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Carolina Lucas

@carolilucas.bsky.social
601 followers 220 following 121 posts

Assistant Professor YaleIbio |ImmunoVirus❤️ | Alum @Virusesimmunity lab | #womeninSTEM

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Carolina Lucas @carolilucas.bsky.social · 04/09/2026
Dengue vaccines face a uniquely difficult challenge: protecting against four distinct viral serotypes at once. 🦟 Our new study in JEM: rupress.org/jem/article/... A 🧵 on why tetravalent vaccine design does not necessarily mean tetravalent immunity.
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Journal of Experimental Medicine @jem.org · 02/09/2026
Conde, Monteiro, Freitas, Teixeira, @carolilucas.bsky.social et al show that Qdenga vaccination induces serotype-skewed immunity shaped by both immune imprinting & vaccine’s DENV-2 backbone, limiting balanced tetravalent responses, particularly in dengue-naïve individuals rupress.org/jem/article/...
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Carolina Lucas @carolilucas.bsky.social · 26/08/2025
🚨New Paper in Cell 🧵🔎 Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox. We were very excited (and lucky!) to contribute to this collab. effort. 🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠 doi.org/10.1016/j.cell.2025.08.004
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Camila Coelho, PhD MBA @camilahcoelho.bsky.social · 12/08/2025
🚨 New Publication!!! I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”. www.cell.com/cell-reports... [1/4]
cell.com
Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope
Rao et al. demonstrate that convergent somatic hypermutations in the light chain, enriched within a sarbecovirus-specific public antibody clonotype, drive affinity maturation. This antibody targets a ...
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Carolina Lucas @carolilucas.bsky.social · 25/08/2025
🧵 New collaborative study just published in Nature Biomedical Engineering: “A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity” doi.org/10.1038/s41551-025-01478-6
doi.org
A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity - Nature Biomedical Engineering
A modular platform for engineering immunogenic lipid nanoparticle mRNA vaccines is used to display antigens from a variety of pathogens to induce antigen responses.
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Camila Coelho, PhD MBA @camilahcoelho.bsky.social · 16/07/2025
Check our important piece below 👇! "We urge authors, reviewers, and editors to revise the default use of MSM as an epidemiological label. Our intention is not to dismiss important epidemiological context but to prevent the stigmatization of affected populations." @thelancetinfdis.bsky.social
thelancet.com
A call to move beyond MSM-centric framing in mpox research
The resurgence of mpox poses urgent public health challenges, and the scientific community has mobilised admirably to understand its transmission, immunity, and therapeutics.1,2 However, the language ...
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Carolina Lucas @carolilucas.bsky.social · 16/07/2025
Words matter. Scientific language shapes public perception and policy. Framing mpox as a disease of GBMSM may have reflected early patterns, but continuing this narrative misrepresents transmission risks and reinforces stigma. With Camila Coelho, Vries & Zucker 🌈 www.thelancet.com/journals/lan...
thelancet.com
A call to move beyond MSM-centric framing in mpox research
The resurgence of mpox poses urgent public health challenges, and the scientific community has mobilised admirably to understand its transmission, immunity, and therapeutics.1,2 However, the language ...
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Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · 03/07/2025
Day 3: Carolina Lucas (Yale) @carolilucas.bsky.social‬ discussing with students and postdocs how her research in immunity to viruses (especially emerging pathogens) shifted from mouse to human systems & the surprises along the way. #Immunology www.ccii.med.kyoto-u.ac.jp/en/events/
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The Lancet Microbe @lancetmicrobe.bsky.social · 01/04/2025
Our April issue is now online: www.thelancet.com/journals/lan... Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #COVID-19 #chikungunya #Neisseria #CHIM #mpox #BSI #Ecoli #Klebsiella #Mycoplasma #IDSky #ClinMicro #OA
Cover of The Lancet Microbe's April issue with a "Coloured transmission electron micrograph of Neisseria lactamica undergoing mitotic division".
