On-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.

On-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.

Adenine base editors (ABEs) are CRISPR effectors that introduce A-T to G-C transitions in the genome using a nucleotide deaminase fused to a Cas protein. ABEs have been evolved to have very high editi...

Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.

Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.

TnpB endonucleases are engineered for improved genome editing.

TnpB is a diverse family of RNA-guided endonucleases associated with prokaryotic transposons. Due to their small size and putative evolutionary relationship to CRISPR-Cas12, TnpB enzymes hold signific...

Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.

TnpB is an evolutionarily diverse family of RNA-guided endonucleases associated with prokaryotic transposons. Due to their small size and putative evolutionary relationship to Cas12s, TnpB holds signi...

Insights from a high-throughput screening assay of rubisco variants could be used to engineer improved versions of this key enzyme.