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Bri Barbu

@bribarbu.bsky.social
1.4K followers 1.4K following 1.2K posts

science reporter @ Chemical & Engineering News | please talk to me about carbon-based molecules | she/her | views mine | @bribarbu.95 on signal

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Bri Barbu @bribarbu.bsky.social · 52m
Of the 20 recipients of this year's MacArthur "genius grants", two —@songlin1.bsky.social at Stanford and Liangfang Zhang at UCSD—have ties to chemistry! Both creatively merge science and tech with implications for building better medicines: Read more @cenmag.bsky.social: cen.acs.org/people/award...
cen.acs.org
Organic chemist and nanoscientist named 2026 MacArthur Fellows
Song Lin and Liangfang Zhang are awarded $800,000 ‘genius grants’
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Bri Barbu @bribarbu.bsky.social · 25/09/2026
Can I use my work card to buy a skeleton outfit for the Phoebe Bridgers concert next week if I then use it to make a video about skeletal editing? (For legal reasons this is a joke! I use work funds responsibly!)
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Bri Barbu @bribarbu.bsky.social · 25/09/2026
2 Atoms, 2 Swapped: the sequel! Now playing in a Science journal near you!
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Bri Barbu @bribarbu.bsky.social · 25/09/2026
Phosphate has stepped into a new role as an autonomous molecular machine! Researchers took cues from biomolecules such as DNA, RNA, and ATP to design this clever lil molecular walker. Read more @cenmag.bsky.social: cen.acs.org/materials/mo...
cen.acs.org
One small step for phosphate, one giant leap for molecular machine-kind
The first chemically fueled small-molecule walker dances around a sugar molecule without falling off
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Bri Barbu @bribarbu.bsky.social · 22/09/2026
TIL that the totality of dark matter on Earth is about the same mass as a squirrel! This illuminating fact and more can be found in @ananyapalivela.bsky.social's superb new feature on the role of chemistry in dark matter detection! cen.acs.org/materials/da...
cen.acs.org
Searching for dark matter with the purest materials on Earth
Using bubbles, crystals, prehistoric rocks, and more, scientists look for signals from the invisible part of the universe
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Bri Barbu @bribarbu.bsky.social · 18/09/2026
Adrian Figg was a delight to profile for T12 and his opinions on ice cream are 100% correct.
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Bri Barbu @bribarbu.bsky.social · 17/09/2026
Trying to get alkyl radicals and alkenes to link up is kind of like trying to get two introverts at a party to talk to each other. @pushingarrows.bsky.social and crew's clever solution was, basically, to get a carboxyl group to introduce the two and then leave them to it. cen.acs.org/synthesis/ca...
cen.acs.org
Polarity switch enables easier alkylation
Sequential decarboxylation lets chemists attach electron-rich groups to carbon-carbon double bonds
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Bri Barbu @bribarbu.bsky.social · 17/09/2026
Hot people do spreadsheets and organic chemistry confirmed
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Bri Barbu @bribarbu.bsky.social · 15/09/2026
When life gives you limonin, make a pyrrole analogue using an atom swap reaction! And observe how it dramatically changes the molecules' interactions with proteins! Cool new science from @ypark-kaist.bsky.social, lovingly distilled by me for @cenmag.bsky.social : cen.acs.org/synthesis/sk...
cen.acs.org
Skeletal editing can transform molecules’ biological activity
Oxygen-to-nitrogen swap changes a natural product’s mechanism of action
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Bri Barbu @bribarbu.bsky.social · 11/09/2026
Unusual radical species whose applications previously sat largely in the territory of physics have become accessible to bench chemists!
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Bri Barbu @bribarbu.bsky.social · 10/09/2026
Synthetic chemists deserve to use whatever radicals they want! cen.acs.org/synthesis/fi...
cen.acs.org
Finally, chemists wrangle the hydrogen radical in synthesis
‘This tiny, beautiful element,’ now accessible with mild conditions, can reduce organic molecules
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Bri Barbu @bribarbu.bsky.social · 08/09/2026
This guy gives "plant milk" a whole new definition.
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Bri Barbu @bribarbu.bsky.social · 03/09/2026
Please enjoy my first attempt at producing a video! s/o to @theanageorgescu.bsky.social for invaluable constructive feedback and not letting me give up on this idea!
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Bri Barbu @bribarbu.bsky.social · 01/09/2026
I still have so many questions about what, exactly, went down at MIT last week but I am glad that it seems like nobody was seriously harmed!
