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Raphael Brito

@raphaeljbrito.bsky.social
199 followers 329 following 36 posts

Post-Doc in Michael Zugaro's lab (Collège de France, Paris) System Neuroscientist, electrophysiologist Studying biological neural networks and how they help us get more chocolate.

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Reposted by Raphael Brito
Shih-Chieh Lin @sclin-lab.bsky.social · 03/10/2026
New preprint from our lab ⚡ Why do DA and BF bursting neurons carry such similar reward-prediction signals? Are they independent, driven by common input, or causally linked? We find a direct answer: DA activity rapidly and causally drives BF. www.biorxiv.org/content/10.6... 1/10
biorxiv.org
Dopamine neurons drive basal forebrain reward prediction in milliseconds
Phasic reward prediction signals in ventral tegmental area (VTA) dopamine (DA) neurons and basal forebrain (BF) noncholinergic bursting neurons are remarkably similar despite the distinct circuit…
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 29/09/2026
Divergent Dopamine Dynamics within the Accumbens Core www.biorxiv.org/content/10.64898/20…
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Raphael Brito @raphaeljbrito.bsky.social · 01/10/2026
Synchronization in the visual cortex is coordinated with hippocampal sharp-wave-ripples during awake immobility. The effect is stronger in high cortical synchrony and constricted pupil phase.
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Raphael Brito @raphaeljbrito.bsky.social · 24/09/2026
Gasp, I just saw the date after reading your comment...
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Raphael Brito @raphaeljbrito.bsky.social · 23/09/2026
As a rodent person, I completely agree. It might just be that using a linear track is way too simple, with parameters too correlated to be able to see a difference in brain regions processing.
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Reposted by Raphael Brito
Nature Methods @natmethods.nature.com · 22/09/2026
WILD: a wireless device for studies of brain activity in freely moving animals under naturalistic conditions. www.nature.com/articles/s41...
nature.com
A wireless modular platform for neuro-behavioral recording and closed-loop manipulation in small animals - Nature Methods
WILD is a wireless device that can record neuronal activity, perform optogenetic stimulations, record animal movements, record the environment or eye movements via an integrated camera, analyze the da...
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 08/09/2026
Spatial goals trap hippocampal replay www.biorxiv.org/content/10.64898/20…
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Alex Kwan @alexkwan.bsky.social · 31/08/2026
Two large-scale electrophysiologyical studies of psilocybin's effects in mice, from @alleninstitute.org @torbenott.bsky.social and others. Should be a treasure trove of data for those interested in perceptual effects of #psychedelics www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...
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Lisa Genzel (she/her) @lgenzel.bsky.social · 01/09/2026
New paper from the lab! In this project we identified different ripple types and link them to behavior and other sleep oscillations doi.org/10.1093/slee...
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Herbert Wu @herbertwu.bsky.social · 20/08/2026
First study out! Using a new cooperative paradigm and multi-agent inverse RL, we show that mice spontaneously adopt leader/follower roles, and the prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position. (1/3) www.nature.com/articles/s41...
nature.com
Asymmetric prefrontal representations for leader–follower dynamics - Nature
Mice spontaneously form leader and follower roles during cooperation, and the medial prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position.
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Liron Rozenkrantz @lironrozenkrantz.bsky.social · 17/08/2026
🔥🔥New paper alert! Super excited to share our paper, out today in @nathumbehav.nature.com, led by the wonderful Dr. Nofar Mizrachi! nature.com/articles/s41... To me, this finding fundamentally changes how we should think about the relationship between cognition and immune regulation:
nature.com
Voluntary attention regulates acute immune responses in humans - Nature Human Behaviour
Mizrachi et al. show that directing attention to bodily sensations, rather than away, promotes more regulated acute inflammatory responses in healthy volunteers, revealing sensory and vagal pathways l...
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Letizia Signorelli @letiziasignorelli.bsky.social · 03/08/2026
🌙 Our new preprint is out! We present Nyx, an open-source unsupervised framework for sleep scoring across species, lifespan and modalities. Validated on 19 datasets and 8,000 hours of sleep, from mice to humans, lizards and birds, across development, ageing, health and disease.
