FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...

Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

New Article! Spontaneous and experimental models of lymph node metastasis https://bit.ly/4fzWoAj

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

In this Review, Erez and colleagues examine the complex interactions among tumours, their microenvironment and the host, shaping a metabolic macroenvironment that drives cancer progression. They explo...

An approach to collect lymph drained from the primary tumor in mice enables the downstream characterization of the samples using metabolomics, lipidomics and flow cytometry.

The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health invites applications for the level of assistant professor. The shared interest of MET faculty is to explor...