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Tatum Mortimer

@tatumdmortimer.bsky.social
946 followers 669 following 6 posts

Bacterial pathogen genomics and evolution, Assistant Professor in the Department of Population Health at University of Georgia, she/her/hers mortimerlab.com

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Reposted by Tatum Mortimer
QinQin Yu @qinqinyu.bsky.social · 19/08/2026
Some bacteria can rapidly change their surface proteins to undergo antigenic variation – what is the diversity of these proteins and how do they evolve? We delved into this question in Neisseria gonorrhoeae, the cause of the sexually transmitted infection gonorrhea: journals.plos.org/plospathogen...
journals.plos.org
Diversity and evolution of a phase-variable multi-locus antigen in Neisseria gonorrhoeae
Author summary The rising levels of antibiotic resistance in Neisseria gonorrhoeae make controlling the spread of this sexually transmitted pathogen a public health priority. N. gonorrhoeae rapidly va...
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Louise H. Moncla @lhmoncla.bsky.social · 23/07/2026
Led by Anna Jaeger and Elena Cruz-Adames, we have a new preprint out on within-sample diversity and local spread of H5N1 in Pennsylvania! www.biorxiv.org/content/10.6.... We developed a sequencing protocol and bioinformatic pipeline to sequence residual RNA from H5+ wild and domestic birds in PA.
biorxiv.org
Within- and between-host dynamics of highly pathogenic avian influenza in domestic birds from Pennsylvania farms and live bird markets
Since late 2021, highly pathogenic avian influenza viruses (HPAI) of the H5 subtype clade 2.3.4.4b have spread across the Americas, devastating wildlife, agricultural animals, and resulting in dozens ...
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M. Stephen Trent @mstrent.bsky.social · 10/04/2026
We are recruiting postdocs to work on antimicrobial resistance and bacterial cell envelope biology. PLEASE SHARE.
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 16/02/2026
🧵 After years out of the field, I and my lab are again working on bacterial type IV pili. We have just posted our first preprints, and I'm excited to share what we have discovered. This shows Neisseria gonorrheae bacteria infecting a human epithelical cell. Here, you can see the pili in red. 1/
Fluorescence micrograph. Emma Miller and Alex Merz, unpublished.
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Yonatan Grad @yhgrad.bsky.social · 26/11/2025
New preprint: with increasing resistance to ceftriaxone, the last recommended antibiotic for gonorrhea, we urgently need new drugs. Two--zoliflodacin & gepotdiacin--are up for approval by the FDA in Dec. Here we show a point mutation can result in cross-resistance. www.biorxiv.org/content/10.1...
biorxiv.org
Zoliflodacin and gepotidacin cross-resistance in Neisseria gonorrhoeae
Resistance to zoliflodacin, a first-in-class antibiotic for gonorrhea treatment, can occur through gyrBD429N, but this mutation's impact on fitness and resistance to other topoisomerase targeting drug...
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Reposted by Tatum Mortimer
Louise H. Moncla @lhmoncla.bsky.social · 12/11/2025
Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...
nature.com
Ecology and spread of the North American H5N1 epizootic - Nature
The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...
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Gc Rox @gcrox.bsky.social · 21/10/2025
Microbiology Postdoctoral Position (Please re-post) A funded postdoctoral position in Chicago will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology. If interested, please get in touch with Hank Seifert h-seifert@northwestern.edu
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Louise H. Moncla @lhmoncla.bsky.social · 15/10/2025
Our lab's first paper is out! Led by Jordan Ort, we developed NextClade datasets that enable rapid H5 clade assignment via NextClade. We deployed these during the start of the H5 cattle outbreak, and we finally published the paper in Virus Evolution academic.oup.com/ve/article/1...
academic.oup.com
Development of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignment
Abstract. The 2022 panzootic of highly pathogenic avian influenza (HPAI) A(H5) viruses has led to unprecedented transmission to multiple mammalian species.
