iiinova — where your digital self keeps evolving

IPNA Pediatric Nephrology @ped-neph.bsky.social · 02/03/2026

Corticosteroids are the cornerstone of therapy for steroid-sensitive nephrotic syndrome, yet the best dosing strategy remains uncertain. Read this Systematic Review /Meta-analysis of single-dose vs. multi-dose steroid therapy in pediatric NS. Open Access link.springer.com/article/10.1...

Single-dose versus multi-dose steroid therapy in pediatric nephrotic syndrome: a systematic review and meta-analysis

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 02/03/2026

Hemoadsorption devices are a major advancement in extracorporeal organ support therapies. Read this Educational Review of technicalities, current evidence, & clinical indications of hemoadsorption in critically ill children. Free access this month. bit.ly/4b8ix74

Technicalities, current evidence, and clinical indications of hemoadsorption in critically ill children

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 27/02/2026

AI is rapidly transforming many areas of medicine, & pediatric nephrology may be a field of particular relevance. Read this Review of AI in pediatric nephrology: current applications & emerging frameworks. Open Access link.springer.com/article/10.1...

Artificial intelligence in pediatric nephrology: current applications and emerging frameworks for evidence generation

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 27/02/2026

Clinical significance of positive urine cultures in febrile infants w/negative dipsticks remains debated. Read this Original Article on urine cultures in low-risk febrile infants < 3 months old w/negative urine dipsticks. Open Access link.springer.com/article/10.1...

Clinical relevance of urine cultures in low-risk febrile infants under 3 months of age with negative urine dipsticks

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 27/02/2026

Anti-CD20 monoclonal antibodies (mAbs), which act as B-cell–depleting therapies, are important treatments for a range of pediatric kidney diseases. Read this Educ Review of infection prophylaxis following mAbs in childhood kidney diseases. Open Access link.springer.com/article/10.1...

Infection prophylaxis following anti-CD20 monoclonal antibodies in childhood kidney diseases

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 26/02/2026

Therapeutic complement inhibitors, which target complement pathway components, could revolutionize treatment for a broad range of kidney diseases. Read this Review of targeted treatments for glomerular diseases. Open Access link.springer.com/article/10.1...

Complement and kidney diseases: unlocking the opportunity of targeted treatments for glomerular diseases, including IgA nephropathy

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 25/02/2026

Children w/chronic liver disease are at increased risk of AKI, which could be non-hepatorenal syndrome AKI (non-HRS-AKI) or hepatorenal syndrome AKI (HRS-AKI). Read this Review of terlipressin in pediatric HRS-AKI. Open Access link.springer.com/article/10.1...

Terlipressin in pediatric hepatorenal syndrome-acute kidney injury (HRS-AKI)

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 25/02/2026

Idiopathic nephrotic syndrome (NS) is the most common glomerular disease in children. Read this Systematic Review /Meta-analysis of steroid-induced adrenal insufficiency in children w/NS. Open Access link.springer.com/article/10.1...

Steroid-induced adrenal insufficiency in children with nephrotic syndrome: a systematic review

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 24/02/2026

Antenatal hydronephrosis (HN) is the most common congenital urinary tract abnormality, but mgmt is controversial. Read this Original Article on safely limiting antibiotic prophylaxis & invasive testing in asymptomatic children w/antenatally detected HN. link.springer.com/article/10.1...

Safely limiting the use of antibiotic prophylaxis and invasive testing in asymptomatic children with antenatally detected hydronephrosis

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 24/02/2026

Primary hyperoxaluria type 2 is a rare genetic disorder of oxalate due to a defect in the glyoxalate reductase/ hydroxypyruvate reductase enzyme. Read this Original Article on characteristics & outcomes in a pediatric population in Pakistan. link.springer.com/article/10.1...

Clinical burden, genetic heterogeneity, and diagnostic implications in primary hyperoxaluria type 2

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 23/02/2026

Despite an increasing number of therapeutic options for pediatric patients w/steroid-resistant nephrotic syndrome (SRNS), treatment resistance & risk of progression to kidney failure are still high. Read this Review of outcomes & ongoing trials in SRNS. link.springer.com/article/10.1...

Treatment outcomes and ongoing pediatric trials in steroid-resistant nephrotic syndrome

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 23/02/2026

Magnetic resonance urography (MRU) examinations allow assessment of kidney functions through recently developed image post-processing techniques. Read this Original Article on prediction of split renal function & obstruction w/MRU. Open Access link.springer.com/article/10.1...

Prediction of split renal function and obstruction with magnetic resonance urography in comparison with dynamic renal scintigraphy

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 20/02/2026

Hypercholesterolemia is considered a consequence of nephrotic syndrome secondary to hypoalbuminemia-induced hepatic overproduction of lipoproteins. Read this Research Letter on serum total cholesterol as an early indicator of proteinuria in children. link.springer.com/article/10.1...

