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Portugues Lab

@portugueslab.bsky.social
552 followers 313 following 40 posts

Official account of the Portugues Lab @Cornell (previously @TUM), studying all things sensorimotor in larval zebrafish.

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Portugues Lab @portugueslab.bsky.social · 24/09/2026
The Department of Neurobiology and Behavior at Cornell University is hiring! Come and do cutting edge research on the neural basis of natural behaviors at NBB (nbb.cornell.edu). No animal too small, no behavior too strange! Apply here: academicjobsonline.org/ajo/jobs/32592
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Benjamin Judkewitz @benjulab.bsky.social · 05/03/2026
First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...
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Adrien Peyrache @apeyrache.bsky.social · 11/02/2026
New paper alert! 🚨 We found that the brain's compass is remarkably stable at two scales 1️⃣ the system maintains its internal organization for weeks 2️⃣ It "remembers" its orientation for weeks, even after a single visit This may be key to how the brain aligns its other maps. Paper: rdcu.be/e3waP
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Portugues Lab @portugueslab.bsky.social · 08/02/2026
Have you ever wondered how the brain should represent the sensory world in order to generate behavior? Read our new preprint: work by Shuhong Huang shuhonghuang.bsky.social with our long-standing collaborator James Fitzgerald at Northwestern.
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Nature @nature.com · 09/01/2026
Nature research paper: Plastic landmark anchoring in zebrafish compass neurons go.nature.com/4qP4HwB
go.nature.com
Plastic landmark anchoring in zebrafish compass neurons - Nature
Using two-photon microscopy with a panoramic virtual reality setup, how head direction cells in larval zebrafish integrate visual landmarks and optic flow to track orientation is revealed.
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Portugues Lab @portugueslab.bsky.social · 07/01/2026
1/6: New publication from the lab: “Plastic landmark anchoring in zebrafish compass neurons” by Ryosuke Tanaka (@ryosuketanaka.bsky.social) and Ruben is available here: rdcu.be/eX1L4
rdcu.be
Plastic landmark anchoring in zebrafish compass neurons
Nature - Using two-photon microscopy with a panoramic virtual reality setup, how head direction cells in larval zebrafish integrate visual landmarks and optic flow to track orientation is revealed.
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Sachin Sethi @sethisachin.bsky.social · 06/01/2026
www.cell.com/cell/fulltex... We had a lot of fun working on this project (led by Itzel Ishida, not on bluesky). Some interesting highlights from the paper -
cell.com
Neuronal calcium spikes enable vector inversion in the Drosophila brain
In the fly central complex, PFNa neurons switch from firing classical sodium spikes when depolarized to firing non-canonical T-type calcium spikes when hyperpolarized. This bidirectional spiking allow...
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Portugues Lab @portugueslab.bsky.social · 02/01/2026
1/n: A new collaborative preprint from the lab to start the year: "A multi-ring shifter network computes head direction in zebrafish" together with Siyuan Mei, Martin Stemmler and Andreas Herz from the LMU, Munich.
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Dinu F Albeanu @dinanthos.bsky.social · 15/12/2025
Adam Kampff’s passion for understanding and explaining the world was unmatched. Living by example and not ever compromising on his dreams, Adam was uncanny in making people realize they can learn and understand anything and everything. Keep his dream alive! In his own words: tinyurl.com/ye29csw3
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Yvette Fisher @yvetteefisher.bsky.social · 15/12/2025
*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️
Schematic of how ER-EPG plasticity enables the bump of activity in EPGs to accurately track visual cues. As a fly makes a counter-clockwise turn (top to bottom) it will view visual cues (e.g. the sun) from a new angle and the EPG activity bump (red) will swing clockwise around the network by integrating self motion signals with these visual inputs. When the fly faces a different angle, distinct visual ER neurons are active. Plasticity forms a trough of weak synapses (large circles - strong synapses, small circles - weak synapses) that allow ER neurons with distinct visual tuning to move the EPG bump via disinhibition.
