Reposted by David SchoppikMichael Lin, MD PhD @michaelzlin.bsky.social · 29/09/2026Excited to share a new study from our lab in Cell: “Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound” We engineered a compact CRISPR system that can be activated at specific locations in the body using focused ultrasound (🧵) www.cell.com/cell/fulltex...cell.comNon-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasoundRemote activation of a single-AAV-deliverable photoswitchable Cas12f system enables precise spatial and temporal control of genome editing in deep tissues without surgery or implanted devices. 1359
David Schoppik @schoppik.com · 29/09/2026Cool, congrats, great, happy for you, and do call me when you get to Deuteronomy. 040
David Schoppik @schoppik.com · 29/09/2026"They get rich, you die. It's trying." was right there 😅 120
Reposted by David SchoppikTessa Montague @tessamontague.bsky.social · 29/09/2026I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain. 13331112
Reposted by David SchoppikbioRxiv Neuroscience @biorxiv-neursci.bsky.social · 28/09/2026Repeated Inertial Stimulation Reveals Divergent Plasticity in Peripheral and Central Vestibular Pathways www.biorxiv.org/content/10.64898/20… 001
Reposted by David SchoppikRebecca Solnit @rebeccasolnit.bsky.social · 28/09/2026Campus rape is really widespread; statistics suggest a significant percent of women who go to college will be raped there; feminism opened up a good conversation about it around 2012-13; it's weird when people treated Cornell like an isolated rather than dramatic example of a pervasive problem. 412405521
Reposted by David SchoppikRainer Friedrich @rainerfriedrichlab.bsky.social · 26/09/2026Precise structural and functional organization of the olfactory bulb neuropil early in development, revealed by volume EM, dense reconstruction and 2P calcium imaging in zebrafish. Great work by Ruth and others in collaboration with @michalwj.bsky.social www.biorxiv.org/content/10.6...biorxiv.orgFine ultrastructural organization of glomerular neuropil in the developing zebrafish olfactory bulbAcross animal phyla, odor information is represented in the first olfactory processing center by combinatorial activation of discrete glomeruli. To examine how this organization of olfactory processin... 02412
Reposted by David SchoppikScott Juntti @scottjuntti.bsky.social · 27/09/2026When a fish sees the world move, it immediately swims with it. This is the optomotor response: a visual reflex found across animals that helps us maintain our position and orientation as our surroundings appear to drift. 🐟👀 14315
Reposted by David SchoppikCaroline Bartman @cbartman.bsky.social · 26/09/2026Are there key discoveries made with spatial RNA seq? Or what are your favorite spatial rna seq papers? Pls reski! 31615
David Schoppik @schoppik.com · 25/09/2026Like the monk said, "Before enlightenment: carry water, chop wood. After enlightenment: carry water, chop wood." 130
David Schoppik @schoppik.com · 25/09/2026static.klipy.comGromit Snapping FingersALT: Gromit Snapping Fingers 010
Reposted by David SchoppikCedric Feschotte @cedricfeschotte.bsky.social · 24/09/2026Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/nscience.orgEscape of the BC200 gene to a human poxvirus reveals its persistent transposition in primatesTransposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta... 216885
David Schoppik @schoppik.com · 24/09/2026I wonder if there is much overlap between the gatekeepers at beauty pageant fellowships and study section members.... 000
Reposted by David SchoppikPortugues Lab @portugueslab.bsky.social · 24/09/2026The Department of Neurobiology and Behavior at Cornell University is hiring! Come and do cutting edge research on the neural basis of natural behaviors at NBB (nbb.cornell.edu). No animal too small, no behavior too strange! Apply here: academicjobsonline.org/ajo/jobs/32592 14834
David Schoppik @schoppik.com · 24/09/2026Yes, there’s a superior (Castelvetrano) and inferior (Kalamata). 020
David Schoppik @schoppik.com · 24/09/2026Let's be fair Harmit none of our first drafts are easy.... 110
Reposted by David SchoppikMatt Lovett-Barron @mlovettbarron.bsky.social · 23/09/2026Our lab's latest paper on the neurobiology of collective behavior is now published www.nature.com/articles/s41... This is the work of a great team in the lab - led by Jo-Hsien Yu, with Geoff Meyerhof, Jimjohn Milan, and Julia Napoli @nature.com @danionella.bsky.social 1011257
Reposted by David SchoppikAnn Clemens @annmclemens.bsky.social · 12/08/2026preprint🚨 ✨A Stickiness Response System in Rats tinyurl.com/4wnu88v9 What underlies that sticky, icky feeling? Sticky sensing is surprisingly underexplored. we investigated its neural and behavioural basis Congrats to Sandra, @simonerencken.bsky.social @jasmine-stone.bsky.social Adam, Tom & Pam! 👏 26013
Reposted by David SchoppikFlorian T. Merkle, PhD @florianmerkle.bsky.social · 22/09/2026Seeking a PhD at Cambridge in collaboration with NovoNordisk? Consider this funded opportunity titled "Human cellular models of leptin signalling and resistance": bbsrcdtp.lifesci.cam.ac.uk/project-refe... Application details: bbsrcdtp.lifesci.cam.ac.uk/how-apply Thanks for spreading the word! 064
Reposted by David SchoppikDan Grimes @dangrimes.bsky.social · 22/09/20261/11. New preprint from our lab! Serotonergic Control of Spine Morphology During Growth in Zebrafish www.biorxiv.org/content/10.6...biorxiv.orgSerotonergic Control of Spine Morphology During Growth in ZebrafishScoliosis is a three-dimensional deformity of the vertebral column that commonly emerges during growth, yet the biological mechanisms that initiate and drive curve progression remain poorly understood... 2112
