the line by fighting here. And she’s fighting for all of us.
News Team,
Thank you for the notes and texts. I apologize for not reaching out earlier.
I learned on Saturday that Bari Weiss spiked our story, INSIDE CECOT, which was supposed to air tonight. We (Ori and I) asked for a call to discuss her decision. She did not afford us that courtesy/opportunity.
Our story was screened five times and cleared by both
CBS attorneys and Standards and Practices. It is factually correct. In my view, pulling it now-after every rigorous internal check has been met is not an editorial decision, it is a political one.
We requested responses to questions and/or interviews with DHS, the White House, and the State Department. Government silence is a statement, not a VETO. Their refusal to be interviewed is a tactical maneuver designed to kill the story.
If the administration's refusal to participate becomes a valid reason to spike a story, we have effectively handed them a "kill switch" for any reporting they
find inconvenient.If the standard for airing a story becomes "the government must agree to be interviewed," then the government effectively gains control over the 60 Minutes broadcast. We go from an investigative powerhouse to a stenographer for the state.
These men risked their lives to speak with us. We have a moral and professional obligation to the sources who entrusted us with their stories.
Abandoning them now is a betrayal of the most basic tenet of journalism: giving voice to the voiceless.
CBS spiked the Jeffrey Wigand interview due to legal concerns, nearly destroying the credibility of this broadcast. It took years to recover from that "low point." By pulling this story to shield an administration, we are repeating that history, but for political optics rather than legal ones.
We have been promoting this story on social media for days. Our viewers are expecting it. When it fails to air without a credible explanation, the public will correctly identify this as corporate censorship. We are trading 50 years of "Gold Standard" reputation for a single week of political quiet.These men risked their lives to speak with us. We have a moral and professional obligation to the sources who entrusted us with their stories.
Abandoning them now is a betrayal of the most basic tenet of journalism: giving voice to the voiceless.
CBS spiked the Jeffrey Wigand interview due to legal concerns, nearly destroying the credibility of this broadcast. It took years to recover from that "low point." By pulling this story to shield an administration, we are repeating that history, but for political optics rather than legal ones.
We have been promoting this story on social media for days. Our viewers are expecting it. When it fails to air without a credible explanation, the public will correctly identify this as corporate censorship. We are trading 50 years of "Gold Standard" reputation for a single week of political quiet.
I care too much about this broadcast to watch it be dismantled without a fight.
Sharyn
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Jon Grimm @dyerfulchymist.bsky.social · 16/12/2025
Lolz, the hallucination engine can't even summarize a season of a TV show correctly. Hundreds of billions well-spent! www.ign.com/articles/eve...
ign.com
'Everyone Disliked That' — Amazon Pulls AI-Powered Fallout Recap After Getting Key Story Details Wrong - IGN
Amazon has pulled its AI-powered Fallout Season 1 recap after fans noticed it made significant errors ahead of the launch of Season 2.
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Jon Grimm @dyerfulchymist.bsky.social · 04/12/2025
🤣🤣🤣 One drop of b̶l̶o̶o̶d̶ EiGhTy MoLeCuLeS!
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Andy Kostrub @andrewkostrub.bsky.social · 23/10/2025
Updating my LEGO White House
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Jon Grimm @dyerfulchymist.bsky.social · 08/10/2025
@edzitron.com has literally been saying this for years.
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Melanie D’Arrigo @darrigomelanie.bsky.social · 08/10/2025
I feel like this photo of masked, armed men pepper spraying a pastor protecting his community is going to be a defining picture of this moment in America for a long, long time.
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Ed Zitron @edzitron.com · 12/09/2025
Also - it is shocking and appalling that OpenAI CFO Sarah Friar signed off on the revenue projections OpenAI leaked, because she is affirming that they project to make *more revenue than NVIDIA and TSMC* in the next four years. Utterly ridiculous.
Here are the projections that CFO Sarah Friar signed off on:
In 2026, OpenAI will make $30 billion in revenue, or just under the $34 billion that Salesforce made in 2024.
In 2027, OpenAI will make $60 billion, or $2.6 billion more than the $57.4 billion Oracle made in their Fiscal Year 2025, or $8.4 billion more than Broadcom made in 2024.
In 2028, OpenAI will make $100 billion, or $2.31 billion more than Tesla made in 2024, or $11.66 billion more than TSMC - the single-largest chip manufacturer in the world - made in 2024.
In 2029, OpenAI will make $145 billion, or $14.5 billion dollars more than the $130.5 billion that NVIDIA made in their Fiscal Year 2025.
In 2030, OpenAI will make $200 billion, or $35.5 billion more than the $164.50 billion that Meta made last year.
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Ed Zitron @edzitron.com · 22/07/2025
OpenAI will, starting in 2028, have to start paying $30bn a year to Oracle, $28bn to Microsoft for Azure, and also $2.9bn to CoreWeave for compute. That’s $60.9 billion *in compute costs alone*. This company is an absolute joke and should be treated as such. www.theinformation.com/articles/ope...
OpenAI’s planned shift from Microsoft to Stargate wouldn’t happen overnight. The company’s spending on Microsoft-owned data centers should ramp up significantly in the next few years, more than doubling from $13 billion this year to $28 billion in 2028. The spending forecast is based on contracts signed between the two companies, OpenAI indicated. OpenAI could end up spending more with Microsoft for data centers than it indicated in the forecasts if Microsoft chooses to build additional data center capacity through 2030.
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Marlena Graves MDiv, PhD @marlenagraves.bsky.social · 30/07/2025
The truth here is so ever relevant, is so simple and profound. I think I might pop it into my next book. Sharing yet again:
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laura olin @lauraolin.bsky.social · 21/07/2025
Post from @suchnerve: Printing out a word document that says “I am a person” and then being like omg my printer is sentient now
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Kai Johnsson @kjohnsson.bsky.social · 03/07/2025
Finally out in Nature Chem Bio: SNAP-tag2 for faster and brighter protein labeling www.nature.com/articles/s41... Thank you Steffi and Veselin.
nature.com
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
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Kat Abughazaleh @katmabu.bsky.social · 02/07/2025
Support your local wannabe hooker by donating to my congressional campaign: secure.actblue.com/donate/abu-b...
secure.actblue.com
Chip in to support Kat Abughazaleh!
Show your support with a contribution.
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Three👁️Eyed👁️Devil👁️ @anarcish.bsky.social · 28/06/2025
“Independence day is canceled because of fear of secret police raids” is really a level of on the nose political symbolism you just can’t make up.
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jamelle @jamellebouie.net · 27/06/2025
it is no exaggeration at all to say that these are people who would rather destroy the state's flagship public university than education a diverse cross-section of the commonwealth's students
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jamelle @jamellebouie.net · 27/06/2025
the president does not actually have the power to fire a university president or a museum director, but if elites simply roll over under pressure, then effectively he does
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