Alzheimer’s disease (AD) features amyloid-β plaques and tau pathology, yet the mechanism underlying early and clinically significant myelin loss remains unresolved. Here, we report human iPSC-derived ...

UCL seeks a Research Fellow to develop Alzheimer’s prognostic models using machine learning, imaging, fluid biomarkers and clinical data.

Neuroimaging and animal research reveal how pregnancy hormones remodel neural circuits and leave a long-lasting mark on women’s bodies and health.

Why do some memories last for weeks, months, or even years, while others quickly fade away? Astrocytes may hold the key.

Zimnik et al. provide a new, interpretable, unsupervised dimensionality approach for neural population activity. Their approach, sparse component analysis (SCA), reveals the latent factors correspondi...

Activating two distinct circuits in the anterior cingulate cortex separately restored social and attention deficits in ASD mice.

Abrar AbuHamdia is a PhD candidate developing brain organoid models and reviewing treatments and surgery for neurological disorders.

Phase 2 LiBBY trial results suggest a THC/CBD combination rapidly and significantly reduces agitation in hospice-eligible people with dementia. #AAIC26

Glucagon-like peptide-1 receptor (GLP-1R) activation is widely assumed to regulate the metabolic disorder in Alzheimer’s disease (AD). However, direct…

Microglia, the brain’s immune cells, are important for neuronal phagocytosis during brain development. Here the authors show that microglial lysosomal protease cathepsin B is required for efficient neuronal efferocytosis during brain development.

Molecular Psychiatry - A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms

Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer's disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APP^NLGF …

Search research papers and clinical trials across all conditions and research areas tracked by the Brain Regeneration Observatory.

Genomic studies implicate RBFOX1 in Alzheimer's disease (AD) risk, highlighting the need to define its role and interactions with other risk factors. Here, CRISPR/Cas9-mediated RBFOX1 loss in APOE4 h...

NPAS3 regulates astrocyte energy metabolism required for cognition, highlighting glial targets for neuropsychiatric disorders.

Astrocytes play essential roles in neuronal development, function, and disease, yet existing methods to derive astrocytes from human pluripotent stem cells (hPSCs) are complex and can involve months o...

University of Oxford seeks a Research Assistant to support the SHINE study on early Alzheimer’s using cognitive, EEG, MEG and MRI assessments.

UCL seeks a Research Fellow to study diet and dementia risk using genetic epidemiology, UK Biobank and large population datasets.

Brain blood vessels interact with neural cells to shape brain development, yet how these communications differ across regions remains unclear. Here, the authors show that region-specific neurovascular...

University of Cambridge seeks a Research Associate to study blood pressure, vascular health and dementia using imaging, genetics and population data.

eJournalPress is mission critical software providing online submission, review and tracking of manuscripts via the Internet. It was designed from the ground up to provide rock solid security, reliabil...

eJournalPress is mission critical software providing online submission, review and tracking of manuscripts via the Internet. It was designed from the ground up to provide rock solid security, reliabil...

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Zhang et al. optimize a label-free single-cell proteomics workflow to profile microglia from the hippocampus and prefrontal cortex of adult and aged mice, generating a dataset of more than 3,000 cells...