Serum total cholesterol as an early indicator of clinically significant proteinuria in children

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 20/02/2026

Acute rheumatic fever (ARF) & acute poststreptococcal glomerulonephritis (APSGN) are serious non-suppurative complications of group A β-hemolytic streptococcal infections. Read this Systematic Review /Meta-analysis of coexistence of APSGN & ARF. Open Access link.springer.com/article/10.1...

Coexistence of acute post-streptococcal glomerulonephritis and acute rheumatic fever: case report and systematic review

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 19/02/2026

Kidney scarring (KS) secondary to urinary tract infections is a common cause of secondary hypertension in children. Read this Original Article on the association between serum cystatin C levels & hypertension in children w/KS. link.springer.com/article/10.1...

Association between serum cystatin C levels and hypertension in children with kidney scarring

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 19/02/2026

The effect of continuous kidney replacement therapy w/regional citrate anticoagulation on bone mineral disease of AKI disease has not been well studied. Read this Original Article on prevalence of bone mineral disease in children w/AKI disease on CKRT. link.springer.com/article/10.1...

Prevalence of bone mineral disease in children with acute kidney disease on continuous kidney replacement therapy: a case-control study

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 18/02/2026

An underlying medical condition as a cause for elevated blood pressure is suspected when hypertension occurs in younger children or those w/markedly high readings. Read these Clinical Insights into polycythemia vera as a cause of systemic hypertension. link.springer.com/article/10.1...

Polycythemia vera as a cause of systemic hypertension

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 18/02/2026

The urinary calcium-to-citrate (Ca/Cit) ratio is an indicator of lithogenic risk in older children, but no reference data exist for infants & toddlers. Read this Original Article on Ca/Cit ratio & kidney stone risk in children under 2 years. Open Access link.springer.com/article/10.1...

Urinary calcium-to-citrate ratio predicts kidney stone risk in children under the age of two years

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 17/02/2026

A 2017 survey of neonatologist & pediatric nephrologist perceptions & practice showed that neonatal AKI was underappreciated. Read this Original Article on an updated survey: have perceptions & practices changed w/increased awareness of AKI? link.springer.com/article/10.1...

Multidisciplinary neonatal acute kidney injury provider perceptions and practice patterns

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 17/02/2026

Children w/cancer have had many improvements in cure rates through advancements in surgery, chemotherapy & radiation therapy. Read this Educational Review of nephrotoxicity of immunotherapy & targeted therapies treating pediatric cancer. Free access this month. bit.ly/3ZJw8fx

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 13/02/2026

AKI is common in critically ill children, frequently necessitating continuous kidney replacement therapy. Procalcitonin (PCT) is widely used as an infection biomarker. Read this Original Article on PCT kinetics in critically ill children. Open Access link.springer.com/article/10.1...

Procalcitonin kinetics in critically ill children: impact of continuous kidney replacement therapy modality and dose

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 13/02/2026

CKD is a common non-communicable disease in children, & kidney dysfunction is the leading metabolic risk factor for death. Significant inequities exist in access to care worldwide. Read this Review of global disparities in pediatric CKD. Open Access link.springer.com/article/10.1...

Little kidneys amid large global inequities

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 12/02/2026

Recurrent focal segmental glomerulosclerosis (rFSGS) is a major cause of graft failure in pediatric patients. Read this Systematic Review/ Meta-analysis of low-density lipoprotein apheresis for rFSGS in pediatric kidney transplant recipients. Open Access link.springer.com/article/10.1...

Low-density lipoprotein apheresis for recurrent focal segmental glomerulosclerosis in pediatric kidney transplant recipients: a systematic review and meta-analysis

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 12/02/2026

AKI is a significant complication for preterm infants, impacting both short- & long-term outcomes. Read this Original Article on perinatal risk factors & 2-year neurodevelopmental outcome of early AKI in preterm & low birth weight infants. Open Access link.springer.com/article/10.1...

Perinatal risk factors and 2-year neurodevelopmental outcome of early acute kidney injury in very preterm and very low birth weight infants

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 10/02/2026

Around half of children w/steroid-sensitive nephrotic syndrome are eventually diagnosed w/frequently relapsing or steroid-dependent disease. Read this Original Article on how prednisone predicts course of childhood nephrotic syndrome. link.springer.com/article/10.1...

Single relapse at ≥ 0.5 mg/kg alternate-day prednisone predicts course of childhood nephrotic syndrome

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 09/02/2026

The selective cytopheretic device for pediatrics (SCD-PED) was granted a Humanitarian Device Exemption in 2024 by the US FDA. Read this Original Article on post-approval experience of the SCD-PED for AKI requiring kidney replacement therapy. Open Access link.springer.com/article/10.1...

