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Srinjan Lab

@srinjan.bsky.social
157 followers 203 following 26 posts

Lecturer @imperiallifesci.bsky.social @imperialsci.bsky.social @imperialcollegeldn.bsky.social |Unravelling DNA mysteries in stem cells by staring at little dots| #salsa dancer| he/him | profiles.imperial.ac.uk/srinjan.basu

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Reposted by Srinjan Lab
Nature Genetics @natgenet.nature.com · 14/09/2026
📢PUBLISHED @natgenet.nature.com 📰Cohesin prevents local mixing of condensed euchromatic domains in living human cells. By Masa A. Shimazoe, Kazuhiro Maeshima and colleagues. ⬇️ www.nature.com/articles/s41...
nature.com
Cohesin prevents local mixing of condensed euchromatic domains in living human cells - Nature Genetics
Single-nucleosome imaging/tracking and super-resolution three-dimensional structured illumination microscopy within euchromatic regions show that cohesin-mediated loops constrain condensed euchromatic...
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Srinjan Lab @srinjan.bsky.social · 21/08/2026
🚨 @prelights.bsky.social just covered our new study with @lakatoslab.bsky.social on how mechanotransduction guides human cortical patterning and cell fate! 🤝Great work by @alexjkingston.bsky.social @imperiallifesci.bsky.social @scicambridge.bsky.social! ❓Great questions @kanishka03.bsky.social!
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Reposted by Srinjan Lab
Teresa Rayon @trayon.bsky.social · 15/08/2026
Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation
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Srinjan Lab @srinjan.bsky.social · 23/07/2026
Some great work led by our PhD student Alex @alexjkingston.bsky.social with help from Gökçe @gokceagsu.bsky.social and others in the labs Thanks to support @imperiallifesci.bsky.social @scicambridge.bsky.social @cneurodept.bsky.social and from our funders @wellcometrust.bsky.social @ukri.org 7/n
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Srinjan Lab @srinjan.bsky.social · 23/07/2026
This links to emerin mislocalisation at the nuclear envelope and altered histone mark deposition - showing how mechanical heterogeneity in a developing tissue may directly instruct cell fate. 6/n
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Srinjan Lab @srinjan.bsky.social · 23/07/2026
🧬 Integrating transcriptomic data with a spatial atlas of developing human fetal cortex reveals impaired density-sensing and ERK activity in LINC-decoupled cells, directly implicating altered mechanosensation in fate allocation. 5/n
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Srinjan Lab @srinjan.bsky.social · 23/07/2026
⚖️ Decoupled cells fail to acquire intermediate progenitor identity, instead adopting a biased neuronal fate skewed toward deep-layer at the expense of upper-layer identity - a phenotype that persists rather than resolves with extended culture. 4/n
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Srinjan Lab @srinjan.bsky.social · 23/07/2026
LINC-decoupled cells lose nuclear shape and local alignment specifically at the VZ-CP boundary, prematurely delaminate from the VZ, and end up mispositioned later in development. 3/n
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Srinjan Lab @srinjan.bsky.social · 23/07/2026
🧠🧫 We use cortical brain organoids and a dominant-negative LINC complex construct to decouple single cells from cytoskeletal force transmission as they move from the dense ventricular zone (VZ) to the sparse cortical plate (CP) - creating mechanically "blind" cells in normal tissue. 2/n
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Srinjan Lab @srinjan.bsky.social · 23/07/2026
Proud to share our latest bioRxiv with Lakatos lab @lakatoslab.bsky.social showing how niche-specific mechanotransduction guides human cortical patterning and cell fate acquisition. How does a tissue's mechanical environment shape which cells it makes, and when? 1/n www.biorxiv.org/content/10.6...
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Reposted by Srinjan Lab
Andras Lakatos @LakatosLab @lakatoslab.bsky.social · 28/05/2026
A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth: Cell Reports www.cell.com/cell-reports...
cell.com
A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth
Gibbons et al. present a human corticospinal organoid slice-based connectoid model, with physically separate but functionally coupled cortical and spinal regions. Allowing cell-type-specific observati...
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Srinjan Lab @srinjan.bsky.social · 23/07/2026
Congrats @alexjkingston.bsky.social!!