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The Lancet Microbe @lancetmicrobe.bsky.social · 28/04/2025
New research article The impact of #orthopoxvirus vaccination and #Mpox infection on cross-protective immunity: a multicohort observational study www.thelancet.com/journals/lan... #IDSky #ViroSky #ClinMicro #OpenAccess #OA
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Carolina Lucas @carolilucas.bsky.social · 28/04/2025
🚨 Our new study is live in The Lancet Microbe! “The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study” Led by @jaycrandell.bsky.social , Valter Monteiro and Lauren Pischel www.sciencedirect.com/science/arti... A thread 🧵!
sciencedirect.com
The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study
Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbrea…
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Eric Topol @erictopol.bsky.social · 10/03/2025
Who funds biomedical research? @nature.com www.nature.com/articles/d41...
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Daniel Mucida @danmucida.bsky.social · 15/02/2025
“Americans who value the spirit of discovery — and eagerly await new ways to confront disease, strengthen our economy and improve the quality of human life — need to issue a strong outcry… This is not a fight that our country can afford to lose.” Indeed www.nytimes.com/2025/02/14/o...
nytimes.com
Opinion | American Science is Under Attack
The Trump administration hobbles research and endangers the public health.
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Nature @nature.com · 15/02/2025
Use this form to tell us how the new US administration is affecting your research, or suggest future coverage go.nature.com/4aYn9Me
go.nature.com
Are the Trump team’s actions affecting your research? How to contact Nature
Use this form to share information with Nature’s news team, or to make suggestions for future coverage.
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Thiago Carvalho @cyrilpedia.bsky.social · 08/12/2024
The set up: "This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host." www.science.org/doi/10.1126/...
science.org
Antibiotics damage the colonic mucus barrier in a microbiota-independent manner
Antibiotics inhibit production of the protective mucus in the colon, thus predisposing to gut inflammation.
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Edward Nirenberg @enirenberg.bsky.social · 07/12/2024
For those wondering why we seem to be so behind when it comes to effective mucosal vaccines against respiratory viruses, this really excellent overview from leaders in the field offers a great summary: www.nature.com/articles/s41... few additional points for those who want a bit more detail🧵:
nature.com
Challenges for developing broad-based mucosal vaccines for respiratory viruses - Nature Biotechnology
Nature Biotechnology - Challenges for developing broad-based mucosal vaccines for respiratory viruses
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Gregg Gonsalves @gregggonsalves.bsky.social · 06/12/2024
So we haven’t seen this occur in nature and there are other hurdles H5N1 would have to surmount to efficiently spread human to human. www.science.org/doi/10.1126/...
science.org
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...
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Sarah Ross @sarahhross.bsky.social · 02/12/2024
ICYMI: Analysis of blood serum found #LongCOVID was characterized by altered levels of certain immune complement proteins. These changes linked to complement activation and signs of dysregulation of the coagulation system. #Immunosky www.science.org/doi/10.1126/...
science.org
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Analysis of blood revealed that Long COVID is characterized by changes to complement proteins and platelet activation.
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Andrew S. MacDonald @profandrewmac.bsky.social · 29/11/2024
Fascinating new paper about how commensal #fungi can promote #type2 responses in mice, a process involving fungal induction of #IL-33 🍄 🧪 #ImmunoSky www.nature.com/articles/s41...
nature.com
Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature
Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.
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Katia Faliti @katyely.bsky.social · 28/11/2024
✨ Ever wondered why B cells are so fond of IL-2? Wonder no more! Our study is now published in Immunity @cellpress.bsky.social 🔍📑 A truly perfect Thanksgiving gift! 🧑‍🔬💉🔬https://authors.elsevier.com/c/1kAq43qNrUxuTR
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Nature Reviews Immunology @natrevimmunol.nature.com · 26/11/2024
The danger theory of immunity strikes back... rdcu.be/d1uQN
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Ellen Foxman @ellenfoxman.bsky.social · 25/11/2024
The measles vaccine is given as a shot but it is surprisingly good at inducing protective immunity in the respiratory tract (mucosal IgA). Our new study provides some clues about why...a thread (1/8) #IDSky #MedSky #lungs #immunology #ImmunoSky academic.oup.com/jid/advance-...