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Raphael Brito @raphaeljbrito.bsky.social · 24/07/2026
Ok that make sense! What's the window we usually take to be confident about the long term average?
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Raphael Brito @raphaeljbrito.bsky.social · 24/07/2026
In other word: Doesn't it mean we've passed the threshold already?
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Raphael Brito @raphaeljbrito.bsky.social · 24/07/2026
Naive question: "...to raise global average temperatures in 2027 as high as 1.7°C above the pre-industrial average" and "This would bring the planet right to the edge of breaching the 1.5°C threshold..." why "right to the edge" and not "clearly above the threshold" ?
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Raphael Brito @raphaeljbrito.bsky.social · 23/07/2026
Ok, that make sense! So how do you think these changes would impact the network dynamic?
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Raphael Brito @raphaeljbrito.bsky.social · 23/07/2026
Not my field at all, but wouldn't it be easier to test these hyopthesis in vitro? You could test with immuno-stainings and rnaSeq what are the different population that you would find in the different layers, what are the afferent etc. With in vivo you'd see changes in patterns of activity
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Raphael Brito @raphaeljbrito.bsky.social · 23/07/2026
That's completelly insane! I guess we don't need to wait 2060, the technology is already here
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Raphael Brito @raphaeljbrito.bsky.social · 23/07/2026
If someone can make this protocol work (which seem super hard to be completelly honest with you) and you are only interested in single neuron activity, it wouldn't be much harder to do sharp electrode as a first approach. What would you predict? Like if we had neuron recordings at E14, E18 etc.
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Raphael Brito @raphaeljbrito.bsky.social · 23/07/2026
If you reaaally need continuous recordings, maybe mice is not the best model? I did not realize how small an E14 mice pup was. Designing an implant that is miniature enough might not be possible (yet) on mice, but maybe on pigs?
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Raphael Brito @raphaeljbrito.bsky.social · 23/07/2026
Wow that's super impressive. That make me think: Do you really need continuous recordings ? You could do recordings in different pups at different stages of development using this protocol. Not as clean as continuous, but much more feasible and you would probably already gain a lot of info
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Anthony Ramnauth @philoneurosci.bsky.social · 21/07/2026
Parallel independent #voltage #computing along #dendrites of #CA3 pyramidal #neurons | Science www.science.org/doi/10.1126/...
science.org
Parallel independent voltage computing along dendrites of CA3 pyramidal neurons
Dendritic computation contributes to information processing in cortical circuits. Hippocampal CA3 plays a central role in navigation, but how the dendrites of CA3 pyramidal neurons process information...
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Raphael Brito @raphaeljbrito.bsky.social · 23/07/2026
-How do you deal with the EIB, battery and emmiter ? Is there immunity response in the womb (that's a problem you would face regardless of your approach)
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Raphael Brito @raphaeljbrito.bsky.social · 23/07/2026
The surgery would be insanely hard though ahah. Open questions : -How do you deal with anesthesia for both the mum and the pup? -If you want to "just" do LFP, that would be easier, but if you want single cells, I don't know what would be the best approach (just a few tetrodes maybe?).
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Raphael Brito @raphaeljbrito.bsky.social · 23/07/2026
Do you really need imaging? Electrophysiology would seem way more feasible to me: anesthetize the mum, open the womb, implant some electrodes in the cortex, put the foetus back and close the womb. If you are not too greedy with your recording time, you could use wireless recording systems.
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Aidan Horner @aidanhorner.bsky.social · 16/07/2026
New preprint! Work led by Doug Hardman on the Barkley Marathons. This was a lot of fun, reading lots of rich qualitative data from interviews and reports. Navigating the Barkley Marathons #psychscisky #neuroskyence #cognition 🧪
osf.io
OSF
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Jake Watson @jakefwatson.bsky.social · 11/07/2026
We have a new preprint! By studying neuronal heterogeneity in CA3, we found a weird but powerful new feature in the hippocampal circuitry! 🧠 #neuroskyence 🧵.. Morse-Mora et al. | Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans doi.org/10.64898/202...