Early post-approval experience of the selective cytopheretic device surveillance registry for pediatric AKI requiring kidney replacement therapy

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 09/02/2026

Despite major advances in antiretroviral therapy, HIV infection remains a significant global public health challenge. Read this Systematic Review /Meta-analysis of prevalence of HIV-associated nephropathy in children. Open Access link.springer.com/article/10.1...

Prevalence of HIV-associated nephropathy in children: a systematic review with meta-analysis of studies published between 2004 and 2019

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 06/02/2026

Although kidney transplantation (KT) improves kidney function, children w/CKD often show incomplete recovery of physical function. Read this Original Article on a telerehabilitation exercise program in pediatric patients after KT. Open Access link.springer.com/article/10.1...

Telerehabilitation exercise program in pediatric patients after kidney transplantation: a randomized clinical trial

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 06/02/2026

Early & accurate detection of AKI in children is difficult because serum creatinine rises late & lacks sensitivity. Read this Systematic Review /Meta-analysis of diagnostic accuracy of serum cystatin C for pediatric AKI. link.springer.com/article/10.1...

Diagnostic accuracy of serum cystatin C for pediatric acute kidney injury: a systematic review and meta-analysis

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 05/02/2026

Infection-related glomerulonephritis (IRGN) is the leading cause of acute glomerulonephritis in children worldwide, particularly in low- and middle-income countries. Read these AsPNA Clinical Practice Guidelines for the management of IRGN. link.springer.com/article/10.1...

AsPNA Clinical Practice Guidelines for the management of infection-related glomerulonephritis

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 05/02/2026

Neonatal AKI is a frequent & severe complication in critically ill newborns. Read this Original Article on the efficacy of the STARZ stratification score in determining risk of AKI in critically ill neonates. link.springer.com/article/10.1...

Efficacy of the STARZ stratification score in determining the risk of acute kidney injury in critically ill neonates

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 04/02/2026

Evidence regarding the risk of incident kidney failure based on developmental disabilities remains scarce. Read this Original Article on the association between intellectual disability & autism spectrum disorder w/kidney failure. Open Access link.springer.com/article/10.1...

Association between intellectual disability and autism spectrum disorder with kidney failure

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 04/02/2026

Fluid overload in children on dialysis can lead to serious complications, i.e., left ventricular hypertrophy (LVH) & cardiac dysfunction. Read this Original Article on subclinical hypervolemia causing LVH in euvolemic children on dialysis. Open Access link.springer.com/article/10.1...

Potential implications of subclinical hypervolemia, identified by a multiparametric approach, in causing left ventricular hypertrophy in clinically euvolemic children on dialysis: a prospective longitudinal pilot study

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 03/02/2026

AKI increases morbidity & mortality risk, yet data about pediatric trauma are limited. Read this Original Article on incidence & outcomes of stage 3 AKI in the setting of pediatric trauma. link.springer.com/article/10.1...

Incidence and outcomes of stage 3 acute kidney injury in the setting of pediatric trauma: a trauma quality improvement program analysis

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 03/02/2026

In preterm neonates, the postnatal course of serum creatinine (sCr) is influenced by maternal sCr levels & physiological changes. Read this Original Article on early postnatal changes in sCr from birth to peak & subsequent decline in preterm neonates. link.springer.com/article/10.1...

Early postnatal changes in serum creatinine from birth to peak and subsequent decline in preterm neonates

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 02/02/2026

Steroid-resistant nephrotic syndrome (SRNS) is a severe glomerular disorder frequently progressing to kidney failure, particularly in children. Read this Original Article on consanguinity-linked genetic variants in Algerian patients w/SRNS. link.springer.com/article/10.1...

Consanguinity-linked genetic variants in Algerian patients with steroid-resistant nephrotic syndrome: a familial study

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 02/02/2026

Children w/cancer have had many improvements in cure rates through advancements in surgery, chemotherapy, & radiation therapy. Read this Educational Review of nephrotoxicity of immunotherapy & targeted therapies treating pediatric cancer. Free access this month. bit.ly/3ZJw8fx

Nephrotoxicity of immunotherapy and targeted therapies used to treat paediatric cancer

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 30/01/2026

Autosomal recessive polycystic kidney disease (ARPKD) is the prototype of the hepato-renal fibrocystic diseases, a subset of the broader ciliopathy disorders. Read this Educational Review of fibrocystin/polyductin: insights into ARPKD pathogenesis. Open Access link.springer.com/article/10.1...

Fibrocystin/polyductin (FPC): new functional insights into ARPKD pathogenesis revealed by informatics, comparative genomics, and model systems

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 30/01/2026

Persistent hematuria has increasingly been interpreted as a therapeutic target & a causal driver of kidney injury. Read this Research Letter on microscopic hematuria as a marker of glomerular injury rather than a direct cause of kidney damage. link.springer.com/article/10.1...

