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Schafer Lab

@ztslab.bsky.social
913 followers 557 following 25 posts

Zach Schafer's Lab @NotreDame. Studying #metabolism, #celldeath, #ECMdetachment, #metastasis, & #cancer. Account maintained by Zach. Views are mine. schaferlaboratory.com

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Felipe H Santiago-Tirado @felipehst.bsky.social · 20/08/2025
Congratulations to my student Robbi Ross on her award from NIH! Robbi will be working on the host-pathogen interactions between the environmental fungus Cryptococcus and human microglia. Looking forward to all of what you will accomplish Robbi! Congrats! fungilab.nd.edu/news/robbi-w...
fungilab.nd.edu
Robbi was awarded a Predoctoral Individual National Research Service Award (NRSA) from the National Institutes of Allergy and Infectious Diseases
Robbi competes sucessfully for the prestigious F31 fellowship from NIH Figure 1. The potential interactions between microglia…
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Ubellacker Lab @ubellackerlab.bsky.social · 18/08/2025
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
rdcu.be
Prospects for ferroptosis therapies in cancer
Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...
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Ubellacker Lab @ubellackerlab.bsky.social · 01/08/2025
Huge thank you to @olzmannlab.bsky.social and Scott Dixon for a phenomenal 1st FASEB Ferroptosis conference! I’m grateful to be part of such a collaborative community and it was especially great to meet all the brilliant trainees whose insights are clearly shaping the exciting future of the field! 🎉
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Brent Stockwell @brentstockwell.bsky.social · 31/07/2025
Thanks to James Olzmann and Scott Dixon for organizing a fantastic #faseb #ferroptosis meeting in Scottsdale AZ! Lots of great science as ferroptosis continues to impact diverse biology and diseases. Can’t wait for the next one! @olzmannlab.bsky.social
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Schafer Lab @ztslab.bsky.social · 29/07/2025
Currently enjoying being in sunny (and WARM) Arizona for the @faseborg.bsky.social meeting on #ferroptosis. Thanks to @olzmannlab.bsky.social and Scott Dixon for the opportunity to share our work and for promoting a welcoming and inclusive environment for scientific discussion.
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Gina DeNicola @ginadenicola.bsky.social · 27/07/2025
Hot science and hot temperatures at the FASEB Ferroptosis conference start tonight. Seriously the highs are 110F here 🥵 but it's beautiful!
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James Olzmann @olzmannlab.bsky.social · 20/07/2025
The count down has begun! 1-week until the 1st FASEB Ferroptosis conference! Looking forward to seeing everyone at the meeting. Get excited!! 🤩 events.faseb.org/event/11797f...
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Schafer Lab @ztslab.bsky.social · 16/06/2025
Happy to welcome summer students Juliana Blazek (@notredame.bsky.social), Yessenia Rodriguez (Stockton University), Ava Lightburn (Penn HS), Kris Shah (Penn HS), and Ranveer Verma (Penn HS) to the #SchaferLab!
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Schafer Lab @ztslab.bsky.social · 03/06/2025
"Federal research funding isn’t a handout to higher education; it’s a strategic investment. The government doesn’t fund university labs to help the schools’ bottom lines — it funds the best ideas and people to meet national priorities." Fantastic piece from @labonnelab.bsky.social!
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Schafer Lab @ztslab.bsky.social · 21/05/2025
Congrats on this exciting paper @rushika-perera.bsky.social lab!
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Schafer Lab @ztslab.bsky.social · 21/05/2025
Congrats to four #SchaferLab members who graduated from @notredame.bsky.social last weekend. Mackenzie will start her Ph.D studies @harvard.edu. Connor, Frances, and Paulina are all off to med school at @nufeinbergmed.bsky.social, @uchicagomedicine.bsky.social, and @uofwa.bsky.social respectively.
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Schafer Lab @ztslab.bsky.social · 04/05/2025
Excited to be part of this meeting this summer! Great opportunity for us to learn from #ferroptosis experts. Looking forward to meeting friends/colleagues old and new.
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Schafer Lab @ztslab.bsky.social · 30/04/2025
A privilege to host my friend @dacolon.bsky.social from @yaleschoolofmed.bsky.social for a #NieuwlandLecture in @notredamescience.bsky.social here @notredame.bsky.social. Proud of my former #KornbluthLab lab mate for all he has accomplished as a scientist, mentor, and person.
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Schafer Lab @ztslab.bsky.social · 27/04/2025
Friends and colleagues in #Chicago for #AACR25, check out some of the latest #SchaferLab work from @notredame.bsky.social graduate students @hannahtanczos.bsky.social and Matthew Fink on Monday and Tuesday.
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Holden Thorp @holdenthorp.bsky.social · 18/04/2025
Another great piece from Danielle Allen. We’re not going to win back hearts and minds by saying just trust us. www.thecrimson.com/article/2025...
thecrimson.com
Time for Harvard To Thank the American People | Opinion | The Harvard Crimson
Yet an even more important ally is the American people. The American people have for many decades given us great gifts — decades of generous support for research, as well as young people to educate an...
