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Rachel Hutto

@rahutto.bsky.social
248 followers 231 following 16 posts

Associate professor + photoreceptor mitochondria and zebrafish enthusiast!

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Reposted by Rachel Hutto
Joy Jeongyoon Choi @joyjoychoi.bsky.social · 14/09/2026
Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells. www.biorxiv.org/content/10.6... 🧵1/8
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Nature @nature.com · 04/09/2026
Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome go.nature.com/4xIUyVW
go.nature.com
Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome
Nobel laureate persisted despite widespread derision and revolutionized structural biology by protecting fragile crystals.
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Embrace the Void @etvpod.bsky.social · 02/09/2026
“Ultimately, though, it is better to risk being ‘tricked’ into having an earnest reaction than to risk never having them at all.” My new piece for The Skeptic on the intrusive thought problem of “did AI write this?” And how to not let it destroy all sincere experiences.
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Zebrafish Rock! @zebrafishrock.bsky.social · 28/08/2026
We've strangely seen this before... 🤔 #zebrafish
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Rachel Hutto @rahutto.bsky.social · 26/08/2026
I can’t seem to find all the words to express my feelings today, only that Dolly was amazing and her cover of The Story is absolutely breathtaking. The benefits from this charity album went to War Child UK. youtu.be/zi_XPQ4tq40?...
youtu.be
Dolly Parton The Story (From Cover Stories: Brandi Carlile Celebrates The Story) (Audio)
YouTube video by DollyPartonVEVO
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Reposted by Rachel Hutto
Bri Barbu @bribarbu.bsky.social · 14/08/2026
This was a fun one! Very classic Newscripts. A friend and I have been texting each other pretty much every morning with our multiplet.app daily puzzle times for a couple months now so I am super curious how the #chemsky #chemchat community will find it!
multiplet.app
Multiplet — Daily NMR Spectrum Puzzle
A daily puzzle game inspired by chemistry and NMR spectroscopy. Build a structure whose spectrum matches today's target.
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Tyler @okty.bsky.social · 08/08/2026
What's wrong babe you've barely driven your Subaru Troutback
A Subaru Outback painted like a trout
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NeuroWoodworks @neurowoodworks.bsky.social · 09/08/2026
Mitochondrion on a block of walnut. I went all out on the sanding to make it super smooth on this one.
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Rachel Hutto @rahutto.bsky.social · 07/08/2026
“The world-class research mission and the undergraduate teaching mission have always been in tension. …The credentialing function was always only loosely connected to the educational one....In a post-AI world, these divergences are being rendered untenable.” www.persuasion.community/p/the-multiv...
persuasion.community
The University As We Know It Is Finished
That’s a good thing.
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Reposted by Rachel Hutto
Yasemin Sancak @yasesancak.bsky.social · 05/08/2026
Excited to share our new preprint! biorxiv.org/content/10.6... We know that mitochondria make contacts with organelles, but determining whether these contacts establish functionally distinct mitochondrial populations has been challenging.
biorxiv.org
A Modular Platform for Purification of Organelle-associated Mitochondria Reveals Functional Specialization at Organelle Contact Sites
Mitochondria perform diverse metabolic and signaling functions, yet how these activities are spatially organized within the mitochondrial network of cells remains poorly understood. Organelle contact ...
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Rachel Hutto @rahutto.bsky.social · 04/08/2026
Today is August 4th, 2026. (Re-reading this today sent me on a rabbit hole investigating the origins of a 9-minute snooze for alarms) short-stories.co/@raybradbury...
short-stories.co
There Will Come Soft Rains by Ray Bradbury
The voice-clock sang, breakfast was ejected, but no doors slammed. The garage chimed and lifted its door to reveal the waiting car. The house sat alone in a city of rubble and…
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Reposted by Rachel Hutto
MPI for Biological Intelligence @mpiforbi.bsky.social · 03/08/2026
#pictureofthemonth: The eye of a zebrafish larva. The cells inside the eye are important for detecting visual features in the environment and sending such information to the brain. More: www.bi.mpg.de/baier August – Calendar of @mpiforbi.bsky.social and @mpibiochem.bsky.social 📸 Man Yung Ng
