Savage Lab @savagecatsonly.bsky.social · 22/12/2025New from Ugrappa Nagalakshmi and Jorge Rodriguez 🌱✂️– Gene editing in plants just got a lot easier! Using engineered TnpB, they demonstrate high-efficiency, heritable, transgene-free editing in plants. (1/7) 1116 11
Savage Lab @savagecatsonly.bsky.social · 22/12/2025Efficient delivery of genome editing reagents to plants remains a major challenge. Although viral vectors offer a promising solution, their limited cargo capacity has constrained their impact. (2/7) 100 1
Savage Lab @savagecatsonly.bsky.social · 22/12/2025In a new preprint, Nagalakshmi and Rodriguez demonstrate that an engineered, compact RNA-guided nuclease, eTnpBc (TnpB-KYLI), can be efficiently delivered via tobacco rattle virus (TRV) to achieve heritable editing efficiencies of up to 90% in Nicotiana benthamiana. (3/7) 100 1