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Portugues Lab @portugueslab.bsky.social · 24/11/2025
(1/n) We are excited to share our new paper in Nature Communications, by Hagar Lavian (@hlavian.bsky.social) and team, revealing how the zebrafish brain integrates visual navigation signals! www.nature.com/articles/s41...
nature.com
Visual motion and landmark position align with heading direction in the zebrafish interpeduncular nucleus - Nature Communications
How are various visual signals integrated in the vertebrate brain for navigation? Here authors show that different spatial signals are topographically organized and align to one another in the zebrafi...
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Emilie Macé @mace-lab.bsky.social · 11/09/2025
Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/
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Misha Ahrens @mishaahrens.bsky.social · 08/09/2025
Preprint - Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo. www.biorxiv.org/content/10.1...
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BonnBrain Conference @bonnbrainconf.bsky.social · 08/09/2025
Application is open! Come join us and our fantastic line-up of speakers next year in March in Bonn!
Flyer advertising the BonnBrain Conference 2026, "From Genes to Circuits and Behavior".
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Siddharth Jayakumar @siddjakes.bsky.social · 02/09/2025
Excited to share our latest!! Thanks to everyone involved especially @neurovenki.bsky.social!
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Isaac Bianco @isaacbianco.bsky.social · 23/08/2025
Latest from the lab. Beautiful work from Joanna Lau and a fantastic collaboration with James Fitzgerald. www.cell.com/current-biol...
cell.com
Supraspinal commands have a modular organization that is behavioral context specific
Lau et al. use calcium imaging and statistical modeling to comprehensively survey reticulospinal activity during diverse locomotor behaviors. They find that a small set of functional modules act combi...
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Portugues Lab @portugueslab.bsky.social · 23/07/2025
@natrevneuro.nature.com just published a beautiful cover for the issue that includes the recent review on analogies in the visual system of vertebrates and invertebrates (@ryosuketanaka.bsky.social). Read it here doi.org/10.1038/s415... Science and Art, what could be better?
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Wyart Lab @wyartlab.bsky.social · 02/07/2025
Let's share @etlunsford.bsky.social's work : to survive, animals avoid drifting involuntarily in their environment. While humans rely on visual & vestibular cues, birds & fish need to sense complex flow changes of the external fluid (air/water) around them to select motor actions. How do they do?(1)
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Fumi Kubo @fumikubo.bsky.social · 10/06/2025
Preprint Alert! How does the brain distinguish different types of optic flow? We combined CaMPARI2 labeling with single-cell RNA-seq (CaMPARI-seq) to dissect visual circuits in zebrafish. Read the full study here 👉 www.biorxiv.org/content/10.1...
biorxiv.org
Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors
Optic flow processing is critical for the visual control of body and eye movements in many animals. Rotational and translational binocular optic flow patterns need to be clearly distinguished to induc...
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Portugues Lab @portugueslab.bsky.social · 23/05/2025
Are you interested in visual systems? How are they similar or different across species? Read the review by Ryosuke @ryosuketanaka.bsky.social and Ruben published today in @natrevneuro.nature.com. It is available here: rdcu.be/enlpC
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Benjamin Judkewitz @benjulab.bsky.social · 12/05/2025
Introducing warpfield, an open source Python library for GPU-accelerated non-rigid 3D registration. Warps and aligns gigavoxel volumes within seconds (not hours). For 3D microscopy, region-to-region and cell-to-cell matching. A collaboration with @mh123.bsky.social 🚀 github.com/danionella/w...
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Markus Meister @mameister4.bsky.social · 21/05/2025
If you're planning a course with mathematical methods content, or use such methods in your own work, please take a look at "Mathematics in Biology", by Meister, Lee, and Portugues, published at MIT Press. 1/2 @portugueslab.bsky.social mitpress.mit.edu/978026204940...
mitpress.mit.edu
Mathematics in Biology
Biology has turned into a quantitative science. The core problems in the life sciences today involve complex systems that require mathematical expression, ye...
