A new genetic roadmap reveals hundreds of hidden players in HIV infection, including two proteins that stop HIV in its tracks.

NLRP3 inflammasome activation is critical for the induction of protective immunity, but molecular insights are still lacking. Here, the authors express NLRP3 variants targeted to different cellular lo...

The neutrophil clockwork boosts daytime immunity against bacterial infection.

RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation mechanism induced by immune ...

Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a framew...

Naydenova, Boyle and Pathe et al. report that Shigella uses the ubiquitin E3 ligase IpaH1.4 to evade lipopolysaccharide ubiquitylation in infected cells by degrading the host E3 ligase RNF213. Using c...

Bacterial pathogens invade our cells in search of nutrients, but cells fight back by tagging these microbes with ubiquitin "death labels", followed by deploying a nanomachine called VCP/p97 that tears...