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Reposted by Srinjan Lab
Stefan Schoenfelder @stefanschoenfelder.bsky.social · 03/06/2025
Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social‬: www.biorxiv.org/content/10.1... 🧵 below
biorxiv.org
Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells
Enhancers are key gene regulatory elements that ensure the precise spatiotemporal execution of developmental gene expression programmes. However recent findings indicate that approaches to identify en...
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Reposted by Srinjan Lab
Anzy Miller @anzymiller.bsky.social · 04/08/2025
My interview as part of @dev-journal.bsky.social Development's Pathway to Independence is live! I had a great time chatting to Saanjbati Adhikari - thank you. journals.biologists.com/dev/article/...
journals.biologists.com
Pathway to Independence – an interview with Anzy Miller
Anzy Miller, former Sir Henry Wellcome Postdoctoral Fellow supported by Nancy Papalopulu (The University of Manchester, UK), is interested in the mechanisms involved in the generation of human pancrea...
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Reposted by Srinjan Lab
Ruben Perez-Carrasco @perez-carrasco.bsky.social · 04/08/2025
We wrote this introductory review on how concepts from dynamical systems can help us understand developmental biology, hope it’s useful to somebody! It was a lot of fun to put together, and great to collaborate with brilliant colleagues across theory and experiments
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Reposted by Srinjan Lab
Kazuhiro Maeshima @kazu-maeshima.bsky.social · 10/07/2025
Our new preprint 🧬🔗 www.biorxiv.org/content/10.1... BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
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Srinjan Lab @srinjan.bsky.social · 24/06/2025
Location: Flowers building G47A 15:30: Annabelle Wurmser: “Capturing chromatin dynamics during neuromesodermal progenitor specification” 16:00: Daniela Dietrich (University of Bristol) – “Hydrotrotropism – how roots search for water" 17:00 Social Happy Hour (SEC, 7th floor).
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Srinjan Lab @srinjan.bsky.social · 24/06/2025
This Friday 27th June, we have another exciting set of talks at our monthly Cell and Developmental Biology Networking Event @imperiallifesci.bsky.social with Daniela Dietrich joining us from Bristol and our very own Annabelle Wurmser from my lab. Please do join us!
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Reposted by Srinjan Lab
Hannah Long @hannahlong.bsky.social · 20/03/2025
📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪
elxw.fa.em3.oraclecloud.com
Postdoctoral Researcher
Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...
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Reposted by Srinjan Lab
Cancer Research UK Cambridge Centre @crukcamcentre.bsky.social · 08/01/2025
📢 Don’t miss the first Cancer Biology and Medicine talk of 2025 tomorrow! Cancer stem cells, evolution and heterogeneity Prof Brian Huntley @scicambridge.bsky.social Thurs 9 Jan, 9:30-10:30 TC lecture theatre, School of Clinical Medicine @cambridge-scm.bsky.social All welcome!
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Pradeepa Madapura @pradeepmadapura.bsky.social · 15/03/2025
Happy holi, the festival of UMAPs
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Srinjan Lab @srinjan.bsky.social · 02/03/2025
Welcome to Bluesky!
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Reposted by Srinjan Lab
Giorgio Gilestro @giorgio.gilest.ro · 26/02/2025
Wanna learn what we know about why we need to sleep? Here's a fun podcast I recorded for the excellent @npr.org "Seeking a scientist" show, conducted by Kate the Chemist. Enjoy! @imperiallifesci.bsky.social @imperialcollegeldn.bsky.social www.kcur.org/podcast/seek...
kcur.org
Why do we need to sleep?
Humans spend one-third of their life sleeping, yet the purpose and function behind this regular state of unconsciousness remains a biological mystery. Sleep researcher Giorgio Gilestro is trying to un...
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Reposted by Srinjan Lab
Imperial Life Sciences @imperiallifesci.bsky.social · 17/02/2025
Don't forget to come to Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines"! Open to all!! 📅 Wed, 12 March 2025 Understanding how pathogen proteins interact with human defence systems means we can develop new ways to prevent disease. @doryenbubeck.bsky.social #OurImperial
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Reposted by Srinjan Lab
Pradeepa Madapura @pradeepmadapura.bsky.social · 13/02/2025
We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics.bsky.social DM me for inquiries pl apply/share tinyurl.com/m6jnksk5
media.tenor.com
a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them .
