iiinova — where your digital self keeps evolving

Reposted by Rachel F. Weissman

Connor Horton @connorhorton.bsky.social · 11/08/2026

I'm excited to share our work providing the first complete mechanistic picture of how R2 proteins nick the second strand, out today in @pnas.org! ✂️🧬 This step in retrotransposition has long been mysterious, but crucial for understanding R2's. Check it out: www.pnas.org/doi/10.1073/... A thread 🧵:

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Reposted by Rachel F. Weissman

Zehan Zhou @zehanzhou.bsky.social · 05/08/2026

We are PUBLISHED!!! Our mechanistic work on how CRISPR-Cas ancestors unwind DNA and how this can be used to engineer hypercompact plant editors can now be found on Mol Cell- if you are interested in what defines a good genome editor, this read is for you 😎 🔗 www.sciencedirect.com/science/arti...

sciencedirect.com

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Reposted by Rachel F. Weissman

Savage Lab @savagecatsonly.bsky.social · 22/12/2025

New from Ugrappa Nagalakshmi and Jorge Rodriguez 🌱✂️– Gene editing in plants just got a lot easier! Using engineered TnpB, they demonstrate high-efficiency, heritable, transgene-free editing in plants. (1/7)

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Reposted by Rachel F. Weissman

Savage Lab @savagecatsonly.bsky.social · 05/08/2025

Congrats to our savage lab undergrads on their research and presentations in our inaugural undergrad research symposium 🎉🥳

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Reposted by Rachel F. Weissman

Savage Lab @savagecatsonly.bsky.social · 01/06/2025

We love generating data! But what should we do with it? We collaborated w/ the Listgarten lab on ProteinGuide - a new method for using experimental data to guide protein generative models. Congrats to @junhaobearxiong.bsky.social, @hnisonoff.bsky.social, @marialukarska.bsky.social, Ishan, & Luke! ⬇️

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Reposted by Rachel F. Weissman

Savage Lab @savagecatsonly.bsky.social · 26/02/2025

What's better than 1 deep mutational scanning (DMS) library? 2! In a new pre-print @brittneywthornton.bsky.social and @rfw.bsky.social et al. map the mutational landscape of ISDra2 TnpB protein and reRNA and leverage these datasets to engineer highly active variants (1/9)

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Reposted by Rachel F. Weissman

Savage Lab @savagecatsonly.bsky.social · 24/01/2025

What limits rubisco function? Is it the chemical mechanism? Evolution? In this paper, @prywes.bsky.social et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7) doi.org/10.1038/s415...

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Reposted by Rachel F. Weissman

Innovative Genomics Institute @innovativegenomics.bsky.social · 22/01/2025

New research from IGI Investigator Dave Savage and first author Noam Prywes details the landscape of possible Rubisco variants, suggesting ways to make the world's most abundant enzyme better at its job. 🌱 Read more: ow.ly/t2JO50ULh10

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