Sign in

Jonas Neher

@jonasneher.bsky.social
160 followers 166 following 7 posts

Neuroscientist, focus on neuroinflammation and amyloid, @LMU_Muenchen, @DZNE_en, @LMU_BMC and @SyNergy_Cluster www.neher-lab.de

PostsRepliesMedia
Jonas Neher @jonasneher.bsky.social · 03/03/2026
Welcome to the institute and department, Alena! 🎉
010
Jonas Neher @jonasneher.bsky.social · 20/02/2026
Very interesting study demonstrating the impact of improving vascular health on Alzheimer’s pathology!
020
Reposted by Jonas Neher
Haass Lab @haasslab.bsky.social · 04/02/2026
📢 Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...
nature.com
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism - Nature Communications
TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficac...
0155
Jonas Neher @jonasneher.bsky.social · 17/01/2026
🧠🦠 New preprint out! Systemic inflammation fundamentally reshapes amyloid plaques — shifting them toward non-compacted, filamentous Aβ states that strongly predict neuritic damage across mouse models and human Alzheimer’s disease. #Alzheimers #Neuroimmunology #Microglia #Amyloid #PET #Inflammation
researchsquare.com
Non-compacted, PET-insensitive amyloid states increase after systemic inflammation and predict neuritic damage across Aβ pathology models and Alzheimer patients
Neuroinflammation is a key modulator of Alzheimer’s disease (AD) risk, yet the impact of non-genetic inflammatory risk factors – such as systemic inflammation – remains poorly defined. Building on our...
153
Jonas Neher @jonasneher.bsky.social · 21/08/2025
Important study for understanding the vascular mechanisms of dementia!
000
Jonas Neher @jonasneher.bsky.social · 26/07/2025
Very cool work! Glad to have been able to contribute.
030
Reposted by Jonas Neher
Sarah Marzi @sj-marzi.bsky.social · 10/07/2025
Good times discussing all things #epigenetics and #microglia at our symposium with this awesome group: @jonasneher.bsky.social, @kooistrasm.bsky.social, @mancusorenzo.bsky.social. And enjoying the sun and science at #glia2025 in Marseille, while hoping that fires can be contained.
Jonas Neher, Sarah Marzi, Susanne Kooistra and Renzo Mancuso at the microglia epigenetics symposium for the Glia conference 2025 in Marseille.
0101
Reposted by Jonas Neher
Shane Liddelow @liddelowsa.bsky.social · 10/12/2024
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)
nature.com
Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...
114451