ALT: a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them .
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Srinjan Lab @srinjan.bsky.social · 26/02/2025
Exciting!
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Reposted by Srinjan Lab
Marco Trizzino @marcotrizzino.bsky.social · 15/02/2025
New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n
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Srinjan Lab @srinjan.bsky.social · 26/02/2025
Look forward to hearing feedback from our colleagues in the field!
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Srinjan Lab @srinjan.bsky.social · 26/02/2025
Thanks also to our collaborator labs for all their help on this: @shamith.bsky.social, Huntly, Klenerman, Holcman @bertiegottgens.bsky.social @pradeepmadapura.bsky.social Mohorianu
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Srinjan Lab @srinjan.bsky.social · 26/02/2025
Huge congrats to first authors Maike Steindel & Oliver Davis! This has also been quite the team effort from the whole lab: Liviu, Shuyue, @gokceagsu.bsky.social @deep-adhya.bsky.social Jorg Annabelle @stanleystrawbridge.bsky.social @scicambridge.bsky.social @imperiallifesci.bsky.social
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Srinjan Lab @srinjan.bsky.social · 26/02/2025
Using single-molecule imaging, we find that MLL2 acts like a tether, restricting chromatin mobility genome-wide and at the Mll2-dependent gene Sox2. This suggests a model where MLL2 tethering increases enhancer-promoter mixing at key neuroectoderm genes to drive differentiation.
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Srinjan Lab @srinjan.bsky.social · 26/02/2025
Micro-C reveals that MLL2’s effect on chromatin architecture is more substantial, stabilising enhancer-promoter loops associated with bivalent genes in primed pluripotent cells. Interestingly, MLL2’s catalytic activity is not required for loop formation or differentiation.
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Srinjan Lab @srinjan.bsky.social · 26/02/2025
However, single-cell transcriptomics and quantitative immunofluorescence of the priming transition reveal that MLL2 has only a subtle change on transcription, increasing the expression of a few important neuroectodermal transcription factors such as SOX2.
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Srinjan Lab @srinjan.bsky.social · 26/02/2025
We build on previous studies that show a requirement for MLL2 in neuroectoderm differentiation. Using conditional knockouts, we reveal that this requirement occurs during pluripotent cell priming, days before differentiation is impaired.
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Srinjan Lab @srinjan.bsky.social · 26/02/2025
New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation. www.biorxiv.org/content/10.1...
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Srinjan Lab @srinjan.bsky.social · 28/01/2025
Please get in touch if you want to be added to the e-mail list for our future events!
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Srinjan Lab @srinjan.bsky.social · 28/01/2025
Next friday February 7th, we have another exciting set of talks at our monthly Cell and Developmental Biology Networking Event @imperiallifesci.bsky.social with Ben Steventon joining us from Cambridge @bensteventon.bsky.social and our very own Floriane Tissot from the Lo Celso lab.
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Reposted by Srinjan Lab
Mikhail Spivakov @mspivakov.bsky.social · 27/01/2025
Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters. www.nature.com/articles/s41...
nature.com
Genetic coupling of enhancer activity and connectivity in gene expression control - Nature Communications
Here, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic...
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Srinjan Lab @srinjan.bsky.social · 28/01/2025
Congrats!!
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Srinjan Lab @srinjan.bsky.social · 23/01/2025
Exciting stuff, congrats to all involved!
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Reposted by Srinjan Lab
Miguel Branco @brancolab.bsky.social · 21/01/2025
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.
qmul-jobs.tal.net
Postdoctoral Research Associate - QMUL Jobs
ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:
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Srinjan Lab @srinjan.bsky.social · 06/12/2024
Basu lab hosted their first department social today @imperiallifesci.bsky.social My lab put together this amazing cell of food alongside fun games like cell fate charades. So proud of our masters students who coordinated everything from start to finish!!
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Reposted by Srinjan Lab
British Society for Developmental Biology @bsdb.bsky.social · 25/11/2024
🚨Abstract deadline- 13th December! 🚨 Join us next March in Liverpool for our Spring Meeting, joined with the BSCB and part of the Biologists@100 @biologists.bsky.social 🎉 Not to be missed! We have annual meetings grants! Next deadline is the 10th of Jan. +Info here : bsdb.org/membership/#...
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