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Zebrafish Rock! @zebrafishrock.bsky.social · 07/07/2026
#Zebrafish for the win! Congrats to Jack Nicholls and this beautiful image of lamination in the zebrafish retina 🐟 🧪 See the rest of the Top 10 here: thenode.biologists.com/results-of-t...
Immunohistochemistry of an 8-day post-fertilisation larval zebrafish retina stained with anti-ChAT in red (star burst amacrine cells), anti-PKCα in green (ON bipolar cells) and grey (photoreceptors), with a DAPI counterstain. The anti-PKCα signal was manually separated into the bipolar and photoreceptor cell regions and coloured in green and grey to highlight the boundary between the two layers. Imaged on a LSM800 confocal microscope.
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Reposted by Rachel Hutto
Nature Reviews Neuroscience @natrevneuro.nature.com · 27/07/2026
Brain mitochondria as key drivers of cognition and behaviour — a Review by Carmen Sandi, Mary Kay Lobo, Fiona Hollis, Yusuke Hirabayashi, Jaime de Juan-Sanz & Juan P. Bolaños #neuroscience #neuroskyence www.nature.com/articles/s41...
nature.com
Brain mitochondria as key drivers of cognition and behaviour - Nature Reviews Neuroscience
Neuronal and glial mitochondria support neuronal circuit function and plasticity through the supply of energetic substrates and the regulation of cellular physiology. Sandi and colleagues describe how...
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Margarita Parada-Kusz @margaritapk.bsky.social · 26/07/2026
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch www.science.org/doi/10.1126/...
science.org
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch
Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...
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Rachel Hutto @rahutto.bsky.social · 24/07/2026
A tragedy. This is an important read for any scientist. When there is incentive to make it work ($$ from parents is playing a role here, but also more abstract incentives like a desire to be first, etc), one can overlook or discount the signs that something is awry. www.science.org/content/arti...
science.org
Exclusive: Death of girl in Chinese gene-editing trial was never made public
Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals
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Reposted by Rachel Hutto
Phil Abitua @ohnolog.bsky.social · 30/06/2026
Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil
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Richard Sever @richardsever.bsky.social · 01/07/2026
"Despite years of failure...doubts about what I was doing with my life...years of lackluster results...my PhD research is not a complete waste" Max's story of how we got checkpoint inhibitors should inspire any PhD worried their work's going nowhere theimmunebeyond.substack.com/p/a-brief-hi...
theimmunebeyond.substack.com
A Brief History of Checkpoint Blockade
A major medical breakthrough, interrupted
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Matthew Cobb @matthewcobb.bsky.social · 01/07/2026
Amazing work, though for the moment these things/devices can’t synthesise new ribosomes, so they die/stop working after a few generations when the ones they have been given wear out. Read it and be amazed! And it’s non-patented!
nytimes.com
This Cell Feeds, Grows and Reproduces. And It’s Manmade.
From chemical building blocks, scientists have created synthetic cells that have most of the hallmarks of life.
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Leah McElrath @leahmcelrath.bsky.social · 27/06/2026
“How much is a magical world worth?” A beautiful thread about Cabo Verde, the Peace Corps, and the World Cup:
Jill Tucker
@jilltucker
X.com
If you ever doubt how magical this world is, one day you will decide to go to a World Cup watch party in Oakland that you found online to root for a country where you spent two years trying to coax English out of the mouths of Cape Verdean teenagers. 1/7
11:42 AM • 6/25/26 • 670K ViewsJill Tucker
@jilltucker
X.com
And at the watch party you will ask the organizer if he's from Cape Verde. He will say yes, from Praia. And you'll say oh! I lived there for two years. I was a teacher. And he will ask, "What's your name?" You will tell him and he will say,
"You were my teacher."
CABO VERDE
11:43 AM • 6/25/26 • 92K ViewsJill Tucker @jilltucker • 20h
And across 30+ years and 6,000 miles you will hug a now man who tried to find you and remembered the songs you taught him and his classmates and he will apologize for how badly behaved they all were. And you will laugh and try not to cry and gape in wonder at at this crazy world.

