Sign in

Casey Theriot

@theriotmicrobe.bsky.social
709 followers 172 following 16 posts

Professor in Infectious Disease, microbiologist, C. difficile, gut microbiome, metabolomics, microbial mediated bile acids, amino acids

PostsRepliesMedia
Reposted by Casey Theriot
Vaughn Cooper @vscooper.micropopbio.org · 25/09/2026
FYI to everyone submitting this October NIH cycle You need to re-certify your ScienCV AFTER Sept 26 (tomorrow) for your application or it may not be accepted. Great timing!
78592
Reposted by Casey Theriot
Joe Zackular @joeyzacks.bsky.social · 04/09/2026
Beautiful perspective on our early-life C. difficile work from Ashley Gilliland and @brucevallance.bsky.social in @science.org! www.science.org/doi/10.1126/...
science.org
Not such a benign colonizer
Clostridioides difficile modulates inflammation and stem cell functions in the infant gut
0237
Reposted by Casey Theriot
Joshua Weitz @joshuasweitz.bsky.social · 13/07/2026
Essential & timely analysis via @techpolicypress.bsky.social on the massive public response to the White House's proposed OMB rule that would politicize grants, science, and federally funded research, including comment analysis dashboard. www.techpolicy.press/the-public-r...
techpolicy.press
The Public Rejects OMB's Federal Financial Assistance Rule
Tens of thousands of scientists, clinicians, and ordinary citizens warned OMB about putting political appointees in charge of which research gets funded.
19253
Reposted by Casey Theriot
Carl T. Bergstrom @carlbergstrom.com · 06/06/2026
If I was invited to speak at a leading medical association meeting and the editor-in-chief of their journal wrote this about me, I'd skip my own talk and call the cops. Wouldn't you?
Just a year ago, in these very pages, we highlighted the many threats the current U.S. administration posed to the health of our nation (1). Since then, there have been actions by the administration that have caused grave health consequences, and their current approach will continue to do so. The numerous measles outbreaks and associated avoidable deaths have resulted in part from hyping disproven theories of harm rather than publicizing the effectiveness of the measles vaccine (2). Plugging the concept that diabetes is curable by “changing the food source” (3) simply ignores the large body of work that has demonstrated that it is not merely a disease of poor nutrition and the immense challenges of reinventing the food industry. Peddling conspiracy theories represents failures by officials of the Department of Health and Human Services (HHS), whose primary goal is to protect our health. These two examples represent just two of the broken promises made by the current HHS leadership during their confirmation hearings (4,5). And, despite promising oversight, representatives on Capitol Hill have shirked their responsibility and have allowed the country to continue along misguided paths that even they recognized as irresponsible (4).
514740
Reposted by Casey Theriot
Mark Peifer (He, him) @peiferlabunc.bsky.social · 02/06/2026
Russell Vought, Director of the OMB, has issued a set of proposed changes that would dramatically alter federal grant funding. However, we can each take action to prevent these from taking effect. Here's how, a 🧵 🧪 1/n www.science.org/content/arti...
science.org
White House seeks to tighten political oversight of grantmaking
Sweeping proposed rule, now open for comments, would also restrict foreign collaborations and remove federal funding for open-access fees
4192167
Reposted by Casey Theriot
NC State University @ncstate.bsky.social · 02/04/2026
