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Victor DeFilippis

@vrdef.bsky.social
525 followers 831 following 52 posts

Innate immunologist, virologist, #cGAS, #STING, #Vaccines. Harpo Marxist.

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Reposted by Victor DeFilippis
A History of Rock Music in 500 Songs @500songspodcast.bsky.social · 17/08/2026
A History of Rock Music in 500 Songs can only brought to you by the generosity of Patreon supporters every month. Sign up today for as little as $1…it’s rumoured to be worth it for all those episodes. Why not find out?
patreon.com
Get more from Andrew Hickey on Patreon
Get more from Andrew Hickey on Patreon. Become a member for just $1/month. I've been writing for several years, and many people have told me they enjoy…
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David Grimm @david-grimm.bsky.social · 13/07/2026
The unprecedented move would have ended hundreds of studies at one of the largest academic monkey centers in the United States. But on Thursday, OHSU President Shereef Elnahal told faculty leaders the plan could not move forward because of a lack of federal funding. My latest for @science.org
science.org
Plan to turn major monkey research facility into sanctuary may be dead
Lack of federal funds may have forced Oregon university to drop idea of converting national primate center into science-free refuge
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Victor DeFilippis @vrdef.bsky.social · 10/02/2026
www.science.org/content/arti...
science.org
In unprecedented move, giant monkey research center may become a primate sanctuary
University votes to consider ending all studies at Oregon National Primate Research Center. But cost and feasibility are still in doubt
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Victor DeFilippis @vrdef.bsky.social · 03/09/2025
Pfizer clearly employs an elite PR team.
cnn.com
Pfizer responds to Trump’s call for Covid-19 vaccine data, says Operation Warp Speed deserves Nobel Peace Prize | CNN
In response to a call from President Donald Trump to make the positive impact of Covid-19 vaccines public, drug giant Pfizer posted a collection of more than 200 press releases and statements and 27 p...
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Reposted by Victor DeFilippis
Jeremy Kamil @macroliter.bsky.social · 11/06/2025
“In 1900, 30 percent of all deaths in the United States occurred among children younger than 5, mostly because of preventable infectious diseases. By the end of the century, that number was just 1.4 percent.” #VaccinesWork #VaccinesSaveLives #ACIP
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Victor DeFilippis @vrdef.bsky.social · 07/05/2025
www.whitehouse.gov/presidential... Jeffrey Taubenberger is the new head of NIAID and is literally famous for research that violated this executive order.
whitehouse.gov
Improving the Safety and Security of Biological Research
By the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered: Section 1.  Purpose.
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Victor DeFilippis @vrdef.bsky.social · 25/04/2025
www.nytimes.com/2025/04/25/h...
nytimes.com
‘Vaguely Threatening’: Federal Prosecutor Queries Leading Medical Journal
The New England Journal of Medicine received a letter suggesting that it was biased and compromised by external pressure. Other journals have also received the letter.
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Reposted by Victor DeFilippis
Vera Mikkilä @veramikkila.bsky.social · 16/04/2025
Are you a professor or assistant professor level researcher in the US or elsewhere outside of Finland? Looking for new opportunities in an inspiring and well-connected research environment? Finland might be just the place for you. Reach out to Finnish universities to explore what’s possible.
aka.fi
Finland invests in research excellence – new funding call by Research Council of Finland to support recruitment of international talents
The Research Council of Finland (RCF) has launched a funding call to improve universities’ ability to recruit international experts to Finland. In line with the RCF’s strategy, the call wi...
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Victor DeFilippis @vrdef.bsky.social · 15/04/2025
journals.asm.org/doi/full/10....
journals.asm.org
A call for the United States to continue investing in science | Journal of Virology
The U.S. life science research mission is critical not only to human health and understanding the natural world but also to agriculture and food production, technological innovations, socioeconomic progress, and our national defense and leadership worldwide. A 2025 Research!America survey reveals that 92% of Americans want government to actively work to promote medical progress, in part by funding infectious and chronic disease research. Why? Because biomedical research saves lives, prevents suffering, and increases quality of life for not only Americans but for people throughout the world. While less well appreciated, science also drives enormous economic growth. Indeed, historically there has been widespread bipartisan support for biomedical funding by the federal government. Below we discuss the U.S. scientific research enterprise and provide evidence and arguments we hope the ASM community can use to advocate for science.