Jill Tucker
@jilltucker
X.com
You will remember how much you love the World Cup. And what the Peace Corps meant to you. What those students, 40 to a class with no glass on the windows, meant to you.
11:43 AM • 6/25/26 • 62K ViewsJill Tucker @jilltucker • 20h
Ivan, the grown man with a touch of grey in his beard, will tell you later he has struggled to describe what it meant to him to meet again - that he shared our photo with classmates.
And when he returns from watching the Cabo Verde game, we will try to find the words together.

Jill Tucker @jilltucker • 20h And then you read that the US
House of Representatives will vote a day before that game on an amendment to eliminate the Peace Corps, which costs 1/6 the price of the Tomahawk missiles the US used in the war on Iran.

Jill Tucker @jilltucker •20h And you wonder: How much is a magical world worth?
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TK (Takashi DY) Kozai @bioniclab.bsky.social · 26/06/2026
🔬 Your tax dollars once paid a physicist whose own colleagues told him he was wasting the university's money. In 1951, Charles Townes sat on a D.C. park bench and worked out, on the back of an envelope, how to force molecules to release coherent radiation. 🧵 1/5
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 26/06/2026
"I have enough money to do research," says Shu, laughing. Meanwhile HHS shut off the NIH grant that funded related work on gene therapy for deafness at Harvard Medical School, because “woke” or something like that Shu trained in the very same lab that HHS defunded
Getting results in Shanghai 

In China, it's a different story.

"I have enough money to do research," says Shu, laughing.

China is pouring huge resources into developing all sorts of biological research, including gene therapy, aiming to curb its reliance on the West and become an even bigger world superpower. This spring, the country pledged billions in additional science funding. Shu, who trained at Harvard Medical School and is working on solving the same problems as David Corey, has plenty of staff in his lab, all the supplies he needs and can just get more done. "My lab is growing bigger and bigger," he says. And it's far bigger than his lab when he was in Boston, training under Corey and his mentees.

For decades, the U.S. has brought the smartest people in the world — like Yilai Shu — to its shores. Many have stayed. Shu wanted to, but family and a scientific opportunity, with lots of funding, drew him back home. That decision was rewarded when his team had a successful trial on a single injection that can restore hearing.
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Rachel Hutto @rahutto.bsky.social · 26/06/2026
An interesting pedagogical approach to help students develop experimental troubleshooting skills: elifesciences.org/articles/100...
elifesciences.org
Point of View: Teaching troubleshooting skills to graduate students
Pipettes and Problem Solving is an initiative that teaches some of the skills needed to figure out why an experiment is producing unexpected results.
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Reposted by Rachel Hutto
Jeff VanderMeer @jeffvandermeer.bsky.social · 24/06/2026
hell yeah! got my lampreypalooza tshirt!
maroon with orange lettering tshirt saying Lampreypalooza with white lamprey mouth2026 Lampreypalooza, back of tshirt, listing band names changed into aquatuc puns, including Billie Frylish, Pearl Clam, Fleetwood Mackerel, the Wu-Tang Clam, Lenny Crabitz, Troutkast, etc.

