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American Journal of Kidney Diseases @ajkd.bsky.social · 7h

Advice for Living With Hemodialysis: A Qualitative Study of Older Patients and Their Care Partners bit.ly/4dWnlPx #OpenAccess

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American Journal of Kidney Diseases @ajkd.bsky.social · 13h

The Role of Angiopoietin-Like Proteins 3 and 4 and Their Target Lipases in CKD: A Drug-Target Mendelian Randomization Study bit.ly/4z0oNb6 (OPEN ACCESS)

Study design and biological mechanisms. ANGPTL3 inhibits lipoprotein lipase and endothelial lipase. ANGPTL4 inhibits lipoprotein lipase and hepatic lipase. Lipoprotein lipase hydrolyzes TG in lipoproteins. Endothelial lipase and hepatic lipase remodel HDL particles from larger, more buoyant HDL2 particles to smaller, denser HDL3 particles, which results in a decrease in HDL-C. Images are provided by NIAID NIH BIOART Source (bioart.niaid.nih.gov/bioart/171) and Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ANGPTL, angiopoietin-like protein; CKD, chronic kidney disease; eGFRcrea, estimated glomerular filtration rate based on serum creatinine; EL, endothelial lipase; HDL, high-density lipoprotein; HL, hepatic lipase; LDL, low-density lipoprotein; LPL, lipoprotein lipase; TG, triglycerides; VLDL, very low-density lipoprotein.

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American Journal of Kidney Diseases @ajkd.bsky.social · 19h

EDITORIAL: Time in Target Range: The Optimal Marker for Kidney Protection bit.ly/3VnDSVG (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 29/09/2026

EDITORIAL: Saying the Quiet Part Out Loud: Resurfacing the Under-Recognized Needs of Patients and Care Partners bit.ly/4jzqNCy (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 29/09/2026

Normoproteic Plant-Dominant Protein Diets, Uremic Toxins, and Gut Microbiota in Patients With Advanced CKD: A Randomized Controlled Trial bit.ly/4hlfL2s

Results of the co-primary outcomes Changes in serum uremic toxin levels from baseline to Week 4 are shown. Serum TMAO levels were significantly reduced in the 70% plant-protein diet group compared with the control group, whereas no significant differences were observed for indoxyl sulfate or p-cresyl sulfate. FDR-adjusted P-values were calculated based on the Benjamini-Hochberg procedure. Bars indicate 95% confidence intervals. Abbreviations: FDR, false discovery rate; TMAO, trimethylamine N-oxide.

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American Journal of Kidney Diseases @ajkd.bsky.social · 29/09/2026

A Call for More Sensitive Patient-Centered Communication and Support After Canceled Transplant Surgeries bit.ly/4xoGKPP (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 28/09/2026

NEW Blog Commentary from AJKD Editorial Intern Dr. Elias John Elenjickal on the #AJKDBlog: Rethinking Osteoporosis Therapy in Chronic Kidney Disease bit.ly/4dPHXbp (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 28/09/2026

Carbamylation as a Novel Marker of Coronary Artery Calcification in People With CKD: Findings from a Phenome-Wide Association Study in CRIC bit.ly/4xMU6VK

PheWAS results for continuous phenotypes. Each linear regression model uses the log-transformed and standardized carbamylated albumin (C-Alb) as the exposure and a log-transformed phenotype as the outcome, adjusted for age, sex, race and ethnicity, eGFR, and urinary protein. Effect sizes are shown as exponentiated beta coefficients, representing the proportional change (i.e., multiplicative effect or fold change) in the phenotype per 1 standard deviation increase in log-C-Alb. Panel A). Filled circles indicate statistical significance at the Benjamini–Yekutieli-corrected False Discovery Rate (FDR) threshold. Panel B) Displays only the significant continuous phenotypes. Abbreviations: SUN, serum urea nitrogen; LAD, left anterior descending; HDL, high density lipoprotein; MAP, Mean Arterial Pressure; CO2, Carbon dioxide; HA1C, Hemoglobin A1C, PLT, platelets; RBC, red blood cells; WBC, white blood cells; VLDL, very low-density lipoprotein.