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Victor DeFilippis @vrdef.bsky.social · 12/04/2025
I have read these e-mail notifications for many years. Horrifying does not even come close to describing the effect of this latest one.
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Reposted by Victor DeFilippis
Jenny Montooth @montoj.bsky.social · 02/04/2025
So long, NIH. The place I grew up in and discovered my passion for science communication. I found a true calling to help take innovative genomics research and make it accessible, interesting and fun for wider audiences. I'm so devastated that my whole team got laid off today.
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Amy Maxmen, PhD @amymaxmen.bsky.social · 19/03/2025
Studies terminated at NIH: -On reducing asthma from mold -On prenatal risks & screening -On statins influence on dementia -On the safety/risk of gender-affirming care -On how Covid vax outcomes & disparities -On improving HIV care -Training programs for the next generation of scientists
taggs.hhs.gov
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Mark Cuban @mcuban.bsky.social · 22/03/2025
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
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Victor DeFilippis @vrdef.bsky.social · 08/03/2025
www.opb.org/article/2025...
opb.org
Oregon researchers join nationwide rally against medical research cuts
Scientists, researchers and students from several Oregon universities were among the crowd of more than 500 people rallying against federal directives threatening funding for scientific and medical re...
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Reposted by Victor DeFilippis
Angie Rasmussen @angierasmussen.bsky.social · 28/02/2025
I have worked with many untenured staff scientists & PIs at NIH. They are incredible colleagues who chose science in public service over more lucrative careers. Devaluing their commitment & professionalism is among the most cruel aspects of the DOGE purge www.science.org/content/arti...
science.org
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
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Bella Rauch @rauchlab.bsky.social · 28/02/2025
Come join us! No excuses!!!
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Reposted by Victor DeFilippis
Vaughn Cooper @vscooper.micropopbio.org · 26/02/2025
As of today, at least 73 study sections have not met. If they review 50 applications, plus 30 triaged, 10% funding rate = 8 grants per SS. That's 584 fundable grants on hold. Probably 5000 researchers affected in those teams composed of our best and brightest. SABOTAGE.
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Ardem Patapoutian @ardemp.bskyverified.social · 25/02/2025
OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs." www.sandiegouniontribune.com/2025/02/25/o...
sandiegouniontribune.com
Opinion: Science funding cuts are based on flawed logic. Here’s the truth.
Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…
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Carolyn Ibberson @cbibberson.bsky.social · 22/02/2025
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
docs.google.com
Graduate Reductions Across Biomedical Sciences (2025)
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Rachel Poretsky @rporetsky.bsky.social · 22/02/2025
“Many grad programs are pausing and reducing admissions in response to NIH funding pauses and pending EO’s on indirect cost reductions. These workforce reductions have the potential to imminently and irreversibly harm research labs & grad programs”
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Reposted by Victor DeFilippis
Arbovirus seminars @arbovirus.bsky.social · 12/02/2025
Excited to announce our next speaker Dr William de Souza who will be presenting work on virus transmission dynamics of #emerging #arboviruses NEXT THURSDAY. Will be great to get some perspective from an up-and-coming investigator. PLEASE help with a repost for this community driven seminar series.
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Reposted by Victor DeFilippis
Michael Glickman @michaelglickman.bsky.social · 01/02/2025
www.nytimes.com/2025/01/30/h... Yet another amazing story of many strands of basic investigation emerging out of our science ecosystem, yielding a new therapeutic class of non opiate analgesics.
nytimes.com
FDA Approves Journavx Drug to Treat Pain Without Addiction Risk
The drug, Journavx by Vertex Pharmaceuticals, blocks pain signals to the brain, making it nonaddictive.