Christina Koch is moon-bound. 🚀🌕 The three-time NC State grad and her fellow Artemis II crew members blasted off from Kennedy Space Center on Wednesday evening. She will see parts of the solar system no human has ever seen before. Read more: ncst.at/uzpN50YC2pl
0275
Reposted by Casey Theriot
Joe Zackular @joeyzacks.bsky.social · 30/03/2026
Only TWO WEEKS left to register for @keystoneSymposia.bsky.social Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection, in Breckenridge! Check out the lineup of speakers - it is going to be an amazing meeting! Join us in May! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
keysym.us
Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia
Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!
023
Reposted by Casey Theriot
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 25/03/2026
Very provocative new paper in @natmicrobiol.nature.com As global temps rise, drought is becoming more frequent and prolonged across many regions Paper shows climate-driven drying of soils can fuel antimicrobial resistance at its ecological source, independent of clinical antibiotic use 🧵 (1 of 6)
22414
Casey Theriot @theriotmicrobe.bsky.social · 24/03/2026
We are looking for a talented research specialist to join our team at NCSU CVM in the Theriot lab! Please take a look and apply if your are interested. jobs.ncsu.edu/postings/228...
jobs.ncsu.edu
Research Specialist - Theriot Lab
The Theriot Lab is seeking a motivated and detail-oriented Research Specialist for a 1 year appointment. This role is ideal for a candidate looking to dive deep into microbiology research, focusing on...
002
Reposted by Casey Theriot
Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 23/03/2026
C. difficile is a terrible condition. Seems like it shouldn't have to be this hard to try to treat a child with a bad case of it. www.statnews.com/2026/03/23/c...
statnews.com
Her son needed a fecal transplant for a fearsome C. diff infection. Getting one required a tortuous journey
Her son needed a fecal transplant for a fearsome C. diff infection. Getting one required a tortuous journey.
1425
Casey Theriot @theriotmicrobe.bsky.social · 13/03/2026
New preprint from the Theriot lab and collaborators, which looks at how strain-dependent bile acid transformations by commensal Clostridia attenuate C. difficile virulence and disease without decreasing colonization! www.biorxiv.org/content/10.6...
biorxiv.org
084
Reposted by Casey Theriot
Keystone Symposia @keystonesymposia.bsky.social · 27/02/2026
⏰ Last chance to save $250! Register for Beyond Antibiotics by 11:59pm MST on March 5. Join @joeyzacks.bsky.social, @kimingeneva.bsky.social, @dariavantyne.bsky.social & @maribyndloss.bsky.social to spark new collaborations. 🎥 youtu.be/8Ppjx-MnvxA keysym.us/KSBeyondAnti... #KSBeyondAntibiotics26
youtu.be
KSQA: Drs. Joseph P. Zackular & Mariana X. Byndloss (Beyond Antibiotics)
YouTube video by KeystoneSymposia
145
Reposted by Casey Theriot
Nature Microbiology @natmicrobiol.nature.com · 22/02/2026
#NatMicroPicks C. diff vaccine! 🦠💉 A protective mucosal vaccine formulation that provides sterilizing immunity to clear C. difficile from the host. #MicroSky www.nature.com/articles/s41...
nature.com
Mucosal vaccination clears Clostridioides difficile colonization - Nature
Mucosal administration of a multivalent, adjuvanted vaccine against Clostridioides difficile promoted bacterial clearance and protected against morbidity, mortality, tissue damage and recurrence ...
05411
Casey Theriot @theriotmicrobe.bsky.social · 16/12/2025
news.cvm.ncsu.edu/how-a-better...
news.cvm.ncsu.edu
How a Better Bile Acid Could Keep C. diff at Bay
161
Casey Theriot @theriotmicrobe.bsky.social · 12/12/2025
