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Steve Jacobsen

@jacobsenucla.bsky.social

461 followers 301 following 1 posts

UCLA Professor and HHMI Investigator interested in plant epigenetics and plant genome editing.

Steve Jacobsen @jacobsenucla.bsky.social · 01/05/2025

Our paper is just out www.nature.com/articles/s41... from the Jacobsen, Doudna, and Banfield labs on viral delivery of a tiny CRISPR system for transgene free germline editing in plants, tinyurl.com/3k223r3x. Looking for postdocs to join the team for the next phase of this work!

nature.com

Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis - Nature Plants

Weiss et al. engineered the tobacco rattle virus to express the RNA-guided TnpB enzyme ISYmu1 and guide RNA for transgene-free germline editing in Arabidopsis thaliana.

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Reposted by Steve Jacobsen

Innovative Genomics Institute @innovativegenomics.bsky.social · 24/04/2025

In a new paper, IGI's Jennifer Doudna @doudna-lab.bsky.social and Jill Banfield @banfieldlab.bsky.social collaborate with UCLA's @jacobsenucla.bsky.social to create a new, tiny #CRISPR tool for quicker, easier plant genome editing! Read more: ow.ly/6Szs50VGElf

A photo of a mix of green and white Arabidopsis thaliana seedlings. They turn white when a particular gene is knocked out. Here, a tiny CRISPR system was used to modify the mother plant’s DNA, which the white seedlings inherited.

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Reposted by Steve Jacobsen

Etienne Bucher 🌾🧬🇪🇺 @plantepigenetics.ch · 14/03/2025

Hi plant epigenetics fans! I have updated the Plant Epigenetics Starter Pack to include additional researchers in the field: @jacobsenucla.bsky.social @pecinka-grp.bsky.social @manavellalab.bsky.social Please let me know if you wish to be added to the Starter Pack! go.bsky.app/HyTwdc2

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Reposted by Steve Jacobsen

Jake Harris @c-jake-harris.bsky.social · 24/02/2025

Back-to-back manuscripts from the Jacobsen and Law labs revealing TFs that direct RdDM! Genetics controlling epigenetics. Reminiscent of KRAB ZFs... shorturl.at/TE4PH shorturl.at/QEHDU

shorturl.at

Transcription factors instruct DNA methylation patterns in plant reproductive tissues

DNA methylation is maintained by forming self-reinforcing connections with other repressive chromatin modifications, resulting in stably silenced genes and transposons. However, these mechanisms fail ...

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