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Joel Topf

@kidneyboy.bsky.social
7.7K followers 821 following 28K posts

Saying the product of the kidneys is urine is like saying the product of a factory is pollution. Urine is a by-product. The product is homeostasis. COI: pbfluids.com/about

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Reposted by Joel Topf
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 13/09/2026
You want a ticket to the hottest event of #KidneyWk? www.nephjc.com/news/2026/9/... Consider a donation to the fall #NephJC pledge drive
nephjc.com
2026 NephJC Night in Denver — NephJC
On FRIDAY night, October 23rd, NephJC will host another legendary NephJC Night during ASN Kidney Week
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Reposted by Joel Topf
thecurbsiders.bsky.social @thecurbsiders.bsky.social · 26/08/2026
The Potassium Switch! 🍌 The potassium switch manages high potassium through inactivation of a sodium-chloride transporter, causing a thiazide-like effect of distal sodium delivery and increased excretion of sodium and potassium. For more lister to episode #537 with our pal @kidneyboy.bsky.social
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Doctor The Frog @skipbidder.bsky.social · 04/04/2026
Also, AI can't pass medical exams.
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Joel Topf @kidneyboy.bsky.social · 18/07/2026
Take a listen. It is a really good episode
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Kieran Laskawy @kieranlaskawy.bsky.social · 18/07/2026
Terrific use of my train journey today: open.spotify.com/episode/4tzC... That is all. @hswapnil.medsky.social @kidneyboy.bsky.social @medpeedskidneys.bsky.social
open.spotify.com
FF94 C3 Glomerulopathy with Carla Nester
Freely Filtered, a NephJC Podcast · Episode
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Nephrology Journal Club @nephjc.bsky.social · 28/06/2026
🦵Had our Kick-off meeting today to welcome a new class of #NephJC interns (year 12 and counting). 👁️Keep an eye out for new blog and VA creators. See if you can Catch'em All🎣 #NephSky #MedSky @hswapnil.medsky.social @kidneyboy.bsky.social @nephroseeker.medsky.social @dramiliflores.bsky.social
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 22/06/2026
Took us more than 10 years to get this to this stage AVF versus catheters - doing an RCT was difficult and we learnt a lot. Hope our community also does?
journals.lww.com
Comparing Catheters to Fistulas in Older Patients Starting... : Journal of the American Society of Nephrology
recommendations were based is observational with potential for bias. Methods A pilot randomized controlled trial was conducted in 12 hemodialysis centers in Canada and Australia. Individuals aged 55…
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Reposted by Joel Topf
Nephrology Times @nephtimes.bsky.social · 12/06/2026
🔗https://www.docwirenews.com/post/era-congress-recap-part-1-find-ckd-and-majesty-trials 🎯Don't miss the two-part conversation between Neph Times board members @kidneyboy.bsky.social and @annagaddy.bsky.social on research highlights from this year's ERA Congress. #nephrology #ERA26
docwirenews.com
ERA Congress Recap, Part 1: FIND-CKD and MAJESTY Trials | Docwire News
Drs. Joel Topf and Anna Gaddy discussed highlights of the 63rd European Renal Association Congress, including the FIND-CKD and MAJESTY trials.
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Joel Topf @kidneyboy.bsky.social · 07/06/2026
This is horrible. The IRB failed in the most basic RCT question, "Would you feel comfortable if your miserably nephrotic grandmother was randomized to the placebo group."
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Joel Topf @kidneyboy.bsky.social · 02/06/2026
I subscribe
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Timothy Caulfield @caulfieldtim.bsky.social · 29/05/2026
"...this review found little to no benefits from use of calcium, vitamin D, or combined supplementation on the prevention of fractures and falls." www.bmj.com/content/393/... via @bmj.com
bmj.com
Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis
Objective To assess the effect of calcium, vitamin D, or combined supplementation on fractures and falls in adults. Design Systematic review and meta-analysis. Data sources Trials included in system...
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Reposted by Joel Topf
🪾santiago, phd 🐈‍⬛ @santiagokique.bsky.social · 21/05/2026
Dr. Fauci came to Stanford for Medicine grand rounds and shared a few reflections I thought were worth passing on: The first was about Operation Warp Speed and the current state of the NIH. As you’ll recall the first mRNA vax was developed at record speed. Fauci atttributes that success to 4 factors
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Ben Collins @bencollins.bsky.social · 24/05/2026
If I told you ten years ago all of the Jeopardy winners, doctors, lawyers, stat-focused sports nerds, and premium shitposters escaped Twitter on a pirate ship to a website that was completely inhospitable to Nazis and phrenologists……. I don’t know, man, I’d be pretty excited.
