Based on data from the CRIC study, this analysis dives deep into whether this lab mismatch is just noise… or a clinical signal we’ve been missing. Check out the beautiful visual abstract made by our NephJC interns Sai Vani Yellampalli and Akshaya Jayachandran . Great team work!!!

JAMA 2023 Dec 19;330(23):2258-2266 doi: 10.1001/jama.2023.23651. Effect of Dietary Sodium on Blood Pressure: A Crossover Trial Deepak K Gupta ,  Cora E Lewis ,  Krista A Varady ,&nbsp...

Check out the beautiful visual abstract made by NephJC intern Michelle Fravel .

This week, we will discuss how the CONFIDENCE trial gets nephrology closer to the magic CKD polypill of CKD.

This week, we will discuss another target trial emulation study. The FDA says to stop metformin at a GFR of 30. Are they right?

This week, we will discuss the first iteration of KDIGO’s 2025 guidelines on ADPKD.  These guidelines are a result of a decade of global collaboration between physicians, researchers, advocates, ...

After publishing chapter 18 part 1, I was listening to it and realized we missed an opportunity to clarify something that was vexing Rose. He said that the mechanism by which bicarbonate reabsorption ...

This review discusses the pathophysiology, clinical presentation, diagnosis, treatment, and prognosis of autosomal dominant polycystic kidney disease diagnosed in adulthood.

A proliferation-inducing ligand (APRIL) is implicated in the pathogenesis of IgA nephropathy. Sibeprenlimab is a humanized IgG2 monoclonal antibody that binds to and neutralizes APRIL. In this phas...

YouTube video by International Society of Nephrology

This week, we will celebrate in advance World Kidney Day by discussing the results of OBInutuzumab in active lupus nephritis. The LUNAR trial (rituximab versus placebo) was “almost” positive, but not ...

Is Obinutuzumab Effective and Safe in Active Lupus Nephritis?  Check out the beautiful VA by NSMC Faculty Dr Divya Bajpai on the REGENCY Trial, answering the same.

Critically ill patients that require kidney replacement therapy (KRT) are among the most ill and complex patients routinely encountered in the intensi…

Submit your picks! | @NephMadness | @nephmadness.bsky.social | NephMadness 2025   Gabriel Miguel Cara Fuentes @carafuentes_g – @carafuentes-neph.bsky.social Dr. Cara Fuentes is an Assistant P…

Posts about NephMadness2025 written by AJKDblog

In this special collaboration with NephMadness, we're diving into the world of nephrotoxins with an expert panel from Virginia Commonwealth University. ...

Background Snakebites are a significant public health problem worldwide, with a global prevalence estimated 2.7 million envenomings and 81,000 to 138,000 deaths annually. Acute kidney injury (AKI) is ...

Podcast Episode · Freely Filtered, a NephJC Podcast · 26/02/2025 · 1h 12m

Should we call 2024 the Renaissance of nephrology? It was probably the richest year in RCTs in the nephrology world, reflected in the higher number of Late-Breaking Clinical Trials sessions at every b...

ALT: a cartoon cat is sleeping in a bed with a patchwork quilt

This week, we will continue with February’s aldosterone leitmotif: do mineralocorticoid receptor antagonists (MRAs) truly blind the diagnostic in unilateral hypraldosteronism? Is this the article the mythbuster? Draw your own conclusions

Do Mineralocorticoid Receptor Antagonists Preclude the Identification of Unilateral Primary Aldosteronism at Adrenal Venous Sampling? Guidelines recommend withholding MRAs prior to PA subtyping by...

NephMadness 2025 starts in less than 3 weeks!  Our 9-member Blue Ribbon Panel (BRP) will decide the outcome of each matchup as we March towards crowning a new champion. Here are the folks to blame …

Alt: a cartoon drawing of a dancing kidney with big eyes.

The MTOR inhibitors have demonstrated antiviral properties, and prior non-randomized studies have suggested they may have a suppressive effect on BKPyV replication. Here, in this randomized, multicent...

The association between primary aldosteronism (PA) and obstructive sleep apnea (OSA) has been a matter of debate. 2016 Endocrine Society guideline recommends screening for PA all hypertensive patients...

VA for Characterizing the Origins of Primary Aldosteronism

This week, we will discuss the origins of primary hyperaldosteronism in normotensive patients. Could this undetected anomaly be the cause of idiopathic hypertension and CKD?