academic.oup.com
Validate User
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Daniela Barillà @danielabarilla.bsky.social · 10/11/2024
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏 🦠🧪🧫🧬
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Carolina Lucas @carolilucas.bsky.social · 04/06/2023
🧪Today, our lab group decided to take a break from scientific experiments and embrace tranquility with some llama yoga! Lhamaste🦙🧘‍♂️
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Carolina Lucas @carolilucas.bsky.social · 16/02/2023
The COVID-19 pandemic is now more challenging due to the Omicron variants. Robust public health measures, research and global cooperation are critical in addressing this crisis. Our recent @ScienceTM study is particularly important for countries relying on CoronaVac vaccines👇👇
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Carolina Lucas @carolilucas.bsky.social · 06/12/2022
In case you were wondering how a lab with Brazilians looks like during the World Cup 🏆…
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Carolina Lucas @carolilucas.bsky.social · 10/10/2022
Our newest study is out! We report an age-dependent impairment in antibody responses elicited by homologous, but not heterologous CoronaVac booster dose during the Omicron wave. www.medrxiv.org/content/10.1101/202… Special thanks to @mab_sp125 @ValterVSM and...
medrxiv.org
Age-dependent impairment in antibody responses elicited b...
The emergence of the SARS-CoV-2 Omicron sublineages resul...
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Carolina Lucas @carolilucas.bsky.social · 02/10/2022
Today Brazilians are faced with a simple choice: democracy or fascism. Today we vote for a new beginning. We vote for public education, public health, to science, against environmental destruction and poverty. #LULA2023 #ForaBolsonaro
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Carolina Lucas @carolilucas.bsky.social · 02/09/2022
First day as assist. prof. at @YaleIBIO after incredible years with @VirusesImmunity! My lab will focus on emerging viruses. The bio has changed but I haven’t. Incredibly honored for this opportunity and grateful to mentors, family, friends that encouraged me to make today happen
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Carolina Lucas @carolilucas.bsky.social · 21/01/2022
Nosso artigo descrevendo a imunogenicidade do regime de vacinacao heteróloga (2 doses de CoronaVac seguidos pela dose de reforco com Pfizer foi publicado hoje: www.nature.com/articles/s41591-022-… Algumas atualizações em relação ao preprint 🧵..
nature.com
Neutralizing antibodies against the SARS-CoV-2 Delta and ...
BNT162b2 booster vaccination in individuals who had previ...
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Carolina Lucas @carolilucas.bsky.social · 30/12/2021
Nosso preprint descreve a imunogenicidade do regime de vacinacao heterologa: 2 doses de CoronaVac seguidos pela dose de reforco com Pfizer 🧵. (verso em português 🇧🇷) www.medrxiv.org/content/early/2021/…
medrxiv.org
Immunogenicity of heterologous BNT162b2 booster in fully ...
The recent emergence of the SARS-CoV-2 Omicron variant is...
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Carolina Lucas @carolilucas.bsky.social · 30/12/2021
Our preprint describing the Immunogenicity of heterologous regimen: CoronaVac prime followed by Pfizer) booster 🧵 www.medrxiv.org/content/early/2021/…
medrxiv.org
Immunogenicity of heterologous BNT162b2 booster in fully ...
The recent emergence of the SARS-CoV-2 Omicron variant is...
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Carolina Lucas @carolilucas.bsky.social · 30/12/2020
Where the Pandemic Will Take America in 2021 - The Atlantic www.theatlantic.com/health/archive/…
theatlantic.com
Where Year Two of the Pandemic Will Take Us
As vaccines roll out, the U.S. will face a choice about w...
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Carolina Lucas @carolilucas.bsky.social · 23/09/2020
A city in Brazil where covid-19 ran amok may be a ‘sentinel’ for the rest of the world www.technologyreview.com/2020/09/22… "It was estimated that up to 66% of the city’s people have been infected, which they...
technologyreview.com
A city in Brazil where covid-19 ran amok may be a ‘sentin...
So many people have gotten sick in Manaus that researcher...
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Carolina Lucas @carolilucas.bsky.social · 02/09/2020
The Amazon is condemned to destruction. “Under Bolsonaro, Brazil is becoming perhaps the greatest global enemy of the environment. ”A tiny number of people grow very rich with this – and all of us lose....