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American Journal of Kidney Diseases @ajkd.bsky.social · 28/09/2026

The October 2026 issue is available now: bit.ly/4hhrLlI Highlights: - Advice for Living With Hemodialysis - Time in Target Range for Hemoglobin A1c and Systolic Blood Pressure - Associations of Pre-Pandemic CKD With Acute and Post-Acute COVID-19: The C4R Study

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American Journal of Kidney Diseases @ajkd.bsky.social · 25/09/2026

Safety of Sodium/Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes and CKD bit.ly/4xIncFW (OPEN ACCESS)

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American Journal of Kidney Diseases @ajkd.bsky.social · 25/09/2026

Closing the Gap? Recent Trends in Racial Differences in Blood Pressure Control in the United States bit.ly/4ejC0TJ

Proportion of non-Hispanic Black and White US adults with hypertension who have uncontrolled blood pressure, NHANES 1999-2020 to 2021-2023. BP control is defined as systolic blood pressure <140 mmHg and diastolic blood pressure <90 mmHg according to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; BP, blood pressure; COVID-19, Coronavirus-19; JNC7, Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

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American Journal of Kidney Diseases @ajkd.bsky.social · 24/09/2026

Racial and Ethnic Disparities in Living Donor Kidney Transplantation in California: 2010-2024 bit.ly/3QL7Uk6 (OPEN ACCESS)

Racial/Ethnic Disparities in 2-Year Living Donor Kidney Transplantation among Waitlisted Candidates Preemptively and on Dialysis in California from 2010 to 2024. (A) and (C): California unadjusted 2-Year Probability of LDKT Following Kidney Transplant Waitlisting Preemptively or on Dialysis, respectively. (B) and (D): California Adjusted Subdistribution hazard ratios of 2-Year LDKT Following Kidney Transplant Waitlisting Preemptively or on Dialysis, respectively. An estimated adjusted subdistribution hazard ratio of less than 1 indicates that the racial/ethnic group is less likely to receive living donor kidney transplantation compared to White candidates. Competing risk analyses were performed using the Fine and Gray method.

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American Journal of Kidney Diseases @ajkd.bsky.social · 24/09/2026

NEW Blog Commentary from AJKD Editorial Intern Dr. Elias John Elenjickal on the #AJKDBlog: Rethinking Osteoporosis Therapy in Chronic Kidney Disease bit.ly/4dPHXbp (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 24/09/2026

Mental Health, Neurodegenerative, and Cardiovascular Health of Korean Kidney Transplant Recipients in Single-Person Households bit.ly/4jlVuet

Kaplan–Meier estimates of mental health and neurodegenerative diseases according to household type. Event-free survival curves were compared using the log-rank test.

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American Journal of Kidney Diseases @ajkd.bsky.social · 24/09/2026

Clinical and Social Risk Factors for 30-Day Readmissions in Children With Kidney Disease bit.ly/4gBQReQ

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American Journal of Kidney Diseases @ajkd.bsky.social · 23/09/2026

Self-Reported Versus Performance-Based Measures of Physical Function and Mortality Among Patients With Kidney Failure: A Cohort Analysis of the CONVINCE Trial bit.ly/4hKW7Mv (OPEN ACCESS) @gstrip3

Kaplan-Meier survival curves stratified by PROMIS physical function score cut-off categories across physical function measures, with corresponding cut point values and log-rank tests.

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American Journal of Kidney Diseases @ajkd.bsky.social · 23/09/2026

Temporal Trends in the Complexity of Nephrology Inpatients: A Population-Based Cohort Study bit.ly/3SmiZc5 (OPEN ACCESS)

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American Journal of Kidney Diseases @ajkd.bsky.social · 22/09/2026

Transplantation and Mortality as Competing Outcomes Among Patients on Dialysis With Newly Diagnosed Cancer: A Longitudinal Cohort Study bit.ly/4ppBDfH #OpenAccess

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American Journal of Kidney Diseases @ajkd.bsky.social · 22/09/2026

