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How the brain maintains a stable world model while swiftly adapting to environmental changes remains unclear. Here, the authors propose that the cerebellum drives cortical dynamics, enabling rapid tas...

Simultaneous imaging of premotor cortex and cerebellar granule cells in mice learning two skills in parallel shows that trajectories generalize in cortex but coherently reorient apart in granule cells...

Neural mechanisms underlying spatial working memory are not fully understood. In this manuscript, simultaneous bilateral monkey recordings and attractor networks show how weakly coupled, redundant pre...

The genomic mechanisms that efficiently encode the initial architecture and synaptic connectivity of neural circuits remain poorly understood. We hypothesise that two primary mechanisms — spatial enco...

Nature Neuroscience - Charbonneau et al. compare how the insula is structured and functions in humans, monkeys and rodents, revealing similarities and differences across species that are likely to...

People often make sequences of decisions to reach a goal. In such situations, when decisions can be undone, people act faster and undo to correct errors. Undoing is driven by both retrospective and pr...

To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...

Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...

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Learning is thought to arise from synaptic modifications embedded in brain-wide circuits, yet how such circuits coordinate plasticity to support complex behaviour is not known. Inspired by deep learni...

Action selection using predictive models of the environment plays a fundamental role in human and animal behaviour, yet is poorly understood at circuit and algorithmic levels. Spatial navigation is an...

In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism through which this ...

YouTube video by Andrew Pruszynski

A drawing-like task designed to study compositional generalization identifies a specific neural population in the ventral premotor cortex in primates that encodes action symbols.

How humans process competing information when making multi-alternative decisions remains unclear. Here, the authors show that the brain resolves the trade-off between “evaluating within” and “comparin...

Humans rapidly learn abstract knowledge when encountering novel environments and flexibly deploy this knowledge to guide efficient and intelligent action. Can modern AI systems learn and plan in a sim...

A leading neuroscientist describes the long evolutionary process that led to the human brain

We, the undersigned academics and researchers from around the world, express our profound concern over recent military strikes on Iran, the retaliatory responses, and the reported impact on civilian l...