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Shih-Chieh Lin

@sclin-lab.bsky.social
414 followers 453 following 43 posts

Neuroscience Professor @ National Yang Ming Chiao Tung University, Taiwan | NIH alum | neurophysiology | decision making | attention | reward | #BasalForebrain

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Shih-Chieh Lin @sclin-lab.bsky.social · 03/10/2026
New preprint from our lab ⚡ Why do DA and BF bursting neurons carry such similar reward-prediction signals? Are they independent, driven by common input, or causally linked? We find a direct answer: DA activity rapidly and causally drives BF. www.biorxiv.org/content/10.6... 1/10
biorxiv.org
Dopamine neurons drive basal forebrain reward prediction in milliseconds
Phasic reward prediction signals in ventral tegmental area (VTA) dopamine (DA) neurons and basal forebrain (BF) noncholinergic bursting neurons are remarkably similar despite the distinct circuit…
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Shih-Chieh Lin @sclin-lab.bsky.social · 20/02/2026
New lab paper in #ScienceAdvances: we identify a modality-common selective-attention signal in noncholinergic #BasalForebrain (BF) “bursting” neurons, distinct from the modality-specific attention signals typically described in corticothalamic circuits. 1/n www.science.org/doi/full/10....
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Malcolm Campbell @malcolmgcampbell.bsky.social · 19/09/2025
🚨Our preprint is online!🚨 www.biorxiv.org/content/10.1... How do #dopamine neurons perform the key calculations in reinforcement #learning? Read on to find out more! 🧵
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Zero-Noise Lab @zeronoiselab.bsky.social · 10/06/2025
Now out in @natcomms.nature.com‬: Mice and monkeys spontaneously shift through comparable cognitive states - and it's written all over their faces! (1/7) www.nature.com/articles/s41...
nature.com
Inferring internal states across mice and monkeys using facial features - Nature Communications
Here, the authors created a virtual reality task for monkeys and mice to explore if internal states like attention are similar across species. Their facial expressions during the task were similar, su...
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Paul Masset @paulmasset.bsky.social · 04/06/2025
Together with this paper by the group of Joe Paton www.nature.com/articles/s41... our results across the two papers complement each other providing strong evidence that distinct dopamine neurons discount future rewards at different rates providing a substrate for multi-timescale RL in the brain
nature.com
A multidimensional distributional map of future reward in dopamine neurons - Nature
An algorithm called time–magnitude reinforcement learning (TMRL) extends distributional reinforcement learning to take account of reward time and magnitude, and behavioural and neurophysiological...
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Paul Masset @paulmasset.bsky.social · 04/06/2025
Our work with Pablo Tano, @hyunggoo-kim.bsky.social Athar Malik, Alexandre Pouget and @naoshigeuchida.bsky.social exploring how dopamine neurons could enable multi-timescale reinforcement learning in the brain is out in @nature.com www.nature.com/articles/s41...
nature.com
Multi-timescale reinforcement learning in the brain - Nature
Individual dopaminergic neurons encode future rewards over distinct temporal horizons.
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Shih-Chieh Lin @sclin-lab.bsky.social · 23/05/2025
Great work from my next door neighbor!
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Ching-Lung Hsu @hiallen72.bsky.social · 22/05/2025
Big Congratulations Tsai-Wen! www.nature.com/articles/s41...
nature.com
Imaging neuronal voltage beyond the scattering limit - Nature Methods
ALI is an approach for analyzing voltage imaging data that is inspired by algorithms used in super-resolution microscopy. It allows resolving the activity of single neurons in densely labeled populati...
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Hugo Spiers @hugospiers.bsky.social · 15/05/2025
Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social www.nature.com/articles/s41...
nature.com
Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
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Marino Pagan @marinopagan.bsky.social · 21/03/2025
1/7 Our paper on individual variability in decision-making is finally out in @nature.com! Inspired by the classic work by Mante and Sussillo, we trained many rats to solve context-dependent decision-making, and we found that different brains use different neural mechanisms to solve the same task!
nature.com
Individual variability of neural computations underlying flexible decisions - Nature
Behavioural experiments to study decision-making in response to context-dependent accumulation of evidence provide testable models that are consistent with the heterogeneity in neural signatures among...
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Shih-Chieh Lin @sclin-lab.bsky.social · 11/04/2025
Congrats to @kepecslab.bsky.social !
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Jeremy Berg @jeremymberg.bsky.social · 16/02/2025
Some glimmers of hope (but mostly confusion) this morning. I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices. I am actively checking into this every way I can. 1/2
media.tenor.com
a picture of a pikachu with the words " i still have hope " written below it
ALT: a picture of a pikachu with the words " i still have hope " written below it
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Shih-Chieh Lin @sclin-lab.bsky.social · 16/02/2025
This is atrocious!
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John Tuthill @tuthill.bsky.social · 31/01/2025
Very interesting paper on a potential role for proprioceptors in sensing muscle acidosis and driving the perception of soreness. "Sng" is a Taiwanese word for both sour taste and muscle soreness. It also imitates the natural vocalization of humans feeling sore. www.science.org/doi/10.1126/...
science.org
A role for proprioceptors in sngception