Some nice press from a recent international collaboration with researchers from Leiden University. news.cvm.ncsu.edu/a-mouse-mode...
news.cvm.ncsu.edu
A Mouse Model of C. diff at NC State is Helping Scientists Around the World Develop Better Antibiotics
090
Reposted by Casey Theriot
ISB @isbscience.org · 10/12/2025
Nearly 1,000 people have registered so far! Don't miss out!
isbscience.org
2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB)
The gut’s microbial ecosystem produces diverse metabolites that actively shape neural, immune, and endocrine function. Join leading researchers on December 12 as they share new discoveries into these ...
072
Casey Theriot @theriotmicrobe.bsky.social · 18/11/2025
Really fun collaboration with Roman Melnyk from The Hospital for Sick Children Research Institute and Peter Dosa from University of Minnesota, making synthetic bile acids to be gut-restricted prevents C. difficile infection in a preclinical mouse model
0197
Reposted by Casey Theriot
Nature Microbiology @natmicrobiol.nature.com · 18/11/2025
#NewResearch A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice. #MicroSky 🦠💊 www.nature.com/articles/s41...
nature.com
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
03617
Casey Theriot @theriotmicrobe.bsky.social · 03/11/2025
Really nice work driven by postdocs Dr. Gancz in my lab and Dr. Zhang in Baker @erinbakerims.bsky.social lab at UNC, looking at novel lipids and how they might play a role in restoring colonization resistance against C. difficile in patients with rCDI post FMT. www.researchsquare.com/article/rs-7...
researchsquare.com
Successful Fecal Microbiota Transplants in Post-antibiotic Treated Recurrent Clostridioides difficile Patients Induce Acylcarnitine and Sphingolipid Lipidomic Shifts
Clostridioides difficile infection (CDI) is an urgent public health threat in the United States, resulting on an annual basis in over half a million cases, more than 29,000 deaths, and $4.8 billion in...
031
Reposted by Casey Theriot
Wiep Klaas Smits (ExpBac/CMAT) @smitslab.bsky.social · 13/10/2025
Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang www.universiteitleiden.nl/nieuws/2025/...
universiteitleiden.nl
Leids ‘superantibioticum’ houdt met lage dosis gevaarlijke darmbacterie in bedwang
Het in Leiden ontwikkelde antibioticum EVG7 slaagt erin om met een minimale dosis de gevaarlijke darmbacterie C. difficile te bestrijden. Bovendien komt de bacterie minder gemakkelijk terug, wat bij b...
021
Reposted by Casey Theriot
Wiep Klaas Smits (ExpBac/CMAT) @smitslab.bsky.social · 11/10/2025
New paper alert! In this work, published in @natcomms.nature.com we show that a new antibiotic is effective against (r)CDI. www.nature.com/articles/s41...
nature.com
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications
Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.
1115
Casey Theriot @theriotmicrobe.bsky.social · 10/10/2025
Really nice collaboration with the Martin and Smits labs at Leiden University Netherlands, designing and testing novel antimicrobials that target C. difficile but spare members of the microbiota, including Lachnospiraceae. www.nature.com/articles/s41...
nature.com
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications
Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.
040
Reposted by Casey Theriot
Mark Peifer (He, him) @peiferlabunc.bsky.social · 01/10/2025
Cool Postdoc opportunity alert! UNC SPIRE (Seeding Postdoctoral Innovators in Research & Education)-it provides scholars with both high quality research training & the opportunity to develop research based teaching skills that will inspire students across the sciences 1/n spire.unc.edu/program-info/
About Seeding Postdoctoral Innovators in Research & Education (SPIRE)