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Carolina Lucas @carolilucas.bsky.social · 04/08/2020
The 'SHECESSION': economic crisis is affecting women more than men. Women are more vulnerable to sudden losses of income. The cracks in your system that were here before the pandemic have now become catastrophes!...
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Carolina Lucas @carolilucas.bsky.social · 22/07/2020
COVID-19 Immunology for Non-immunologists by Akiko Iwasaki, Ph.D. youtu.be/jeN8v5I5VNA via @YouTube
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Carolina Lucas @carolilucas.bsky.social · 22/07/2020
Today I finally got to see the Neowise comet. Amazing! Today, too, I received the acceptance letter from my first article in the lab. Amazing! This means that the next one will be 6800 years from...
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Carolina Lucas @carolilucas.bsky.social · 15/07/2020
Excellent explanation in 6m of what's happening in Brazil during COVID-19 pandemic. link:https://www.youtube.com/watch?v=XvK6Y_txWEE Trump Isn’t the Worst Pandemic President www.nytimes.com/2020/07/15/opinion/…
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Carolina Lucas @carolilucas.bsky.social · 07/07/2020
Continuous attacks on immigrants, democratic rights and students, post-docs, researchers on visas. These uncertainties are is so stressful... www.cnn.com/2020/07/06/politics/int…
cnn.com
International students may need to leave US if their univ...
International students who are pursuing degrees in the Un...
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Carolina Lucas @carolilucas.bsky.social · 04/07/2020
(07/02/20)Covid-19 Seminar Series by Akiko Iwasaki (⁦@VirusesImmunity⁩) hhmi.hosted.panopto.com/Panopto/Pag…
hhmi.hosted.panopto.com
Panopto
Capture, manage, and search all your video content.
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Carolina Lucas @carolilucas.bsky.social · 24/06/2020
Our longitudinal analyses revealed key temporal features of viral load, early predictive markers and distinct dynamics between types of immune response among moderate and severe COVID-19 outcomes. www.medrxiv.org/content/10.1101/202…
medrxiv.org
Longitudinal immunological analyses reveal inflammatory m...
Recent studies have provided insights into the pathogenes...
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Carolina Lucas @carolilucas.bsky.social · 15/05/2020
The coronavirus pandemic has been causing even larger gaps in different aspects of gender inequality. The most recent of these is the the research productivity among women. Women's research plummets during lockdown - but articles from men increase ...
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Carolina Lucas @carolilucas.bsky.social · 26/04/2020
Bolsonaro caindo por um vazamento de Moro - roteiro mais previsível impossível! Única surpresa é que em vez de liberarem como Novela das 9 saiu no Jornal Nacional. E assim completamos- crise na saúde, econômica e política! #ForaBolsonaro #ForaMoro
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Carolina Lucas @carolilucas.bsky.social · 22/03/2020
So difficult to process this image. So disturbing. Yale gym being prepared for the pandemic. All support to doctors, nurses and all health workers. Stay strong! #COVIDー19 #staystrong #yale
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Carolina Lucas @carolilucas.bsky.social · 18/03/2020
A total of 184,976 confirmed #COVID19 cases. Intervention measures disproportionally impact communities raising poverty and inequality. Each one knows it's own reality but everyone needs to be responsible and take action to minimize the virus spread.
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Carolina Lucas @carolilucas.bsky.social · 22/11/2019
Environmental researchers were sentenced to ten years in prison. They were dedicated to save the asiatic cheetah. They used a camera trap in their studies and have been accused of spying on Iran for enemy countries. #anyhopefornature ...
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Carolina Lucas @carolilucas.bsky.social · 15/11/2019
www.nature.com/articles/d41586-019-… “...the truth is that the system is making young people ill ... The research...
nature.com
The mental health of PhD researchers demands urgent atten...
Anxiety and depression among graduate students seems to b...
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Carolina Lucas @carolilucas.bsky.social · 14/11/2019
reut.rs/2X4hmyL Evo called new elections - yet they called for his resignation. Evo resigned - yet they broke into his house and burned his sister's. They do not want democracy. Which US-backed coup will be the model for Bolivia? Chile,Guatemala, Honduras, Haiti.
reut.rs
reuters.com
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