Proprioceptors mediate acidosis sensation that contributes to acid-induced pain chronicity.
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David G. Clark @david-g-clark.bsky.social · 29/01/2025
(1/30) New preprint! "Symmetries and continuous attractors in disordered neural circuits" with Larry Abbott and Haim Sompolinsky bioRxiv: www.biorxiv.org/content/10.1...
biorxiv.org
Symmetries and Continuous Attractors in Disordered Neural Circuits
A major challenge in neuroscience is reconciling idealized theoretical models with complex, heterogeneous experimental data. We address this challenge through the lens of continuous-attractor networks...
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Blake Richards @tyrellturing.bsky.social · 03/01/2025
Two papers out showing that thalamic inputs determine how cortex responds to a hierarchical task with rule switching: www.nature.com/articles/s41... journals.plos.org/plosbiology/... 🧠📈 🧪
nature.com
Prefrontal transthalamic uncertainty processing drives flexible switching - Nature
By examining neural responses from tree shrews performing hierarchical decision tasks with rule reversals, the authors identify a thalamocortical mechanism for regulating cognitive flexibility.
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The Transmitter @thetransmitter.bsky.social · 18/12/2024
These essays offer the neuroscience community a place to explore the culture and practice of the field; to debate major questions; to examine the craft of neuroscience; and to trace its evolution over time. Download the book now: www.thetransmitter.org/transmitter-...
thetransmitter.org
The Transmitter books
The Transmitter’s first book, “Thinking about neuroscience: Essays from the field,” features a rich collection of writing from researchers Nicole Rust, Anthony Zador and many more.
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Clément Pouget @clementpouget.bsky.social · 13/12/2024
Our preprint of my PhD’s work in @gisellavetere.bsky.social lab is finally out on BiorXiv: doi.org/10.1101/2024..., and I’m so excited to share it! If you’ve ever wondered about reconciling engram manipulation experiments and neuronal activity during encoding, you’re on the right thread! 1/14
doi.org
Deconstruction of a memory engram reveals distinct ensembles recruited at learning
How are associative memories formed? Which cells represent a memory, and when are they engaged? By visualizing and tagging cells based on their calcium influx with unparalleled temporal precision, we ...
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Luke Sjulson @lukesjulson.bsky.social · 13/12/2024
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵
youtube.com
Neuroscience methods - YouTube
Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...
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Shih-Chieh Lin @sclin-lab.bsky.social · 11/12/2024
Really elegant work by @behrenstimb.bsky.social group. The idea of structured memory buffers provides a nice framework to understand 'goal-progress cells’ activity in the mPFC while mice learn a common task structure across many tasks. Not the easiest paper to read but really worthwhile!
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Moita Lab @moitalab.bsky.social · 02/12/2024
Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵
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Tony Zador @tonyzador.bsky.social · 28/11/2024
Thanks Kevin! And thanks to my collaborators @alexkoulakov.bsky.social Sergey Shuvaev and Divyansha Lachi ! (S & D -- have you joined the party here yet?)
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Christos Constantinidis @cconstan.bsky.social · 30/11/2024
Another huge influx of colleagues to BlueSky this week, so let me attach the fully updated Neurophysiology starter pack for anyone interested. go.bsky.app/9FY1ReG
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Neurodata.tokyo @neurodata.tokyo · 24/11/2024
OpenScholar: AI for scientific paper research - Finds papers & summarizes content for user queries - Trained on 45M+ Semantic Scholar papers - 8B parameters GitHub: github.com/AkariAsai/Op...
github.com
GitHub - AkariAsai/OpenScholar: This repository includes the official implementation of OpenScholar: Synthesizing Scientific Literature with Retrieval-augmented LMs.
This repository includes the official implementation of OpenScholar: Synthesizing Scientific Literature with Retrieval-augmented LMs. - GitHub - AkariAsai/OpenScholar: This repository includes the...
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Shih-Chieh Lin @sclin-lab.bsky.social · 24/11/2024
Just immigrated to Bsky. Really like the atmosphere and discussions here and reminded me of why I loved science twitter. Starter packs are very helpful and there are tools to convert starter packs into lists like this one: nws-bot.us/bskyStarterP...
nws-bot.us
Convert BSky Starter Pack to List
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Earl K. Miller @earlkmiller.bsky.social · 23/11/2024
Huge influx of neuroscientists migrates to Bluesky www.thetransmitter.org/community/hu... #Neuroscience
thetransmitter.org
‘Huge influx’ of neuroscientists migrates to Bluesky
Daily neuroscience-related posts on the social-media platform this week have increased more than 400 percent, on average, compared with October.
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Laura Grima @lauragrima.bsky.social · 10/11/2024
Just put together the beginnings of a systems & behavior neuro starter pack (focus on rodent work) - obviously a lot of people missing, and most included are in my own little bubble, so if you want to be added do reply here! go.bsky.app/Hxpe53o
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Guido Meijer @guidomeijer.com · 11/11/2024
I made a systems neuroscience starter pack, focused on experimentalists who study the brain at the level of populations of neurons! Also want to be on the list? Reply or DM me a picture of your ephys rig or 2p setup and I'll add you 🤭 go.bsky.app/UiqX7ry
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Shih-Chieh Lin @sclin-lab.bsky.social · 20/11/2024
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