iiinova — where your digital self keeps evolving

Reposted by Dan Grimes

Alessandro De Simone @desimonelab.bsky.social · 17/09/2026

How is proliferation modulated in regeneration for tissues to reach their right size? We found that, in zebrafish scales, proliferation is shut down by a moving front of osteoblast maturation. The front's dynamics scale with tissue size, ensuring proper osteoblast amplification. tinyurl.com/5e45twx3

tinyurl.com

A moving front of osteoblast maturation scales regenerating zebrafish bone

Successful regeneration recovers lost tissues to their original form. Here, we investigate how proliferation of bone-forming osteoblasts is timely regulated to control tissue size during zebrafish sca...

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Dan Grimes @dangrimes.bsky.social · 07/02/2025

I walked past a group of students running a stall to raise awareness about library closures and ways to support libraries. Mixed emotions. Sad that they have to fight for this, but deeply inspired by their passion.

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Dan Grimes @dangrimes.bsky.social · 21/01/2025

As a big soccer fan, I'm so glad to see so many soccer subreddits calling for a stop to linking 'news' from that other place.

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Dan Grimes @dangrimes.bsky.social · 21/01/2025

Still time to apply for @uoregon.bsky.social Summer Program for Undergraduate Research — a paid 10-week research opportunity this summer for undergrads in the life sciences. Details in the flyer below. Please share.

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Reposted by Dan Grimes

Nathalie Jurisch-Yaksi @nathaliejuya.bsky.social · 17/01/2025

Have you ever wondered what role motile #cilia and cerebrospinal fluid (#CSF) play in brain development and physiology? If yes, please check out our latest article now published in Cell Reports and spearheaded by the newly minted Dr D'Gama www.sciencedirect.com/science/arti...

sciencedirect.com

Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain

The brain uses a specialized system to transport cerebrospinal fluid (CSF), consisting of interconnected ventricles lined by motile ciliated ependymal…

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Dan Grimes @dangrimes.bsky.social · 03/01/2025

Today, I saw daybreak twice. On a short flight I saw the sun come up; a beautiful orange sky. Then we descended and the sun disappeared. The stars came back out. I was at the gate waiting for my next flight when I saw daybreak number 2. I guess the earth really is round!

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Dan Grimes @dangrimes.bsky.social · 10/12/2024

I'm a soccer fan (Arsenal). Recently, the Premier League ran an anti-homophobia campaign where captains wore rainbow armbands. Some refused or altered the message. A common response from fans has been "keep politics out of football [soccer]". Let's unpack why this isn't a serious argument. (1/6)

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Michal Caspi Tal, PhD @immunofever.bsky.social · 03/12/2023

There is a human tissue that builds itself up and breaks itself down every 28 days (on average) using non-scarring wound healing and instead of studying that and learning everything we can about it we think it's gross and look for other less relevant models to understand wound healing.

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Paulina Arancibia @pauliarancibia.bsky.social · 30/11/2024

I created this stater pack with women in ecology and evolution. If you want to be added you can comment or DM me, but also please suggest the names of those I am missing 🧪🌎🌐 go.bsky.app/8jFH7cS

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Dan Grimes @dangrimes.bsky.social · 22/11/2024

For #FluorescenceFriday, here's the spinal canal of a zebrafish embryo filled with #cilia (cyan).

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Dan Grimes @dangrimes.bsky.social · 22/11/2024

"The overriding ambition (of Biology research) should be to capture meaning, rather than simply catalogue complexity" — from Paul Nurse's charming book What is Life?

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Dan Grimes @dangrimes.bsky.social · 21/11/2024

Scoliosis is a common condition in which the spine curves to the side and rotates, often onsetting during adolescence. In our lab, we generate zebrafish with scoliosis-like spinal curves to try to understand the causes of this disease.

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Dan Grimes @dangrimes.bsky.social · 20/11/2024

I always liked this quote in defense of basic science: "To feed applied science by starving basic science is like economizing on the foundations of a building so that it may be built higher. It is only a matter of time before the whole edifice crumbles". — George Porter

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Dan Grimes @dangrimes.bsky.social · 12/04/2024

Many congratulations to Professor Judith Eisen @uoregon.bsky.social for winning the Streisinger Award for "sustained and foundational" work in the zebrafish field. Well deserved!

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Dan Grimes @dangrimes.bsky.social · 12/02/2024

Arturo Rosenblueth was a pioneer of cybernetics and, along with Norbert Wiener, had this to say: "The price of metaphor is eternal vigilance". Let's remember that metaphors are useful for thinking and discussing science, but they are not reality.

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Reposted by Dan Grimes

Crystal Rogers, PhD @rogerslabucd.bsky.social · 12/02/2024

Please check out our recent perspective paper, “Pluripotency of a founding field: rebranding developmental biology.” Huge thanks to the 50 scientists who came to California to discuss the future of #DevBio and contributed to the paper, and thanks to NSF for $! journals.biologists.com/dev/article/...

journals.biologists.com

Pluripotency of a founding field: rebranding developmental biology

ABSTRACT. The field of developmental biology has declined in prominence in recent decades, with off-shoots from the field becoming more fashionable and highly funded. This has created inequity in disc...