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Kate Baker @ksbakes.bsky.social · 27/07/2025
There are half a million cases of invasive non-Typhoidal Salmonella (iNTS) every year and while you might know S. Typhimurim and Enteritidis, you may not have heard of S. Panama 💩 🩸 🧫 💊 Check out our latest in @lancetmicrobe.bsky.social doi.org/10.1016/j.la... and the 🧵 below to find out more 1/n
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Megan Behringer @megbehri.bsky.social · 29/09/2025
Our lab is hiring!! We are looking for a research assistant who will be involved with our experimental evolution studies on how stress affects population dynamics in E. coli. Great opportunity for recent grads! E-mail for more info and apply here: ecsr.fa.us2.oraclecloud.com/hcmUI/Candid...
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Tim Read @timothyread.bsky.social · 10/09/2025
Delighted to see the first version of our new ELife paper. A collaboration with Levi Morran, we show how an intact antibiotic resistance gene (mecA) changes the course of S. aureus evolution on a new host. Kudos to Michelle Su and Kim Hoang for making this happen. elifesciences.org/reviewed-pre...
elifesciences.org
Host and antibiotic jointly select for greater virulence in Staphylococcus aureus
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
⚠️ New preprint ⚠️: Two new antibiotics are likely coming for gonorrhea 💊. How should we deploy them in the US to minimize drug resistance? @kroster.bsky.social @dhelekal.bsky.social Eva Rumpler @yhgrad.bsky.social [1/10] www.medrxiv.org/content/10.1...
medrxiv.org
Comparing Strategies to Introduce Two New Antibiotics for Gonorrhea: A Modeling Study
Introduction Drug resistance in Neisseria gonorrhoeae is an urgent public health threat. The anticipated approval of two new antimicrobials for gonorrhea prompts the need for evidence-based rollout st...
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Helen Branswell 🇨🇦 @helenbranswell.bsky.social · 09/07/2025
Using doxycycline after unprotected sex — doxy PEP — is effective at reducing some sexually transmitted infections in some people. But new research suggests is probably also driving development of resistance to tetracycline antibiotics in some bacteria. www.statnews.com/2025/07/09/d...
statnews.com
Use of antibiotic to reduce STIs appears to be fueling some antibiotic resistance, research shows
The use of the antibiotic doxycycline to reduce STIs appears to be fueling some antibiotic resistance, according to new research.
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Yonatan Grad @yhgrad.bsky.social · 10/07/2025
Now out in NEJM. Kudos to @dhelekal.bsky.social and @tatumdmortimer.bsky.social : www.nejm.org/doi/10.1056/...
nejm.org
Expansion of tetM-Carrying Neisseria gonorrhoeae in the United States, 2018–2024 | NEJM
During 2018–2024, the percentage of N. gonorrhoeae isolates carrying tetM, which confers tetracycline resistance, increased from less than 10% to more than 30% across the United States.
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Tatum Mortimer @tatumdmortimer.bsky.social · 09/07/2025
The Poultry Diagnostic and Research Center at UGA is looking for an avian microbiologist (open rank, tenure-track position) to lead the bacteriology/mycology diagnostic section! Find out more about the position and apply here: www.ugajobsearch.com/postings/437...
ugajobsearch.com
Avian Diagnostic Microbiologist
The University of Georgia, College of Veterinary Medicine, Department of Population Health invites applications for a tenure-track position at the rank of Assistant or Associate Professor in the field...
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Tatum Mortimer @tatumdmortimer.bsky.social · 26/06/2025
If you are an early career research attending @stihiv2025.org and interested in learning more about data visualization in R, @odileharrison.bsky.social , Sim Dabee, and I are organizing a workshop during the conference (11:30am-1:30pm on Wednesday). Register here: forms.gle/e4UL1NG62PUD...
forms.gle
ECR Data Visualisation Workshop
Please complete this application to attend the Data Viz workshop. This event will be held at the 2025 STI & HIV World Congress in Montreal, Canada on Wednesday, July 30th from 11:30-13:30. Effective...
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CCDD @ccdd-hsph.bsky.social · 23/06/2025
Dr. Yonatan Grad @yhgrad.bsky.social, Professor of immunology and infectious diseases comments on the potential impact of recent decisions related to vaccines made by Health and Human Services Secretary (HHS) Robert F. Kennedy Jr. Read it here at bit.ly/3T2KPqX
bit.ly
RFK Jr. moves on vaccines could have broad ramifications for public health, says expert | Harvard T.H. Chan School of Public Health
Yonatan Grad, professor of immunology and infectious diseases, comments on the potential impact of recent decisions related to vaccines made by Health and Human Services Secretary Robert F. Kennedy Jr...