Bonneville Dam June 24
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c0nc0rdance @c0nc0rdance.bsky.social · 14/06/2026
These jellyfish larvae: * . * . * . * . * * . * . * * . *
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Heidi B. Hammel @hbhammel.bsky.social · 05/06/2026
The Planetary Society created a fact sheet and action alert about the recent OMB proposal that would, among other things, insert politics into the proposal review process across science. More discussion here: www.planetary.org/articles/whe...
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Robert Kozol @cavefish.bsky.social · 04/06/2026
I am happy to announce that my penultimate post-doc paper (Erik Duboue lab/X) is finally out in Science Advances. This work stems from my first cavefish experiments, examining how dark-adapted cavefish larvae respond to changes in illumination. www.science.org/doi/10.1126/...
science.org
Evolution of a central dopamine circuit underlies adaptation of a light-evoked sensorimotor response in the blind cavefish
Evolution shifts dopamine neuron responses in cavefish, reversing how light drives their behavior.
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American Society for Cell Biology @ascbiology.bsky.social · 04/06/2026
Scientists: Your voice is needed. New federal regulations could reshape research funding, publishing, and collaboration. Comments close July 13. www.ascb.org/science-policy/propose…
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Dr. Lucky Tran @luckytran.com · 02/06/2026
Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)
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Thiago Carvalho @cyrilpedia.bsky.social · 31/05/2026
'If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research.' link.springer.com/article/10.1...
link.springer.com
The controls that got out of control - EMBO Reports
EMBO Reports - When experimental controls go wrong, it does not necessarily mean your experiment is flawed. It might well be the first sign of something unexpected.
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Will Ratcliff @wcratcliff.bsky.social · 13/05/2026
1/23 New preprint! Been thinking about the origin of cellular life. Specifically, how protocells (or *any* compartments) just aren't enough to support the evolution of increasingly complex cells. You gotta de-Darwinize the parts! The ribosome/genome do this. www.biorxiv.org/content/10.6...
biorxiv.org
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American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 12/05/2026
Teaching, for Fatahiya Kashif, began with a question: “Why are so many students afraid of biochemistry?” Determined to change that, she transformed her classroom with handmade interactive learning tools that helped students move from fear to curiosity. 🔬 www.asbmb.org/asbmb-today/... #STEMEducation
asbmb.org
When biochemistry stopped being scary
Professor challenges the idea that biochemistry must feel abstract by designing hands-on models and games that turn fear into curiosity, transforming classrooms across Pakistan into spaces for experim...
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Liz Neeley @lizneeley.bsky.social · 06/05/2026
“With access to real names, email addresses and even teacher-student messages, the next wave of phishing will not be generic. It will reference real courses and real conversations, which makes it far more likely to succeed.”
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Reiner @erlangen.bsky.social · 05/05/2026
The way the retina metabolizes glucose directly influences which genes are activated in photoreceptor cells, a finding that may help explain how metabolic changes in aging contribute to retinal conditions such as age-related macular degeneration www.nei.nih.gov/research-and...
nei.nih.gov
NIH research points to new therapeutic opportunities for retinal diseases | National Eye Institute
NEI scientists have found that the way the retina metabolizes glucose directly controls which genes get switched on and off in light-sensing photoreceptors.
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allen institute @alleninstitute.org · 01/05/2026
Happy Birthday to Santiago Ramón y Cajal - the "father of modern neuroscience."
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Richard Sever @richardsever.bsky.social · 30/04/2026
"These findings...raise the possibility that mitochondria can be reprogrammed to generate new organelles with specialized functions" www.biorxiv.org/content/10.6... www.nature.com/articles/d41...
nature.com
Mitochondria can spawn new ‘organelles’ — hinting at how modern cells evolved
Discovery bolsters theory that ancient mitochondria formed brand-new, specialized ‘sacs’ in cells by shedding their outer membranes.
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Rachel Hutto @rahutto.bsky.social · 16/04/2026
www.nature.com/articles/d41...
nature.com
Female mice grow testes after this single DNA tweak
Small changes in the non-coding part of the genome have a key role in sex determination.
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Matthew R Francis (backup account) @matthewrfrancis.bsky.social · 08/04/2026