Reposted by David SchoppikMargarita Parada-Kusz @margaritapk.bsky.social · 18/09/2026Two parallel neural ectoderm progenitors contribute to the developing brain www.nature.com/articles/s41...nature.comTwo parallel neural ectoderm progenitors contribute to the developing brain - Nature NeuroscienceThis study shows that the brain arises from two distinct progenitors: one forms the forebrain and midbrain, whereas the other generates the hindbrain. These insights enable the generation of human hin... 082
Reposted by David SchoppikSweta Agrawal @hokuba.bsky.social · 16/09/2026The Agrawal lab has published its first paper! "Sticking the landing: leg mechanosensory feedback coordinates the transition from flight to landing" www.biorxiv.org/content/10.6... This project was led by a technician in the lab, Tse-Wei (Wayne) Kuo. Brief 🧵on what we foundagrawal-lab-workspace.slack.comSlack 88228
David Schoppik @schoppik.com · 12/09/2026This is timely, lucid, and something worth having handy the next time it comes up. Because it will keep coming up. 030
Reposted by David SchoppikNeedhi Bhalla 💅🏽 @needhibhalla.bsky.social · 11/09/2026“the only certainty we have is the certainty we had at the start: At fifteen seconds after 9:41 a.m., on September 11, 2001, a photographer named Richard Drew took a picture of a man falling through the sky—falling through time as well as through space…The picture is his cenotaph“ 041
Reposted by David SchoppikPhilippe Batut @philippebatut.bsky.social · 10/09/2026🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇science.orgNoncoding transcription controls the developmental dynamics of long-range gene regulationThe genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ... 5233114
Reposted by David SchoppikRainer Friedrich @rainerfriedrichlab.bsky.social · 10/09/2026Just out in Nat Neurosci: disentangling of neural odor manifolds in "olfactory cortex" of adult zebrafish after learning. Great work by Bo, Nesibe et al and wonderful collaboration with @sueyeonchung.bsky.social that fundamentally changed my view of olfactory cortex. www.nature.com/articles/s41...rdcu.be 14718
David Schoppik @schoppik.com · 10/09/2026This is a great resource that encapsulates a lot of hard-won knowhow. 040
Reposted by David SchoppikH. P. Read @readhpr.bsky.social · 06/09/2026Lovely article about a 99-year-old retired math professor who recently published a major result. It's the story of mentorship and multi-generational collaboration. www.nytimes.com/2026/09/06/s...nytimes.comThe 92-Year-Old Mathematician and the Teenage Apprentice (Gift Article)Joan Birman thought her major discoveries were behind her. Then came an email from a young neighbor — a girl who knew little but wanted to learn. 15325
David Schoppik @schoppik.com · 06/09/2026100% agree! This will be the first year in decades that I don't make this cake, but it's only b/c my daughter got into baking and I am excited to pass the torch.... 030
David Schoppik @schoppik.com · 05/09/2026Excellent points. This might be your best “I am large, I contain multitudes.” thread yet. Thanks. 020
Reposted by David SchoppikMekka Okereke @mekka.mekka-tech.com · 05/09/2026Nathan wrote a good article. I'm quote tweeting in the Black way (to talk about a different point without derailing his thread). 🤔If Ben thinks you need to play football to build character, learn teamwork, leadership, etc, and girls don't play football... what does that say about his view of women? 528855
Reposted by David SchoppikAndrew Straw @andrewstraw.bsky.social · 04/09/2026We are hiring! Come join us in the Straw Lab at the @biologyunifreiburg.bsky.social . Seeking a scientist to work on the neural and computational mechanisms of visual navigation in honey bees. uni-freiburg.de/en/job/00005... 18061
David Schoppik @schoppik.com · 01/09/2026jo-newyork.com is truly special and it looks like they have spots for the 5:30-6 seating tomorrow b/c nobody really knows about it yet.jo-newyork.comJō -Japanese cuisine-JŌ(縄)refers to a rope composed of plant stalks, fibers, or paper, that in Japanese culture has been utilized for centuries for various purposes. 000
Reposted by David SchoppikAl Yankovic @alyankovic.bsky.social · 31/08/2026“Lost media” no longer! I finally got permission to upload “AL’S BRAIN,” an 11-minute educational 3-D film attraction which ran at the Orange County and Western Washington fairs, and hasn’t been seen publicly since 2009. You can watch the whole thing here: youtu.be/2xujU87ZHt4 10492262509
David Schoppik @schoppik.com · 31/08/2026On the off-chance you're serious or someone reading this is, this sticks nicely to the underside of the fabric and you'll feel so silly about putting it there that you'll never forget your umbrella again: www.elevationlab.com/collections/...elevationlab.comAirTag Fabric ExtremeThe first waterproof AirTag fabric mount. Installs in seconds to luggage, purses, bags or jackets. Flexes & moves with your fabric. Discreet. Top easily screws on and off. Engineered to withstand... 000
Reposted by David SchoppikDayu Lin @moccalin.bsky.social · 26/08/2026Happy to share our new study comparing aggression level across 7 strains of mice, led by a talented undergraduate student, Xiuzhi Dai. Strain differences in aggression can be explained a lot by differences in the physiological properties of VMHvl cells. www.nature.com/articles/s41...nature.comHypothalamic representation of aggressiveness across mouse strains - Nature CommunicationsGenetics profoundly influences aggression by shaping neural circuits, but the underlying mechanisms remain unclear. Here, authors show that strain differences in male mouse aggression are linked to di... 1229