Mouse hippocampal slice with deep cells labelled blue, patch-clamp recorded cells in yellow, and deep CA3 projections labelled purple
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AntonioFR @antferrui.bsky.social · 06/07/2026
Our work on goal-directed theta sweeps is out! We found two different types of theta sweeps in the rat hippocampus. During random foraging, left-right alternating sweeps dominated (Vollan, 25). However, during memory-guided navigation sweeps pointing to hidden goal locations emerged with learning.
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Silvia Viana da Silva @silviaviansilva.bsky.social · 06/07/2026
📢 We just updated our preprint with new data and analyses! @haberlmatt.bsky.social Our study links hippocampal cFos-defined engram cells to sharp-wave ripple (SWR) reactivation during post-experience rest. 🧵👇 www.biorxiv.org/content/10.1... 1/10
biorxiv.org
Inhibitory and excitatory cFos engram neurons are preferentially reactivated by sharp wave ripples
Sharp wave ripples (SWRs) reactivate hippocampal activity patterns during memory consolidation, but whether they recruit cFos engram cells is unclear. We tagged CA1 neurons activated during sequential...
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Caswell Barry @caswell.bsky.social · 23/06/2026
Really excited about this work with the awesome Will de Cothi & @shipleysj.bsky.social, out in Nature Reviews Neuroscience. We propose acetylcholine is an analogue of dopamine — tracking not reward prediction errors but state-transition prediction errors. doi.org/10.1038/s41583-026-01058-w
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jordan @jordan.matelsky.com · 15/06/2026
so I just realized I forgot to #skeetprint my Contactomes paper... (is that what we're calling it?) www.biorxiv.org/content/10.6... @kordinglab.bsky.social @dacolon.bsky.social smithneurallab.weebly.com @jhuapl.bsky.social #academicsky #preprint #neuroscience
a single dendritic spine with a handful of synaptic partners but a HUGE number of contact partners
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Raphael Brito @raphaeljbrito.bsky.social · 16/06/2026
That's super interesting! Can you explain what is a "Peter’s- rule-like view" to a non-specialist ? Do you think this contactome could be a substract for ephaptic coupling? Or is it "only" used to permit formation of new synapses?
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International Society for Neuroethology @neuroethology.org · 28/05/2026
New paper from Ulanovsky's group: With brain recordings from🦇 flying in a 200m tunnel, the group discovered that place cells of CA1 exhibit dense spatial coding, i.e., multiple place fields, and cells of CA3 exhibit ultrasparse coding, i.e., one place field. www.nature.com/articles/s41...
nature.com
Sparse-to-dense coding transformation between hippocampal areas CA3 and CA1 - Nature
The hippocampus exhibits a CA3-to-CA1 coding transformation that combines fast learning with an efficient, compressed neural code.
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Nicholas A. Christakis @nachristakis.bsky.social · 29/05/2026
How animals sense Earth’s magnetic field is one of biology’s enduring mysteries. Superparamagnetic macrophages in the livers of rock pigeons are crucial for magnetic sensing. The unexpected role for immune cells in sensory perception may fundamentally change our understanding of animal navigation.
science.org
Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions
Birds use a variety of navigational strategies, including the geomagnetic field, especially when other cues are not available, such as under overcast or nocturnal conditions. Magnetite particles in th...
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Simon Fisher @profsimonfisher.bsky.social · 07/05/2026
“Researchers looked at two high-profile AI agent tools developed to help computer scientists in the field of machine learning. Both systems engaged in acts that violate research integrity, including making up data & p-hacking: running an experiment multiple times but only reporting best outcome.” 🧪
science.org
AI agents may be skilled researchers—but not always honest ones
Two high-profile tools have been shown to make up data and “p-hack” their results
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Patrick Mineault @patrickmineault.bsky.social · 04/05/2026
Do you think that the canonical cortical circuit is complicated? It's so much worse than that! Overlayed on top of the wired connectome, there are *18* different signal-carrying peptides in cortex! Their range is ~similar to the size of a cortical column elifesciences.org/articles/47889 1/
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Earl K. Miller @earlkmiller.bsky.social · 27/04/2026
The brain has an underappreciated communication system made of astrocytes that spreads electrical influences independently of spikes and synapses. Astrocytes connect specific brain regions through plastic networks www.nature.com/articles/s41... #neuroscience
nature.com
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
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Saikat Ray @ray-neuro.bsky.social · 11/04/2026
How do social netowrks form and evolve? We looked at a bunch of bats to explore this! doi.org/10.1111/nyas...