Microscopic hematuria as a marker of glomerular injury rather than a direct cause of kidney damage

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 29/01/2026

AKI in children is a major cause of morbidity & mortality & is associated w/dehydration, sepsis, or nephrotoxic exposures. Read these Clinical Insights into T-cell lymphoblastic lymphoma presenting w/type B lactic acidosis & AKI in an adolescent. link.springer.com/article/10.1...

T-cell lymphoblastic lymphoma presenting with type B lactic acidosis and acute kidney injury in an adolescent

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 29/01/2026

Children w/CKD are at risk of hypertension & increased arterial stiffness. Read this Original Article on BP & kidney function in development of arterial stiffening in children w/early CKD. A longitudinal study from the HOT-KID cohort. Open Access link.springer.com/article/10.1...

Arterial stiffening in children with early chronic kidney disease is associated with blood pressure but not decline in kidney function: a longitudinal study from the HOT-KID cohort

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 28/01/2026

AKI is a frequent complication in critically ill neonates & is associated w/adverse outcomes. Read this Original Article comparing creatinine- & cystatin C–based definitions of AKI in neonates w/congenital diaphragmatic hernia. Open Access link.springer.com/article/10.1...

Comparison of creatinine- and cystatin C–based definitions of acute kidney injury in neonates with congenital diaphragmatic hernia

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 28/01/2026

An outbreak of AKI among children in The Gambia caused 66 deaths among 82 cases, linked to medicines contaminated w/diethylene glycol (DEG) & ethylene glycol. Read this Original Article on phenotypes & severity stratification in pediatric DEG poisoning. link.springer.com/article/10.1...

Clinical phenotypes and severity stratification in pediatric diethylene glycol poisoning: a latent class analysis of the Gambia acute kidney injury outbreak

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 27/01/2026

Children & adolescents w/CKD often exhibit reduced physical fitness due to physical inactivity, fatigue, & muscle weakness. Read this Original Article on an m-Health-based exercise program among children & adolescents w/CKD. link.springer.com/article/10.1...

m-Health-based exercise program among children and adolescents with chronic kidney disease: a feasibility study

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 27/01/2026

Steroid-resistant nephrotic syndrome (SRNS) constitutes the 2nd most common cause of CKD in children. Read this Original Article on identification of monogenic variants in SRNS & steroid-sensitive NS. link.springer.com/article/10.1...

Identification of monogenic variants in steroid-resistant and steroid-sensitive nephrotic syndrome

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 26/01/2026

For mycophenolic acid (MPA), therapeutic drug monitoring (TDM) is recommended due to its complex pharmacokinetics, & a non-invasive TDM approach using saliva is promising. Read this Original Article on plasma-saliva correlations for MPA in children w/NS. link.springer.com/article/10.1...

Plasma-saliva correlations for total and unbound mycophenolic acid and its glucuronide in children with nephrotic syndrome

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 26/01/2026

Pediatric hypertension is increasing in prevalence & is associated w/cardiovascular & kidney outcomes in adulthood. Read this Review of how environmental stressors drive pediatric hypertension risk. link.springer.com/article/10.1...

Beyond genetics: how environmental stressors drive pediatric hypertension risk

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 23/01/2026

AKI is common in children treated w/extracorporeal membrane oxygenation (ECMO) & is associated w/increased morbidity & mortality. AKI may also increase risk of long-term CKD. Read this Original Article on kidney & BP sequelae after pediatric ECMO. link.springer.com/article/10.1...

Kidney and blood pressure sequelae after pediatric extracorporeal membrane oxygenation: a secondary analysis of the Kidney Injury During Membrane Oxygenation pediatric ECMO cohort

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 23/01/2026

Cyclosporine A is an effective steroid-sparing agent for steroid-dependent nephrotic syndrome, but long-term use can cause chronic kidney injury. Read this Original Article on how corticosteroids augment cyclosporine nephrotoxicity in pediatric NS. link.springer.com/article/10.1...

Corticosteroids augment cyclosporine nephrotoxicity in pediatric nephrotic syndrome: potential role of alternatively activated macrophages

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IPNA Pediatric Nephrology @ped-neph.bsky.social · 22/01/2026

BK polyomavirus–associated nephropathy is a challenge in kidney transplant recipients, often leading to allograft dysfunction. Read these Clinical Insights into treatment of severe, refractory polyomavirus disease in a pediatric kidney recipient. link.springer.com/article/10.1...

$Successful treatment of severe, refractory polyomavirus disease with partially HLA-matched donor-derived BKPyV-specific T cells in a pediatric kidney recipient$

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