Complement in Kidney Disease: Core Curriculum 2026 bit.ly/4cTLy85

Overview of complement effects. Complement activation generates multiple effector molecules. C3 fragments (C3b, iC3b, C3d) are covalently bound to target cell membranes. C3b on the surface of target cells can form C3 convertase, leading to further complement activation at that site. Both iC3b and C3d are ligands for 4 complement receptors (CR1-4) expressed by leukocytes and dendritic cells. C3a and C5a are soluble peptides that are released during the cleavage of C3 and C5, respectively. They are ligands for receptors expressed by leukocytes and parenchymal cells. They induce multiple downstream functions, including the chemotaxis and activation of myeloid cells to sites of inflammation. Activation can also generate C5b-9 multimers on cell membranes. C5b-9 forms a pore through the outer membrane. In sublytic quantities this can cause cell activation. If sufficient C5b-9 is formed it can cause osmotic lysis of the cell. Created with BioRender.

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American Journal of Kidney Diseases @ajkd.bsky.social · 22/09/2026

Seasonality, Hospitalization, and Initiation of Home Dialysis: A Retrospective Cohort Study bit.ly/4vXICOM

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American Journal of Kidney Diseases @ajkd.bsky.social · 21/09/2026

Prevalence Estimates of Predicted Pathogenic COL4A3-COL4A5 Variants in the Chinese Population and Its Implications for Clinical Practice bit.ly/43r4RQY

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American Journal of Kidney Diseases @ajkd.bsky.social · 21/09/2026

Racial and Ethnic Variations in Reductions in Etelcalcetide Use After Withdrawal of the Transitional Drug Add-on Payment Adjustment bit.ly/46vR4Ky (OPEN ACCESS)

A: Unadjusted etelcalcetide, and cinacalcet prescriptions per quarter. Total bar represents sum of etelcalcetide and cinacalcet prescriptions (total calcimimetic use). Proportion of patients receiving at least one prescription per quarter. B: Percentage-point difference in etelcalcetide prescriptions per quarter, relative to Q4 2017, after adjustment for covariates, stratified by patient race/ethnicity. Estimates obtained by interacting indicators for each quarter with patient race/ethnicity. C: Percentage-point difference in any calcimimetic prescription per quarter, relative to Q4 2017, after adjustment for covariates, stratified by patient race/ethnicity. Estimates obtained by interacting indicators for each quarter with patient race/ethnicity. Dashed vertical lines represents January 1, 2018 and December 31, 2020, the beginning and end of TDAPA reimbursement payments, respectively. Asian/Other includes Asian, American Indian, Alaska Native, Native Hawaiian, Pacific Islander, Other

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American Journal of Kidney Diseases @ajkd.bsky.social · 20/09/2026

⚡️AJKD Express is an expedited consideration process for full-length original research articles: Authors of eligible #AJKDExpress articles will be notified of decision within 7-16 business days.⚡️ Details on #AJKDBlog: bit.ly/2Ws8rtp

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American Journal of Kidney Diseases @ajkd.bsky.social · 18/09/2026

Allocation of Kidney Allografts From Donors With Kidney Donor Profile Index <35% and the Impact of Kidney Donor Profile Index Revisions on Access to Transplantation for Children bit.ly/42iKSDu (OPEN ACCESS) @super_jrub

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American Journal of Kidney Diseases @ajkd.bsky.social · 18/09/2026

Allocation of Kidney Allografts From Donors With Kidney Donor Profile Index <35% and the Impact of KDPI Revisions on Access to Transplantation for Children bit.ly/42iKSDu #OpenAccess

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American Journal of Kidney Diseases @ajkd.bsky.social · 18/09/2026

Beyond Genotype: Proteomic Risk Stratification for APOL1-Mediated Kidney Disease bit.ly/471bxqK

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American Journal of Kidney Diseases @ajkd.bsky.social · 18/09/2026

#KDOQI US Commentary on theKDIGO 2026 Clinical Practice Guideline for the Management of Anemia in CKD bit.ly/KDOQI26Anemia (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 15/09/2026

Joint Impact of Aldosterone and Low-Density Lipoprotein Cholesterol on Cardiovascular Risk in CKD bit.ly/4A2iUvt

Restricted cubic spline plota,b,c,d of the association of serum aldosterone with major cardiovascular events (MACE) across levels of low-density lipoprotein (LDL) in persons with CKD and without baseline cardiovascular disease aThe plot depicts the hazard ratio for each doubling of serum aldosterone across varying levels of LDL. Hazard ratios are calculated using LDL = 70 mg/dL as the reference. The solid line represents the estimated hazard ratio, while the shaded area indicates the 95% confidence interval.