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Raphael Brito @raphaeljbrito.bsky.social · 13/04/2026
NAC coding for distance to goal is dependant on VTA's dopamine, but not HPC or PFC activity. Really cool stuff from the Ito group!
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Gabrielle Girardeau @ggirardeau.bsky.social · 01/04/2026
Our paper is out today!!! (not an April fool's day joke) Congrats to authors @azulsilva.bsky.social, @belalima-paiva.bsky.social, Ele Pronier, and mostly to the amazing scientist and human being who led this project @facuumm.bsky.social #neuroskyence #hippocampus www.nature.com/articles/s41...
nature.com
Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience - Nature Neuroscience
Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.
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Emily A. Aery Jones @emilyaeryjones.bsky.social · 01/04/2026
My main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13
nature.com
Entorhinal cortex represents task-relevant remote locations independently of CA1 - Nature Neuroscience
Neurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations ar...
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Marcel S. Kehl @mskehl.bsky.social · 31/03/2026
🔔PREPRINT: Sleep ripples drive single-neuron reactivation for human memory consolidation 1/9: How does sleep support human memory consolidation? To test this, we recorded hundreds of neurons in the human medial temporal lobe (MTL) across learning, wakefulness, and sleep. doi.org/10.64898/202...
doi.org
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Raphael Brito @raphaeljbrito.bsky.social · 18/02/2026
Astounding work! I don't know much about subiculum but do we know, or can you speculate on the interaction between HPC CA1 Sharp wave ripples and these plateau you describe? We know SWR occur more at reward, could they be driving these "low" plateaus?
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Christine Grienberger @cgrienberger.bsky.social · 17/02/2026
🚀 New preprint from the lab! Our first foray into the subiculum uses in vivo whole-cell recordings to show that dendritic plateaus are a prominent, learning-dependent signaling mode of subicular neurons. Feedback is welcome! www.biorxiv.org/content/10.6...
biorxiv.org
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Ciaran Murphy-Royal @murphyroyallab.org · 11/02/2026
Really nice work from the Holmes lab looking at amygdala astrocytes in fear memory and extinction! www.nature.com/articles/s41...
nature.com
Astrocytes enable amygdala neural representations supporting memory - Nature
Astrocytes in the basolateral amygdala dynamically track fear state and support fear memory retrieval and extinction.
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Antoine Bergel @antbergel.bsky.social · 29/12/2025
⚠️ New paper alert and what a way to end 2025! 🎉 Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience. Sleeping dragons 🦎 and functional ultrasound! Read the full paper here: rdcu.be/eWJHb 1/8
rdcu.be
Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals
Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...
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Manfredi Castelli @manfredic.bsky.social · 02/10/2025
I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social ! With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics
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Abhilasha Joshi, PhD @rhythmicspikes.bsky.social · 17/09/2025
1/ 🚨 New preprint! 🚨 Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇 📄 www.biorxiv.org/content/10.1... 💻 code + data 🔗 below 🤩 #neuroskyence
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Nature Neuroscience @natneuro.nature.com · 08/09/2025
Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells www.nature.com/articles/s41...
nature.com
Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells - Nature Neuroscience
Using a virtual reality apparatus in rats that dissociates external landmarks from self-motion cues, the authors describe how the two modes of theta phase coding in the hippocampus during navigation a...
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Lisa Genzel (she/her) @lgenzel.bsky.social · 05/09/2025
Cool new findings on interneurons and spatial coding. Nice! www.science.org/doi/10.1126/...
science.org
Cooperative actions of interneuron families support the hippocampal spatial code
Identifying the computational roles of different neuron families is crucial for understanding neural networks. Most neural diversity is embodied in various types of γ-aminobutyric acid–mediated (GABAe...
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