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Andrew Pruszynski @andpru.bsky.social · 02/05/2025
I bought this book and its great! Highly recommend to have around the lab.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 20/04/2025
Algorithmic dissection of optic flow memory in larval zebrafish www.biorxiv.org/content/10.1101/202…
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Max Planck Institute for Neurobiology of Behavior – caesar @mpinb.mpg.de · 15/04/2025
🧠 Interested in a postdoc in neuroscience? Our Department of Computational Neuroethology is hiring for two exciting projects: 🔬 Retinal circuitry evolution 🐟 Mechanistic cognition in Danionella cerebrum mpinb.mpg.de/en/research-... 📅 Apply by May 13 via the Max Planck #PostdocProgram #Neuroethology
mpinb.mpg.de
Research Focus - MAX PLANCK INSTITUTE FOR NEUROBIOLOGY OF BEHAVIOR — CAESAR
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Cedric Feschotte @cedricfeschotte.bsky.social · 16/04/2025
Cornell’s new homepage: RESEARCH MATTERS 🔬🔭🧪⚗️🧬💪😍 www.cornell.edu
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Portugues Lab @portugueslab.bsky.social · 02/04/2025
1/3 Starting this summer, and after 11 wonderful years in Munich, the Portugues Lab will be starting a new adventure at the Department of Neurobiology and Behavior (NBB) (nbb.cornell.edu) at Cornell University in Ithaca, NY.
nbb.cornell.edu
Department of Neurobiology and Behavior | Department of Neurobiology and Behavior
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Nencki Open Lab @openlab.bsky.social · 05/03/2025
We are super happy to present our first preprint - the effect of our Rethinking Naturalistic Behaviour Workshop - where we look more critically at the term "naturalistic behaviour" and point to its vagueness and inconsistency in its use! osf.io/preprints/os...
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Dinu F Albeanu @dinanthos.bsky.social · 26/02/2025
New preprint: a simple method (ADePT) for optical control and recording of activity by axially-decoupling the focal planes for widefield patterned photo-stimulation and two photon imaging. Proof-of-principle analysis of functional connectivity in the olfactory bulb. 1/7 #neuroscience
doi.org
Axially decoupled photo-stimulation and two photon readout (ADePT) for mapping functional connectivity of neural circuits
All optical physiology in vivo provides a conduit for investigating the function of neural circuits in 3-D. Here, we report a new strategy for flexible, axially-decoupled photo-stimulation and two pho...
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Venki Murthy @neurovenki.bsky.social · 24/02/2025
Stand up for Science, on March 7th, in Boston. Please help spread this widely.
standupforscience2025.org
Boston, MA
Location: Massachusetts State House 24 Beacon St, Boston, MA, United States Address: 24 Beacon St., Boston, MA, 02133 Time: 12-4 PM Important information: Please do not fully block the sidewalk, st…
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Markus Meister @mameister4.bsky.social · 20/02/2025
Table of contents, sample chapter, and lots of other materials are here: www.mathinbio.com. 3/3
mathinbio.com
Mathematics in Biology
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Markus Meister @mameister4.bsky.social · 20/02/2025
What a super collaboration – stretching over 12 years now – with Kyu Hyun Lee and Ruben Portugues! Here is why we did it: markusmeister.com/2025/02/20/w.... @portugueslab.bsky.social 2/3
markusmeister.com
Why we wrote a math book for biologists
Mathematics in Biology by Markus Meister, Kyu Hyun Lee, and Ruben Portugues Biology has rapidly become a quantitative science, with mathematical methods infusing all aspects of the scientific proce…
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Markus Meister @mameister4.bsky.social · 20/02/2025
Here it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology. @portugueslab.bsky.social. 1/3
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Benjamin Judkewitz @benjulab.bsky.social · 03/11/2024
We’re seeking a postdoc/student excited about animal communication, brain-wide circuits, microscopy, singing fish (Danionella), wacky ideas and who likes to: get things done, experiment, analyze, ask, learn, help and cooperate. jlab.berlin
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MIT Press @mitpress.bsky.social · 18/02/2025
"Mathematics in Biology" is a concise but rigorous textbook for advanced undergraduate and graduate students across the biological sciences that provides a foundation for understanding the methods used in quantitative biology: @mameister4.bsky.social
mitpress.mit.edu
Mathematics in Biology
Biology has turned into a quantitative science. The core problems in the life sciences today involve complex systems that require mathematical expression, ye...