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Bailey Bowcutt @baileybowcutt.bsky.social · 30/05/2025
I got the opportunity to speak with Science about my individual research fellowship being terminated. I was awarded the NSF GRFP before I chose Harvard for graduate school, but I still got cut. I study how we can improve treatments for a common antibiotic resistant bacteria, so this is sad to see
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Gc Rox @gcrox.bsky.social · 23/05/2025
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
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Yonatan Grad @yhgrad.bsky.social · 23/05/2025
In this preprint, we consider the explanations for the observed drop in gonorrhea incidence in the US and the evidence needed to evaluate them. A critical takeaway: without the CDC data & monitoring, we're unlikely to know. Those huge cuts to the CDC undermine efficient, effective healthcare.
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Kirstin Oliveira Roster @kroster.bsky.social · 21/05/2025
New preprint. After years of increases, gonorrhea diagnosis rates dropped in the US in 2022 and 2023. While the news is promising, understanding WHY is key to sustaining progress. dash.harvard.edu/handle/1/427...
dash.harvard.edu
Why are gonorrhea diagnoses declining in the US?
After a decade of rising cases, the US CDC reported a decline in the rate of gonorrhea diagnoses for two years in a row in 2022 and 2023, especially among young adults. Primary and secondary syphilis ...
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Bailey Bowcutt @baileybowcutt.bsky.social · 22/05/2025
I'm a current Harvard graduate student and I found out today that I had my NSF GRFP terminated without notification. I was awarded this individual research fellowship before even choosing Harvard as my graduate school
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Courtney Ellison @ckellison.bsky.social · 22/05/2025
Excited to share the newest preprint from the lab for my first post! Driven by @tayellisonwrites.bsky.social and @ianyyen.bsky.social with Lynne Howell we show the protein FimX has diverged in function away from regulating pilus extension to instead regulate pilus localization in A. baylyi
biorxiv.org
FimX regulates type IV pilus localization via the Pil-Chp chemosensory system in Acinetobacter baylyi
Type IV pili (T4P) are widespread dynamic appendages required for diverse prokaryotic behaviors including twitching motility, biofilm formation, and DNA uptake leading to natural transformation. Altho...
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Kat Holt @katholt.bsky.social · 22/05/2025
Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight) interpretamr.github.io/AMRrules
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Harvard T.H. Chan School of Public Health @hsph.harvard.edu · 16/05/2025
With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
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Michael Baym @baym.lol · 14/05/2025
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
A screenshot of the termination notice showing "Outstanding Investigator Grants"A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted
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Dr. Michael D. L. Johnson @copperbae.bsky.social · 01/05/2025
Are you able to mentor a summer student and have a good project that can be virtually administered, sign up to be an NSURP mentor today! If you can't, hit that share button please and thank you! #NoLabNoProblem #NSURP uarizona.co1.qualtrics.com/jfe/form/SV_...
uarizona.co1.qualtrics.com
Online Survey Software | Qualtrics Survey Solutions
The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.
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Yonatan Grad @yhgrad.bsky.social · 07/04/2025
Our preprint and much other work was only possible because of data generated by the CDC STD lab, which was shuttered in the HHS layoffs last week. This is a huge blow to efforts to monitor resistance, guide clinical care, & inform policy www.statnews.com/2025/04/05/c... @helenbranswell.bsky.social
statnews.com
CDC’s top laboratory on sexually transmitted diseases is shut by Trump administration
The Trump administration fired everyone in a CDC lab that is crucial to tracking drug-resistant gonorrhea and other sexually transmitted diseases. "We are blind," an expert says.
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David Helekal @dhelekal.bsky.social · 28/03/2025
(1/10) New preprint: Expansion of tetM-carrying Neisseria gonorrhoeae in the US, 2018-2024; Link: www.medrxiv.org/content/10.1...
