Interactions between the prefrontal cortex (PFC) and hippocampus (HPC) are crucial for flexible and memory guided behaviour. Because there are no direct projections from PFC to HPC, it is widely presu...

Kevin Mitchell talks with Timothy Behrens about ring attractors, the role of innate structure, and an expanded view of cognitive maps.

Theta sweeps have been mired in controversy for decades, but the emerging consensus view suggests that they function in attention and goal direction.

To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...

Action selection using predictive models of the environment plays a fundamental role in human and animal behaviour, yet is poorly understood at circuit and algorithmic levels. Spatial navigation is an...

The prefrontal cortex (PFC) is critical for our ability to rapidly and flexibly adapt our behavior in new environments based on our previous experience. Despite its importance, the neural substrates a...

Significance The combination of two-photon calcium imaging and two-photon optogenetic stimulation, termed all-optical interrogation, provides spatial and temporal precision when recording and manipula...

Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...

Large-scale projects run the risk of stifling scientific independence. Instead, let’s explore alternative mechanisms of collaboration.

Our group investigates how cells and circuits in the brain work together to perform computations that support memory. Using a wide range of technical approaches, we investigate how these computations ...

A model of compositional state spaces in the hippocampus shows latent learning and rapid generalization. Bakermans et al. show that this model predicts the emergence of place responses in replay.

By Kristopher T. Jensen. Reinforcement learning for neuroscientists