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Rizzuto lab

@pregnancyimmunolab.bsky.social
348 followers 348 following 12 posts

Studying fetomaternal tolerance since 2022 at Memorial Sloan Kettering Cancer Center. therizzutolab.com

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Reposted by Rizzuto lab
Maternal-Fetal Immunology Group (MFIG) @pollheimerlab.bsky.social · 28/09/2026
Proud and honored to share our new paper in @sciimmunology.bsky.social! Fibrinoid-associated neutrophils promote invasive placentation and shape neutrophil reprogramming at the maternal–fetal interface. @ailackner.bsky.social ial, @meduniwien.ac.at ien.ac.at doi.org/10.1126/scii...
doi.org
Fibrinoid-associated neutrophils promote invasive placentation and neutrophil reprogramming at the maternal-fetal interface
Neutrophils adopt a tissue-adapted state at the early maternal-fetal interface that supports trophoblast invasion.
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Reposted by Rizzuto lab
Nature Portfolio @natureportfolio.nature.com · 05/09/2026
A study in Nature Medicine shows that low levels of maternal serum ISM2 in early pregnancy may indicate increased risk of preeclampsia and fetal growth restriction. go.nature.com/4iaOReD #medsky 🧪
This is figure 4, which shows ISM2 regulates cell migration.
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Reposted by Rizzuto lab
Nature @nature.com · 20/08/2026
Adding albumin to popular antibody-based medicines helps to block their passage through the placenta go.nature.com/4ikDmkB
go.nature.com
To shield the fetus, link a protein to these drugs
Adding albumin to popular antibody-based medicines helps to block their passage through the placenta.
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Reposted by Rizzuto lab
Phil Ross @philippzross.com · 14/08/2026
Feels like something @devoevomed.bsky.social should know about: www.science.org/doi/10.1126/...
science.org
Reassessing the role of progesterone receptor isoforms PGR-A and PGR-B in female fertility
Progesterone is a critical reproductive hormone that acts via progesterone receptor transcriptional regulators. The short PGR-A isoform lacks a 164–amino acid amino-terminal region present in PGR-B th...
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Reposted by Rizzuto lab
Science Magazine @science.org · 02/08/2026
A scientist is helping uncover the role of the immune system in endometriosis—while managing the disease herself. Learn more: scim.ag/4oDvjAa #ScienceMagArchives
Pathways to pain: graphic illustrating the symptoms and mechanisms of endometriosis. Panel 1: diagram of the pelvic area showing common locations of lesions and cysts: the abdominal wall, the peritoneal membrane, the ovaries, between the uterus and rectum, and the vagina. Panel 2: Illustration of a reproductive system with endometriosis, showing locations of lesions and an ovarian cyst, as well as menstrual blood flowing out of the fallopian tube, which is thought to seed lesions. Panel 3: comparison of neutrophils in the menstrual effluent (ME) of women with endometriosis versus without; with endometriosis, the neutrophils have shrunken, many-lobed nuclei and vacuoles in their cytoplasm. Panel 4: Illustration of immune factors involved in endometriosis lesions: decreased natural killer cells, and increased neutrophils and macrophages.
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Nature Reviews Immunology @natrevimmunol.nature.com · 31/05/2026
ICYMI: Eosinophils shape barrier immunity during reproduction
dlvr.it
Eosinophils shape barrier immunity during reproduction
Nature Reviews Immunology, Published online: 29 May 2026; doi:10.1038/s41577-026-01317-yEosinophils remodel the maternal intestine during pregnancy and lactation, promoting goblet cell differentiation and strengthening barrier immunity.
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Dr. Jessie Christiansen @aussiastronomer.bsky.social · 01/04/2026
I went back to capture what the astronauts said in full when the clock was stopped at T-10 minutes and they were asked if they were go for launch: This is Victor. We are going for our families. This is Christina. We are going for our teammates. This is Jeremy. We are going for all humanity.
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Claire Ang @claireang.bsky.social · 12/03/2026
Excited to share my new preprint from the McKinley lab, where we explored regenerative mechanisms across menstruation and pregnancy! We thought specialized glands would regenerate everything. We were wrong. But the real mechanism turned out to be way cooler :) 🧪🧵 www.biorxiv.org/content/10.6...
biorxiv.org
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Rizzuto lab @pregnancyimmunolab.bsky.social · 05/03/2026
This was so fun! Thank you so much to @cindyleifer.bsky.social and @microbetv.bsky.social for the opportunity to discuss pregnancy immunology ✨
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Ana Codo @anaccodo.bsky.social · 25/02/2026
I'm thrilled to share that the first paper from my PhD is out today in @cp-immunity.bsky.social! Here, we investigated how phagocytes, such as macrophages, handle microplastics (MPs) during their normal functions. www.sciencedirect.com/science/arti...
sciencedirect.com
Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis
Microplastics (MPs), microparticles from plastic degradation, pose a substantial threat to human health. Macrophages, the body’s immune sentinels, are…
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Reposted by Rizzuto lab
Jessica Stark @jcstark.bsky.social · 16/12/2025
Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy. www.nature.com/articles/s41... www.nature.com/articles/s41... @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
nature.com
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 16/12/2025
Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions
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Scripps Research @scripps.edu · 08/11/2025
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
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Scripps Research team identifies sugar molecules that trigger placental formation
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Rizzuto lab @pregnancyimmunolab.bsky.social · 31/10/2025
“Rizz-ard of Oz: there’s no place like lab” Happy Halloween! Thanks IGO for the annual party 🎃
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NY-CURES @nycures.bsky.social · 04/09/2025
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/
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Klebanoff Lab @klebanofflab.bsky.social · 23/07/2025
🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social
rdcu.be
CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit
Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...
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Rizzuto lab @pregnancyimmunolab.bsky.social · 25/06/2025
We are so proud of Mergim for passing his quals! Definitely warrants lollipops advertising his favorite model antigen.
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Reposted by Rizzuto lab
The Francis Crick Institute @crick.ac.uk · 19/03/2025
Researchers at the Crick have found that pregnancy in mice leads to the irreversible growth of their small intestine. www.crick.ac.uk/news/2025-03...
crick.ac.uk
Pregnancy irreversibly remodels the mouse intestine
Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare ...
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Rizzuto lab @pregnancyimmunolab.bsky.social · 17/02/2025
Exciting news! To welcome our new lab members from the past year and reaffirm our commitment to women’s health and pregnancy immunology, we’ve launched our lab website. Check it out- and if this fascinating niche in immunology speaks to you, let’s connect! www.therizzutolab.com
therizzutolab.com
The Rizzuto lab
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Rizzuto lab @pregnancyimmunolab.bsky.social · 21/01/2025
What determines the length of gestation? A short thread… (1/5)
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