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Dr. Michael D. L. Johnson @copperbae.bsky.social · 24/02/2025
Although we are not federally funded for this summer, WE WILL STILL RUN The National Summer Undergraduate Research Project (NSURP) in 2025. We remain committed to the work that needs to be done and will continue to meet people where they are. 1/4 nsurp.org
nsurp.org
NSURP.org
National Summer Undergraduate Research Project
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Stephen Kissler @skissler.bsky.social · 14/02/2025
Some of the most talented people I know have joined, or were about to join, the EIS. This is an immense loss.
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Marco Galardini @mgalactus.bsky.social · 12/02/2025
Our paper describing the microGWAS pipeline was published yesterday in Microbial Genomics. Lots of fixes and additions to the code/documentation since the preprint, including a hard to reproduce bug that only showed up in a specific HPC 🥵 www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
microGWAS: a computational pipeline to perform large-scale bacterial genome-wide association studies
Identifying genetic variants associated with bacterial phenotypes, such as virulence, host preference and antimicrobial resistance, has great potential for a better understanding of the mechanisms inv...
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David Helekal @dhelekal.bsky.social · 07/02/2025
How do changes in antibiotic use, various pathways to resistance, multiple drug resistance, and more come together to shape the success and failure of bacterial lineages in a real-world epidemic? #AMR #microsky A preprint: www.biorxiv.org/content/10.1... (1/15)
biorxiv.org
Quantifying the impact of antibiotic use and genetic determinants of resistance on bacterial lineage dynamics
The dynamics of antimicrobial resistance in bacteria are informed by the fitness advantages conferred by genetic determinants of resistance in the presence of antibiotic pressure and the potential fit...
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Louise H. Moncla @lhmoncla.bsky.social · 28/01/2025
Call your senators! Do it today! It's better than wallowing
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Tabea Elsener @tabeaelsener.bsky.social · 08/01/2025
A hitchhiker’s guide to the gonococcal population: biorxiv.org/content/10.1...
biorxiv.org
The origin and evolution of the gonococcal beta-lactamase plasmid, and implications for public health
Neisseria gonorrhoeae is a leading cause of sexually transmitted infection (STI) and a priority AMR pathogen. Two narrow host range plasmids, p bla and pConj, have contributed to ending penicillin and...
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Noémie Lefrancq @noemielefrancq.bsky.social · 02/01/2025
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉 buff.ly/4gyYCzx We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies. 🧵 A thread... 1/n #IDSky #IDModelling
buff.ly
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of…
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Kate Baker @ksbakes.bsky.social · 19/12/2024
Certain sublineages of antimicrobial resistant bacteria dominate the surveillance landscape, but what causes them to become resistant? Check out our latest work in Shigella to find out and/or read the thread below www.medrxiv.org/content/10.1101/2024.10.27.24316207v2 1/n
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Kirstin Oliveira Roster @kroster.bsky.social · 27/11/2024
New preprint: Drug resistant gonorrhea is a big public health problem. Resistance to ceftriaxone, the last approved antibiotic, is spreading globally. When we first detect one of these very resistant isolates, how many undetected cases are there likely to be? www.medrxiv.org/content/10.1...
medrxiv.org
Estimating the undetected burden of infections and the likelihood of strain persistence of drug-resistant Neisseria gonorrhoeae
Antimicrobial resistance (AMR) is a serious public health threat. Neisseria gonorrhoeae has developed resistance to all antibiotics recommended for treatment and reports of reduced susceptibility to c...
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Mat Beale @typemat12.bsky.social · 29/10/2024
Pleased to share this preprint on Yaws transmission dynamics following mass azithromycin administration, led by Amber Barton www.medrxiv.org/content/10.1... Following MDA campaign, we sequenced >half of infections, showing recrudescence driven by existing lineages & persistence linked to key SNPs.
medrxiv.org
The Effect of Repeated Mass Drug Administration on the Transmission of Yaws: A Genomic Epidemiology Study
Background: Yaws, a neglected tropical disease caused by Treponema pallidum subspecies pertenue, has evaded eradication, in part due to a high proportion of asymptomatic cases. A cluster-randomised tr...