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Reposted by Dan Grimes

Lil (Lillian Fritz-Laylin) @fritzlaylin.bsky.social · 06/02/2024

🧪 My department is hiring! Tenure track faculty position in genetics. Researchers using any eukaryotic model, including fungi and plants are encouraged to apply! We are a broad biology department with strengths across all kingdoms. Join us! Apply by March 1 tinyurl.com/y4evds8p

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Reposted by Dan Grimes

James Briscoe @jamesbriscoe.bsky.social · 19/01/2024

Postdocs going on the academic job market this year: there's still time to apply to Development's 'Pathway to Independence' programme: mentoring, training & networking to help with the transition to a PI position. Application deadline 31 Jan: journals.biologists.com/dev/pages/pi...

journals.biologists.com

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Dan Grimes @dangrimes.bsky.social · 18/01/2024

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Dan Grimes @dangrimes.bsky.social · 16/01/2024

Random thought: Playing a game, one person says a word and the next person makes a new word by changing only a single letter: E.g. Rain — Raid — Paid — Pain — Gain — Grin — Grit — etc. Can all 4-letter words in the dictionary be connected like this? Do some miss out? How many?

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Dan Grimes @dangrimes.bsky.social · 15/01/2024

The Biology Department at the University of Oregon @uoregon.bsky.social is hiring a department head. Apply by Feb 12th if interested, and share with others who might be. Reposts appreciated. careers.uoregon.edu/en-us/job/53...

careers.uoregon.edu

Current Opportunities | UO HR Website

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Dan Grimes @dangrimes.bsky.social · 14/01/2024

It's very cold and strikingly beautiful in Eugene, Oregon, today.

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Dan Grimes @dangrimes.bsky.social · 09/01/2024

I watched The Wizard of Oz over Christmas, and last night the sequel, Return to Oz. I'm not sure what I expected from the sequel, but it certainly wasn't this terrifying Foucauldian nightmare about childhood mental illness at the turn of the century A "children's" horror movie!

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Dan Grimes @dangrimes.bsky.social · 08/01/2024

Paid 10-week summer research opportunity for life science undergraduates at University of Oregon @uoregon.bsky.social. Our American Heart Association-sponsored prepares fellows for life science careers, and includes mentored research, training workshops and networking opportunities. Please share!

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Dan Grimes @dangrimes.bsky.social · 05/01/2024

12 asymmetric animals, bonus number 13: the Dahu The Dahu is a goat-like creature from Southern France. Amazingly, Dahu legs on one side (either left or right) are longer than its legs on the other side… this means the Dahu can only walk around mountains in one direction!

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Reposted by Dan Grimes

ClutchScience (Jen Phillips) @clutchscience.bsky.social · 04/01/2024

Okeydoke let’s do this thing 📢Preprint klaxon 📢 (h/t @mads100tist.bsky.social for that alert) I’m excited to share this work featuring cool data from a succession of 3 undergraduate researchers + contributions from collaborators at Harvard & Emory Med schools: www.biorxiv.org/content/10.1...

biorxiv.org

Hexafluoro slows retinal degeneration and improves visual function in zebrafish models of Usher synd...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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Dan Grimes @dangrimes.bsky.social · 04/01/2024

12 asymmetric animals, day 12: slugs Land slugs breathe air through a pore called a pnemostome, an opening which connects to the animals single lung. This breathing pore is always on the right side, as exemplified here by the European red slug.

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Reposted by Dan Grimes

Christian Mosimann @chrmosimann.bsky.social · 03/01/2024

Fellow #zebrafish PIs: looking to get started with pIGLET and attending #SCZI2024? Rob Lalonde prepared pIGLET vector starter packs that @aburger2009.bsky.social and I will bring along! 🐽 Let me know if you're interested - looking forward to seeing everyone in Asilomar! 🐟

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Dan Grimes @dangrimes.bsky.social · 04/01/2024

12 asymmetric animals, day 11: Honey badger Honey badgers are found in Africa, Southwest Asia and India. The subspecies signata, also called the speckled ratel and found in Sierra Leone, has asymmetric teeth, with an extra lower molar on the left side of the jaw.

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Dan Grimes @dangrimes.bsky.social · 02/01/2024

12 asymmetric animals, day 10: P. microlepis This cichlid fish has an asymmetric mouth, twisted either to the left or right. Both left-sided and right-sided morphs live together in Lake Tanganyika.

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Dan Grimes @dangrimes.bsky.social · 01/01/2024

12 asymmetric animals, day 9: cockeyed squid This deep-sea squid has a small right eye which faces downwards, scanning for bioluminescence below. The left eye, around twice the size of the right, bulges out of the head with a prominent yellow lens to see ambient sunlight.