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Schafer Lab @ztslab.bsky.social · 14/04/2025
Thrilled to be in Chicago with #SchaferLab member Jianping He, who gave a dynamite talk this evening at the @asbmb.bsky.social ferroptosis meeting.
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Schafer Lab @ztslab.bsky.social · 20/03/2025
Really beautiful and thoughtful piece by @holdenthorp.bsky.social on his personal experience with autism diagnosis and the harms of the misguided notion that there remains legitimate "debate" about whether vaccines cause autism. Thanks for this Holden.
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UChicago Cancer @uchicagocancer.bsky.social · 10/03/2025
Thrilled to welcome Jeffrey Rathmell, PhD, as the new Chair of the Ben May Department for Cancer Research and Director of the Ludwig Center for Metastatic Cancer at the University of Chicago. We look forward to his leadership and impactful contributions on our research community. ow.ly/WN8f50Vf6Ja
ow.ly
UChicago names Jeffrey Rathmell, PhD, as Chair of the Ben May Department for Cancer Research
Rathmell, a pioneer in immune and cancer cell metabolism research, has been named Chair of the Ben May Department for Cancer Research and Director of the Ludwig Center for Metastasis Research at the University of Chicago, effective July 1, 2025.
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Schafer Lab @ztslab.bsky.social · 07/03/2025
Fantastic perspective here on the importance of NIH funding. medium.com/@lguercio/am...
medium.com
America’s Innovation Engine Under Threat: Why Protecting NIH Funding Matters Now More Than Ever
There are few institutions that exemplify our nation’s commitment to progress and shared prosperity like the National Institutes of Health…
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Schafer Lab @ztslab.bsky.social · 07/03/2025
#SouthBend is standing up for science! Here with #SchaferLab members @hannahtanczos.bsky.social and Michael Douglas! @notredame.bsky.social @notredamescience.bsky.social @standupforscience.bsky.social
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Science Magazine @science.org · 07/03/2025
Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4
scim.ag
Thousands gather across U.S. in Stand Up for Science events
Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration
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Schafer Lab @ztslab.bsky.social · 04/03/2025
Awesome to see the #SouthBend community coming together to stand up for science! @standupforscience.bsky.social @notredame.bsky.social
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Eran Andrechek @eranandrechek.bsky.social · 27/02/2025
Did you register for THE conference that covers breast cancer AND normal mammary gland development yet? The GRC Mammary Gland Biology and Neoplasia abstracts will be evaluated for short talks from trainees soon, so get your abstract in! www.grc.org/mammary-glan...
grc.org
2025 Mammary Gland Biology Conference GRC
The 2025 Gordon Research Conference on Mammary Gland Biology will be held in Newry, Maine. Apply today to reserve your spot.
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notredamescience.bsky.social @notredamescience.bsky.social · 26/02/2025
Biochemistry major, Emma Powers, has been awarded the prestigious Gates Cambridge Scholarship! During her undergraduate studies, Emma interned with leading research institutes. Next, she plans to pursue a Master of Philosophy degree in oncology. science.nd.edu/news-and-med...
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Lyssiotis Lab @lyssiotislab.bsky.social · 23/02/2025
Inspiring write-up on Prof Zeribe Nwosu. Way to go Zeribe! “Around the Globe and Back: Cornell Professor Approaches Cancer Research with an International Perspective” cornellsun.com/2025/02/20/a...
cornellsun.com
Around the Globe and Back: Cornell Professor Approaches Cancer Research with an International Perspective - The Cornell Daily Sun
The Nwosu Lab at Cornell leads groundbreaking research on cancer metabolism.
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American Association for Cancer Research (AACR) @theaacr.bsky.social · 18/02/2025
The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. Read our statement: buff.ly/4gRXNB8
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James Olzmann @olzmannlab.bsky.social · 13/02/2025
Registration is open for our summer FASEB #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help us to spread the word. 🤩 shorturl.at/QA6T1
Schedule of speakers at the 2025 FASEB Ferroptosis conference
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Felipe H Santiago-Tirado @felipehst.bsky.social · 11/02/2025
IN universities received $414 million in grants. That translated into $1.1 BILLION in economic activity. With the proposed cuts from the Trump administration, the state of IN will generate ~$451 million less. Check out NIH impact in your state here: www.unitedformedicalresearch.org/nih-in-your-...
unitedformedicalresearch.org
NIH In Your State - United For Medical Research
Select a state on the map to see the impact of NIH funding across America.
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American Society for Cell Biology @ascbiology.bsky.social · 10/02/2025
@NIH’s new 15% cap on research funds threatens U.S. science. Call Congress now to oppose it! Your voice matters—act today. Find your rep’s number at govtrack.us. #SupportScience #cellbiology
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Coloff Lab @colofflab.com · 10/02/2025
A restaurant might be a useful analogy for explaining direct vs indirect costs: Direct costs pay for the day's ingredients and the wages of the cooks. Indirect costs pay for the kitchen. Both are essential, but they need to be managed differently. Which is why they are separate.
