Alternative RNA processing generates extensive transcript diversity, yet how transcript architecture influences selective m6A deposition is incompletely understood. Exon-junction-based models explain ...

Nature Reviews Molecular Cell Biology, Published online: 09 January 2026; doi:10.1038/s41580-025-00944-yUFMylation, a ubiquitin-like modification, regulates endoplasmic reticulum-associated ribosome quality control by conjugating UFM1 to the ribosomal subunit RPL26, preserving ribosome integrity under stress. This Review explores the structural basis of UFMylation and its emerging functional breadth, and it discusses putative UFMylation substrates.

This paper examines the labor market effects of Florida's 2022 post-tenure review policy, which weakened tenure protections at public universities. Using a diff

Despite the United States being a global leader in many areas, Americans are not healthy. Life expectancy is lower than in other industrialized nations,...

Cuts and layoffs to the National Institutes of Health threaten medical research around the U.S., agency insiders warn.

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

Facing the potential loss of hundreds of millions of dollars in federal funding, Duke University is preparing for the worst.

Facing the potential loss of hundreds of millions of dollars in federal funding, Duke University is preparing for the worst.

Administration officials pressured the NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.

Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

People around the world are watching with disbelief as the new US government closes down its aid programme, withdraws from the World Health Organization (WHO) and the Paris agreement on climate change...

ALT: a poster that says if life gives you lemon make lemonade on it

NIH directly supports the economy through investments in research institutions and job formation.

For many RNA viruses, immunity is triggered when RIG-I-like receptors (RLRs) detect viral RNA. However, only a minority of infected cells undergo inna…

America’s best scientific minds are scrambling to determine the impact of the disruption.

ZIKV is a major concern due to its association with birth defects, including microcephaly. We previously identified a physical interaction between ZIKV NS4A and host microcephaly protein ANKLE2. Mutat...

Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

The annual direct medical cost attributable to human papillomavirus (HPV) in the United States over the period 2004–2007 was estimated at $9.36 billio…