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J. Offir, PhD @joffirphd.bsky.social · 25/05/2026
Gift 🎁 link: what sort of person is complicit in killing democracy? "It turns out...the kinds of career pressures familiar to employees everywhere — the desire to revive a stalled career or obtain a minor promotion — can be enough to incentivize lower- and... 1/2 www.nytimes.com/2026/05/18/w...
nytimes.com
Actually, Democracy Dies in H.R.
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Joel Topf @kidneyboy.bsky.social · 17/05/2026
Nice recap of the morning session of the Irish Nephrology Society
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 16/05/2026
Bigger story? The Japanese company marketing Tavneos, Kissei - has told docs to stop using Avacopan WSJ story (Apple News link; apple.news/A8Woi0mr1QIm...)
“Kissei told doctors Friday to stop prescribing the drug to new patients.
The Japanese drugmaker said the 20 deaths occurred in people who had suffered a serious liver “impairment” and attributed 13 of the deaths to a condition, called vanishing bile duct syndrome, marked by the destruction of the ducts that carry bile out of the liver.
Kissei said causal links to Tavneos hadn’t been confirmed in all 20 deaths. Amgen shares were down more than 2% late Friday.
An Amgen spokeswoman said the 20 deaths occurred among more than 8,500 patients treated in Japan, and that some cases involved deaths where a causal link to Tavneos hadn’t been established. She added that no deaths linked to serious liver injury have been reported among the more than 8,000 U.S. patients who have taken the drug.
CSL, which holds the rights to sell the drug outside the U.S. and licensed it to Kissei for sale in Japan, said it “takes all matters of patient safety seriously” and is committed to working with regulators.
“Kissei has begun providing information to healthcare professionals, urging them to refrain from using this drug for new patients and to carefully assess the continuation of treatment for ”

Excerpt From
“20 People in Japan Died After Taking Amgen Drug”
Xavier Martinez
The Wall Street Journal
https://apple.news/A8Woi0mr1QImP29g7fxzZfQ
This material may be protected by copyright.
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Joel Topf @kidneyboy.bsky.social · 09/05/2026
Slipped into the #NephMadness Fellows debate a bit late. Looks like they are talking PLEX in AAV #NKFClinicals
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Joel Topf @kidneyboy.bsky.social · 09/05/2026
Jeff Willian Shaul G Massry Speakership by Ann OHare #NKFClinicals
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Nephrology Times @nephtimes.bsky.social · 08/05/2026
Catch more highlights of #NKFClinicals from @kidneyboy.bsky.social and @annagaddy.bsky.social on day 2! #nephrology #nephsky youtu.be/OGdxvTBQ2Ys?...
youtu.be
NKF Spring Clinicals May 8, 2026
Drs. Joel Topf and Anna Gaddy from the Nephrology Times editorial board discuss highlights of #NKFClinicals (so far) on day 2 of the conference. #nephrology
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Alice Stollmeyer @stollmeyer.eurosky.social · 08/05/2026
European Commission has updated its follow buttons. ✅ Mastodon and Bluesky are in; ⛔ X, Facebook, YouTube are out. (Only when you scroll all the way down, FB and YT are still there, but no longer X.) commission.europa.eu/index_en
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Joel Topf @kidneyboy.bsky.social · 08/05/2026
Welcome to Friday At #NKFClinicals
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Joel Topf @kidneyboy.bsky.social · 07/05/2026
Back here for Renal Manifestations of Sickle Cell Disease #NKFClinicals
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Nephrology Times @nephtimes.bsky.social · 07/05/2026
🔗 www.docwirenews.com/post/kidneyc... Did you miss KIDNEYcon? Catch up on the 2026 highlights courtesty of Joel Topf, MD. #nephrology #nephsky #kidneycon @kidneyboy.bsky.social
docwirenews.com
KIDNEYcon 2026 | Docwire News
Joel Topf, MD, shares highlights from the 2026 KIDNEYcon nephrology conference.
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Nephrology Times @nephtimes.bsky.social · 07/05/2026
We had a stellar day at #NKFClinicals filming interviews with @kidneyboy.bsky.social. And you can't do much better than chatting with both NKF's president and past president at the org's signature event. Keep an eye on nephtimes.com for these interviews and more in the coming days. #nephrology
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kottke.org @kottke.org · 07/05/2026
“Podcast sloplords” are flooding the zone with AI-generated podcasts. By one count, almost 40% of new podcasts are written by AI chatbots and presented by “AI voice synthesizers [that] can sound eerily humanlike”. [futurism.com]
futurism.com
Approaching Half of New Podcasts Appear to Be AI Slop
New data shows that nearly half of new podcasts show signs of being AI-generated, with some companies churning out thousands of AI podcasts.