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Bri Barbu @bribarbu.bsky.social · 01/09/2026
Very very cool interactive data story from some of C&EN's finest!
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Reposted by Bri Barbu
Laurel Oldach @laureloldach.bsky.social · 27/08/2026
Pharma journalism focuses a lot on the great new thing - the daraxonrasib, the tirzepatide. But I think it can be useful to look back at the 90% of drug candidates that fail and try to get a handle on why. That's what this story tries to do. /5. cen.acs.org/pharmaceutic...
cen.acs.org
These drug candidates excited researchers 10 years ago. What happened?
Acetyl CoA carboxylase inhibitors have been investigated for treating acne and liver disease, but the discarded candidates show why it’s so hard to make a metabolic medicine
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Bethany Halford @bethanyhalford.bsky.social · 28/08/2026
Curious about the clinical candidates presented in #FirstTimeDisclosures at #ACSFall2026? You can now read my write up for @cenmag.bsky.social. It's mostly molecular structures with bullet points, but there are some notes on things I learned during the talks. #chemsky cen.acs.org/pharmaceutic...
cen.acs.org
13 clinical candidates revealed in Chicago
First-time disclosures session at ACS Fall 2026 debuted compounds designed to treat cancer, acne, urinary tract infections, and more
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 26/08/2026
Researchers at The University of Chicago have developed a new skeletal editing technique that lets chemists create challenging pyrrole compounds from easier-to-assemble isoxazole molecules through an oxygen to-carbon swap. #chemsky 🧪
cen.acs.org
Skeletal editing helps chemists access elusive pyrroles
Oxygen-to-carbon swap expands synthesis options for 5-membered aromatics
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Reposted by Bri Barbu
Bethany Halford @bethanyhalford.bsky.social · 27/08/2026
Anyone who was at the session where this happened at #ACSFall2026, please get in touch. My colleague @laureloldach.bsky.social is working on something for @cenmag.bsky.social Thanks
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Kyle Griffin @kylegriffin1.bsky.social · 25/08/2026
Reminder: Dolly Parton helped fund the Moderna vaccine for COVID.
nytimes.com
Dolly Parton, who helped fund the Moderna vaccine, gets a ‘dose of her own medicine.’ (Published 2021)
The country music star broke into song before she was inoculated, and urged her fans to “get out there and get your shot.”
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Bri Barbu @bribarbu.bsky.social · 25/08/2026
Nixed title: "O no, here comes another atom swap story!" But seriously this is some cool skeletal editng work from @levinchem.bsky.social and squad. Just 3 easy steps to turn an $11/g molecule into a $2300/g one! #chemsky @cenmag.bsky.social cen.acs.org/synthesis/sk...
cen.acs.org
Skeletal editing helps chemists access elusive pyrroles
Oxygen-to-carbon swap expands synthesis options for 5-membered aromatics
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Bri Barbu @bribarbu.bsky.social · 14/08/2026
This was a fun one! Very classic Newscripts. A friend and I have been texting each other pretty much every morning with our multiplet.app daily puzzle times for a couple months now so I am super curious how the #chemsky #chemchat community will find it!
multiplet.app
Multiplet — Daily NMR Spectrum Puzzle
A daily puzzle game inspired by chemistry and NMR spectroscopy. Build a structure whose spectrum matches today's target.
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 13/08/2026
There’s truly nothing like space travel to bring people together. And chemistry plays a pivotal—but perhaps underappreciated—role in mission success. #chemsky 🧪
cen.acs.org
Editorial: Celebrating a chemical renaissance in space
Space is big again. Chemists should jump on the opportunity for exploratory research
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Bri Barbu @bribarbu.bsky.social · 13/08/2026
Making sure that different labs can repeat experiments in catalysis and get the same result is crucial for translating research to applications and building trust in science. And it's an effort that takes the whole community. Read more @cenmag.bsky.social: cen.acs.org/research-int...
cen.acs.org
Chemists join forces to boost reproducibility in catalysis research
Collective effort is key to avoiding reproducibility struggles that have plagued many scientific fields
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Chemjobber @chemjobber.bsky.social · 03/08/2026
TIL the University of Chicago has a Botany Pond It's a shame there isn't a Chemistry Pond, you could have a big open reactor, some stir bars within, whiteboards explaining the chemistry and some condensers recirculating solvent
A greenish pond at the University of ChicagoA sign advertising the Botany Pond at the University of Chicago
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Bethany Halford @bethanyhalford.bsky.social · 30/07/2026
How do you like this Appel? That's my latest rejected headline about new work in which the @gouverneurgroup.bsky.social riffs on the classic Appel reaction to make alkyl fluorides. Read about it in @cenmag.bsky.social #chemsky🧪 cen.acs.org/synthesis/fl...