SPIRE’s Mission:

1) To provide scholars with both high quality research training and the opportunity to develop research based teaching skills that will inspire students across the sciences

2) To promote effective teaching and research partnerships between research intensive institutions and partner institutions with a large population of underrepresented students

The four major components of the SPIRE Postdoctoral Fellowship Program include:

Research
Teaching
Professional Development
Additional Opportunities
11623
Reposted by Casey Theriot
Leigh Knodler @leighknodler.bsky.social · 09/09/2025
"We became inconvenient".
cbsnews.com
NIH whistleblower details clash over childhood vaccines with Trump administration: "We became inconvenient"
A former NIH official says she was removed after clashes over vaccines, accusing RFK Jr. and his deputies of posing "a substantial and specific danger to public health and safety."
001
Reposted by Casey Theriot
Angie Rasmussen @angierasmussen.bsky.social · 24/08/2025
If you believe that keeping your head down and being quiet will spare you from this fate, you are mistaken. This will be all of us.
3495171
Reposted by Casey Theriot
Julie Pfeiffer @jkpfeiff.bsky.social · 18/08/2025
Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.
361100
Reposted by Casey Theriot
Pieter Dorrestein @pieterdorrestein.bsky.social · 13/08/2025
The best of both worlds with awesome speakers that will focus on how the microbiome affects ecosystems at a mechanistic level. Can’t wait for this meeting.
0122
Reposted by Casey Theriot
Jeff Jackson @jeffjacksonnc.bsky.social · 29/07/2025
A federal agency - which controls an enormous amount of money - is breaking the law to hide its decisions from you and avoid accountability. Hey OMB, see you in court.
16440148
Reposted by Casey Theriot
Roy Cooper @roycoopernc.bsky.social · 28/07/2025
I have thought on it and prayed about it, and I have decided: I am running to be the next U.S. Senator from North Carolina.
56390641763
Reposted by Casey Theriot
Mark Peifer (He, him) @peiferlabunc.bsky.social · 26/07/2025
Thank you Senator Tillis! NC folks drop him an email or make a call and thank him
0175
Reposted by Casey Theriot
Don Moynihan @donmoyn.bsky.social · 26/07/2025
We’ve known for months now that Vought was illegally impounding funds with the goals of rescissions. Better late than never for GOP Senators to politely ask that he stop breaking the law.
11448121
Reposted by Casey Theriot
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 25/07/2025
Enterococcus faecalis modulates phase variation in Clostridioides difficile www.biorxiv.org/content/10.1101/202…
1137
Reposted by Casey Theriot
Pieter Dorrestein @pieterdorrestein.bsky.social · 21/07/2025
I am so excited about this meeting. I will cover the discovery of 10,000s new metabolites, including an entirely new class of molecules. Looking forward to hearing and discussing your science on microbiome metabolites and metabolism.
0317
Casey Theriot @theriotmicrobe.bsky.social · 21/07/2025
New paper is out from our lab showing that some probiotics can accelerate and prolong the return of colonization resistance to C. difficile after antibiotics. news.ncsu.edu/2025/07/prob...
news.ncsu.edu
Probiotics Can Help or Hinder Gut Recovery After Antibiotic Treatment
1208
Casey Theriot @theriotmicrobe.bsky.social · 18/07/2025
Join us in Banff, CAN January 19-22 for the Keystone meeting on Microbiome Metabolism and Metabolites! Early scholarship deadline is September 23!
132
Reposted by Casey Theriot
Mark Peifer (He, him) @peiferlabunc.bsky.social · 27/06/2025
Thanks to WRAL for documenting the tremendous impact of the Trump administration efforts to end important research grants www.wral.com/news/local/u...
wral.com
100+ UNC research projects lose federal funding
UNC-Chapel Hill is navigating a significant $126 million reduction in federal grant funding compared to last fiscal year.
082
Reposted by Casey Theriot
Casey Theriot @theriotmicrobe.bsky.social · 17/06/2025
We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...
jobs.ncsu.edu
PostDoc Research Fellow - Gut Microbiology - Theriot Lab
A postdoctoral scientist position (1+ years) is available in Prof. Casey Theriot’s group at North Carolina State University College of Veterinary Medicine (NCSU CVM).Duties and ResponsibilitiesThe suc...
054
Reposted by Casey Theriot
Joshua Weitz @joshuasweitz.bsky.social · 23/06/2025
The #SCIMaP team announces a major update: an analysis of the economic impacts of the White House's NIH FY26 budget. Bottom-line, we estimate $46B in total economic loss, 202K lost jobs, and impacts in communities nationwide. Interactive map and shareable report: scienceimpacts.org/fy26 a 🧵
Economic loss due to NIH budget cuts by congressional district, scienceimpacts.org/fy26
25620411