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Joel Topf @kidneyboy.bsky.social · 07/05/2026
President Kirk Campbell for #NKFSpringClinical leads off with CKD. Love it
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Joel Topf @kidneyboy.bsky.social · 05/05/2026
Have you heard the news? Dapagliflozin is now $8/month at @costplusdrugs.com Wrote my first script this AM From $1935 to $15 for 90 days at 10 mg per day Inflation is everywhere except #Flozins
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Joel Topf @kidneyboy.bsky.social · 04/05/2026
I wrote about the NEJM Image in Clinical Medicine Retraction at PBFluids (still blogging) pbfluids.com/2026/05/the-...
pbfluids.com
The retracted NEJM Image in Clinical Medicine
On Saturday, I saw a post by Rahul Ganatra on Roon about NEJM retracting their Image in Clinical Medicine due to it being altered with AI. I immediately jumped over to Twitter to post this juicy ti…
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Joel Topf @kidneyboy.bsky.social · 03/05/2026
KIDNEYcon after dark pbfluids.com/2026/05/one-...
pbfluids.com
One of the lesser known reasons to go to KIDNEYcon
Kidney COn is a great conference and one of the highlights are the nights. Thursday night is the faculty dinner. This year it included the students who got scholarships from KIDNEYcon to attend. Th…
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Joel Topf @kidneyboy.bsky.social · 02/05/2026
It's Bandcamp Friday that means all of your money goes right to the artists! That makes this the perfect time to support my daughter's band, Sleep Tight Tiger! sleeptighttiger.bandcamp.com/album/plum-s...
sleeptighttiger.bandcamp.com
Plum Something, by Sleep Tight Tiger
7 track album
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Joel Topf @kidneyboy.bsky.social · 29/04/2026
media.tenor.com
a man in a suit and tie is talking on a phone in front of a sign that says " targets in megadeaths "
ALT: a man in a suit and tie is talking on a phone in front of a sign that says " targets in megadeaths "
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Joel Topf @kidneyboy.bsky.social · 28/04/2026
Overheard at morning report "Being chief resident is 80% tech support" Chief resident is the medical equivalent of the AV club president
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Joel Topf @kidneyboy.bsky.social · 28/04/2026
You ever read a title and feel it reach through your consciousness, tap you on the shoulder, and whisper, "It's all been worth it. Expertise matters."
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 27/04/2026
Highlights from the upcoming first issue of KICR! www.theisn.org/blog/2026/04... @arvindcanchi.bsky.social @theisn.org
theisn.org
First edition of KICR highlights real-world lessons in kidney care  - International Society of Nephrology
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Minimal viable product (MVP) for a bioimplantable kidney
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Next up: Pathways to tolerance by Mandy Ford Starts talking unmet needs #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
And we are off for transplant this afternoon Roslyn Mannon Kicks it off with immunosupression #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Next up VUS WTF (my title is better)
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Next up Eric Wallace, MD from University of Alabama on Fabry Disease #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Great interview with the Sleep Tight Tiger (That’s my daughter in position 3) uglyhug.com/2026/04/24/s...
uglyhug.com
Sleep Tight Tiger Wants to Invite You to Their Party | Interview
Written by Shea Roney | Photo Courtesy of Sleep Tight Tiger “In a small town called Ypsilanti, where Iggy Pop would listen to Motown and catch flying frogs by the river, arose four friends with a m…
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Next you APOL1 APOL1 Risk Alleles and Associated Nephropathies by Opeyemi Olabisi, MD, PhD from Duke #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
What’s the P value? 2.81 x 10^ –43 Oh, that’s pretty small #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Next up Koyal Jain to talk about steroids in glomerular disease She is not a fan of steroids She is going to talk about three diseases #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
ANCA positivity is common #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Next up JC Velez to talk about endocarditis associated GN #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Next up Corey Cavanaugh To talk about advanced IgAN #KIDNEYcon
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 24/04/2026
And my last comment here is The people who benefit the most from the CRRT dose discussions are the makers of CRRT fluid (which is outrageously priced for a salt water cocktail) They also fund the AKI/CRRT meetings and many of the guideline writers It’s worse than the Kt/V mafia #NephSky
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Joel Topf @kidneyboy.bsky.social · 24/04/2026
Zainab Obaidi To talk about PLA2 membranous nephropathy up first at #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 23/04/2026
Fatima Ayoub is back up for Anticoagulation in CRRT #KIDNEYcon
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Joel Topf @kidneyboy.bsky.social · 23/04/2026
Next talk Leo on advances in CRRT UF strategies He says there is not much… #KIDNEYcon
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