cen.acs.org
Appel reaction can finally fluorinate
The classic alkyl halide–making reaction can, at long last, be used to generate alkyl fluorides
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 25/07/2026
Chemistry is key to the success of current and future space missions: cen.acs.org/physical-che... #chemsky 🧪
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Bri Barbu @bribarbu.bsky.social · 24/07/2026
It should not be a radical position to say that tomatoes are berries (botanically speaking, if not culturally, they are more berry than stawberries and raspberries). And also that they can lowkey rock in sweet contexts.
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shenvi.bsky.social @shenvi.bsky.social · 19/07/2026
This is just to say I have consumed the ligand that was in the glovebox and which you were probably saving for scale-up Forgive me it didn't even work so scarce and so back-ordered
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 20/07/2026
In a chemistry version of whipping up a delicious dinner from pantry staples, researchers in Korea have found a recipe for forging amide bonds using inexpensive chemicals stocked in nearly any organic laboratory: dichloromethane (DCM) and a basic salt. #chemsky 🧪
cen.acs.org
Dichloromethane was an amide coupling reagent this whole time
Chemists make simple amides using only inexpensive lab chemicals
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Paul Byrne @theplanetaryguy.com · 15/07/2026
Left: Venus, 1 March 1982 Centre: Titan, 14 January 2005 Right: Boston, 15 July 2026
Left: Venus. Centre: Titan. Right: Earth.
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Bri Barbu @bribarbu.bsky.social · 17/07/2026
DCM has been here the whole time...but will its newfound amide-coupling abilities be a game changer? Yet another new thing from me @cenmag.bsky.social : cen.acs.org/synthesis/re...
cen.acs.org
Dichloromethane was an amide coupling reagent this whole time
Chemists make simple amides using only inexpensive lab chemicals
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Bri Barbu @bribarbu.bsky.social · 16/07/2026
Selectively giving an electron to the more reluctant of two possible acceptors is hard. Researchers go around this by indiscriminately reducing both so that reversibility controls the reaction selectivity instead: cen.acs.org/synthesis/re...
cen.acs.org
Flipping photoredox selectivity with indiscriminate electron transfer
Mechanistic hack enables chemists to couple molecules that have mismatched reduction potentials
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 14/07/2026
Setting up a permanent lunar base means thoughtfully considering the life cycle of all materials we send there. Researchers are investigating several different strategies to make a long-term human presence on the moon (or Mars!) sustainable: #chemsky 🧪
cen.acs.org
Reduce, reuse, regolith: Why sustainability matters for a moon base
Reducing, reusing, and recycling materials will be essential for long-term extraterrestrial living
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Bri Barbu @bribarbu.bsky.social · 13/07/2026
🚀Space package launch is a go!🚀 @cenmag.bsky.social's physical sciences team has been working hard on this for over half a year and I'm so excited to finally show it to the world! cen.acs.org/physical-che...
cen.acs.org
To the moon, Mars, and beyond
Chemistry is key to the success of current and future space missions
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Bri Barbu @bribarbu.bsky.social · 06/07/2026
Regardless of your overall feelings about the US's semiquincentennial this past weekend, I am here to tell you that the (nonpartisan) America250 time capsule is genuinely very cool. Engineered by NIST, curated by the Library of Congress, buried in Philly. Read more: cen.acs.org/analytical-c...
cen.acs.org
Can a qubit survive being buried for 250 years?
The chemistry and engineering inside a time capsule built for America's birthday
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Bri Barbu @bribarbu.bsky.social · 24/06/2026
@bethanyhalford.bsky.social followed 3 students' grad school application journeys for @cenmag.bsky.social and...yikes, it's brutal out there. cen.acs.org/education/gr...
cen.acs.org
US chemistry graduate programs scale back
Faced with uncertainty in federal funding and rising costs, chemistry departments are taking fewer students
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Bri Barbu @bribarbu.bsky.social · 24/06/2026
I heard that there's a special place /with clouds of salt particles 57 light-years away... 🩷pink planet club🩷By @fmorningstar.bsky.social cen.acs.org/physical-che...