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Gina Lewin @ginalewin.bsky.social · 25/10/2024
Hi BlueSky friends! Postdoc(s) available in my lab! Multiple projects on how bacterial genomic and functional diversity impacts microbial interactions & disease. 🦠🧫 See www.thelewinlab.com/join-us/post... for more information. Please RT & share. #Postdoc #Microbiology #OralMicro #VaginalMicro
Ad for postdoc position
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Onisillos @onisillos.bsky.social · 04/10/2024
New research article in The Lancet Microbe Effects of #doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections on #gonorrhoea prevalence and antimicrobial resistance among men who have sex with men in the USA: a modelling study www.thelancet.com/journals/lan...
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Mui Pham @tmpham.bsky.social · 16/08/2024
Happy that this piece is finally out! Very grateful for all the input and support by Matt Samore, Marc Lipsitch, @yhgrad.bsky.social, Yue Zhang, McKenna Nevers, Haojia Li, and Karim Khader. www.thelancet.com/journals/lan...
thelancet.com
Trends in infection incidence and antimicrobial resistance in the US Veterans Affairs Healthcare System: a nationwide retrospective cohort study (2007–22)
Significant reductions in methicillin resistance in S aureus, vancomycin-resistant E faecium, and fluoroquinolone resistance across multiple pathogens suggest that control efforts have had an effect o...
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Yonatan Grad @yhgrad.bsky.social · 01/07/2024
New preprint led by Adi Bandekar and w Ethan Garner. What leads to N. gonorrhoeae being diplococci, and how is it that they have sequentially perpendicular division planes? Using beautiful live cell imaging and genetics, Adi showed it’s all about axial asymmetry www.biorxiv.org/content/10.1...
biorxiv.org
Axial asymmetry organizes division plane orthogonality in Neisseria gonorrhoeae
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Yonatan Grad @yhgrad.bsky.social · 09/05/2024
New preprint on doxycycline post-exposure prophylaxis for bacterial STIs: all doxy-PEP guidelines suggest we should monitor for the impact of resistance, but what is the best way to do so in N. gonorrhoeae? www.medrxiv.org/content/10.1...
medrxiv.org
Molecular surveillance to monitor the prevalence of tetracycline resistance in Neisseria gonorrhoeae
medRxiv - The Preprint Server for Health Sciences
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Louise H. Moncla @lhmoncla.bsky.social · 01/04/2024
In response to the H5N1 infections in cows and now a human in Texas, we've just updated our North America specific H5Nx Nextstrain build with the cow and goat sequences, which are viewable under "Species-grouped: Ruminant": nextstrain.org/groups/moncl.... A few notes.
nextstrain.org
auspice
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Zamin Iqbal @zaminiqbal.bsky.social · 11/03/2024
First step in a community project to provide a uniformly assembled, annotated and searchable set of bacterial genomes, our preprint on our initial release of 1.9 million genome assemblies+taxonomic estimates. (figure compares with previous 661k dataset) www.biorxiv.org/content/10.1... #microsky
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Louise H. Moncla @lhmoncla.bsky.social · 20/02/2024
Have you been wondering what's going on with avian influenza in North America? Check out our lab's @nextstrain narrative on phylodynamic analysis of H5Nx evolution and transmission here! nextstrain.org/groups/moncl...
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National Summer Undergraduate Research Project @nsurp.bsky.social · 13/02/2024
Applications for 2024 are now OPEN! Please share widely amongst your networks! Mentee (undergrad) app: etap.nsf.gov/award/407/op... Mentor (grad student/post doc/faculty) app: uarizona.co1.qualtrics.com/jfe/form/SV_...
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Adam Phillippy @aphillippy.bsky.social · 01/02/2024
10 years on, @bkille.bsky.social @treangen.bsky.social and co. have refreshed Parsnp with a version 2! Build a core genome multi-alignment for 100k SARS genomes or 1k Mtb genomes in under an hour 💨
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Gavin Douglas @gmdouglas.bsky.social · 04/01/2024
Happy to see my new paper with @bjesseshapiro.bsky.social published! www.nature.com/articles/s41.... Bonus of this great News and Views article that was a surprise to us both: www.nature.com/articles/s41... Along with our own blog post on the topic where we summarize the work: tinyurl.com/34r87kr9
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