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Vallance Lab

@brucevallance.bsky.social
55 followers 46 following 8 posts
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Reposted by Vallance Lab
Joe Zackular @joeyzacks.bsky.social · 04/09/2026
Beautiful perspective on our early-life C. difficile work from Ashley Gilliland and @brucevallance.bsky.social in @science.org! www.science.org/doi/10.1126/...
science.org
Not such a benign colonizer
Clostridioides difficile modulates inflammation and stem cell functions in the infant gut
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Vallance Lab @brucevallance.bsky.social · 04/08/2026
Abstract submission deadline extended to August 15th! Submit here: ubc.ca1.qualtrics.com/jfe/form/SV_...
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Vallance Lab @brucevallance.bsky.social · 20/07/2026
Join us on September 23rd 2026 as we convene experts in 3D tissue modelling across Vancouver and beyond! Our goal is to spark new discussions and collaborations as this exciting field continues to expand. @bcchresearch.bsky.social ubc.ca1.qualtrics.com/jfe/form/SV_...
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Vallance Lab @brucevallance.bsky.social · 13/04/2026
🚨New paper from our lab!🚨 We show that disrupting mucin sugar utilization in Citrobacter rodentium causes the build-up of a sugar phosphate, which compromises bacterial growth, colonization, and pathogenesis. A metabolic bottleneck with big virulence consequences. journals.asm.org/doi/10.1128/...
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Vallance Lab @brucevallance.bsky.social · 12/02/2026
🚨NEW FINDINGS! In the age of personalized medicine, we find that biopsy-derived organoids from ulcerative colitis patients show impaired mucus and epithelial barriers, mimicking patient pathologies and providing a platform to test new drugs to repair these barriers. academic.oup.com/ibdjournal/a...
academic.oup.com
Biopsy-derived colonoid air-liquid interface monolayers reveal persistent mucosal defects in ulcerative colitis patients
AbstractBackground. The inflammatory bowel disease (IBD) ulcerative colitis (UC) is characterized by colonic mucosal inflammation and barrier dysfunction.
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Reposted by Vallance Lab
BCCHR ResDev (DM) @resdevbcch.bsky.social · 29/09/2025
Congratulations to all including two projects co-led by @bcchresearch.bsky.social’s @mklevings.bsky.social and @brucevallance.bsky.social 🎉🎉🎉🎉🎉
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Reposted by Vallance Lab
BCCHR ResDev (DM) @resdevbcch.bsky.social · 13/08/2025
Fab work led by @brucevallance.bsky.social and @ctropini.bsky.social @bcchresearch.bsky.social
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Vallance Lab @brucevallance.bsky.social · 02/06/2025
🚨 We’re featured in @CBCNews! Our team is using organoids to study how microbes interact with the gut mucus layer, and how this relationship impacts diseases like IBD 💩🔬 📰 Read the full story: www.cbc.ca/news/health/... #Microbiome #GutHealth #Organoids #IBD
cbc.ca
How much does your gut health impact your overall health? A lot, doctors say | CBC News
Doctors are tapping into to the emerging field of the gut microbiome to try to treat some diseases differently.
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Reposted by Vallance Lab
Dr. Paula Littlejohn, PhD, MHS @sistainscience.bsky.social · 19/05/2025
Very grateful to be a part in this project now finally published. www.frontiersin.org/journals/imm...
frontiersin.org
Frontiers | Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model
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Vallance Lab @brucevallance.bsky.social · 09/05/2025
New paper from our lab! We developed an organoid-based air-liquid interface (ALI) model that produces physiologically relevant intestinal mucus and discovered that EspC has a mucinolytic superpower which enables C. rodentium to degrade mucus. 🧫🦠https://pmc.ncbi.nlm.nih.gov/articles/PMC12054374/
pmc.ncbi.nlm.nih.gov
Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus
Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. F...
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