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Dan Grimes @dangrimes.bsky.social · 31/12/2023

12 asymmetric animals, day 8: Iwasaki's snail-eater This species of snake has asymmetric jaws, with more teeth on the right than the left. This helps the snake eat its major food source, snails with dextral (clockwise coiled) shells. For the snails, it's good to be sinister.

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Reposted by Dan Grimes

Mark Peifer (He, him) @peiferlabunc.bsky.social · 30/12/2023

The impact of ancient DNA on our understanding of both human origins and recent history is one of the most amazing stories of our time. As technology continues to advance, new approaches offer new insights. A recent paper provides a cool example. 1/n www.nature.com/articles/s41...

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Dan Grimes @dangrimes.bsky.social · 30/12/2023

12 asymmetric animals, day 7: sperm whale The right nostril of sperm whales is part of the "phonic lip" used to make the loudest sounds in the animal kingdom. While the left nostril is on top of the head (still offset to the left) and is used as a blowhole.

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Dan Grimes @dangrimes.bsky.social · 30/12/2023

Congratulations to Prof. Liz Robertson for being appointed CBE (Commander of the Order of the British Empire). Liz has made several significant contributions to mouse embryology and genetics including how to introduce mutations into the germline using engineered stem cells.

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Dan Grimes @dangrimes.bsky.social · 29/12/2023

12 asymmetric animals, day 6: barn owl Barn owls show ear asymmetry, with the left ear opening being located higher on the head than the right. This asymmetry contributes to the owls remarkable ability to localize sounds.

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Dan Grimes @dangrimes.bsky.social · 28/12/2023

12 asymmetric animals, day 5: fiddler crabs Male fiddler crabs have a large 'major' claw and a small 'minor' claw. The major claw is used for display signals and fighting. If a fiddler crab loses its major claw, it will grow a new one on the opposite side.

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Dan Grimes @dangrimes.bsky.social · 27/12/2023

12 asymmetric animals, day 4: flatfish Flatfish have both eyes on one side of their head. Eyes begin in the normal place, then one migrates around the skull to join the other Some species have all left-sided eyes, others all right-sided while some show left/right randomization.

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Dan Grimes @dangrimes.bsky.social · 26/12/2023

12 asymmetric animals, day 3: the wrybill. Another example from the world of birds, this New Zealand plover has an asymmetric beak which is bent sideways to the right. This is a directional asymmetry because all individuals of the species have a right-sided beak.

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Dan Grimes @dangrimes.bsky.social · 25/12/2023

12 asymmetric animals, day 2: red crossbill. Red crossbills have asymmetric beaks in which the upper and lower mandibles cross each other such that the lower mandible sits to the left or right of the upper. The direction is random and so is referred to as an anti-symmetry.

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Dan Grimes @dangrimes.bsky.social · 24/12/2023

12 asymmetric animals, day 1: the narwhal. Narwhals of the polar oceans have a large tusk. But it is not centrally located on their head; it grows from the left side. It is a modified upper left tooth that erupts through the lip and extends several feet. A curious canine!

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Reposted by Dan Grimes

Joel Boerckel @jboerckel.bsky.social · 22/12/2023

Woohoo! Our latest paper, from PhD student Joseph Collins is out today in Developmental Cell! YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development. cell.com/developmental-…

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Reposted by Dan Grimes

Moe Mahjoub @mahjoublab.bsky.social · 18/12/2023

🚨🚨 Cool conference alert! Mark your calendars and start booking your flights to beautiful Dublin for the 6th European #Cilia2024 meeting. Check out the amazing program, with much more to come: cilia2024.ie I also hear they’ve got some decent beer over there…

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Reposted by Dan Grimes

Scott Wilcockson @wilcocksonscott.bsky.social · 04/12/2023

First post, first Postdoc paper, first 🦓🐟 paper, first journal cover! 🥳 🎶On the fourth day of Christmas, Dev Cell gave to me: An improved Erk biosensor that detects oscillatory Erk dynamics driven by mitotic erasure during early development🎶 www.cell.com/developmenta...

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Reposted by Dan Grimes

Society for Developmental Biology @socdevbio.bsky.social · 15/12/2023

Mark your calendars: SDB 83rd Annual Meeting: July 14-17, 2024, Atlanta, GA. www.sdbonline.org/2024mtg

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Reposted by Dan Grimes

The Lenhart Lab @lenhartlab.com · 16/12/2023

First preprint from the lab! Do you care about environmental effects on reproduction? Cytokinesis? Maybe stem cells? We’ve got something for everyone! pubmed.ncbi.nlm.nih.gov/37905121/

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Reposted by Dan Grimes

Alex Eve @amjeve.uk · 12/12/2023

Development has announced the next call for applications for the 'Pathway to Independence' programme - aimed at supporting postdocs going on the job market. Application deadline 31 January 2024. Full details can be found at journals.biologists.com/dev/pages/pi...

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