Casey Theriot @theriotmicrobe.bsky.social · 17/06/2025
We are looking for a new postdoctoral fellow to join our team at NC State University College of Veterinary Medicine, near Research Triangle Park. If you are interested please DM me and or also apply here: jobs.ncsu.edu/postings/219...
jobs.ncsu.edu
PostDoc Research Fellow - Gut Microbiology - Theriot Lab
A postdoctoral scientist position (1+ years) is available in Prof. Casey Theriot’s group at North Carolina State University College of Veterinary Medicine (NCSU CVM).Duties and ResponsibilitiesThe suc...
054
Reposted by Casey Theriot
Isako Di Tomassi @isakoditomassi.bsky.social · 16/06/2025
Incredible work, JP! #McClintockLetters
086
Reposted by Casey Theriot
Pieter Dorrestein @pieterdorrestein.bsky.social · 12/06/2025
If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...
cell.com
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids
Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library containing hundreds of N-acyl lipids, including conjugates with short-chain fatty acids. This resource enabled the...
29341
Reposted by Casey Theriot
Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 08/06/2025
Jay Bhattacharya & Russ Vought are taking $566 million in NIH funding from my state (we are #2 in terminated grants) The impact will be truly horrific, but these 2 men will rejoice 😡 Bhattacharya took $129 million from Duke’s HIV vaccine development efforts: www.dukechronicle.com/article/2025... 🤬
26235
Reposted by Casey Theriot
Gc Rox @gcrox.bsky.social · 23/05/2025
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
3422381315
Reposted by Casey Theriot
Jeremy Berg @jeremymberg.bsky.social · 21/05/2025
Testifying tomorrow at a Senate hearing showcasing damage done to HHS by (personnel) terminations 3:00-4:30 convened by Senators Welch and Baldwin. With former leaders from CDC, SAMSHA< AHRQ, ACL (Admin. for Community Living) www.cbsnews.com/news/rfk-jr-...
cbsnews.com
Senate Democrats to hold hearings on mass terminations at HHS, decrying RFK Jr. "destructive rampage"
The widespread terminations at the Department of Health and Human Services have drawn questions about the functioning of key health programs.
915331
Reposted by Casey Theriot
Rachel W. Martin @rwmartin.bsky.social · 20/05/2025
It's worth commenting on the proposed plan to take away COVID boosters for people under 65. It takes 2 minutes. That said, I am really tired of having to comment on every dumb-ass thing every day. Could we just not destroy our society?
4183
Reposted by Casey Theriot
Ed Yong is offline @edyong209.bsky.social · 19/05/2025
I can’t recommend this enough. UNBREAKING, a new project from @lizneeley.bsky.social & co, documents & explains our many concurrent institutional collapses. It’s beautifully executed work, full of intellectual & moral clarity. 3 pages are live, more will come. It’s SO GOOD, & I learned so much.
10582223
Reposted by Casey Theriot
Joe Zackular @joeyzacks.bsky.social · 16/05/2025
Excited to share our new work in @aga-gastro.bsky.social! We show that dietary fiber alters the window of susceptibility to C. difficile following antibiotic exposure. This really fantastic study was co-led by an amazing team @rinniehewlett.bsky.social @alhecht.bsky.social and Amanda PeBenito.
gastrojournal.org
Dietary fiber modulates the window of susceptibility to Clostridioides difficile infection
Clostridioides difficile epidemiology is rapidly evolving, and understanding the factors that contribute to one’s risk of C. difficile infection (CDI) is urgently needed. Based on our observations in ...
65020
Reposted by Casey Theriot
Angie Rasmussen @angierasmussen.bsky.social · 16/05/2025
Hey do you guys remember the promises @SecKennedy made to @SenBillCassidy? I do. youtu.be/QrJcBtkfwvo?si…
youtu.be
Sen. Cassidy Says RFK Jr. Promised Key Vaccine Safety Commitments
YouTube video by KFF Health News
917166
Reposted by Casey Theriot
Wiep Klaas Smits (ExpBac/CMAT) @smitslab.bsky.social · 14/05/2025
Important: if a bug does not make the WHO's priority list, this does not mean it is not relevant. We present arguments why investment in R&D for surveillance, control and treatment of C. difficile (CDI) is of critical importance: www.sciencedirect.com/science/arti...
sciencedirect.com
Clostridioides difficile is a bacterial priority pathogen
22110
Reposted by Casey Theriot
Joe Zackular @joeyzacks.bsky.social · 09/05/2025
Delighted to announce the @keystonesymposia.bsky.social meeting: Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection. Join us in Breckenridge in May 2026!! You can check out the program and amazing lineup of speakers below: keysym.us/KSAntibiotics26 #KSAntibiotics26
keysym.us
Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia
Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!
14929