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Reposted by Victor DeFilippis
Harmit Singh Malik @harmitmalik.bsky.social · 09/12/2024
I participated in a faculty panel a few weeks ago in which senior (ahem) faculty gave advice on careers in academia by pretending luck had very little to do with our success. One piece of advice riled me up, in which it was argued that a reason for their success was their ability to say no. 1/
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Marc Veldhoen @marcveld.bsky.social · 29/12/2024
The generation of disinformation is easy. You make a graph, type something, and you are done. Showing how wrong it is takes more time. This is an easy example. The graph is made up, but for some, it will not be clear why this is wrong and is dangerous disinformation. 1/7
Screenshot of X post, which reads: ""In the United States, COVID-19 genetic injections are estimated to have caused more deaths than American casualties in WWI and WWII combined. The death toll even rivals the scale of the Civil War. This is a profound national tragedy, and accountability is urgently warranted. 
@RobertKennedyJr
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MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · 29/12/2024
40 years ago all of Genbank was published in print form by NAR. The same format today would require over 4 light seconds of shelf space. To a year of progress in 2025.
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BK. Titanji @boghuma.bsky.social · 26/12/2024
NIH funded research made important breakthroughs in 2024. Another reminder of why sustained funding for science and research is so vital. Of note 3 NIH funded scientists were recognized with the nobel prize. 5 top health related research highlights here 👇🏾 www.nih.gov/news-events/...
nih.gov
2024 NIH Research Highlights - Promising Medical Findings
NIH findings with potential for enhancing human health include insights into the mechanisms of ME/CFS, a skin test to detect Parkinson’s disease and related disorders, and a promising target for catar...
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Seth Thomas Scanlon @immunoeditor.bsky.social · 20/12/2024
This week in #Science #Immunology: Glen Barber & colleagues report that #cGas – #STING signaling in phagocytosed DNA-damaged cells facilitates #APC activation via formation of STING-inducible endosomal vesicles (SIEVES) containing immune-activating proteins and cytosolic DNA!
science.org
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells
Both cytosolic DNA species and innate immune STING signaling are required for stressed cells to activate phagocytes.
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Jacob Yount @yountlabosu.bsky.social · 20/12/2024
NIH has reclassified SARS-CoV-2 as a risk group 2 agent. I think this is the right move and will greatly increase the speed at which research can be performed. osp.od.nih.gov/policies/bio...
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Victor DeFilippis @vrdef.bsky.social · 05/12/2024
www.cell.com/molecular-ce...
cell.com
Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma
Nishimura et al. demonstrate that NBR1 is a synthetic vulnerability of p62 deficiency in HSCs by opposingly regulating the STING-interferon cascade. NBR1 ablation results in the accumulation of STING and its ability to activate IFN signaling, antagonizing the effect of p62 deficiency, which increases anti-tumor immunity in HCC.
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Victor DeFilippis @vrdef.bsky.social · 04/12/2024
www.jci.org/articles/vie...
jci.org
JCI - HO-1 impairs the efficacy of radiotherapy by redistributing cGAS and STING in tumors
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Victor DeFilippis @vrdef.bsky.social · 02/12/2024
Please consider joining this starter pack! go.bsky.app/V76NjxQ
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Bella Rauch @rauchlab.bsky.social · 26/11/2024
For those not in academia: Postdoc= researcher with a doctoral degree that is not a Professor. They do a majority of the actual science. Salary is too low to support a family in many major cities. Maybe show to your relative at Thanksgiving who believes "Scientists support vaccine policies to get $"
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Reposted by Victor DeFilippis
Victor DeFilippis @vrdef.bsky.social · 21/11/2024
Please consider joining this sure to be intriguing and impactful group!! go.bsky.app/V76NjxQ
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Dichromat Chloe (4% of scientists) @dichromat-chloe.bsky.social · 25/11/2024
(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why
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Jalees Rehman @jalees.bsky.social · 24/11/2024
Cytosolic delivery of innate immune agonists www.cell.com/trends/immun...
cell.com
Cytosolic delivery of innate immune agonists
Solute carrier proteins (SLCs) are pivotal for maintaining cellular homeostasis by transporting small molecules across cellular membranes. Recent discoveries have uncovered their involvement in modula...
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Reposted by Victor DeFilippis
Sasha Gusev @sashagusevposts.bsky.social · 24/11/2024
I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that have been floating around. It is important to understand how this agency actually functions and point criticism at the right problems. A short 🧵:
open.substack.com
Distinguishing real from invented problems with the NIH
How does the NIH work and where does it work well?