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American Journal of Kidney Diseases @ajkd.bsky.social · 14/09/2026

NEW Commentary by Natasha Freeman on the #AJKDBlog: A Call for Better Cancer Screening Guidelines for Patients with Glomerular Disease bit.ly/4A5ziLx

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American Journal of Kidney Diseases @ajkd.bsky.social · 14/09/2026

Donor Self-Esteem Before and After Living Kidney Donation bit.ly/3V0cpJp (OPEN ACCESS)

Rosenberg Self-Esteem Scale score at each follow-up visit. a Data are shown at the pre-donation period (“Baseline”), and at 3 months, 1 year, and annually until 5 years post-donation. Boxplot circles show the mean RSES score; boxes show the median, 25th percentile, and 75th percentile RSES score; and whiskers show the minimum and maximum values. The 5 years post-donation data summary includes some data from after the 5-year visit for those with missing 5-year data. b The number of donors with complete Rosenberg Self-Esteem Scale data is shown for each timepoint. Multiple imputation was used for missing data as described in the text.

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American Journal of Kidney Diseases @ajkd.bsky.social · 13/09/2026

Progressive Kidney Dysfunction and Ocular Clues: A Quiz bit.ly/4xgJoXk (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 13/09/2026

12-year Follow-up of a Family With CKD Caused by an mtDNA Variant bit.ly/4A2TxcJ

Pedigree of this family and renal pathology of three siblings. A. Pedigree demonstrates a maternal inheritance pattern of this family. Black denotes renal disease. Proband is denoted with arrow (III.18); A male patient with intellectual disability is denoted in dark gray (III.3); another female patient with muteness is denoted in light gray (III.5). Percentages indicate heteroplasmy level of the mutation in blood. B1-D5, B1-D5. Light microscopic findings of the elder brother(III.13), eldest sister(III.14), and second sister (III.16). The first column (B1-B5), second column (C1-C5) and third column (D1-D5) represent the renal pathology of the elder brother (III.13), eldest sister (III.14), and second sister (III.16), respectively. B1-D1: Whole slide image of kidney biopsy tissues from three siblings (Masson’s trichrome). B2-D2: All three cases showed focal tubular atrophy and interstitial fibrosis with mild (B2) to severe (C2 and D2) inflammatory cells infiltration (yellow star).

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American Journal of Kidney Diseases @ajkd.bsky.social · 13/09/2026

This Special Collection features the top cited Original Investigations published in 2023 and 2024 that contributed to AJKD’s 2025 Impact Factor of 9.4: bit.ly/AJKDTopCited (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 13/09/2026

Meaningful Engagement of Patients in Research bit.ly/4fcuMl0 (OPEN ACCESS)

Framework for meaningful engagement of patients in research. The framework (adapted from Harrison et al.)15 includes three distinct but inter-related elements of stakeholder engagement in research: research phases, foundational principles, and best practices. The framework elements are inter-related as shown by the arrows surrounding the figure. For example, the foundational engagement principles serve as the foundation for the best practices and are relevant to activities across the research continuum from design to dissemination.

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American Journal of Kidney Diseases @ajkd.bsky.social · 12/09/2026

Association of Histological Features of Cortical and Medullary Peritubular Capillaries With Progressive CKD bit.ly/4gbL1z7 (OPEN ACCESS)

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American Journal of Kidney Diseases @ajkd.bsky.social · 12/09/2026

Reproductive Health in CKD and Kidney Failure: Core Curriculum 2026 bit.ly/4gaZj4j (OPEN ACCESS)

A simplified figure of the hypothalamic-pituitary-gonadal (HPG) axis is shown normally and affected by kidney disease. Blue arrows indicate the normal axis, which involves the pulsatile release of gonadotropin-releasing hormone (GnRH), resulting in the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that then stimulates the testes and ovaries. The broken arrows represent the normal negative feedback that occurs. In kidney disease, uremia affects all levels of the axis, inhibiting hormone production. High prolactin primarily acts at the level of the hypothalamus, further augmenting the suppression of the axis.

