Animals must balance exploration with threat avoidance, yet how neuromodulatory signals shape information-seeking states remains unclear. Using fibre photometry recordings in the basolateral amygdala ...

The ARP2/3 complex works together with actomyosin in an oscillatory program at the soma to govern neuronal polarization.

Sharp wave ripples (SWRs) reactivate hippocampal activity patterns during memory consolidation, but whether they recruit cFos engram cells is unclear. We tagged CA1 neurons activated during sequential...

BackgroundWhile Alzheimer’s disease (AD) is well known for progressive memory impairment, less is understood about how amyloid pathology affects flexible upd...

NASA astronaut and Artemis II Commander Reid Wiseman took this picture of Earth from the Orion spacecraft's window after completing the translunar injection

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Nature Methods - A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even...

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A neuroscientist presents an intimate portrait of engram research

In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Sosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible popu...

Mesial temporal lobe epilepsy (MTLE) is a prevalent form of focal epilepsy characterized by seizures originating from the hippocampus and adjacent reg…

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...

Podcast Episode · What Now? with Trevor Noah · 03/27/2025 · 1h