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 14/02/2025
A zebrafish circuit for behavioral credit assignment www.biorxiv.org/content/10.1101/202…
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Inbal Shainer @ishainer.bsky.social · 13/02/2025
Excited to share our new paper in Nature! 'Transcriptomic neuron types vary topographically in function and morphology' explores how neurons in the zebrafish optic tectum exhibit diverse functions and shapes despite similar transcriptional profiles. 🔗 rdcu.be/d9GVM
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Stanley Heinze @stanley-heinze.bsky.social · 03/02/2025
Interested in how ants navigate? Have a look at our new review in Current Biology! This piece has resulted from a collaboration with Tom Collett, Paul Graham. Open access: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... @ercresearch.bsky.social @lundvision.bsky.social @biologylu.bsky.social
kwnsfk27.r.eu-west-1.awstrack.me
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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MPI for Biological Intelligence @mpiforbi.bsky.social · 28/01/2025
Do you want to connect with neuroscience enthusiasts around Munich? Then register now for the 3rd Munich Brain Day on May 16th! We are happy to host the event again at our Institute in Martinsried. More info & registration: munichbrainday.com
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St. Jude Children's Research Hospital @stjuderesearch.bsky.social · 22/01/2025
St. Jude welcomes Elizabeth Hillman, PhD, as the founding chair of the new Department of Imaging Sciences. Her team will develop innovative tools to accelerate discovery and improve patient care. ow.ly/GZQG50UL653
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Portugues Lab @portugueslab.bsky.social · 20/01/2025
Interested in research in freely-moving mice? Apply for a PhD or postdoc in the lab of Weijian Zong @weijianzong.bsky.social in beautiful Trondheim, Norway, to use the miniature two-photon microscopes he developed. Exciting research, wonderful environment, great PI. www.jobbnorge.no/en/available...
jobbnorge.no
PhDs and/or postdocs (272467) | NTNU - Norwegian University of Science and Technology
Job title: PhDs and/or postdocs (272467), Employer: NTNU - Norwegian University of Science and Technology, Deadline: Sunday, March 2, 2025
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Marine Biological Laboratory @mblscience.bsky.social · 17/01/2025
Calling all neuroscientists! 🧠 The MBL's 2025 Neural Systems & Behavior course is accepting applications until February 1. Don't miss your chance to apply! Read more: bit.ly/4jetcAc #ScienceStartsHere
A flyer for the MBL's 2025 Neural Systems & Behavior course
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Dinu F Albeanu @dinanthos.bsky.social · 14/01/2025
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro Apply by: February 16th!
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David Schoppik @schoppik.com · 30/12/2024
Closing out the year, @cbellegarda.bsky.social and @franziau.bsky.social argue that zebrafish have much to teach us about diversity. Well, diversity among motor neurons that move the eyes, anyway 👀. Plus read our opinionated takes on current articles too! authors.elsevier.com/a/1kL%7Eb3Q9...
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Portugues Lab @portugueslab.bsky.social · 20/12/2024
1/3 How does visual input affect the heading direction (HD) network? In our latest lab preprint, Ryosuke presents "visual landmarks" to larval zebrafish and shows that the HD network tethers to the visual environment. The experiments are again inspired by the beautiful recent work in Drosophila.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 19/12/2024
Mechanisms for plastic landmark anchoring in zebrafish compass neurons www.biorxiv.org/content/10.1101/202…
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Portugues Lab @portugueslab.bsky.social · 17/12/2024
Is your summer 2025 looking boring and monotonous? Apply to the Neural Systems and Behavior course (www.mbl.edu/education/ad...) at MBL in Woods Hole for an 8-week experience that will change your (scientific) life. Deadline: Feb 1st, 2025.
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adrienjouary.bsky.social @adrienjouary.bsky.social · 29/11/2024
This is my first post here, and I'm happy to share some news. We've just launched megabouts.ai! 🐟📈 1/n
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