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American Journal of Kidney Diseases @ajkd.bsky.social · 12/09/2026

Advances in Understanding of Long-Term Living Kidney Donor Risks bit.ly/46LEh6H (OPEN ACCESS)

Model of shared decision making. The physician and potential donor exchange knowledge, experience, values relevant to inform the donation decision.

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American Journal of Kidney Diseases @ajkd.bsky.social · 12/09/2026

NEW Commentary by Natasha Freeman on the #AJKDBlog: A Call for Better Cancer Screening Guidelines for Patients with Glomerular Disease bit.ly/4A5ziLx

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American Journal of Kidney Diseases @ajkd.bsky.social · 11/09/2026

Influence of Lactate Dehydrogenase on the Measurement of Blood Bicarbonate bit.ly/3U2E7oh (FREE)

Difference in CO2 and HCO3 in relation to LDH values. Plasma and serum bicarbonate results in patients with concurrently measured LDH results >4,000 U/L are shown as orange triangles, 2000-4000 U/L as purple squares, and < 2000 U/L as green dashes.

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American Journal of Kidney Diseases @ajkd.bsky.social · 11/09/2026

Evidence for the Use of Steroidal Aldosterone Antagonists in Patients With Kidney Failure bit.ly/46L6JFP

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American Journal of Kidney Diseases @ajkd.bsky.social · 11/09/2026

Heat Stress and Kidney Injury in Taiwanese Farmers: Associations With Renal Artery Resistance and Urinary Acidification bit.ly/4eSLbMy

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American Journal of Kidney Diseases @ajkd.bsky.social · 10/09/2026

Urinary CXCL9 and CXCL10, Interstitial Inflammation and Disease Activity Over Time in Acute Interstitial Nephritis bit.ly/3RF3s6X (OPEN ACCESS)

Longitudinal monitoring of urinary CXCL9 levels and serum creatinine in six patients with biopsy-proven acute interstitial nephritis (AIN) after corticosteroid therapy initiation. Urinary CXCL9 concentrations (solid blue lines, left y-axis) and serum creatinine levels (dashed red lines, right y-axis) were measured over time in patients with different etiologies of AIN: immune checkpoint inhibitor (ICI)-associated AIN (P1, P3, P4 & P5), tubulointerstitial nephritis and uveitis (TINU) syndrome (P2) and NSAID-associated AIN (P6). Periods of corticosteroid therapy (orange bars) and immune checkpoint inhibitor administration (green bars) are indicated below each graph.

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American Journal of Kidney Diseases @ajkd.bsky.social · 10/09/2026

Blood Pressure, Kidney Function, and Kidney Mortality Among Mexican Adults bit.ly/4A2kvkT (OPEN ACCESS)

Association of usual SBP with kidney failure mortality at ages 40-84 years, by baseline diabetes. Analyses and exclusions as for Figure 1, except that HRs are now estimated separately by baseline diabetes status and, in the right panel, also by age-at-risk.

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Reposted by American Journal of Kidney Diseases

NKF Nephrology Professionals @nkf-professionals.bsky.social · 06/09/2026

Anemia in CKD is more than fatigue and quality of life. In this new episode, Dr. Diana Jalal discusses the broader cardiovascular and vascular implications of anemia in kidney disease. 🎧 bit.ly/3DamjQ9 (Episode 055) #CKD #Anemia #KidneyHealth #Nephrology

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American Journal of Kidney Diseases @ajkd.bsky.social · 10/09/2026

Kidney Outcomes After Contrast Exposure in Patients Recovering From Dialysis-Requiring Acute Kidney Injury: A Target Trial Emulation Study bit.ly/4wsFue2

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American Journal of Kidney Diseases @ajkd.bsky.social · 10/09/2026

NEW Commentary by Natasha Freeman on the #AJKDBlog: A Call for Better Cancer Screening Guidelines for Patients with Glomerular Disease bit.ly/4A5ziLx

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American Journal of Kidney Diseases @ajkd.bsky.social · 09/09/2026

Electronic Phenotype for Detection, Staging, and Subtyping of Acute Kidney Injury bit.ly/4beAGRi (OPEN ACCESS)

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