cen.acs.org
Scientists peek into the Pink Planet’s atmosphere
They find clouds of salt particles and a diversity of gaseous molecules
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Bri Barbu @bribarbu.bsky.social · 23/06/2026
What's going on with the water in the Lincoln Memorial Reflecting Pool? The situation is---well, murky--and many mysteries still remain. @theanageorgescu.bsky.social dauntlessly emailed a bunch of algae experts in search of a smidge of clarity:
cen.acs.org
Why the Reflecting Pool keeps turning green
Nitrogen, phosphorus, sunlight, and stagnant water can combine to create the perfect conditions for algal blooms
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Bri Barbu @bribarbu.bsky.social · 18/06/2026
A new dataset of over 50,000 C-N couplings may bring organic chemistry closer to its "AlphaFold moment"...and away from palladium catalysis! Latest from me @cenmag.bsky.social: cen.acs.org/synthesis/ca...
cen.acs.org
Chemists ran 50,688 reactions to make a huge open dataset
The data will help train AI to predict C–N coupling conditions using cheaper catalysts
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Bri Barbu @bribarbu.bsky.social · 11/06/2026
"Chemists are trained to focus on outcomes that are immediate and measurable: yields, efficiencies, innovations. But neekokaabijigan [generational thinking] invites a different kind of accounting. It asks us to consider what our work carries forward and what it repeats."
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Bethany Halford @bethanyhalford.bsky.social · 09/06/2026
The #WorldCup starts this week. Check out Prachi Patel's feature on the evolution of the football for @cenmag.bsky.social. It's a real kick! cen.acs.org/materials/ho...
cen.acs.org
How soccer ball materials have evolved
All eyes will be <i>on</i> the ball during the FIFA World Cup, but let’s take a peek at the science and engineering that go into footballs
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Bri Barbu @bribarbu.bsky.social · 10/06/2026
Carbon isn't the only element worth paying attention to in CO2! The molecule also has two oxygen atoms. Researchers in Germany came up with a strategy to pop oxygen off of CO2 and transfer it to double bonds in organic molecules. Read more in @cenmag.bsky.social: cen.acs.org/environment/...
cen.acs.org
Carbon dioxide can selectively oxidize alkenes
Iron catalyst plucks oxygen from the molecule at room temperature
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Bri Barbu @bribarbu.bsky.social · 02/06/2026
Sally Ride became the first woman in space at age 32. Meanwhile my big accomplishment today was taking out the trash.
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Bri Barbu @bribarbu.bsky.social · 26/05/2026
Your periodic reminder that plastic recycling is mostly fake and made up by corporations to make consumers feel like they have a sustainable choice where none exists!
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Bri Barbu @bribarbu.bsky.social · 20/05/2026
🚨Weird molecule alert!🚨 Putting oxonium and alcohol groups into the same molecule should be a recipe for self-destruction. Researchers at UC Davis found a way to get them to coexist peacefully with the help of clever 3D geometry and hydrogen bonding. cen.acs.org/synthesis/sy...
cen.acs.org
This molecule lives on the brink of self-destruction
Chemists coax strong electrophile to coexist peacefully with nucleophilic groups
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Reposted by Bri Barbu
C&EN (Chemical & Engineering News) @cenmag.bsky.social · 17/05/2026
Adrian Figg, an Assistant Professor at @virginiatech.bsky.social @vtchemdept.bsky.social and one of C&EN's 2026 Talented Twelve, is constructing polymers to bridge with proteins: cen.acs.org/materials/po... #CENT12 #chemsky 🧪
2026 Talented 12: Adrian Figg
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Danielle Kurtzleben @titonka.bsky.social · 13/05/2026
Inside you are two wolves. One says “I want everyone to read my story.” The other says “oh God everyone is reading my story” and also that wolf is vomiting.
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Bri Barbu @bribarbu.bsky.social · 13/05/2026
Working on @cenmag.bsky.social's Talented 12 package was the highlight of my spring! And now it's online for the world to see and discover all of these amazing early-career scientists!
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Bri Barbu @bribarbu.bsky.social · 12/05/2026
Canvas falling to a cyberattack hit different instructors differently depending on the class size, school size, academic calendar, course format, and many other factors. But chemists are used to creative problem solving! cen.acs.org/education/un...
cen.acs.org
Chemical & Engineering News
Chemical & Engineering News is a weekly news magazine published by the American Chemical Society, providing professional and technical news and analysis in the fields of chemistry and chemical enginee...
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