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Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 10/01/2025
Excited to co-chair #ASBMB2025 with the incredible Dave Pagliarini! This year’s ASBMB meeting promises to showcase cutting-edge science, foster dynamic collaborations, & inspire new ideas. Don’t miss your chance to be part of it—register & submit your late breaking abstracts. t.co/UwgMdxBo15
t.co
https://bit.ly/3YGLQIx
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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 07/01/2025
Congrats @faubert.bsky.social! Brandon's work on lung cancer will be supported by the V Foundation. This is so fitting because Brandon was instrumental in VFound-funded lung cancer research at UTSW. @rjdlab.bsky.social and @cri-utsw.bsky.social are proud of you! www.nhl.com/news/univers...
nhl.com
Faubert honored at Winter Classic for cancer research | NHL.com
University of Chicago professor receives V Scholar Award for work on lung cancer
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ESPN @espn.com · 03/01/2025
Riley Leonard thanked his teammates after beating No. 2 Georgia to reach the CFP semis ❤️ Class act 👏
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Schafer Lab @ztslab.bsky.social · 19/12/2024
Big perk of working at @notredamescience.bsky.social @notredame.bsky.social in the Galvin Life Science Center? This is outside our front door. Cant wait for Notre Dame Stadium to host a @cfbplayoff.bsky.social game! Go Irish!
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Schafer Lab @ztslab.bsky.social · 19/12/2024
Happy Holidays from the #SchaferLab @notredame.bsky.social! Pic from annual holiday party and white elephant gift exhange.
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Cosimo Commisso @cosimocommisso.bsky.social · 05/12/2024
🚨 New bioRxiv study! 🚨 PDAC adapts to glutamine depletion via macropinocytosis, reshaping CAF subtypes & tumor stroma. Blocking it sensitizes tumors to therapy. Shoutout to Dr. Yijuan Zhang for leading this amazing work! Read more: 🔗 www.biorxiv.org/content/10.1... #CancerResearch #PDAC #TME
biorxiv.org
Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) tumors are deficient in glutamine, an amino acid that tumor cells and CAFs use to sustain their fitness. In PDAC, both cell types stimulate macropinocytosis as ...
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Katherine Aird @airdlab.bsky.social · 04/12/2024
Want a cliffsnote version of amazing cancer discoveries from 2024? Check out the Dec issue of Cancer Discovery. It was hard to pick just 1 paper to highlight!
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University of Notre Dame @notredame.bsky.social · 03/12/2024
We're keeping track of the official University of Notre Dame accounts that are launching on 🦋 Check out our Starter Pack to see which ones have joined us here: go.bsky.app/DkXoNM6
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Krishna Mudumbi @krishnamudumbi.bsky.social · 23/11/2024
Let's get more signal transduction enthusiasts in here! Let me know if you'd like to be added! go.bsky.app/MVvjypg
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Schafer Lab @ztslab.bsky.social · 23/11/2024
Thanks to @ivanoamelio.bsky.social for helping get cell death researchers together here on #BlueSky! go.bsky.app/R6mGrKU
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Johanna Joyce @johannajoyce.bsky.social · 23/11/2024
Both #Cancer #Research starter packs are now completely full! ~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️ I hope you'll find these useful to build our community here Pack 1: go.bsky.app/FEoaJMc Pack 2: go.bsky.app/6EcjWNA
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Jalees Rehman @jalees.bsky.social · 21/11/2024
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria www.nature.com/articles/s41...
nature.com
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria - Nature
Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...
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Christian Frezza @frezzalab.bsky.social · 13/11/2024
People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.
media.tenor.com
a bald man in a blue suit is making a funny face and pointing at something .
ALT: a bald man in a blue suit is making a funny face and pointing at something .
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Ivano Amelio @ivanoamelio.bsky.social · 16/11/2024
Let's bring the #CellDeath community together here on 🦋 Just get in touch to join this Starter Pack go.bsky.app/R6mGrKU
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Gomes Lab @gomeslab.bsky.social · 16/11/2024
Super happy to share our lab new paper spearheaded by graduate student Joanne Tejero describing a role for the age-induced oncometabolite methylamlonic acid in promoting T cell exhaustion and contributing to lung cancer immune evasion. www.nature.com/articles/s41...
nature.com
Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity - Oncogene
Oncogene - Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity
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Schafer Lab @ztslab.bsky.social · 15/11/2024
I work with a fantastic group of scientists here at Notre Dame, you can learn more about the lab and our research here: schaferlaboratory.com
schaferlaboratory.com
Schafer Lab @ Notre Dame
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Schafer Lab @ztslab.bsky.social · 15/11/2024
Hello BlueSky! I run a research lab @notredame.bsky.social focused on the intersection of #celldeath and #metabolism in cancer cells. Excited to connect with this community. Here’s a link to one of our most recent papers: www.cell.com/cell-reports...
cell.com
Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides
Schofield et al. report that cancer cells upregulate Acod1 as a survival strategy in response to αPD-1 therapy. Acod1hi cancer cells secrete inhibitory peptides that block the activation of naive CD8+...
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