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Victor DeFilippis @vrdef.bsky.social · 23/11/2024
www.nature.com/articles/s41...
nature.com
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer - Nature Immunology
Here, the authors show that signal transducer and activator of transcription 3 (STAT3) has dual functions in small cell lung cancer as its deletion inhibited primary tumor growth but boosted metastati...
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Victor DeFilippis @vrdef.bsky.social · 22/11/2024
www.embopress.org/doi/full/10....
embopress.org
STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NF-κB signaling | The EMBO Journal
imageimageUpon activation, STING traffics to the Golgi and induces NF-κB signaling through poorly understood mechanisms. This study shows that E3 ligase HOIP recruitment to STING-positive Golgi-relate...
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Reposted by Victor DeFilippis
Waggoner Lab @labwaggoner.bsky.social · 22/11/2024
STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer www.nature.com/articles/s41...
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Victor DeFilippis @vrdef.bsky.social · 21/11/2024
Please consider joining this sure to be intriguing and impactful group!! go.bsky.app/V76NjxQ
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Stephen Turner @stephenturner.us · 21/11/2024
Tidyplots empowers life scientists with easy code-based data visualization www.biorxiv.org/content/10.1101/202… #rstats
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STAT @statnews.com · 21/11/2024
Bluesky is the new destination for X/Twitter’s health and science community. Here’s why www.statnews.com/2024/11/21/b...
statnews.com
Bluesky is the new destination for X/Twitter’s health and science community. Here's why
#MedTwitter is migrating en masse from X to Bluesky, suddenly making it an essential hub for scientific discourse. Here's why.
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Eric Topol @erictopol.bsky.social · 16/11/2024
And now this......... www.washingtonpost.com/health/2024/...
washingtonpost.com
Jay Bhattacharya, an NIH critic, emerges as a top candidate to lead the agency
The Stanford physician was excoriated by NIH’s director in 2020 for his “fringe” ideas on covid. Four years later, he’s poised for power in Trump’s Washington.
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Prof Sheena Cruickshank @sheencr.bsky.social · 04/11/2024
So if Trump is voted in expect a wave of infectious disease (also from rawmilk) and dental issues as Trump indicates he is open to RFK Jr’s proposal to ban vaccines 🧪
theguardian.com
Trump indicates he is open to RFK Jr’s proposal to ban vaccines if elected
RFK Jr, an anti-vaccine conspiracy theorist, says Trump promised him control over public health policy if he wins
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Victor DeFilippis @vrdef.bsky.social · 14/02/2024
We are hiring! Please consider applying or disseminating!
ohsu.edu
VGTI Recruitment | OHSUOHSU HomeSearch iconOHSU flame logo in whiteFacebookTwitterLinkedInYouTubeInstagramOHSU Braille servicesOHSU sign language servicesOHSU interpreter services
Vaccine and gene therapy institute Faculty Recruitment page Ad 021323
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BWJones @bwjones.bsky.social · 24/01/2024
1999 NIH Modular R01 Grant mechanisms: $250,000 / year. 2024 NIH Modular R01 Grant mechanisms: $250,000 / year. 25 years with no adjustment for inflation means scientists have lost ~48% of purchasing power while having to cover an increasing portion of salary and costs.
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Victor DeFilippis @vrdef.bsky.social · 23/01/2024
legacy.com
Jay Nelson Obituary (1948 - 2024) - Legacy Remembers
It is with heavy hearts that we announce the passing of our beloved Jay A. Nelson, who left us on January 20th. He was a loving husband, a devoted father, and grandfather. His presence will be deeply
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Victor DeFilippis @vrdef.bsky.social · 05/01/2024
Huh. Guess he'll be demanding her resignation. And someone let Christopher Rufo know.
businessinsider.com
Bill Ackman's celebrity academic wife Neri Oxman's dissertation is marred by plagiarism
Bill Ackman used plagiarism charges in pushing to remove Harvard president Claudine Gay. But new reporting shows his wife Neri Oxman also plagiarized.
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Matt Aliota @aliotalab.bsky.social · 21/12/2023
I unexpectedly have a position available in my laboratory. If you know anyone interested in relocating to the Twin Cities, tell them to get in touch. Could involve genomic surveillance, mosquito-virus interactions, and/or molecular virology.
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