Single-nucleosome imaging/tracking and super-resolution three-dimensional structured illumination microscopy within euchromatic regions show that cohesin-mediated loops constrain condensed euchromatic...

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

Mechanical instabilities provide a general design principle for shaping developing organs and engineering soft materials. However, in slender structures, simple elastic buckling tends to erase rather ...

Living Architectures - Case studies

Biologists at the Flatiron Institute’s Center for Computational Biology used mathematical models to improve our understanding of sperm structure and function.

Living cells dynamically coordinate gene expression with the spatial organization of their membranes and cytoskeletons. Unraveling how membrane-less organelles arise and interact with cytoskeletal net...

Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.

Some of the world’s most imaginative scientific minds have been celebrated at the Ig Nobel awards, which recognize discoveries that make people “laugh, then think.”

Biomolecular condensates are made of multiple components but current techniques cannot capture their complex composition quantitatively. Now it has been shown that the dense-phase binodal point defini...

Text written by Olga Afonso, Helena Cantwell, and Shuzo Kato This is one of three reports about the "Physics of the Early Embryonic Divisions" Workshop,