My latest story is up! The components required for DNA and RNA are all present on asteroid Ryugu, which lends strong support to the hypothesis that the raw ingredients for life were present before the Sun even formed. A very fun and fascinating tale!
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Juan C. Landoni @jclandoni.bsky.social · 03/04/2026
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
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Michalis Averof @michalis-averof.bsky.social · 04/02/2026
Just discovered the wonderful covers of 'Genes to Cells', the journal of the Molecular Biology Society of Japan @mbsj-official.bsky.social – absolutely beautiful! here some examples inspired by mitosis, CRISPR, the DNA helix, and plant pigments
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Vivek Mutalik @vivekmutalik.bsky.social · 03/04/2026
www.biorxiv.org/content/10.6... There is so much to explore in this data that one can spend life time going through. To make it easier to go through the data, @miloj.bsky.social put together this beautiful “Phage Datasheet”🤩 iseq.lbl.gov/PhageDataShe...
iseq.lbl.gov
Phage Foundry Data Browser
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Richard Sever @richardsever.bsky.social · 05/04/2026
“first drafts of Results, Discussion, and Introduction should be the trainee’s own work. AI can help with grammar…tightening prose…critiquing the logic of an argument you’ve already made. But the hard part of forming the argument needs to be yours.’ blekhman.substack.com/p/you-need-t...
blekhman.substack.com
You need to make AI guidelines for your lab
Here's why you should, and how to start
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samuel mehr @mehr.nz · 19/03/2026
out now in Science: @loganjames.bsky.social collected pairs of sounds in 16 species where we *know* which sound is more attractive (to that species) he played them to ppl on themusiclab.org, asking, in each pair, which was nicer. humans agreed w other animals doi.org/10.1126/science.aea1202
cOMPaRatiVe cOGNitiONHumans share acousticpreferences with other animalsLogan S. James1,2,3,4* Sarah C. Woolley 1,2, Jon T. Sakata1,2,Courtney B. Hilton5,6, Michael J. Ryan3,4, Samuel A. Mehr5,7,8Many animals produce courtship sounds, and receivers prefersome sounds over others. Shared ancestry and convergentevolution may generate similarities in preference across speciesand underlie Darwin’s conjecture that some animals “havenearly the same taste for the beautiful as we have.” In this study,we show that humans share acoustic preferences with a rangeof animals, that the strength of human preferences correlateswith that in other animals, and that humans respond fasterwhen in agreement with animals. Furthermore, we foundgreatest agreement in preference for adorned, ancestral, andlower-frequency sounds. humans’ music listening experiencewas associated with preferences. These results are consistentwith theories arguing that biases in processing sculpt acousticpreferences, and they confirm Darwin’s century-old hunchabout the conservation of aesthetics in nature
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Oded Rechavi @odedrechavi.bsky.social · 13/03/2026
A new mechanism for “RNA memory”! This time in Planaria! (Here's a video of a Planarian with mulitple heads, one of the heritable phenotypes we studied). This work summarizes >10 years of research and is an amazing collaboration with the labs of Jochen Rink and Omri Wurtzel labs. Read thrad below👇
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Thibaut Brunet @thibautbrunet.bsky.social · 28/02/2026
Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)
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Hayden Center @haydencenter.bsky.social · 20/02/2026
Silence your phone, put the dogs out and the kids down for a nap. Then curl up and read this article/-it’s a long one, but very good. www.theguardian.com/world/ng-int...
theguardian.com
A war foretold: how the CIA and MI6 got hold of Putin’s Ukraine plans and why nobody believed them
Drawing on more than 100 interviews with senior intelligence officials and other insiders in multiple countries, this exclusive account details how the US and Britain uncovered Vladimir Putin’s plans ...
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Aubry K. Miller @aubrykmiller.bsky.social · 16/02/2026
Strikingly, we found that some well-known clinically investigated PROTACs are potent complex I inhibitors. In a case study, we demonstrate that the strategic introduction of “kinks” or steric “bumps” into a PROTAC scaffold can abolish complex I inhibition while preserving degrader potency. (2/4)
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Jaime de Juan-Sanz @jdejuan-sanz.bsky.social · 11/02/2026
Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!
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Zebrafish Rock! @zebrafishrock.bsky.social · 01/02/2026
Dynamic actin waves in a zebrafish embryo. Credit to @aaandmoore.bsky.social & Dvir Gur. #ZebrafishZunday 🧪
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